Details of the Target

General Information of Target

Target ID LDTP07397
Target Name THO complex subunit 7 homolog (THOC7)
Gene Name THOC7
Gene ID 80145
Synonyms
NIF3L1BP1; THO complex subunit 7 homolog; Functional spliceosome-associated protein 24; fSAP24; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1-binding protein 1; hTREX30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQC
EFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYD
ALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQT
LENDEKLSEVEEAQEASMETDPKP
Target Bioclass
Transporter and channel
Family
THOC7 family
Subcellular location
Cytoplasm
Function
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.; The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Uniprot ID
Q6I9Y2
Ensemble ID
ENST00000295899.10
HGNC ID
HGNC:29874

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.68  LDD0402  [1]
BTD
 Probe Info  		C90(1.75)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C90(2.99)  LDD0169  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C38(1.36)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C90(0.00); C60(0.00); C38(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C90(0.00); C60(0.00); C38(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C90(0.00); C60(0.00); C38(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
NHS
 Probe Info  		K159(0.00); K32(0.00)  LDD0010  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C90(0.00); C60(0.00); C38(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C355
 Probe Info  		24.93  LDD2016  [14]
C361
 Probe Info  		17.03  LDD2022  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C90(0.69)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C90(1.12)  LDD2112  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C90(1.03)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C90(1.21)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C90(1.02)  LDD2103  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C90(2.99)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C38(1.36)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C38(1.02)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C38(0.86); C90(0.91)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C38(0.98); C90(1.04)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C38(0.94); C90(0.92)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C38(1.00); C90(1.09)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C38(1.16); C90(0.98)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C38(1.20); C90(0.98)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C38(0.60); C90(0.96)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C38(0.89); C90(0.99)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C38(0.79); C90(0.98)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C38(0.97); C90(0.93)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C38(1.23)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C38(0.79); C90(0.95)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C38(0.90); C90(1.05)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C38(0.88); C90(1.07)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C38(1.00); C90(1.00)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C38(0.99); C90(1.07)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C38(0.93); C90(0.97)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C38(1.06); C90(1.02)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C38(0.85); C90(0.95)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C38(1.00); C90(0.92)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C38(1.10); C90(1.19)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C38(1.08)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C38(1.11); C90(1.05)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C38(0.95); C90(0.75)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C38(1.13); C90(0.98)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C38(0.98); C90(0.82)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C38(1.19); C90(0.91)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C38(1.34); C90(0.99)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C38(1.12); C90(0.99)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C38(1.14); C90(0.89)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C38(0.98); C60(1.11)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C38(1.08); C60(1.38)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C38(1.15); C60(1.33)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C38(0.98); C60(1.11)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C38(0.87); C60(1.16)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C38(1.08); C60(1.25)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C38(0.98); C60(1.22)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C38(0.78); C60(0.86)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C38(0.96); C60(0.91)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C38(0.88); C60(1.01)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C38(0.71); C60(0.72)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C38(0.79); C60(0.85)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C38(1.22)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C38(0.92); C60(0.96)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C38(0.94); C60(1.05)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C38(1.04); C60(1.20)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C38(0.97); C90(1.32)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C38(0.82); C90(1.21)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C38(0.83); C90(0.94)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C38(0.74); C90(1.31)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C38(1.02); C90(1.48)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C38(0.86); C90(1.95)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C38(0.73); C90(1.40)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C38(1.13)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C38(0.84); C90(1.13)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C38(0.76); C90(1.07)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C38(0.85); C90(1.22)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C38(0.95); C90(1.91)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C38(0.90); C90(1.45)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C38(0.81); C90(1.40)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C38(0.81); C90(1.11)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C38(0.77); C90(0.82)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C38(0.91); C90(0.98)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C90(0.85); C38(0.86)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C38(0.73); C90(0.88)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C38(1.18)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C38(0.84); C90(0.96)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C90(0.87); C38(0.93)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C90(0.82); C38(0.85)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C90(0.76); C38(0.78)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C38(0.80); C90(0.92)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C60(0.89); C38(1.30)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C60(0.80); C38(1.17)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C60(0.94); C38(1.60)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C60(0.98); C38(1.89)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C60(0.85); C38(0.88)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C38(1.39)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C60(0.80); C38(0.90)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C60(0.93); C38(1.19)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C38(0.84); C60(0.86)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C60(0.86); C38(1.18)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C60(0.82); C38(1.36)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C38(1.02)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C38(1.01)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C38(1.06)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C38(0.93)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C38(0.92)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C38(1.37)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C38(0.88)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C38(1.01)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C38(0.90)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C38(0.82)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C38(1.06)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C38(1.39)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C38(0.82)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C38(0.86)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C38(1.26)