Details of the Target

General Information of Target

Target ID LDTP12720
Target Name Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14)
Gene Name FKBP14
Gene ID 55033
Synonyms
FKBP22; Peptidyl-prolyl cis-trans isomerase FKBP14; PPIase FKBP14; EC 5.2.1.8; 22 kDa FK506-binding protein; 22 kDa FKBP; FKBP-22; FK506-binding protein 14; FKBP-14; Rotamase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHI
GGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGV
ACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRI
RNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFM
RVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEP
RGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRL
GIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERY
GHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRG
SYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREA
ARLIEMYRDLFQQGT
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum lumen
Function
PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens.
Uniprot ID
Q9NWM8
Ensemble ID
ENST00000222803.10
HGNC ID
HGNC:18625
ChEMBL ID
CHEMBL2342

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y52(0.69)  LDD0264  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
SF
 Probe Info  		N.A.  LDD0028  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]
HHS-465
 Probe Info  		K113(0.00); Y52(0.00); Y111(0.00)  LDD2240  [5]
PAL-AfBPP Probe
Click To Hide/Show 99 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.87  LDD1714  [6]
C017
 Probe Info  		20.53  LDD1725  [6]
C022
 Probe Info  		10.56  LDD1728  [6]
C053
 Probe Info  		7.78  LDD1751  [6]
C055
 Probe Info  		20.39  LDD1752  [6]
C056
 Probe Info  		23.92  LDD1753  [6]
C063
 Probe Info  		14.12  LDD1760  [6]
C070
 Probe Info  		10.78  LDD1766  [6]
C072
 Probe Info  		7.41  LDD1768  [6]
C087
 Probe Info  		15.14  LDD1779  [6]
C091
 Probe Info  		12.13  LDD1782  [6]
C092
 Probe Info  		25.99  LDD1783  [6]
C106
 Probe Info  		24.93  LDD1793  [6]
C108
 Probe Info  		11.55  LDD1795  [6]
C112
 Probe Info  		28.25  LDD1799  [6]
C131
 Probe Info  		10.63  LDD1813  [6]
C134
 Probe Info  		33.36  LDD1816  [6]
C135
 Probe Info  		11.47  LDD1817  [6]
C138
 Probe Info  		9.92  LDD1820  [6]
C139
 Probe Info  		15.56  LDD1821  [6]
C140
 Probe Info  		8.34  LDD1822  [6]
C143
 Probe Info  		17.27  LDD1825  [6]
C158
 Probe Info  		25.81  LDD1838  [6]
C159
 Probe Info  		8.51  LDD1839  [6]
C160
 Probe Info  		27.47  LDD1840  [6]
C161
 Probe Info  		24.59  LDD1841  [6]
C163
 Probe Info  		5.62  LDD1843  [6]
C166
 Probe Info  		9.45  LDD1846  [6]
C169
 Probe Info  		29.86  LDD1849  [6]
C174
 Probe Info  		4.92  LDD1854  [6]
C178
 Probe Info  		17.15  LDD1857  [6]
C183
 Probe Info  		5.03  LDD1861  [6]
C186
 Probe Info  		11.00  LDD1864  [6]
C191
 Probe Info  		13.45  LDD1868  [6]
C194
 Probe Info  		17.75  LDD1870  [6]
C196
 Probe Info  		12.73  LDD1872  [6]
C197
 Probe Info  		4.96  LDD1873  [6]
C198
 Probe Info  		11.31  LDD1874  [6]
C201
 Probe Info  		26.17  LDD1877  [6]
C210
 Probe Info  		56.49  LDD1884  [6]
C213
 Probe Info  		17.15  LDD1887  [6]
C214
 Probe Info  		6.28  LDD1888  [6]
C218
 Probe Info  		11.55  LDD1892  [6]
C220
 Probe Info  		29.04  LDD1894  [6]
C225
 Probe Info  		8.17  LDD1898  [6]
C228
 Probe Info  		25.46  LDD1901  [6]
C231
 Probe Info  		11.71  LDD1904  [6]
C232
 Probe Info  		75.06  LDD1905  [6]
C234
 Probe Info  		5.62  LDD1907  [6]
C238
 Probe Info  		13.83  LDD1911  [6]
C243
 Probe Info  		23.92  LDD1916  [6]
C244
 Probe Info  		18.25  LDD1917  [6]
C246
 Probe Info  		13.93  LDD1919  [6]
C249
 Probe Info  		13.00  LDD1922  [6]
C252
 Probe Info  		8.69  LDD1925  [6]
C282
 Probe Info  		14.22  LDD1952  [6]
C285
 Probe Info  		20.82  LDD1955  [6]
C288
 Probe Info  		14.93  LDD1958  [6]
C289
 Probe Info  		46.53  LDD1959  [6]
C293
 Probe Info  		18.00  LDD1963  [6]
C299
 Probe Info  		6.92  LDD1968  [6]
C305
 Probe Info  		11.00  LDD1974  [6]
C313
 Probe Info  		20.11  LDD1980  [6]
C314
 Probe Info  		15.67  LDD1981  [6]
C317
 Probe Info  		8.82  LDD1983  [6]
C338
 Probe Info  		38.05  LDD2001  [6]
C339
 Probe Info  		7.52  LDD2002  [6]
C348
 Probe Info  		31.34  LDD2009  [6]
C349
 Probe Info  		11.79  LDD2010  [6]
C350
 Probe Info  		35.75  LDD2011  [6]
C353
 Probe Info  		6.50  LDD2014  [6]
C354
 Probe Info  		12.64  LDD2015  [6]
C355
 Probe Info  		22.47  LDD2016  [6]
C357
 Probe Info  		5.10  LDD2018  [6]
C361
 Probe Info  		19.97  LDD2022  [6]
C362
 Probe Info  		37.27  LDD2023  [6]
C363
 Probe Info  		16.56  LDD2024  [6]
C364
 Probe Info  		19.03  LDD2025  [6]
C366
 Probe Info  		10.27  LDD2027  [6]
C373
 Probe Info  		5.74  LDD2033  [6]
C376
 Probe Info  		6.63  LDD2036  [6]
C380
 Probe Info  		6.06  LDD2039  [6]
C382
 Probe Info  		14.83  LDD2041  [6]
C383
 Probe Info  		16.34  LDD2042  [6]
C386
 Probe Info  		6.73  LDD2045  [6]
C388
 Probe Info  		77.71  LDD2047  [6]
C389
 Probe Info  		5.94  LDD2048  [6]
C390
 Probe Info  		20.97  LDD2049  [6]
C391
 Probe Info  		32.45  LDD2050  [6]
C403
 Probe Info  		19.84  LDD2061  [6]
C407
 Probe Info  		27.28  LDD2064  [6]
C409
 Probe Info  		5.13  LDD2066  [6]
C420
 Probe Info  		17.75  LDD2075  [6]
C429
 Probe Info  		14.22  LDD2084  [6]
C431
 Probe Info  		25.81  LDD2086  [6]
C433
 Probe Info  		7.31  LDD2088  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe2
 Probe Info  		20.00  LDD0463  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y52(0.69)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y52(0.84)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y52(0.23)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y52(0.14)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y52(0.52)  LDD0268  [1]

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.