Details of the Target

General Information of Target

Target ID LDTP08346
Target Name Cerebellar degeneration-related protein 2-like (CDR2L)
Gene Name CDR2L
Gene ID 30850
Synonyms
HUMPPA; Cerebellar degeneration-related protein 2-like; Paraneoplastic 62 kDa antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQV
QEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIE
RLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSS
LELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEAC
RLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQD
GVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQY
HALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQ
HVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK
Target Bioclass
Other
Family
CDR2 family
Uniprot ID
Q86X02
Ensemble ID
ENST00000337231.5
HGNC ID
HGNC:29999

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K441(8.33); K451(10.00)  LDD0277  [2]
NAIA_5
 Probe Info  		C317(0.95)  LDD2227  [3]
DBIA
 Probe Info  		C160(0.96)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		C374(0.00); C160(0.00)  LDD0148  [7]
Phosphinate-6
 Probe Info  		C317(0.00); C160(0.00)  LDD0018  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C383
 Probe Info  		11.08  LDD2042  [10]
C386
 Probe Info  		6.68  LDD2045  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C160(5.53)  LDD0371  [11]
 LDCM0214  AC1 HEK-293T C160(1.08)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C160(1.08); C317(0.98); C165(1.06)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C160(1.07)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C160(0.96); C317(1.00); C165(0.98)  LDD1510  [12]
 LDCM0270  AC15 HEK-293T C160(1.02)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C160(1.08)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C160(1.06); C317(1.00); C165(0.96)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C160(1.25)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C160(1.00); C317(1.00); C165(1.01)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C160(0.93); C317(1.02); C165(1.07)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C160(0.97); C317(0.99)  LDD1520  [12]
 LDCM0283  AC23 HEK-293T C160(0.94)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C317(0.98)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C160(1.08)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C160(1.05); C317(1.11); C165(0.99)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C160(1.04)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C160(0.93); C317(1.04); C165(0.98)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C160(1.02); C317(0.96)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C160(1.05)  LDD1529  [12]
 LDCM0292  AC31 HEK-293T C160(0.99)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C317(0.85)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C160(1.06)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C160(1.06); C317(1.08); C165(1.18)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C160(1.10)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C160(0.98); C317(0.99); C165(1.06)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C160(0.96); C317(0.97)  LDD1537  [12]
 LDCM0300  AC39 HEK-293T C160(1.04)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C160(0.93); C317(0.95); C165(1.04)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C317(0.93)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C160(1.06)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C160(1.14); C317(1.16); C165(1.05)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C160(1.04)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C160(0.97); C317(1.12); C165(0.99)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C160(1.01); C317(1.01)  LDD1546  [12]
 LDCM0309  AC47 HEK-293T C160(1.06)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C317(1.17)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C160(1.08)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C160(1.03); C317(1.10)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C160(1.08); C317(1.20); C165(1.09)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C160(1.10)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C160(0.97); C317(1.01); C165(1.21)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C160(0.92); C317(1.14)  LDD1555  [12]
 LDCM0318  AC55 HEK-293T C160(1.06)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C317(0.87)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C160(1.10)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C160(1.02); C317(0.99); C165(1.05)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C160(1.10)  LDD1561  [12]
 LDCM0324  AC60 HEK-293T C160(0.87); C317(1.12); C165(1.04)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C160(0.97); C317(1.10)  LDD1564  [12]
 LDCM0327  AC63 HEK-293T C160(1.02)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C317(1.00)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C160(0.96)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C317(0.95)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C160(0.98); C317(1.09)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C160(1.06)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C317(0.85)  LDD1514  [12]
 LDCM0020  ARS-1620 HCC44 C160(0.96)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C317(0.95)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C160(1.08); C317(0.84)  LDD1571  [12]
 LDCM0369  CL100 HEK-293T C160(1.01)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C160(1.03); C317(0.78)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C160(1.12)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C160(1.00)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C160(0.96)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C160(1.10); C317(0.83)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C160(0.98)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C160(1.01)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C160(0.92)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C160(1.04); C317(0.83)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C160(1.04)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C160(1.18)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C160(0.94)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C160(1.01)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C160(1.07); C317(0.74)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C160(1.07)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C160(1.06)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C160(1.00)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C160(1.09); C317(0.91)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C160(1.00)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C160(1.00)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C317(0.86)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C160(0.94)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C160(1.03); C317(0.90)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C160(1.04)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C160(1.08)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C160(0.98)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C160(0.98); C317(0.91)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C160(1.04)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C160(0.99)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C160(0.92)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C160(1.12); C317(1.01)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C160(0.98)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C160(1.09)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C160(0.96)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C160(1.09)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C160(1.08); C317(1.07); C165(1.09)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C160(1.15)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C160(1.05)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C160(0.94); C317(0.88); C165(1.35)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C160(1.27); C317(0.99)  LDD1613  [12]
