Details of the Target

General Information of Target

Target ID LDTP10862
Target Name Proteasome subunit beta type-7 (PSMB7)
Gene Name PSMB7
Gene ID 5695
Synonyms
Z; Proteasome subunit beta type-7; EC 3.4.25.1; Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit Z
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Peptidase T1B family
Subcellular location
Cytoplasm
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
TTD ID
T55986
Uniprot ID
Q99436
DrugMap ID
TT49BVC
Ensemble ID
ENST00000259457.8
HGNC ID
HGNC:9544
ChEMBL ID
CHEMBL3347256

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GAMG SNV: p.S5L .
Ishikawa (Heraklio) 02 ER SNV: p.I77T .
OVISE SNV: p.L210V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.21  LDD0402  [1]
TH211
 Probe Info  		Y136(20.00)  LDD0257  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K237(8.47); K238(0.68); K41(10.00)  LDD0277  [4]
P11
 Probe Info  		14.63  LDD0201  [5]
DBIA
 Probe Info  		C219(1.64)  LDD3332  [6]
BTD
 Probe Info  		C74(1.28)  LDD1700  [7]
5E-2FA
 Probe Info  		H78(0.00); H109(0.00); H152(0.00); H159(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		K72(0.00); K249(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C74(0.00); C219(0.00); C86(0.00); C87(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C74(0.00); C86(0.00); C87(0.00); C219(0.00)  LDD0036  [10]
IPIAA_L
 Probe Info  		C86(0.00); C74(0.00)  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C74(0.00); C219(0.00); C86(0.00); C87(0.00)  LDD0037  [10]
IPM
 Probe Info  		C74(0.00); C247(0.00)  LDD0025  [12]
NAIA_4
 Probe Info  		C74(0.00); C247(0.00)  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
MPP-AC
 Probe Info  		N.A.  LDD0428  [15]
NAIA_5
 Probe Info  		C74(0.00); C247(0.00)  LDD2223  [13]
TPP-AC
 Probe Info  		N.A.  LDD0427  [15]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		7.67  LDD1779  [16]
C166
 Probe Info  		6.77  LDD1846  [16]
C218
 Probe Info  		12.13  LDD1892  [16]
C233
 Probe Info  		9.51  LDD1906  [16]
C239
 Probe Info  		5.62  LDD1912  [16]
C353
 Probe Info  		7.89  LDD2014  [16]
C354
 Probe Info  		8.28  LDD2015  [16]
C433
 Probe Info  		6.41  LDD2088  [16]
FFF probe11
 Probe Info  		10.76  LDD0472  [17]
FFF probe12
 Probe Info  		14.26  LDD0473  [17]
FFF probe13
 Probe Info  		14.88  LDD0475  [17]
FFF probe14
 Probe Info  		10.09  LDD0477  [17]
FFF probe15
 Probe Info  		5.39  LDD0478  [17]
FFF probe2
 Probe Info  		17.09  LDD0463  [17]
FFF probe3
 Probe Info  		20.00  LDD0465  [17]
FFF probe4
 Probe Info  		20.00  LDD0466  [17]
FFF probe6
 Probe Info  		7.48  LDD0468  [17]
FFF probe9
 Probe Info  		15.48  LDD0470  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]
OEA-DA
 Probe Info  		11.54  LDD0046  [19]
STS-1
 Probe Info  		N.A.  LDD0068  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C74(0.31)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C74(0.47)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C74(0.83)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C74(1.43)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C74(1.04)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C74(0.24)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C74(0.76)  LDD2131  [7]
 LDCM0214  AC1 HEK-293T C219(1.10)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C219(0.97)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C219(0.93)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C219(0.93)  LDD1510  [21]
 LDCM0270  AC15 HEK-293T C219(0.81)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C219(0.90)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C219(1.04)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C219(0.99)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C219(0.97)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C219(1.06)  LDD1519  [21]
 LDCM0283  AC23 HEK-293T C219(0.67)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C219(1.03)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C219(0.97)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C219(1.02)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C219(1.08)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C219(0.90)  LDD1527  [21]
 LDCM0290  AC3 HEK-293T C219(0.96)  LDD1529  [21]
 LDCM0292  AC31 HEK-293T C219(0.86)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C219(1.09)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C219(1.17)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C219(0.98)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C219(1.02)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C219(0.96)  LDD1536  [21]
 LDCM0300  AC39 HEK-293T C219(0.80)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C219(0.88)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C219(1.04)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C219(1.00)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C219(1.01)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C219(1.17)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C219(0.96)  LDD1545  [21]
 LDCM0309  AC47 HEK-293T C219(0.77)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C219(1.00)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C219(1.11)  LDD1550  [21]
 LDCM0313  AC50 HEK-293T C219(1.22)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C219(1.12)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C219(1.10)  LDD1554  [21]
 LDCM0318  AC55 HEK-293T C219(0.91)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C219(0.99)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C219(0.98)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C219(0.95)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C219(0.92)  LDD1561  [21]
 LDCM0324  AC60 HEK-293T C219(0.92)  LDD1563  [21]
 LDCM0327  AC63 HEK-293T C219(0.74)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C219(0.91)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C219(0.85)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C219(0.88)  LDD1569  [21]
 LDCM0545  Acetamide MDA-MB-231 C74(0.27)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C74(0.75)  LDD2113  [7]
 LDCM0356  AKOS034007680 HEK-293T C219(1.01)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C219(1.11)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 10.47  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C74(0.42)  LDD2091  [7]
