Details of the Target

General Information of Target

Target ID LDTP03394
Target Name Ceramide synthase 1 (CERS1)
Gene Name CERS1
Gene ID 10715
Synonyms
LAG1; LASS1; UOG1; Ceramide synthase 1; CerS1; LAG1 longevity assurance homolog 1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1; Sphingoid base N-stearoyltransferase CERS1; EC 2.3.1.299
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAGPAAGPTGPEPMPSYAQLVQRGWGSALAAARGCTDCGWGLARRGLAEHAHLAPPEL
LLLALGALGWTALRSAATARLFRPLAKRCCLQPRDAAKMPESAWKFLFYLGSWSYSAYLL
FGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYGHSIYATLYMDTWRKDSVVML
LHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTKLNIYFKSRGGSYHRLHALAA
DLGCLSFGFSWFWFRLYWFPLKVLYATSHCSLRTVPDIPFYFFFNALLLLLTLMNLYWFL
YIVAFAAKVLTGQVHELKDLREYDTAEAQSLKPSKAEKPLRNGLVKDKRF
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum membrane
Function
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way. Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function. In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria.
Uniprot ID
P27544
Ensemble ID
ENST00000429504.6
HGNC ID
HGNC:14253

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C37(6.09); C40(6.09)  LDD0080  [1]
TFBX
 Probe Info  		C90(0.00); C89(0.00)  LDD0027  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 63 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		5.10  LDD1711  [5]
C017
 Probe Info  		25.63  LDD1725  [5]
C039
 Probe Info  		9.19  LDD1739  [5]
C040
 Probe Info  		26.91  LDD1740  [5]
C041
 Probe Info  		18.25  LDD1741  [5]
C049
 Probe Info  		7.11  LDD1747  [5]
C055
 Probe Info  		34.30  LDD1752  [5]
C056
 Probe Info  		37.79  LDD1753  [5]
C063
 Probe Info  		15.67  LDD1760  [5]
C082
 Probe Info  		5.70  LDD1774  [5]
C085
 Probe Info  		5.94  LDD1777  [5]
C091
 Probe Info  		17.03  LDD1782  [5]
C092
 Probe Info  		23.10  LDD1783  [5]
C094
 Probe Info  		27.67  LDD1785  [5]
C106
 Probe Info  		19.70  LDD1793  [5]
C107
 Probe Info  		8.17  LDD1794  [5]
C108
 Probe Info  		10.27  LDD1795  [5]
C112
 Probe Info  		27.28  LDD1799  [5]
C131
 Probe Info  		5.62  LDD1813  [5]
C140
 Probe Info  		9.32  LDD1822  [5]
C153
 Probe Info  		22.63  LDD1834  [5]
C158
 Probe Info  		10.78  LDD1838  [5]
C159
 Probe Info  		17.39  LDD1839  [5]
C160
 Probe Info  		16.00  LDD1840  [5]
C161
 Probe Info  		28.05  LDD1841  [5]
C166
 Probe Info  		7.62  LDD1846  [5]
C169
 Probe Info  		34.54  LDD1849  [5]
C174
 Probe Info  		9.19  LDD1854  [5]
C178
 Probe Info  		15.24  LDD1857  [5]
C187
 Probe Info  		50.91  LDD1865  [5]
C191
 Probe Info  		14.83  LDD1868  [5]
C210
 Probe Info  		44.02  LDD1884  [5]
C218
 Probe Info  		13.18  LDD1892  [5]
C220
 Probe Info  		18.77  LDD1894  [5]
C225
 Probe Info  		9.85  LDD1898  [5]
C226
 Probe Info  		7.78  LDD1899  [5]
C228
 Probe Info  		28.25  LDD1901  [5]
C239
 Probe Info  		7.41  LDD1912  [5]
C241
 Probe Info  		5.78  LDD1914  [5]
C264
 Probe Info  		17.03  LDD1935  [5]
C269
 Probe Info  		6.73  LDD1939  [5]
C270
 Probe Info  		6.28  LDD1940  [5]
C280
 Probe Info  		10.34  LDD1950  [5]
C310
 Probe Info  		8.51  LDD1977  [5]
C314
 Probe Info  		15.56  LDD1981  [5]
C348
 Probe Info  		10.27  LDD2009  [5]
C349
 Probe Info  		12.91  LDD2010  [5]
C350
 Probe Info  		22.94  LDD2011  [5]
C355
 Probe Info  		35.75  LDD2016  [5]
C356
 Probe Info  		11.71  LDD2017  [5]
C357
 Probe Info  		8.94  LDD2018  [5]
C376
 Probe Info  		16.91  LDD2036  [5]
C382
 Probe Info  		15.24  LDD2041  [5]
C383
 Probe Info  		25.63  LDD2042  [5]
C386
 Probe Info  		8.22  LDD2045  [5]
C387
 Probe Info  		6.87  LDD2046  [5]
C388
 Probe Info  		71.01  LDD2047  [5]
C407
 Probe Info  		14.72  LDD2064  [5]
C429
 Probe Info  		21.26  LDD2084  [5]
C431
 Probe Info  		27.86  LDD2086  [5]
FFF probe11
 Probe Info  		20.00  LDD0471  [6]
FFF probe13
 Probe Info  		20.00  LDD0475  [6]
OEA-DA
 Probe Info  		20.00  LDD0046  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C37(1.14); C40(1.14)  LDD0812  [1]
 LDCM0215  AC10 PaTu 8988t C37(0.84); C40(0.73)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C37(0.81); C40(0.74)  LDD1105  [1]
 LDCM0230  AC113 PaTu 8988t C37(1.05); C40(1.05)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C37(1.12); C40(1.12)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C37(0.98); C40(0.98)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C37(0.89); C40(0.89)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C37(0.95); C40(0.95)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C37(0.92); C40(0.92)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C37(0.95); C40(0.95)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C37(0.75); C40(0.72)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C37(1.52); C40(1.52)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C37(1.24); C40(1.24)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C37(1.00); C40(1.00)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C37(1.03); C40(1.03)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C37(0.97); C40(0.97)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C37(0.98); C40(0.98)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C37(0.85); C40(0.85)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C37(1.25); C40(1.25)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C37(1.03); C40(1.03)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C37(0.76); C40(0.76)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C37(1.01); C40(1.01)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C37(0.82); C40(0.82)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C37(0.89); C40(0.89)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C37(1.15); C40(1.15)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C37(1.05); C40(1.05)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C37(0.98); C40(0.98)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C37(0.93); C40(0.93)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C37(0.89); C40(0.89)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C37(1.03); C40(1.03)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C37(0.97); C40(0.97)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C37(0.82); C40(0.97)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C37(0.86); C40(0.86)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C37(1.05); C40(1.05)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C37(0.90); C40(0.90)  LDD1141  [1]
