Details of the Target

General Information of Target

Target ID LDTP09850
Target Name Proline-rich protein PRCC (PRCC)
Gene Name PRCC
Gene ID 5546
Synonyms
TPRC; Proline-rich protein PRCC; Papillary renal cell carcinoma translocation-associated gene protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Target Bioclass
Other
Subcellular location
Nucleus
Function May regulate cell cycle progression through interaction with MAD2L2.
Uniprot ID
Q92733
Ensemble ID
ENST00000271526.9
HGNC ID
HGNC:9343

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K454(5.26)  LDD0277  [1]
HHS-465
 Probe Info  		Y459(10.00)  LDD2237  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.06  LDD1740  [5]
C041
 Probe Info  		6.28  LDD1741  [5]
C106
 Probe Info  		19.97  LDD1793  [5]
C108
 Probe Info  		8.75  LDD1795  [5]
C187
 Probe Info  		18.64  LDD1865  [5]
C191
 Probe Info  		20.39  LDD1868  [5]
C193
 Probe Info  		5.46  LDD1869  [5]
C249
 Probe Info  		12.47  LDD1922  [5]
C348
 Probe Info  		13.18  LDD2009  [5]
C349
 Probe Info  		8.94  LDD2010  [5]
C353
 Probe Info  		6.77  LDD2014  [5]
C354
 Probe Info  		7.41  LDD2015  [5]
C355
 Probe Info  		24.76  LDD2016  [5]
C361
 Probe Info  		25.99  LDD2022  [5]
C391
 Probe Info  		14.03  LDD2050  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587