Details of the Target

General Information of Target

Target ID LDTP10304
Target Name Sororin (CDCA5)
Gene Name CDCA5
Gene ID 113130
Synonyms
Sororin; Cell division cycle-associated protein 5; p35
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLLAWVQAFLVSNMLLAEAYGSGGCFWDNGHLYREDQTSPAPGLRCLNWLDAQSGLASAP
VSGAGNHSYCRNPDEDPRGPWCYVSGEAGVPEKRPCEDLRCPETTSQALPAFTTEIQEAS
EGPGADEVQVFAPANALPARSEAAAVQPVIGISQRVRMNSKEKKDLGTLGYVLGITMMVI
IIAIGAGIILGYSYKRGKDLKEQHDQKVCEREMQRITLPLSAFTNPTCEIVDEKTVVVHT
SQTPVDPQEGTTPLMGQAGTPGA
Target Bioclass
Other
Family
Sororin family
Subcellular location
Nucleus
Function
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
Uniprot ID
Q96FF9
Ensemble ID
ENST00000275517.8
HGNC ID
HGNC:14626

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C185(4.54)  LDD0168  [2]
DBIA
 Probe Info  		C165(0.62); C185(0.62)  LDD0531  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0151  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		C195(0.00); C185(0.00)  LDD0007  [7]
Phosphinate-6
 Probe Info  		C195(0.00); C185(0.00); C165(0.00)  LDD0018  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C163
 Probe Info  		6.54  LDD1843  [10]
C166
 Probe Info  		7.52  LDD1846  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C185(4.54)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C195(7.80); C185(4.42)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C165(0.62); C185(0.62)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C165(1.10)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C165(0.71); C185(0.71)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C165(0.69); C185(0.69)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C165(1.08); C185(1.08)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C165(1.55); C185(1.55)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C165(1.25); C185(1.25)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C165(1.02); C185(1.02)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C165(1.10); C185(1.10)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C165(0.89); C185(0.89)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C165(0.77); C185(0.77)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C165(1.19); C185(1.19)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C165(1.03)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C165(0.98); C185(0.98)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C165(0.99); C185(0.99)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C165(1.07); C185(1.07)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C165(1.13); C185(1.13)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C165(1.15); C185(1.15)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C165(1.09); C185(1.09)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C165(1.36); C185(1.36)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C165(1.01); C185(1.01)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C165(0.90); C185(0.90)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C165(1.03); C185(1.03)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C165(1.07)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C165(1.13); C185(1.13)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C165(0.96); C185(0.96)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C165(0.99); C185(0.99)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C165(0.82); C185(0.82)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C165(1.17); C185(1.17)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C165(0.91); C185(0.91)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C165(1.45); C185(1.45)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C165(1.36); C185(1.36)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C165(0.98)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C165(1.62)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C165(1.59)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C165(1.15)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C165(1.50)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C165(1.97)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C165(1.89)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C165(1.75)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C165(2.19)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C165(1.94)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C165(3.08)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C165(3.15)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C165(1.20)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C165(2.01)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C165(2.08)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C165(1.72)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C165(0.73)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C165(1.02)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C165(0.98)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C165(1.01)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C165(0.78)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C165(0.67)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C165(0.76)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C165(1.27)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C165(0.76)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C165(0.94)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C165(0.89)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C165(0.87)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C165(0.97)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C165(0.89)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C165(0.86)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C165(1.05)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C165(0.87); C185(0.87)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C165(0.88); C185(0.88)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C165(1.16); C185(1.16)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C165(0.59); C185(0.59)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C165(1.06); C185(1.06)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C165(1.38); C185(1.38)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C165(1.09); C185(1.09)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C165(1.15); C185(1.15)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C165(1.11); C185(1.11)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C185(1.92)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C185(1.43)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C185(1.17)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C185(5.34)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C185(1.87)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C165(0.56); C185(0.56)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C185(1.56)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C185(2.08)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C185(1.71)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C185(1.85)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C185(1.87)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C165(0.68)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C165(0.92)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C165(0.89)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C165(1.00)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C165(0.95)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C165(0.60); C185(0.60)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C165(1.00)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C165(1.05)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C165(1.28)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C165(1.02)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C165(1.05)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C165(0.95)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C185(1.23); C165(0.79)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C185(1.13); C165(0.93)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C185(0.95); C165(0.98)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C185(1.63); C165(0.90)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C165(0.40); C185(0.40)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C185(1.25); C165(0.95)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C185(1.30); C165(0.84)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C185(1.27); C165(1.00)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C185(1.51); C165(1.02)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C185(1.27); C165(1.02)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C185(1.38); C165(0.96)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C185(1.11); C165(0.76)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C185(1.15); C165(1.04)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C185(1.23); C165(1.00)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C185(1.11); C165(1.00)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C165(1.33)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C185(1.65); C165(2.03)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C185(1.12); C165(1.07)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C185(1.01); C165(0.89)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C185(1.15); C165(1.08)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C185(1.09); C165(1.00)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C185(1.11); C165(0.99)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C185(1.24); C165(0.92)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C185(1.25); C165(1.01)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C185(1.00); C165(0.97)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C185(1.10); C165(1.01)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C165(1.21)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C185(0.93); C165(1.12)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C185(0.97); C165(1.16)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C185(1.09); C165(1.19)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C185(1.02); C165(1.18)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C185(0.93); C165(1.23)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C185(1.17); C165(1.39)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C185(0.99); C165(1.01)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C185(0.93); C165(1.22)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C185(1.07); C165(1.24)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C185(1.09); C165(1.17)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C165(1.66)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C185(1.15); C165(1.22)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C185(1.00); C165(1.28)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C185(0.95); C165(1.53)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C165(0.98)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C165(1.17)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C165(1.14)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C165(1.12)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C165(1.09)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C165(1.12)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C165(1.12)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C165(1.27)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C165(1.11)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C165(1.20)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C165(1.22)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C165(1.12)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C165(1.16)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C165(1.06)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C165(1.51)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C165(1.75); C185(1.75)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C165(0.93); C185(0.93)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C165(1.08)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C165(1.35)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C165(1.38)  LDD0873  [3]
