Details of the Target

General Information of Target

Target ID LDTP12636
Target Name Lysosomal cobalamin transport escort protein LMBD1 (LMBRD1)
Gene Name LMBRD1
Gene ID 55788
Synonyms
C6orf209; NESI; Lysosomal cobalamin transport escort protein LMBD1; LMBD1; HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVT
CPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRS
IDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKAR
LNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHS
EQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ
Target Bioclass
Transporter and channel
Family
LIMR family, LMBRD1 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane. Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2. Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis.; [Isoform 3]: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV).
Uniprot ID
Q9NUN5
Ensemble ID
ENST00000370570.6
HGNC ID
HGNC:23038

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.D128A .
HT115 SNV: p.N237H; p.Q441R .
JHH4 SNV: p.T380I .
MEWO SNV: p.S171F .
MFE319 SNV: p.R406S .
NCIH23 SNV: p.T144S .
RL952 SNV: p.R40W .
SUDHL4 SNV: p.I372V .
SUPT1 SNV: p.R39Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
IA-alkyne
 Probe Info  		1.48  LDD2187  [2]
DBIA
 Probe Info  		C466(1.03); C475(1.03)  LDD0531  [3]
IPM
 Probe Info  		C475(0.00); C466(0.00)  LDD2156  [4]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		14.32  LDD1752  [5]
C056
 Probe Info  		30.27  LDD1753  [5]
C141
 Probe Info  		22.32  LDD1823  [5]
C143
 Probe Info  		64.45  LDD1825  [5]
C147
 Probe Info  		8.57  LDD1829  [5]
C383
 Probe Info  		16.91  LDD2042  [5]
C386
 Probe Info  		7.73  LDD2045  [5]
C388
 Probe Info  		79.34  LDD2047  [5]
VE-P
 Probe Info  		N.A.  LDD0396  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C466(1.03); C475(1.03)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C466(1.11); C475(1.11)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C466(0.45); C475(0.45)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C466(0.58); C475(0.58)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C466(0.51); C475(0.51)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C466(0.48); C475(0.48)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C466(0.41); C475(0.41)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C466(0.53); C475(0.53)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C466(0.52); C475(0.52)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C466(0.63); C475(0.57)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C466(0.36); C475(0.42)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C466(0.41); C475(0.45)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C466(1.06); C475(1.06)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C466(0.51); C475(0.44)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C466(0.50); C475(0.46)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C466(0.57); C475(0.54)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C466(0.96); C475(0.96)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C466(0.73); C475(0.73)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C466(0.94); C475(0.94)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C466(0.94); C475(0.94)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C466(0.76); C475(0.76)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C466(0.74); C475(0.74)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C466(0.95); C475(0.95)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C466(1.07); C475(1.07)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C466(0.70); C475(0.70)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C466(0.90); C475(0.90)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C466(1.19); C475(1.19)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C466(1.12); C475(1.12)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C466(1.19); C475(1.19)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C466(1.13); C475(1.13)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C466(1.17); C475(1.17)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C466(0.82); C475(0.82)  LDD0562  [3]
 LDCM0246  AC128 PaTu 8988t C466(1.22); C475(1.22)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C466(0.92); C475(0.92)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C466(1.15); C475(1.15)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C466(1.33); C475(1.33)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C466(0.85); C475(0.85)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C466(0.92); C475(0.92)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C466(0.77); C475(0.77)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C466(0.95); C475(0.95)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C466(1.24); C475(1.24)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C466(1.09); C475(1.09)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C466(1.14); C475(1.14)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C466(1.53); C475(1.53)  LDD1137  [3]
 LDCM0259  AC14 HCT 116 C466(0.94); C475(0.94)  LDD0576  [3]
 LDCM0260  AC140 PaTu 8988t C466(0.91); C475(0.91)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C466(1.05); C475(1.05)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C466(0.95); C475(0.95)  LDD1141  [3]
 LDCM0263  AC143 HCT 116 C466(0.95); C475(0.95)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C466(1.34); C475(1.34)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C466(1.16); C475(1.16)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C466(0.91); C475(0.91)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C466(1.20); C475(1.20)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C466(1.13); C475(1.13)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C466(1.18); C475(1.18)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C466(0.79); C475(0.79)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C466(1.09); C475(1.09)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C466(1.11); C475(1.11)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C466(0.95); C475(0.95)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C466(0.93); C475(0.93)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C466(1.09); C475(1.09)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C466(1.14); C475(1.14)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C466(1.51); C475(1.51)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C466(1.29); C475(1.29)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C466(0.95); C475(0.95)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C466(0.59); C475(0.59)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C466(0.83); C475(0.83)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C466(0.99); C475(0.99)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C466(0.93); C475(0.93)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C466(0.70); C475(0.70)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C466(0.91); C475(0.91)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C466(0.64); C475(0.64)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C466(0.83); C475(0.83)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C466(1.11); C475(1.11)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C466(1.00); C475(1.00)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C466(1.05); C475(1.05)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C466(1.29); C475(1.29)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C466(0.97); C475(0.97)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C466(1.05); C475(1.05)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C466(0.91); C475(0.91)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C466(0.85); C475(0.85)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C466(0.86); C475(0.86)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C466(1.09); C475(1.09)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