Details of the Target

General Information of Target

Target ID LDTP05384
Target Name Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)
Gene Name SLC25A11
Gene ID 8402
Synonyms
SLC20A4; Mitochondrial 2-oxoglutarate/malate carrier protein; OGCP; alpha-oxoglutarate carrier; Solute carrier family 25 member 11; SLC25A11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTRE
YKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFL
LKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTL
WRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPV
DIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFL
EQMNKAYKRLFLSG
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis. Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria.
Uniprot ID
Q02978
Ensemble ID
ENST00000225665.12
HGNC ID
HGNC:10981

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.M33I .
LS123 SNV: p.T148P .
MFE319 SNV: p.F119C .
MOLT4 SNV: p.R90C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		100.00  LDD0244  [1]
TH211
 Probe Info  		Y202(7.11); Y102(20.00)  LDD0260  [2]
C-Sul
 Probe Info  		4.45  LDD0066  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
BTD
 Probe Info  		C184(0.41)  LDD1699  [5]
ONAyne
 Probe Info  		K57(1.79)  LDD0275  [6]
OPA-S-S-alkyne
 Probe Info  		K57(1.95)  LDD3494  [7]
DBIA
 Probe Info  		C184(1.04)  LDD0531  [8]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		C184(0.00); C221(0.00); C224(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
Alkyne tyramide
 Probe Info  		Y94(0.00); Y259(0.00)  LDD0003  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
NHS
 Probe Info  		K57(0.00); K15(0.00)  LDD0010  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C224(0.00); C221(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C006
 Probe Info  		5.17  LDD1715  [16]
C017
 Probe Info  		8.22  LDD1725  [16]
C094
 Probe Info  		26.54  LDD1785  [16]
C129
 Probe Info  		5.70  LDD1811  [16]
C166
 Probe Info  		7.06  LDD1846  [16]
C228
 Probe Info  		15.03  LDD1901  [16]
C232
 Probe Info  		41.93  LDD1905  [16]
C242
 Probe Info  		6.87  LDD1915  [16]
C303
 Probe Info  		7.31  LDD1972  [16]
FFF probe11
 Probe Info  		8.29  LDD0471  [17]
FFF probe13
 Probe Info  		10.92  LDD0475  [17]
FFF probe2
 Probe Info  		10.23  LDD0463  [17]
FFF probe3
 Probe Info  		12.96  LDD0464  [17]
FFF probe4
 Probe Info  		5.19  LDD0466  [17]
JN0003
 Probe Info  		8.16  LDD0469  [17]
STS-2
 Probe Info  		N.A.  LDD0138  [18]
Alk-rapa
 Probe Info  		2.67  LDD0213  [19]
DA-2
 Probe Info  		N.A.  LDD0072  [20]
OEA-DA
 Probe Info  		4.08  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C184(0.84)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C184(1.28)  LDD2152  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C184(0.78)  LDD2132  [5]
 LDCM0214  AC1 HCT 116 C184(1.04)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C184(0.92)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C184(0.72)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C184(0.64)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C184(0.80)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C184(0.60)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C184(0.75)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C184(0.61)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C184(0.66)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C184(0.71)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C184(0.94)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C184(0.83)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C184(0.93)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C184(0.67)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C184(0.72)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C184(0.65)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C184(1.17)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C184(0.90)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C184(0.96)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C184(0.92)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C184(0.97)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C184(0.90)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C184(0.99)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C184(0.96)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C184(1.01)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C184(1.04)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C184(0.86)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C184(1.10)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C184(1.12)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C184(1.00)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C184(0.89)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C184(0.98)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C184(1.12)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C184(1.07)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C184(0.98)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C184(1.04)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C184(1.15)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C184(0.98)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C184(0.91)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C184(0.96)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C184(1.00)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C184(1.17)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C184(1.05)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C184(1.07)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C184(0.87)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C184(1.13)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C184(1.13)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C184(1.03)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C184(0.85)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C184(0.76)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C184(0.86)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C184(0.72)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C184(0.92)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C184(0.68)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C184(0.67)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C184(0.98)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C184(0.87)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C184(0.83)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C184(0.76)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C184(0.65)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C184(0.75)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C184(0.72)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C184(0.80)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C184(0.80)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C184(1.34)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C184(1.12)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C184(1.04)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C184(1.10)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C184(1.17)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C184(1.11)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C184(1.23)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C184(1.19)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C184(1.18)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C184(0.91)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C184(1.09)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C184(0.81)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C184(0.97)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C184(0.87)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C184(1.08)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C184(0.89)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C184(1.02)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C184(0.94)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C184(0.80)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C184(0.79)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C184(1.38)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C184(1.09)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C184(1.24)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C184(0.99)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C184(1.07)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C184(1.12)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C184(1.02)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C184(1.09)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C184(0.93)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C184(1.02)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C184(1.22)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C184(1.25)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C184(1.02)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C184(1.16)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C184(1.10)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C184(1.12)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C184(1.18)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C184(0.97)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C184(0.92)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C184(0.95)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C184(0.99)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C184(0.99)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C184(1.13)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C184(1.08)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C184(1.09)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C184(1.19)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C184(0.95)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C184(0.94)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C184(0.91)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C184(1.19)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C184(0.97)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C184(1.03)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C184(0.83)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C184(0.96)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C184(1.05)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C184(0.90)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C184(0.97)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C184(1.23)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C184(1.00)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C184(1.22)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C184(1.25)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C184(1.14)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