Details of the Target

General Information of Target

Target ID LDTP13938
Target Name Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6)
Gene Name COQ6
Gene ID 51004
Synonyms
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; EC 1.14.13.-; Coenzyme Q10 monooxygenase 6
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIE
LPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLG
DPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQ
HLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRV
QLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPF
ELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGR
EGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIP
DGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL
Target Bioclass
Enzyme
Family
UbiH/COQ6 family
Subcellular location
Mitochondrion inner membrane
Function
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown. {|HAMAP-Rule:MF_03193}.
Uniprot ID
Q9Y2Z9
Ensemble ID
ENST00000334571.7
HGNC ID
HGNC:20233

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.Q249Ter .
DOTC24510 SNV: p.M110I .
HCT15 SNV: p.Y56H; p.A310D .
HUH7 SNV: p.M1? .
JHH7 SNV: p.S407R .
NCIH2170 SNV: p.F60C .
SNU308 SNV: p.N294T .
WM793 SNV: p.G349R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.95  LDD0402  [1]
DBIA
 Probe Info  		C99(1.04)  LDD3352  [2]
Curcusone 37
 Probe Info  		2.54  LDD0188  [3]
IA-alkyne
 Probe Info  		C108(0.00); C178(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
AOyne
 Probe Info  		12.40  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C361
 Probe Info  		33.36  LDD2022  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C178(1.08)  LDD1507  [7]
 LDCM0215  AC10 PaTu 8988t C108(0.37)  LDD1094  [8]
 LDCM0226  AC11 PaTu 8988t C108(0.56)  LDD1105  [8]
 LDCM0237  AC12 PaTu 8988t C108(0.63)  LDD1116  [8]
 LDCM0259  AC14 PaTu 8988t C108(0.69)  LDD1138  [8]
 LDCM0270  AC15 PaTu 8988t C108(0.63)  LDD1149  [8]
 LDCM0276  AC17 HEK-293T C178(1.00)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C108(0.96); C178(0.89); C124(1.00)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C108(0.98); C178(0.73); C124(0.87)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C108(1.08); C178(0.94); C124(1.09)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C108(1.17); C178(1.01); C124(1.09)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C178(1.00)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C108(0.96); C178(1.04); C124(1.00)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C108(1.05); C178(1.02); C124(1.00)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C108(0.96); C178(1.01); C124(1.15)  LDD1523  [7]
 LDCM0285  AC25 PaTu 8988t C108(1.06)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C108(1.00)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C108(1.05)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C108(1.09)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C108(0.69)  LDD1168  [8]
 LDCM0290  AC3 HEK-293T C108(1.13); C178(0.92); C124(1.07)  LDD1529  [7]
 LDCM0291  AC30 PaTu 8988t C108(1.17)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C108(0.97)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C108(1.14)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C108(0.91)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C108(0.65)  LDD1174  [8]
 LDCM0296  AC35 HEK-293T C108(1.15); C178(1.01); C124(1.03)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C108(1.09); C178(1.10); C124(1.08)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C178(0.96)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C108(0.77); C178(0.99); C124(1.01)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C108(1.20); C178(1.07); C124(1.21)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C108(1.16); C178(1.16); C124(1.12)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C108(0.93); C178(1.08); C124(1.12)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C178(0.98)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C108(1.10); C178(1.00); C124(0.96)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C108(1.02); C178(0.95); C124(0.99)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C108(1.31); C178(1.01); C124(1.06)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C178(0.94)  LDD1546  [7]
 LDCM0308  AC46 PaTu 8988t C108(1.06)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C108(0.91)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C108(0.76)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C108(0.80)  LDD1190  [8]
 LDCM0312  AC5 HEK-293T C178(0.97)  LDD1551  [7]
 LDCM0313  AC50 PaTu 8988t C108(0.51)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C108(0.39)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C108(0.80)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C108(0.84)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C108(0.69)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C108(0.82)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C108(0.89)  LDD1198  [8]
 LDCM0320  AC57 HEK-293T C178(0.92)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C108(1.11); C178(0.87); C124(1.14)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C108(1.12); C178(0.87); C124(1.08)  LDD1561  [7]
 LDCM0323  AC6 PaTu 8988t C108(0.49)  LDD1202  [8]