 LDCM0263  AC143 PaTu 8988t C37(0.80); C40(0.80)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C37(0.91); C40(0.91)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C37(0.85); C40(0.85)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C37(1.07); C40(1.07)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C37(0.91); C40(0.91)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C37(0.81); C40(0.81)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C37(0.92); C40(0.92)  LDD1148  [1]
 LDCM0270  AC15 PaTu 8988t C37(0.96); C40(0.71)  LDD1149  [1]
 LDCM0271  AC150 PaTu 8988t C37(1.01); C40(1.01)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C37(0.91); C40(0.91)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C37(0.84); C40(0.84)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C37(0.90); C40(0.90)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C37(0.85); C40(0.85)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C37(0.84); C40(0.84)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C37(0.92); C40(0.92)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C37(1.23); C40(1.23)  LDD2169  [1]
 LDCM0276  AC17 HEK-293T C37(0.59); C40(0.59)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C37(0.61); C40(0.61)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C37(0.58); C40(0.58)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C37(1.06); C40(1.06)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C37(0.67); C40(0.67)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C37(0.63); C40(0.63)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C37(0.62); C40(0.62)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C37(0.60); C40(0.60)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C37(0.70); C40(0.70)  LDD0882  [1]
 LDCM0285  AC25 PaTu 8988t C40(0.95)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C40(1.22)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C40(1.21)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C40(1.08)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C40(1.17)  LDD1168  [1]
 LDCM0290  AC3 HEK-293T C37(1.33); C40(1.33)  LDD0888  [1]
 LDCM0291  AC30 PaTu 8988t C40(1.02)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C40(1.08)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C40(1.13)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C40(1.20)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C40(1.08)  LDD1174  [1]
 LDCM0296  AC35 PaTu 8988t C37(0.66); C40(0.66)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C37(0.61); C40(0.61)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C37(0.65); C40(0.65)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C37(0.56); C40(0.56)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C37(0.71); C40(0.71)  LDD1179  [1]
 LDCM0301  AC4 HEK-293T C37(1.09); C40(1.09)  LDD0899  [1]
 LDCM0302  AC40 PaTu 8988t C37(0.58); C40(0.58)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C37(0.73); C40(0.73)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C37(0.81); C40(0.81)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C37(0.82); C40(0.82)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C37(0.78); C40(0.78)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C37(0.91); C40(0.91)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C37(0.94); C40(0.94)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C37(1.04); C40(1.04)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C37(1.16); C40(1.16)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C37(2.44); C40(2.44)  LDD1190  [1]
 LDCM0312  AC5 HEK-293T C37(1.07); C40(1.07)  LDD0910  [1]
 LDCM0313  AC50 PaTu 8988t C37(1.38); C40(1.38)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C37(0.35); C40(0.35)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C37(1.53); C40(1.53)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C37(1.91); C40(1.91)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C37(1.87); C40(1.87)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C37(1.27); C40(1.27)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C37(1.34); C40(1.34)  LDD1198  [1]
 LDCM0320  AC57 HEK-293T C37(1.49)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C37(1.07)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C37(1.11)  LDD0920  [1]
 LDCM0323  AC6 PaTu 8988t C37(0.69); C40(0.79)  LDD1202  [1]
 LDCM0324  AC60 HEK-293T C37(1.54)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C37(1.22)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C37(0.93)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C37(1.20)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C37(0.96)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C37(0.86)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C37(1.10)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C37(1.01)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C37(0.92); C40(0.86)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C37(0.88); C40(0.94)  LDD0931  [1]