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C38(0.67)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C38(1.31)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C38(0.83)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C38(0.75)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C38(0.78)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C38(0.78)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C38(0.92)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C38(1.06)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C38(0.71)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C38(0.95); C60(1.10)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C38(0.83); C60(1.13)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C38(0.94); C60(1.01)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C38(0.88)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C38(0.94); C60(1.13)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C38(1.00); C60(1.04)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C38(0.89); C60(1.30)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C60(0.97); C38(1.04)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C38(0.91); C60(1.20)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C38(0.73); C60(0.93)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C38(0.76); C60(0.99)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C38(0.73); C60(1.08)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C60(1.14); C38(1.36)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C60(1.15); C38(1.51)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C38(0.99)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C38(1.05); C60(1.29)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C60(1.21); C38(1.49)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C60(1.08); C38(1.47)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C38(1.36); C60(1.62)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C60(1.51); C38(1.56)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C38(1.34); C60(1.74)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C60(1.12); C38(1.24)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C60(1.26); C38(1.35)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C60(1.14); C38(1.37)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C60(1.13); C38(1.16)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C38(1.09)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C60(1.32); C38(1.45)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C60(1.32); C38(1.51)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C38(1.32); C60(1.97)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C38(0.72); C90(1.04)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C38(0.68); C90(0.97)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C38(0.67); C90(1.00)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C38(0.82); C90(1.10)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C38(0.91); C90(0.97)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C38(0.73); C90(0.94)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C38(0.80); C90(1.10)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C90(0.96); C38(0.98)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C38(0.69); C90(1.02)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C38(0.81); C90(1.00)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C38(0.71); C90(0.96)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C38(0.67); C90(1.21)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C38(0.84); C90(0.91)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C38(0.82); C90(0.84)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C38(0.79); C90(1.06)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C38(0.97); C90(1.19)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C90(1.09); C38(1.09)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C90(0.34)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C38(1.45)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C38(1.03)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C38(1.01)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C60(1.23); C90(1.19)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C38(1.10)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C38(1.01)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C38(1.19)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C38(1.06)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C38(1.11)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C38(1.21)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C38(1.01)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C90(0.86); C38(0.88)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C90(0.76); C38(0.91)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C90(0.75); C38(0.89)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C90(0.82); C38(0.97)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C38(0.79); C90(0.96)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C38(1.01)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C38(0.71); C90(0.93)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C38(0.74); C90(0.84)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C60(0.83); C38(1.28)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C60(0.81); C38(1.04)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C60(0.77); C38(1.10)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C60(0.85); C38(1.20)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C60(0.81); C38(1.86)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C38(1.05)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C38(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C38(0.87)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C38(0.94)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C38(0.90)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C38(0.95)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C38(0.85)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C38(0.74)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C38(0.80)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C38(0.88); C60(0.97)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C38(0.86); C60(0.91)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C60(0.84); C38(0.87)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C38(0.82); C60(1.02)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C38(1.05)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C38(0.89)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C38(1.10)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C38(1.14)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C38(0.94)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C38(1.00)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C38(0.94)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C38(0.98)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C38(0.94)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C38(0.90)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C38(1.09)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C38(0.85)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C38(0.80)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C38(0.78)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C38(1.12)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C38(0.91)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C38(0.92)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C38(0.73)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C38(1.05)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C38(0.91)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C38(0.84); C60(1.02); C90(0.85)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C38(1.05); C60(1.12); C90(0.86)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C38(0.88); C60(0.98); C90(0.90)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C38(1.00); C60(1.16); C90(0.94)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C38(1.10); C60(1.00); C90(0.93)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C38(1.04); C60(1.04); C90(1.02)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C38(1.09); C60(1.03); C90(1.05)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C38(1.17); C60(1.16); C90(0.85)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C38(0.88)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C38(0.90); C60(1.07); C90(0.80)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C38(1.10); C60(1.05); C90(0.97)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C38(0.98); C60(1.44); C90(0.80)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C38(1.05); C60(1.31); C90(0.74)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C38(1.13); C60(1.13); C90(0.82)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C38(1.16); C60(1.37); C90(0.91)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C38(0.53)