Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C166  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 52.7
 LDTP09155  Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) 33.4
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 28.8
 LDTP03842  Squalene synthase (FDFT1) 26.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 20.5
 LDTP08664  SET and MYND domain-containing protein 4 (SMYD4) 20.3
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 17.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 16.7
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 16.0
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 15.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 14.9
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 13.7
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 13.1
 LDTP10329  Ceramide synthase 2 (CERS2) 12.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 12.2
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 12.0
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 12.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 12.0
 LDTP04689  Adenosine kinase (ADK) 11.6
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 11.6
 LDTP01768  Glutamate dehydrogenase 1, mitochondrial (GLUD1) 11.2
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 11.0
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 10.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 10.9
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 10.6
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 10.3
 LDTP10286  Corrinoid adenosyltransferase MMAB (MMAB) 10.1
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 10.1
 LDTP04874  Ubiquitin-conjugating enzyme E2 G2 (UBE2G2) 10.1
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 10.0
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 9.9
 LDTP11127  ADP-dependent glucokinase (ADPGK) 9.8
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 9.7
 LDTP14534  Arginyl-tRNA--protein transferase 1 (ATE1) 9.6
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 9.6
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 9.5
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 9.4
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 9.3
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 9.3
 LDTP00886  Nardilysin (NRDC) 9.2
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 9.1
 LDTP00325  Pirin (PIR) 9.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 8.9
 LDTP02868  Fumarylacetoacetase (FAH) 8.9
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 8.9
 LDTP03608  RAC-beta serine/threonine-protein kinase (AKT2) 8.8
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 8.8
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 8.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 8.5
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 8.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 8.3
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 8.0
 LDTP04183  Lanosterol synthase (LSS) 8.0
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 7.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 7.9
 LDTP00344  Stearoyl-CoA desaturase (SCD) 7.8
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 7.7
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 7.7
 LDTP03394  Ceramide synthase 1 (CERS1) 7.6
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 7.6
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 7.5
 LDTP07966  COP9 signalosome complex subunit 6 (COPS6) 7.3
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 7.2
 LDTP02260  Beta-glucuronidase (GUSB) 7.2
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 7.2
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 7.2
 LDTP08017  Endoplasmic reticulum metallopeptidase 1 (ERMP1) 7.1
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 7.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 7.0
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 7.0
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 6.9
 LDTP03145  Catechol O-methyltransferase (COMT) 6.9
 LDTP11728  Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (QRSL1) 6.9
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 6.8
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 6.8
 LDTP10862  Proteasome subunit beta type-7 (PSMB7) 6.8
 LDTP05842  C-terminal-binding protein 1 (CTBP1) 6.7
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 6.7
 LDTP02359  Heme oxygenase 1 (HMOX1) 6.7
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 6.6
 LDTP00482  Peripheral plasma membrane protein CASK (CASK) 6.6
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 6.5
Transporter and channel
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 34.5
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 25.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 22.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 16.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 16.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 14.3
 LDTP05900  Metaxin-1 (MTX1) 14.0
 LDTP07236  Protein GPR107 (GPR107) 13.7
 LDTP12383  Protein GPR108 (GPR108) 13.6
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 13.1
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 12.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 12.6
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 12.6
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 12.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 12.1
 LDTP15948  Transmembrane protein 126A (TMEM126A) 11.6
 LDTP07667  Transmembrane protein 205 (TMEM205) 11.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 10.9
 LDTP01217  Metaxin-2 (MTX2) 10.4
 LDTP08881  Transmembrane protein 199 (TMEM199) 10.3
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 10.0
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 9.7
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 9.6
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 9.4
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 9.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 9.2
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 8.9
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 8.2
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 8.2
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 8.1
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 7.9
 LDTP11213  Nucleoporin NDC1 (NDC1) 7.9
 LDTP02215  Prosaposin (PSAP) 7.9
 LDTP15648  BRI3-binding protein (BRI3BP) 7.9
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 7.7
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 7.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 7.6
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 7.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 7.5
 LDTP16190  Protein FAM8A1 (FAM8A1) 7.4
 LDTP10065  Transmembrane protein 230 (TMEM230) 7.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 7.3
 LDTP09288  Vang-like protein 1 (VANGL1) 7.2
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 7.2
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 7.2
 LDTP05384  Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) 7.1
 LDTP11245  Derlin-1 (DERL1) 7.0
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 7.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 7.0
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 7.0
 LDTP07058  Transmembrane protein 201 (TMEM201) 6.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 6.8
 LDTP09515  Importin-4 (IPO4) 6.7
 LDTP17797  Transmembrane protein 104 (TMEM104) 6.7
 LDTP02071  Amyloid-beta precursor protein (APP) 6.6
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 6.5
 LDTP05780  Syntaxin-5 (STX5) 6.5
Other
Click to Show/Hide to Show 49 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00105  Protein unc-119 homolog B (UNC119B) 30.9
 LDTP11076  Apolipoprotein L2 (APOL2) 23.9
 LDTP12091  Spermatogenesis-defective protein 39 homolog (VIPAS39) 20.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 19.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 16.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 16.6
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 15.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 14.4
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 13.5
 LDTP10093  Mitochondrial calcium uniporter regulator 1 (MCUR1) 13.3
 LDTP12412  Reticulon-4 (RTN4) 12.8
 LDTP05868  Protein unc-119 homolog A (UNC119) 11.3
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 11.2
 LDTP05188  Large ribosomal subunit protein eL42 (RPL36A) 11.2
 LDTP07335  Rho GTPase-activating protein 17 (ARHGAP17) 10.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 10.1
 LDTP15623  Neuferricin (CYB5D2) 10.1
 LDTP01522  Reticulon-3 (RTN3) 9.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 9.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 9.0
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 8.9
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 8.6
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 8.5
 LDTP09970  RNA-binding protein with multiple splicing (RBPMS) 8.5
 LDTP13086  Syntaxin-18 (STX18) 8.5
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 8.4
 LDTP08594  Negative elongation factor C/D (NELFCD) 8.2
 LDTP06097  Reticulocalbin-2 (RCN2) 8.2
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 8.1
 LDTP14259  Testis-expressed protein 264 (TEX264) 8.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 8.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 7.9
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 7.8
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 7.7
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 7.7
 LDTP00887  Calumenin (CALU) 7.6
 LDTP10304  Sororin (CDCA5) 7.5
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 7.4
 LDTP10381  Peroxisomal membrane protein 11C (PEX11G) 7.4
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 7.3
 LDTP05375  Nucleobindin-1 (NUCB1) 7.2
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 7.2
 LDTP19963  TraB domain-containing protein (TRABD) 7.1
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 7.0
 LDTP03775  RNA-binding protein FUS (FUS) 7.0
 LDTP01652  Centrosomal protein 43 (CEP43) 6.9
 LDTP14812  Cleavage stimulation factor subunit 1 (CSTF1) 6.9
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 6.9
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 6.6

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587