 LDCM0088  C45 HEK-293T 14.63  LDD0201  [5]
 LDCM0632  CL-Sc Hep-G2 C74(0.87)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C219(0.95)  LDD1571  [21]
 LDCM0369  CL100 HEK-293T C219(1.10)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C219(1.03)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C219(0.89)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C219(1.04)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C219(1.15)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C219(1.10)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C219(1.12)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C219(0.98)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C219(0.97)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C219(1.31)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C219(0.70)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C219(0.72)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C219(0.93)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C219(0.89)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C219(1.09)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C219(0.66)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C219(0.94)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C219(1.05)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C219(1.22)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C219(0.82)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C219(1.04)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C219(0.99)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C219(1.01)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C219(1.03)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C219(0.76)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C219(0.89)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C219(1.08)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C219(1.08)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C219(1.00)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C219(0.98)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C219(1.00)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C219(0.97)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C219(0.77)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C219(0.95)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C219(1.05)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C219(0.84)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C219(1.15)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C219(0.88)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C219(1.10)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C219(1.13)  LDD1612  [21]
 LDCM0411  CL23 HEK-293T C219(1.03)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C219(1.05)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C219(1.05)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C219(0.98)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C219(0.97)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C219(0.92)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C219(1.11)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C219(0.95)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C219(1.24)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C219(0.81)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C219(0.99)  LDD1625  [21]
 LDCM0424  CL35 HEK-293T C219(0.88)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C219(1.18)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C219(1.07)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C219(1.15)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C219(1.08)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C219(1.12)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C219(1.13)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C219(1.11)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C219(0.97)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C219(0.95)  LDD1638  [21]
 LDCM0437  CL47 HEK-293T C219(1.03)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C219(1.20)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C219(1.06)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C219(1.03)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C219(0.74)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C219(1.10)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C219(1.05)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C219(1.11)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C219(1.06)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C219(1.01)  LDD1650  [21]
 LDCM0450  CL59 HEK-293T C219(0.85)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C219(0.98)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C219(1.17)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C219(1.08)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C219(1.14)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C219(1.05)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C219(1.02)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C219(1.15)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C219(1.15)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C219(0.94)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C219(1.30)  LDD1663  [21]
 LDCM0462  CL7 HEK-293T C219(0.89)  LDD1665  [21]
 LDCM0464  CL71 HEK-293T C219(0.88)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C219(1.22)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C219(0.98)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C219(1.15)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C219(0.86)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C219(0.99)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C219(1.21)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C219(0.88)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C219(0.77)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C219(1.12)  LDD1677  [21]
 LDCM0477  CL83 HEK-293T C219(0.92)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C219(0.95)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C219(0.99)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C219(1.09)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C219(0.90)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C219(0.95)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C219(1.04)  LDD1686  [21]
