Details of the Target

General Information of Target

Target ID LDTP16730
Target Name Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L)
Gene Name RABGAP1L
Gene ID 9910
Synonyms
HHL; KIAA0471; Rab GTPase-activating protein 1-like, isoform 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKL
GKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSCHKPKAIVHTE
KVNMMSLTVLGLRMLFAKTVAVNFLLTAKLFFL
Target Bioclass
Other
Uniprot ID
B7ZAP0
Ensemble ID
ENST00000367688.3
HGNC ID
HGNC:24663

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C139(2.59); C202(3.61)  LDD3310  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
AOyne
 Probe Info  		11.50  LDD0443  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C355
 Probe Info  		28.44  LDD2016  [4]
C361
 Probe Info  		19.70  LDD2022  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C139(1.72)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C139(1.89)  LDD2661  [1]
 LDCM0024  KB05 COLO792 C139(2.59); C202(3.61)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587