 LDCM0324  AC60 HEK-293T C108(1.10); C178(1.19); C124(1.06)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C178(0.97)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C108(0.78); C178(0.90); C124(1.13)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C108(1.18); C178(0.93); C124(1.02)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C108(1.02); C178(0.89); C124(0.98)  LDD1567  [7]
 LDCM0334  AC7 PaTu 8988t C108(0.58)  LDD1213  [8]
 LDCM0345  AC8 PaTu 8988t C108(0.47)  LDD1224  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C108(0.65)  LDD1127  [8]
 LDCM0356  AKOS034007680 PaTu 8988t C108(0.79)  LDD1235  [8]
 LDCM0275  AKOS034007705 PaTu 8988t C108(0.52)  LDD1154  [8]
 LDCM0367  CL1 HEK-293T C108(1.11); C178(0.98)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C108(1.18); C178(1.34); C124(1.19)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C108(0.98); C178(0.97); C124(0.75)  LDD1573  [7]
 LDCM0370  CL101 PaTu 8988t C108(0.55)  LDD1249  [8]
 LDCM0371  CL102 PaTu 8988t C108(0.35)  LDD1250  [8]
 LDCM0372  CL103 PaTu 8988t C108(0.47)  LDD1251  [8]
 LDCM0373  CL104 PaTu 8988t C108(0.82)  LDD1252  [8]
 LDCM0374  CL105 HEK-293T C108(1.02); C178(0.93)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C108(1.10); C178(1.01); C124(1.00)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C108(1.03); C178(1.03)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C108(1.01); C178(0.90); C124(0.98)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C108(0.66); C178(0.95)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C108(1.17); C178(1.30); C124(1.28)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C108(1.08); C178(0.99); C124(1.09)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C108(0.90); C178(1.09)  LDD1585  [7]
 LDCM0382  CL112 PaTu 8988t C108(0.92)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C108(1.31)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C108(1.12)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C108(0.90)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C108(0.71)  LDD1265  [8]
 LDCM0387  CL117 HEK-293T C108(1.12); C178(0.98)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C108(1.02); C178(0.91); C124(1.18)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C108(1.00); C178(0.98)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C108(1.03); C178(1.22); C124(1.52)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C108(1.06); C178(1.03); C124(0.93)  LDD1595  [7]
 LDCM0392  CL121 PaTu 8988t C108(0.78)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C108(1.02)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C108(0.87)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C108(1.04)  LDD1274  [8]
 LDCM0396  CL125 HEK-293T C108(1.06); C178(0.68)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C108(0.89); C178(0.78); C124(1.13)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C108(0.87); C178(0.85)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C108(1.14); C178(0.83); C124(1.03)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C108(0.97); C178(0.87)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C108(1.11); C178(0.98); C124(1.33)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C108(0.81); C178(1.04)  LDD1606  [7]
 LDCM0403  CL16 PaTu 8988t C108(0.88)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C108(0.83)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C108(0.88)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C108(0.87)  LDD1285  [8]
 LDCM0407  CL2 HEK-293T C108(0.95); C178(0.97); C124(1.05)  LDD1611  [7]
 LDCM0408  CL20 PaTu 8988t C108(1.02)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C108(0.90)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C108(1.06)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C108(0.72)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C108(1.05)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C108(1.76)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C108(0.88)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C108(1.57)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C108(0.83)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C108(0.88)  LDD1296  [8]
 LDCM0418  CL3 HEK-293T C108(0.96); C178(1.26)  LDD1622  [7]
 LDCM0419  CL30 PaTu 8988t C108(0.96)  LDD1298  [8]
 LDCM0420  CL31 HEK-293T C108(0.88); C178(0.84); C124(1.02)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C108(1.07); C178(0.98); C124(0.73)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C178(1.09)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C108(0.85); C178(1.01); C124(0.53)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C108(1.24); C178(1.04); C124(0.95)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C108(1.05); C178(0.98); C124(1.17)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C108(0.91); C178(0.92)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C108(0.95); C178(1.12)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C108(1.02); C178(0.88); C124(1.28)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C108(1.06); C178(1.09); C124(1.08)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C178(1.04)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C108(1.06); C178(0.85); C124(1.09)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C108(1.13); C178(0.93); C124(