 LDCM0334  AC7 PaTu 8988t C37(1.81); C40(1.56)  LDD1213  [1]
 LDCM0335  AC70 HEK-293T C37(1.02); C40(0.76)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C37(1.06); C40(0.86)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C37(1.11); C40(0.72)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C37(1.08); C40(0.60)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C37(1.15); C40(0.54)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C37(1.17); C40(0.48)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C37(1.04); C40(0.39)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C37(0.97); C40(0.50)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C37(1.04); C40(0.59)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C37(0.95); C40(0.48)  LDD0942  [1]
 LDCM0345  AC8 PaTu 8988t C37(0.92); C40(0.82)  LDD1224  [1]
 LDCM0346  AC80 HEK-293T C37(0.88); C40(0.64)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C37(0.92); C40(0.50)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C37(1.03); C40(0.83)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C37(1.20)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C37(1.13)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C37(1.09)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C37(1.05)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C37(1.21)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C37(1.14)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C37(1.18)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C37(0.89)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C37(0.94)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C37(1.55)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C37(1.18)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C37(1.13)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C37(1.16)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C37(0.92)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C37(1.05)  LDD0962  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C37(0.68); C40(0.82)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C37(0.80); C40(0.71)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C37(0.89); C40(0.84)  LDD1154  [1]
 LDCM0367  CL1 HEK-293T C37(1.01); C40(1.01)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C37(1.04); C40(1.04)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C37(1.54); C40(1.54)  LDD0967  [1]
 LDCM0370  CL101 PaTu 8988t C37(0.81); C40(0.75)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C37(1.07); C40(0.96)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C37(0.90); C40(0.89)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C37(0.86); C40(0.92)  LDD1252  [1]
 LDCM0374  CL105 HEK-293T C37(0.70); C40(0.70)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C37(0.67); C40(0.67)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C37(0.63); C40(0.63)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C37(0.64); C40(0.64)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C37(0.63); C40(0.63)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C37(1.00); C40(1.00)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C37(0.61); C40(0.61)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C37(0.70); C40(0.70)  LDD0979  [1]
 LDCM0382  CL112 PaTu 8988t C40(0.74)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C40(1.07)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C40(1.17)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C40(1.03)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C40(1.00)  LDD1265  [1]
 LDCM0387  CL117 PaTu 8988t C37(0.91); C40(0.91)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C37(0.89); C40(0.89)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C37(0.74); C40(0.74)  LDD1268  [1]
 LDCM0390  CL12 HEK-293T C37(1.09); C40(1.09)  LDD0988  [1]
 LDCM0391  CL120 PaTu 8988t C37(0.73); C40(0.73)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C37(1.35); C40(1.35)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C37(1.51); C40(1.51)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C37(1.27); C40(1.27)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C37(1.39); C40(1.39)  LDD1274  [1]
 LDCM0396  CL125 HEK-293T C37(1.15)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C37(1.23)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C37(1.01)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C37(1.52)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C37(1.31); C40(1.31)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C37(1.09); C40(1.09)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C37(1.07); C40(1.07)  LDD1000  [1]
 LDCM0403  CL16 PaTu 8988t C40(1.12)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C40(1.21)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C40(1.25)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C40(1.30)  LDD1285  [1]
 LDCM0407  CL2 HEK-293T C37(0.99); C40(0.99)  LDD1005  [1]
 LDCM0408  CL20 PaTu 8988t C40(1.39)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C40(1.44)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C40(1.29)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C40(1.04)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C40(1.08)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C40(1.15)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C40(1.24)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C40(1.10)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C40(1.38)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C40(1.31)  LDD1296  [1]