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C38(0.58)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C38(0.62)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C38(0.75)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C38(1.13)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C38(0.79)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C38(0.68)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C38(0.65)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C38(0.90)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C38(0.59)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C38(0.96)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C38(0.58)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C38(0.71)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C38(0.89)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C38(0.82)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C38(1.02)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C38(0.65)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C38(0.87)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C38(1.05)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C38(1.00)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C38(1.04)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C38(1.03)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C38(0.84)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C38(0.95)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C38(0.87)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C38(0.81)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C38(1.16)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C38(0.91)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C38(0.93)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C38(1.07)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C38(0.82)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C38(0.88)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C38(0.75)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C38(0.67)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C38(0.95)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C38(0.69)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C38(1.03)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C38(1.17)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C38(0.96)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C38(0.81)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C38(0.93)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C38(1.03)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C38(0.90)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C38(1.26)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C38(1.05)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C38(1.12)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C38(1.01)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C38(0.86)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C38(0.73)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C38(1.09)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C38(1.26)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C38(1.24)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C38(1.18)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C38(1.14)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C38(1.12)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C38(1.32)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C38(1.27)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C38(1.15)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C90(1.06)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C90(0.91); C38(1.07); C60(1.17)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C90(1.21)  LDD1702  [2]
 LDCM0625  F8 Ramos C60(0.85); C90(2.22); C38(0.73)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C60(0.97); C90(0.85); C38(0.36)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C60(0.34); C90(0.41); C38(0.87)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C60(1.01); C90(0.64); C38(0.42)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C60(1.15); C90(0.69)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C60(1.25); C90(1.10); C38(0.70)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C60(0.89); C90(0.62); C38(0.33)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C60(0.93); C90(1.09); C38(0.48)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C60(0.98); C90(0.99); C38(0.65)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C60(0.90); C90(2.01); C38(0.78)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C60(1.07); C90(0.69)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C60(0.89); C90(0.96); C38(0.67)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C60(1.28); C90(1.10)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C60(0.72); C90(1.10); C38(0.45)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C38(0.96)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C60(0.79); C90(0.80); C38(0.27)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C60(0.92); C90(0.88); C38(0.63)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C38(0.85); C60(1.28); C90(0.70)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C60(0.85); C90(0.43); C38(0.64)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C60(0.63); C90(0.94); C38(0.51)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C60(0.79); C90(0.86); C38(0.52)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C60(1.00); C90(0.45); C38(0.40)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C38(0.99); C90(0.91); C60(1.02)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C38(0.91); C90(0.94); C60(0.88)  LDD1497  [15]
 LDCM0024  KB05 G361 C38(2.06)  LDD3311  [17]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C90(1.31)  LDD2102  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C90(1.17)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C90(1.03)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C90(1.18)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C90(1.49)  LDD2094  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C90(1.37)  LDD2096  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C90(1.16)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C90(0.88)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C90(0.86)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C90(0.50)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C90(0.84)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C90(1.32)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C90(0.67)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C90(1.03)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C90(0.75)  LDD2108  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C90(1.73)  LDD2110  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C90(1.04)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C90(0.62)  LDD2114  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C90(1.10)  LDD2118  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C90(0.72)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C90(1.29)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C90(0.88)  LDD2123  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C90(1.07)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C90(0.87)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C90(1.10)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C90(0.93)  LDD2127  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C90(0.78)  LDD2128  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C90(0.98)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C90(0.95)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C90(0.86)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C90(0.81)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C90(1.75)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C90(0.84)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C90(0.89)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C90(1.01)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C90(3.02)  LDD2144  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C90(5.32)  LDD2145  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C90(1.21)  LDD2146  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C90(1.55)  LDD2147  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C90(1.39)  LDD2149  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C90(1.62)  LDD2151  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C90(1.89)  LDD2153  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C60(0.87); C90(0.71)  LDD2207  [18]
 LDCM0131  RA190 MM1.R C38(2.38); C60(1.78); C90(1.27)  LDD0304  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THO complex subunit 5 homolog (THOC5) THOC5 family Q13769
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Meiosis-specific nuclear structural protein 1 (MNS1) MNS1 family Q8NEH6
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.