1.12)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C108(1.17); C178(1.00); C124(1.01)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C178(1.09)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C108(0.81); C178(1.06); C124(1.04)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C108(1.17); C178(1.12); C124(1.14)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C108(0.86); C178(1.00); C124(1.26)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C108(0.97); C178(0.78)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C178(0.91)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C108(1.02); C178(0.97); C124(1.14)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C108(1.01); C178(0.97); C124(0.94)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C178(1.03)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C108(0.94); C178(0.92); C124(1.01)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C108(1.07); C178(0.99); C124(1.21)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C108(1.11); C178(0.90); C124(0.87)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C178(0.99)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C108(1.04); C178(0.97); C124(0.67)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C108(1.15); C178(1.04); C124(1.08)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C108(0.98); C178(0.85); C124(1.18)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C108(0.91); C178(1.02); C124(1.41)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C108(1.04); C178(0.93)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C108(1.08); C178(1.08); C124(1.04)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C108(0.93); C178(1.01)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C108(0.98); C178(1.04); C124(0.99)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C178(0.99)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C108(1.02); C178(0.96); C124(1.05)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C108(1.12); C178(0.95); C124(1.13)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C108(1.22); C178(1.05); C124(0.95)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C178(0.96)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C108(1.01); C178(0.97); C124(1.17)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C108(0.80); C178(1.03); C124(0.83)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C108(0.95); C178(1.02); C124(1.03)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C108(0.82); C178(1.01); C124(1.29)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C108(1.02); C178(0.86)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C108(1.12); C178(0.92); C124(1.12)  LDD1670  [7]
 LDCM0469  CL76 PaTu 8988t C108(1.29)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C108(1.64)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C108(1.26)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C108(1.41)  LDD1351  [8]
 LDCM0473  CL8 HEK-293T C108(0.89); C178(0.92); C124(1.19)  LDD1676  [7]
 LDCM0474  CL80 PaTu 8988t C108(1.24)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C108(1.55)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C108(1.76)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C108(1.26)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C108(1.71)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C108(1.71)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C108(1.64)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C108(2.48)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C108(1.37)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C108(2.27)  LDD1362  [8]
 LDCM0484  CL9 HEK-293T C178(1.03)  LDD1687  [7]
 LDCM0485  CL90 PaTu 8988t C108(1.42)  LDD1364  [8]
 LDCM0486  CL91 HEK-293T C108(0.95); C178(0.65); C124(1.11)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C108(1.10); C178(0.83); C124(1.11)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C178(0.99)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C108(0.95); C178(1.17); C124(0.90)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C108(0.97); C178(0.98); C124(0.96)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C108(1.02); C178(0.78); C124(1.02)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C108(1.06); C178(0.90)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C108(0.92); C178(1.08); C124(0.92)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C108(0.83); C178(1.20)  LDD1697  [7]
 LDCM0033  Curcusone1d MCF-7 2.54  LDD0188  [3]
 LDCM0495  E2913 HEK-293T C108(0.94); C178(1.33)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C108(0.95); C178(0.91)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C108(1.07); C178(1.02); C124(1.12)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C108(1.16); C178(1.01); C124(0.97)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C108(1.02); C178(0.81); C124(0.93)  LDD1497  [7]
 LDCM0024  KB05 NCI-H1975 C99(1.04)  LDD3352  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) MenG/UbiE family Q5HYK3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3) UbiG/COQ3 family Q9NZJ6
5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7) COQ7 family Q99807
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (COQ4) COQ4 family Q9Y3A0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.