C466(0.81); C475(0.81)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C466(0.87); C475(0.87)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C466(0.94); C475(0.94)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C466(1.44); C475(1.44)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C466(1.03); C475(1.03)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C466(0.99); C475(0.99)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C466(1.01); C475(1.01)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C466(1.05); C475(1.05)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C466(0.98); C475(0.98)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C466(0.89); C475(0.89)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C466(1.07); C475(1.07)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C466(1.21); C475(1.21)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C466(1.20); C475(1.20)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C466(0.92); C475(0.92)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C466(1.14); C475(1.14)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C466(1.32); C475(1.32)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C466(0.87); C475(0.87)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C466(1.01); C475(1.01)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C466(0.93); C475(0.93)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C466(1.17); C475(1.17)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C466(1.07); C475(1.07)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C466(0.91); C475(0.91)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C466(0.91); C475(0.91)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C466(1.13); C475(1.13)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C466(1.00); C475(1.00)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C466(0.93); C475(0.93)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C466(0.91); C475(0.91)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C466(0.95); C475(0.95)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C466(0.73); C475(0.73)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C466(0.71); C475(0.71)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C466(0.89); C475(0.89)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C466(1.10); C475(1.10)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C466(0.85); C475(0.85)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C466(0.95); C475(0.95)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C466(1.49); C475(1.49)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C466(1.15); C475(1.15)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C466(0.97); C475(0.97)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C466(0.94); C475(0.94)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C466(0.78); C475(0.78)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C466(0.99); C475(0.99)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C466(0.81); C475(0.81)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C466(1.16); C475(1.16)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C466(1.01); C475(1.01)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C466(0.97); C475(0.97)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C466(0.90); C475(0.90)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C466(1.07); C475(1.07)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C466(1.35); C475(1.35)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C466(1.34); C475(1.34)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C466(1.02); C475(1.02)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C466(1.00); C475(1.00)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C466(0.81); C475(0.81)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C466(0.99); C475(0.99)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C466(0.80); C475(0.80)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C466(0.75); C475(0.75)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C466(0.87); C475(0.87)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C466(0.86); C475(0.86)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C466(0.90); C475(0.90)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C466(1.28); C475(1.28)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C466(0.99); C475(0.99)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C466(0.86); C475(0.86)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C466(1.14); C475(1.14)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C466(1.05); C475(1.05)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C466(0.96); C475(0.96)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C466(1.18); C475(1.18)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C466(0.87); C475(0.87)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C466(1.41); C475(1.41)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C466(0.88); C475(0.88)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C466(1.34); C475(1.34)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C466(0.96); C475(0.96)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C466(0.32); C475(0.32)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C466(0.43); C475(0.43)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C466(0.95); C475(0.95)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C466(0.88); C475(0.88)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C466(0.67); C475(0.67)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C466(1.33); C475(1.33)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C466(1.18); C475(1.18)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C466(0.91); C475(0.91)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C466(0.82); C475(0.82)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C466(0.97); C475(0.97)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C466(1.05); C475(1.05)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C466(0.93); C475(0.93)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C466(1.04); C475(1.04)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C466(0.43); C475(0.43)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C466(0.57); C475(0.57)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C466(0.58); C475(0.58)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C466(0.77); C475(0.77)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C466(1.20); C475(1.20)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C466(0.82); C475(0.82)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C466(0.65); C475(0.65)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C466(0.91); C475(0.91)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C466(0.72); C475(0.72)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C466(0.88); C475(0.88)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C466(0.80); C475(0.80)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C466(1.12); C475(1.12)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C466(0.88); C475(0.88)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C466(0.90); C475(0.90)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C466(0.92); C475(0.92)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C466(1.30); C475(1.30)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C466(1.03); C475(1.03)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C466(1.63); C475(1.63)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C466(0.84); C475(0.84)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C466(1.14); C475(1.14)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C466(1.04); C475(1.04)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C466(1.12); C475(1.12)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C466(1.21); C475(1.21)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C466(1.06); C475(1.06)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