 LDCM0418  CL3 HEK-293T C37(0.94); C40(0.94)  LDD1016  [1]
 LDCM0419  CL30 PaTu 8988t C40(1.29)  LDD1298  [1]
 LDCM0420  CL31 HEK-293T C37(0.94); C40(0.94)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C37(0.90); C40(0.90)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C37(1.25); C40(1.25)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C37(0.94); C40(0.94)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C37(0.89); C40(0.89)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C37(1.01); C40(1.01)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C37(0.90); C40(0.90)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C37(0.90); C40(0.90)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C37(1.10); C40(1.10)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C37(1.03); C40(1.03)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C37(1.05); C40(1.05)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C37(1.08); C40(1.08)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C37(0.99); C40(0.99)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C37(1.19); C40(1.19)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C37(1.22); C40(1.22)  LDD1033  [1]
 LDCM0436  CL46 PaTu 8988t C37(0.82); C40(0.95)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C37(0.77); C40(0.96)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C37(0.79); C40(0.92)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C37(0.96); C40(1.06)  LDD1318  [1]
 LDCM0440  CL5 HEK-293T C37(1.24); C40(1.24)  LDD1038  [1]
 LDCM0441  CL50 PaTu 8988t C37(0.84); C40(0.91)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C37(0.85); C40(0.93)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C37(0.75); C40(0.99)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C37(0.85); C40(0.91)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C37(1.05); C40(1.07)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C37(0.73); C40(0.80)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C37(0.76); C40(0.50)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C37(0.78); C40(1.17)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C37(0.81); C40(0.89)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C37(0.87); C40(1.18)  LDD1329  [1]
 LDCM0451  CL6 HEK-293T C37(1.05); C40(1.05)  LDD1049  [1]
 LDCM0452  CL60 PaTu 8988t C37(0.79); C40(1.02)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C37(1.09); C40(0.80)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C37(0.72); C40(0.86)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C37(0.74); C40(0.92)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C37(0.73); C40(0.83)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C37(0.78); C40(0.86)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C37(0.81); C40(0.80)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C37(0.90); C40(1.12)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C37(0.96); C40(1.12)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C37(0.87); C40(0.87)  LDD1340  [1]
 LDCM0462  CL7 HEK-293T C37(1.03); C40(1.03)  LDD1060  [1]
 LDCM0463  CL70 PaTu 8988t C37(0.93); C40(0.93)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C37(0.70); C40(0.89)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C37(0.93); C40(0.66)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C37(0.97); C40(0.97)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C37(0.84); C40(0.90)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C37(0.92); C40(0.91)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C37(1.01); C40(1.00)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C37(1.05); C40(1.01)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C37(1.20); C40(1.13)  LDD1351  [1]
 LDCM0473  CL8 HEK-293T C40(0.37)  LDD1071  [1]
 LDCM0474  CL80 PaTu 8988t C37(0.85); C40(1.00)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C37(1.04); C40(1.01)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C37(0.83); C40(0.90)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C37(1.05); C40(0.96)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C37(0.91); C40(0.93)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C37(0.73); C40(0.99)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C37(1.20); C40(1.13)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C37(1.19); C40(1.18)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C37(1.01); C40(0.97)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C37(0.95); C40(0.95)  LDD1362  [1]
 LDCM0484  CL9 HEK-293T C40(0.66)  LDD1082  [1]
 LDCM0485  CL90 PaTu 8988t C37(1.03); C40(1.18)  LDD1364  [1]
 LDCM0486  CL91 HEK-293T C37(0.94); C40(0.94)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C37(0.65); C40(0.65)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C37(0.80); C40(0.80)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C37(0.77); C40(0.77)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C37(0.66); C40(0.66)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C37(0.72); C40(0.72)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C37(0.61); C40(0.61)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C37(0.82); C40(0.82)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C37(0.79); C40(0.79)  LDD1092  [1]
 LDCM0468  Fragment33 PaTu 8988t C37(0.85); C40(0.87)  LDD1347  [1]
 LDCM0427  Fragment51 HEK-293T C37(1.07); C40(1.07)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C37(6.09); C40(6.09)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C37(5.74); C40(5.74)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C37(3.45); C40(3.45)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570