 LDCM0411  CL23 HEK-293T C160(1.03)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C317(0.89)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C160(1.08); C317(0.83)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C160(1.00)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C160(1.04)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C160(0.97)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C160(1.06)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C160(1.09)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C160(1.01); C317(1.21); C165(1.00)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C160(1.03)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C160(0.95); C317(0.93); C165(1.41)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C160(1.20); C317(1.06)  LDD1626  [12]
 LDCM0424  CL35 HEK-293T C160(1.05)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C317(1.08)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C160(0.97); C317(0.82)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C160(1.08)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C160(0.95)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C160(1.01)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C160(1.03)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C160(1.01); C317(1.10); C165(1.10)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C160(1.11)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C160(0.93); C317(1.03); C165(1.11)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C160(1.22); C317(0.81)  LDD1639  [12]
 LDCM0437  CL47 HEK-293T C160(1.08)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C317(1.11)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C160(1.05); C317(0.93)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C160(1.05)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C160(1.14)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C160(0.95)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C160(1.16)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C160(1.41); C317(1.25); C165(1.09)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C160(1.03)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C160(0.96); C317(0.94); C165(1.18)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C160(1.25); C317(1.01)  LDD1651  [12]
 LDCM0450  CL59 HEK-293T C160(1.06)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C160(1.12); C317(1.09); C165(1.14)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C317(0.89)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C160(1.04); C317(0.75)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C160(1.09)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C160(1.01)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C160(1.01)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C160(1.08)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C160(1.07); C317(1.14); C165(1.30)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C160(0.97)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C160(1.08); C317(0.91); C165(1.22)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C160(1.11); C317(0.93)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C160(0.99)  LDD1665  [12]
 LDCM0464  CL71 HEK-293T C160(1.00)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C317(1.22)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C160(1.01); C317(0.82)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C160(1.06)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C160(0.99)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C160(1.11)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C160(0.99); C317(1.14); C165(1.07)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C160(1.00)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C160(1.35); C317(1.18); C165(1.31)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C160(0.90); C317(1.01); C165(1.17)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C160(1.01); C317(1.01)  LDD1678  [12]
 LDCM0477  CL83 HEK-293T C160(1.07)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C317(1.07)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C160(0.95); C317(1.10)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C160(1.04)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C160(1.05)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C160(0.94)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C160(1.06)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C160(1.17); C317(0.87)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C160(1.44); C317(1.11); C165(1.06)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C160(1.10)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C160(0.94); C317(1.06); C165(1.16)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C160(1.08); C317(0.99)  LDD1691  [12]
 LDCM0490  CL95 HEK-293T C160(1.33)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C317(1.08)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C160(1.15); C317(0.78)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C160(1.08)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C160(0.98)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C160(1.08)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C160(1.91)  LDD1702  [13]
 LDCM0468  Fragment33 HEK-293T C160(1.04)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C160(1.04)  LDD1631  [12]
 LDCM0022  KB02 HEK-293T C160(1.01); C165(0.82)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C160(0.99); C165(0.94)  LDD1497  [12]
 LDCM0024  KB05 OAW-28 C317(3.26)  LDD3368  [14]
 LDCM0021  THZ1 HCT 116 C235(1.11); C240(1.11)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
FAST kinase domain-containing protein 4 (TBRG4) FAST kinase family Q969Z0
Dexamethasone-induced Ras-related protein 1 (RASD1) RasD family Q9Y272
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) Krueppel C2H2-type zinc-finger protein family Q3MJ62
Zinc finger protein 19 (ZNF19) Krueppel C2H2-type zinc-finger protein family P17023
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 629 (ZNF629) Krueppel C2H2-type zinc-finger protein family Q9UEG4
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 669 (ZNF669) Krueppel C2H2-type zinc-finger protein family Q96BR6
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
Zinc finger protein 80 (ZNF80) Krueppel C2H2-type zinc-finger protein family P51504
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Zinc finger and SCAN domain-containing protein 26 (ZSCAN26) . Q16670
Other
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Phakinin (BFSP2) Intermediate filament family Q13515
LRP chaperone MESD (MESD) MESD family Q14696
Protein Mis18-beta (OIP5) Mis18 family O43482
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Keratin-associated protein 13-4 (KRTAP13-4) PMG family Q3LI77
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Sperm microtubule inner protein 6 (SPMIP6) SMRP1 family Q8NCR6
Protein sprouty homolog 1 (SPRY1) Sprouty family O43609
Syntaxin-11 (STX11) Syntaxin family O75558
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
Elongin-A (ELOA) . Q14241
Heat shock factor 2-binding protein (HSF2BP) . O75031
INO80 complex subunit B (INO80B) . Q9C086
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Phostensin (PPP1R18) . Q6NYC8
RAS protein activator like-3 (RASAL3) . Q86YV0
Renal cancer differentiation gene 1 protein (C4orf46) . Q504U0
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840