 LDCM0485  CL90 HEK-293T C219(0.96)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C219(1.38)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C219(1.01)  LDD1690  [21]
 LDCM0490  CL95 HEK-293T C219(0.61)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C219(0.95)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C219(0.97)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C219(0.83)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C219(1.04)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C219(1.11)  LDD1698  [21]
 LDCM0625  F8 Ramos C74(0.96)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C74(0.64)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C74(0.15)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C74(0.85)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C74(1.42)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C74(0.87)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C74(0.62)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C74(1.06)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C74(1.20)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C74(1.16)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C74(0.88)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C74(1.55)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C74(1.15)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C74(0.80)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C219(0.87)  LDD1671  [21]
 LDCM0596  Fragment38 Ramos C74(1.20)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C74(0.74)  LDD2184  [22]
 LDCM0427  Fragment51 HEK-293T C219(0.76)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C74(1.60)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C74(1.94)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C74(0.57)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C74(0.59)  LDD2188  [22]
 LDCM0022  KB02 HEK-293T C219(0.97)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C219(1.08)  LDD1497  [21]
 LDCM0024  KB05 MKN45 C219(1.64)  LDD3332  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C74(0.47)  LDD2121  [7]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C74(0.49)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C74(1.18)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C74(0.97)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C74(0.78)  LDD2093  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C74(0.25)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C74(0.82)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C74(0.61)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C74(0.86)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C74(0.39)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C74(0.92)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C74(0.43)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C74(1.82)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C74(0.21)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C74(1.13)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C74(0.52)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C74(0.42)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C74(0.56)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C74(0.70)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C74(0.58)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C74(0.61)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C74(0.64)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C74(0.74)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C74(2.52)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C74(0.74)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C74(0.38)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C74(0.77)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C74(0.42)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C74(0.60)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C74(0.43)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C74(1.00)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C74(0.64)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C74(0.78)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C74(0.68)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C74(0.74)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C74(0.90)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C74(0.95)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C74(0.98)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C74(1.28)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C74(0.44)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C74(0.46)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C74(0.71)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C74(2.73)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C74(0.19)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C74(0.55)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C74(3.91)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C74(0.53)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C74(0.44)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C74(0.40)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C74(0.34)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C74(1.63)  LDD2153  [7]
 LDCM0131  RA190 MM1.R C74(1.19)  LDD0304  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Proteasome subunit beta type-5 (PSMB5) Peptidase T1B family P28074
Proteasome subunit beta type-6 (PSMB6) Peptidase T1B family P28072
Proteasome subunit beta type-9 (PSMB9) Peptidase T1B family P28065
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome maturation protein (POMP) POMP/UMP1 family Q9Y244

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(3ar6r6as)-6-((S)-((S)-cyclohex-2-enyl)(Hydroxy)Methyl)-6a-methyl-4-oxo-hexahydro-2h-furo[32-c]Pyrrole-6-carbaldehyde . DB08515
Patented
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Peptide Analog 21 Small molecular drug D02PJI
Peptide Analog 23 Small molecular drug D0T1YB
Peptide Analog 36 Small molecular drug D0DY3A
Peptide Analog 37 Small molecular drug D00GGB
Peptide Analog 38 Small molecular drug D01GON
Peptide Analog 39 Small molecular drug D02CQG
Peptide Analog 41 Small molecular drug D01OOO

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
20 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.