 LDCM0156  Aniline NCI-H1299 14.96  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C165(0.85); C185(0.85)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C165(1.40); C185(1.40)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C165(0.51); C185(0.51)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C165(1.43)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C165(1.56)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C165(1.39)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C165(1.57)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C165(0.84); C185(0.84)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C165(1.16); C185(1.16)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C165(0.82); C185(0.82)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C165(0.88); C185(0.88)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C165(1.28); C185(1.28)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C165(1.12); C185(1.12)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C165(1.30); C185(1.30)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C165(1.13); C185(1.13)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C185(1.22)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C185(1.29)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C185(1.24)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C185(1.33)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C185(1.58)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C165(0.91)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C165(0.80)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C165(1.19)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C165(1.23); C185(1.23)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C165(1.05)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C185(1.34); C165(0.84)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C185(1.11); C165(0.90)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C185(1.41); C165(0.92)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C185(1.19); C165(0.99)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C185(1.25); C165(1.10)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C185(0.81); C165(0.90)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C185(1.12); C165(1.02)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C185(1.21); C165(0.98)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C165(1.39); C185(1.39)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C165(0.91); C185(0.91)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C165(1.15); C185(1.15)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C165(1.26)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C165(1.14)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C165(1.13)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C165(1.18)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C165(0.74); C185(0.74)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C165(1.08)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C165(1.10)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C165(1.19)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C165(0.78)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C165(0.94)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C165(1.04)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C165(1.01)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C165(1.07)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C165(0.82)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C165(0.94)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C165(0.73); C185(0.73)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C165(1.17)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C185(1.28)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C185(1.26)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C185(1.22)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C185(0.91)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C185(0.95)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C185(1.03)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C185(1.19)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C185(0.99)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C165(0.89); C185(0.89)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C185(1.34)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C185(1.11)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C185(0.97)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C185(0.95)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C185(1.02)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C185(1.03)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C185(1.49); C165(1.57)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C185(1.38); C165(1.17)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C185(1.07); C165(1.31)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C185(1.14); C165(1.14)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C165(0.92); C185(0.92)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C185(1.39); C165(1.32)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C185(1.19); C165(1.23)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C185(0.84); C165(0.93)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C185(1.04); C165(0.96)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C185(1.05); C165(0.92)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C185(1.46); C165(1.22)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C185(0.95); C165(0.94)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C185(1.15); C165(1.21)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C185(1.13); C165(1.00)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C185(1.29); C165(1.22)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C165(1.27); C185(1.27)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C185(1.22); C165(1.41)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C165(1.51)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C165(1.07)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C165(1.67)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C165(1.20)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C165(1.29)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C165(1.03)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C165(1.02)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C165(0.82)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C165(0.97)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C165(0.99); C185(0.99)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C165(0.96)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C165(1.00)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C165(1.07)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C165(0.95)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C165(1.18)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C185(1.27); C165(1.42)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C185(1.27); C165(1.40)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C185(2.84); C165(2.58)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C185(2.35); C165(1.73)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C165(1.78); C185(1.78)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C185(1.27); C165(1.32)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C185(1.00); C165(1.45)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C185(0.60); C165(0.92)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C185(1.01); C165(1.03)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C185(1.82); C165(2.03)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C185(1.51); C165(2.00)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C185(1.41); C165(1.98)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C185(1.52); C165(1.56)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C185(1.04); C165(1.77)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C185(1.41); C165(2.01)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C165(1.00); C185(1.00)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C185(0.93); C165(2.20)  LDD1083  [3]
 LDCM0486  CL91 HCT 116 C165(0.71); C185(0.71)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C165(0.60); C185(0.60)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C165(0.71); C185(0.71)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C165(1.11); C185(1.11)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C165(0.70); C185(0.70)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C165(0.57); C185(0.57)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C165(0.56); C185(0.56)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C165(0.49); C185(0.49)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C165(0.59); C185(0.59)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C185(1.11)  LDD1698  [11]
 LDCM0625  F8 Ramos C195(1.11)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C195(1.10)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C195(0.29)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C195(0.78)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C195(0.86)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C195(1.03)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C195(0.80)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C195(0.68)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C195(0.90)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C195(0.81)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C195(0.73)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C195(0.77)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C195(0.95)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C195(1.10)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C165(1.24)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C195(0.63)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C195(0.94)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C185(0.84)  LDD1025  [3]
 LDCM0610  Fragment52 Ramos C195(0.69)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C195(0.62)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C195(1.59)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C195(0.79)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C185(1.17)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C185(1.19)  LDD1497  [11]
 LDCM0024  KB05 HEK-293T C185(1.01)  LDD1502  [11]
 LDCM0131  RA190 MM1.R C165(2.30); C185(2.30); C195(2.10)  LDD0304  [13]
 LDCM0170  Structure8 Ramos 20.00  LDD0433  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
N-alpha-acetyltransferase 11 (NAA11) Acetyltransferase family Q9BSU3
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sister chromatid cohesion protein PDS5 homolog A (PDS5A) PDS5 family Q29RF7
Shugoshin 1 (SGO1) Shugoshin family Q5FBB7
Structural maintenance of chromosomes protein 1A (SMC1A) SMC family Q14683

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
14 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.