Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C386  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 96 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 42.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 41.4
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 31.1
 LDTP02837  Beta-galactosidase (GLB1) 30.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 30.1
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 26.0
 LDTP05905  Acid ceramidase (ASAH1) 25.8
 LDTP01769  Dihydrofolate reductase (DHFR) 23.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.5
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 18.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 18.1
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 18.0
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 17.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.3
 LDTP00697  Cytochrome b5 type B (CYB5B) 16.1
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 15.7
 LDTP12163  Calcyclin-binding protein (CACYBP) 15.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 15.3
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 15.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 14.9
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 14.2
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 14.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 13.7
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 13.6
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 13.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 13.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 12.6
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 12.6
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 12.2
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 12.0
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 11.8
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 11.8
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 11.7
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 11.6
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 11.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 10.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 10.4
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 10.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 9.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 9.8
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 9.6
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 9.6
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 9.5
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 9.3
 LDTP12386  Polyamine-transporting ATPase 13A2 (ATP13A2) 9.3
 LDTP10329  Ceramide synthase 2 (CERS2) 9.2
 LDTP02359  Heme oxygenase 1 (HMOX1) 9.2
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 9.1
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 9.0
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 8.8
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 8.8
 LDTP02505  Lysosomal protective protein (CTSA) 8.8
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 8.6
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 8.6
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 8.6
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 8.3
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 8.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 8.3
 LDTP03394  Ceramide synthase 1 (CERS1) 8.2
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 8.1
 LDTP03787  Choline kinase alpha (CHKA) 8.1
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) 8.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 8.1
 LDTP02141  Alpha-galactosidase A (GLA) 7.9
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 7.8
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 7.7
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 7.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 7.4
 LDTP04519  Kinesin-like protein KIF11 (KIF11) 7.4
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 7.4
 LDTP01018  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) 7.3
 LDTP01329  Lathosterol oxidase (SC5D) 7.2
 LDTP02539  Lysosomal acid phosphatase (ACP2) 7.2
 LDTP00316  Ribonuclease T2 (RNASET2) 7.2
 LDTP04542  Thimet oligopeptidase (THOP1) 7.2
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 7.1
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 7.1
 LDTP11127  ADP-dependent glucokinase (ADPGK) 7.1
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 7.1
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 7.1
 LDTP00415  Acyl-coenzyme A thioesterase 8 (ACOT8) 7.0
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 7.0
 LDTP01803  Adenosine deaminase (ADA) 7.0
 LDTP11199  DCN1-like protein 5 (DCUN1D5) 7.0
 LDTP01004  Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) 7.0
 LDTP15758  ADP-ribosylation factor-like protein 5B (ARL5B) 6.9
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 6.9
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 6.8
 LDTP04884  Proteasome subunit alpha type-6 (PSMA6) 6.8
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 6.8
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 6.7
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 6.7
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 6.6
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 6.5
Transporter and channel
Click to Show/Hide to Show 47 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 45.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 44.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 37.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 29.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 29.2
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 28.6
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 26.4
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 17.1
 LDTP07236  Protein GPR107 (GPR107) 15.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 14.6
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 14.2
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 13.6
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 13.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 13.3
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 12.9
 LDTP00970  Gasdermin-E (GSDME) 12.3
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 12.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.0
 LDTP11615  Protein tweety homolog 3 (TTYH3) 11.7
 LDTP16813  Tetraspanin-3 (TSPAN3) 11.6
 LDTP05900  Metaxin-1 (MTX1) 11.6
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 11.3
 LDTP02215  Prosaposin (PSAP) 10.9
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 10.3
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 10.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 10.0
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 9.6
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.3
 LDTP00592  Surfeit locus protein 4 (SURF4) 9.3
 LDTP15948  Transmembrane protein 126A (TMEM126A) 9.1
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 8.9
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 8.9
 LDTP01804  ATP synthase subunit a (MT-ATP6) 8.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 8.1
 LDTP11406  Transmembrane protein 59 (TMEM59) 8.0
 LDTP12636  Lysosomal cobalamin transport escort protein LMBD1 (LMBRD1) 7.7
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 7.7
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 7.7
 LDTP11213  Nucleoporin NDC1 (NDC1) 7.7
 LDTP15648  BRI3-binding protein (BRI3BP) 7.6
 LDTP10073  Protein RFT1 homolog (RFT1) 7.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 7.4
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 7.0
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 6.9
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 6.8
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 6.5
 LDTP04502  Importin subunit alpha-5 (KPNA1) 6.5
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 7.0
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03538  HLA class I histocompatibility antigen, alpha chain F (HLA-F) 17.4
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 6.8
Other
Click to Show/Hide to Show 63 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 83.3
 LDTP05160  Nucleobindin-2 (NUCB2) 36.5
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 33.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 31.8
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 24.3
 LDTP11076  Apolipoprotein L2 (APOL2) 21.6
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 19.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 18.3
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 15.6
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 15.6
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 14.4
 LDTP14939  Membralin (TMEM259) 14.4
 LDTP14458  Tetraspanin-6 (TSPAN6) 13.5
 LDTP05375  Nucleobindin-1 (NUCB1) 13.5
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 13.2
 LDTP16006  Optic atrophy 3 protein (OPA3) 12.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.3
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 12.2
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 11.8
 LDTP13630  Neudesin (NENF) 11.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 10.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.4
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 10.4
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 10.3
 LDTP01522  Reticulon-3 (RTN3) 9.8
 LDTP18883  Protein CEBPZOS (CEBPZOS) 9.8
 LDTP01652  Centrosomal protein 43 (CEP43) 9.6
 LDTP11825  Phosducin-like protein 3 (PDCL3) 9.4
 LDTP07839  Capping protein-inhibiting regulator of actin dynamics (CRACD) 9.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 9.0
 LDTP15623  Neuferricin (CYB5D2) 8.9
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 8.7
 LDTP00494  Vacuolar protein sorting-associated protein 26C (VPS26C) 8.6
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 8.2
 LDTP10442  Thioredoxin domain-containing protein 15 (TXNDC15) 8.2
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 8.2
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 8.2
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 8.1
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 8.1
 LDTP17808  SHC SH2 domain-binding protein 1 (SHCBP1) 8.1
 LDTP04395  RNA-binding protein FXR1 (FXR1) 7.8
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 7.7
 LDTP16577  DENN domain-containing protein 11 (DENND11) 7.6
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 7.6
 LDTP13086  Syntaxin-18 (STX18) 7.5
 LDTP10184  HAUS augmin-like complex subunit 1 (HAUS1) 7.4
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 7.3
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) 7.2
 LDTP01075  Protein CutA (CUTA) 7.2
 LDTP02927  Ganglioside GM2 activator (GM2A) 7.2
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 7.2
 LDTP06097  Reticulocalbin-2 (RCN2) 7.2
 LDTP10056  Protein FAM162A (FAM162A) 7.1
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 6.8
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 6.8
 LDTP19963  TraB domain-containing protein (TRABD) 6.8
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3) 6.7
 LDTP08346  Cerebellar degeneration-related protein 2-like (CDR2L) 6.7
 LDTP09920  Golgi apparatus protein 1 (GLG1) 6.7
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 6.7
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 6.6
 LDTP01359  Dynactin subunit 3 (DCTN3) 6.5
 LDTP08606  Nurim (NRM) 6.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587