C466(1.05); C475(1.05)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C466(0.98); C475(0.98)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C466(1.24); C475(1.24)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C466(1.30); C475(1.30)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C466(0.86); C475(0.86)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C466(1.02); C475(1.02)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C466(0.95); C475(0.95)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C466(1.01); C475(1.01)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C466(1.52); C475(1.52)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C466(1.10); C475(1.10)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C466(1.10); C475(1.10)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C466(0.89); C475(0.89)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C466(0.97); C475(0.97)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C466(0.96); C475(0.96)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C466(0.90); C475(0.90)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C466(0.76); C475(0.76)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C466(1.18); C475(1.18)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C466(1.03); C475(1.03)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C466(1.23); C475(1.23)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C466(1.31); C475(1.31)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C466(1.00); C475(1.00)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C466(0.44); C475(0.44)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C466(0.39); C475(0.39)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C466(0.56); C475(0.56)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C466(0.43); C475(0.43)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C466(0.48); C475(0.48)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C466(0.46); C475(0.46)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C466(0.73); C475(0.73)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C466(0.73); C475(0.73)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C466(1.17); C475(1.17)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C466(0.61); C475(0.61)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C466(0.42); C475(0.42)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C466(0.44); C475(0.44)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C466(0.44); C475(0.44)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C466(0.34); C475(0.34)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C466(0.34); C475(0.34)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C466(2.15); C475(2.15)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C466(1.92); C475(1.92)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C466(2.11); C475(2.11)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C466(1.52); C475(1.52)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C466(1.27); C475(1.27)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C466(1.83); C475(1.83)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C466(2.31); C475(2.31)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C466(1.89); C475(1.89)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C466(1.42); C475(1.42)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C466(1.43); C475(1.43)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C466(2.22); C475(2.22)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C466(1.28); C475(1.28)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C466(1.74); C475(1.74)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C466(1.40); C475(1.40)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C466(1.84); C475(1.84)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C466(1.05); C475(1.05)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C466(1.05); C475(1.05)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C466(1.31); C475(1.31)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C466(1.34); C475(1.34)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C466(0.96); C475(0.96)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C466(1.40); C475(1.40)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C466(1.04); C475(1.04)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C466(1.05); C475(1.05)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C466(0.84); C475(0.84)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C466(0.99); C475(0.99)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C466(1.13); C475(1.13)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C466(0.97); C475(0.97)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C466(0.99); C475(0.99)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C466(0.82); C475(0.82)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C466(0.88); C475(0.88)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C466(1.01); C475(1.01)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C466(0.82); C475(0.82)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C466(0.86); C475(0.86)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C466(1.09); C475(1.09)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C466(0.92); C475(0.92)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C466(0.91); C475(0.91)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C466(1.24); C475(1.24)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C466(0.88); C475(0.88)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C466(1.06); C475(1.06)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C466(1.02); C475(1.02)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C466(0.88); C475(0.88)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C466(0.96); C475(0.96)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C466(0.92); C475(0.92)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C466(1.00); C475(1.00)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C466(0.95); C475(0.95)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C466(1.03); C475(1.03)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C466(0.86); C475(0.86)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C466(1.17); C475(1.17)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C466(1.12); C475(1.12)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C466(0.97); C475(0.97)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C466(0.81); C475(0.81)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C466(0.94); C475(0.94)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C466(0.94); C475(0.94)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C466(0.90); C475(0.90)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C466(0.91); C475(0.91)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C466(0.80); C475(0.80)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C466(1.01); C475(1.01)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C466(0.92); C475(0.92)  LDD0811  [3]
 LDCM0625  F8 Ramos 1.48  LDD2187  [2]
 LDCM0575  Fragment13 Ramos 1.46  LDD2192  [2]
 LDCM0576  Fragment14 Ramos 1.63  LDD2193  [2]
 LDCM0580  Fragment21 Ramos 1.19  LDD2195  [2]
 LDCM0582  Fragment23 Ramos 0.78  LDD2196  [2]
 LDCM0578  Fragment27 Ramos 0.91  LDD2197  [2]
 LDCM0588  Fragment30 Ramos 1.07  LDD2199  [2]
 LDCM0589  Fragment31 Ramos 0.95  LDD2200  [2]
 LDCM0468  Fragment33 HCT 116 C466(0.95); C475(0.95)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos 1.53  LDD2203  [2]
 LDCM0427  Fragment51 HCT 116 C466(0.42); C475(0.42)  LDD0744  [3]
 LDCM0614  Fragment56 Ramos 1.36  LDD2205  [2]
 LDCM0022  KB02 HEK-293T C475(0.63)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C475(0.97)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C475(0.93)  LDD1502  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysosomal cobalamin transporter ABCD4 (ABCD4) ABCD family O14678

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402