C184(1.07)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C184(1.19)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C184(1.02)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C184(1.22)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C184(1.07)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C184(0.94)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C184(1.19)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C184(0.88)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C184(1.10)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C184(1.27)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C184(1.08)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C184(0.79)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C184(0.76)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C184(0.72)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C184(0.77)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C184(0.95)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C184(0.90)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C184(0.88)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C184(1.31)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C184(0.83)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C184(0.80)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C184(0.78)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C184(1.03)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C184(0.70)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C184(0.98)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C184(0.81)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C184(0.70)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C184(1.03)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C184(0.83)  LDD2138  [5]
 LDCM0248  AKOS034007472 HCT 116 C184(1.13)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C184(0.98)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C184(0.99)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C184(1.26)  LDD2171  [8]
 LDCM0498  BS-3668 MDA-MB-231 C184(0.48)  LDD2091  [5]
 LDCM0367  CL1 HCT 116 C184(0.88)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C184(1.12)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C184(1.05)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C184(0.86)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C184(0.96)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C184(0.85)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C184(1.00)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C184(1.05)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C184(1.07)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C184(1.18)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C184(1.17)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C184(1.04)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C184(1.14)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C184(1.05)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C184(1.14)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C184(0.95)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C184(0.81)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C184(0.94)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C184(0.79)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C184(0.82)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C184(0.89)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C184(1.18)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C184(1.19)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C184(1.19)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C184(1.07)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C184(0.91)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C184(1.00)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C184(0.98)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C184(0.97)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C184(0.86)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C184(0.97)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C184(0.98)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C184(1.09)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C184(1.22)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C184(1.08)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C184(1.21)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C184(0.83)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C184(1.04)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C184(1.09)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C184(0.98)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C184(0.85)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C184(0.91)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C184(0.95)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C184(0.77)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C184(0.82)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C184(1.02)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C184(0.89)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C184(0.96)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C184(0.86)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C184(1.02)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C184(0.80)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C184(0.95)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C184(1.00)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C184(0.85)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C184(0.68)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C184(0.64)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C184(0.75)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C184(0.76)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C184(0.75)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C184(0.90)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C184(0.91)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C184(1.03)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C184(0.86)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C184(0.74)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C184(0.90)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C184(0.73)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C184(0.72)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C184(0.93)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C184(1.26)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C184(1.16)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C184(1.35)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C184(1.13)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C184(1.09)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C184(1.09)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C184(1.09)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C184(1.18)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C184(1.04)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C184(0.97)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C184(1.06)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C184(0.96)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C184(0.95)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C184(0.99)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C184(1.06)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C184(0.96)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C184(1.39)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C184(0.97)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C184(0.95)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C184(0.87)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C184(0.84)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C184(1.03)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C184(0.94)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C184(0.97)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C184(0.94)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C184(0.78)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C184(1.23)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C184(0.94)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C184(0.98)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C184(0.96)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C184(0.94)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C184(0.87)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C184(0.82)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C184(0.93)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C184(0.98)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C184(0.89)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C184(0.82)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C184(0.88)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C184(1.00)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C184(1.02)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C184(0.96)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C184(1.01)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C184(0.96)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C184(1.00)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C184(0.90)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C184(0.88)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C184(1.11)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C184(0.94)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C184(1.05)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C184(0.94)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C184(0.92)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C184(1.21)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C184(0.89)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C184(1.07)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C184(0.97)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C184(1.02)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C184(1.03)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C184(0.92)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C184(1.08)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C184(11.31)  LDD1702  [5]
 LDCM0625  F8 Ramos C184(1.07)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C184(5.88)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C184(0.01)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C184(7.35)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C184(1.43)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C184(5.61)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C184(13.67)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C184(1.49)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C184(1.10)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C184(0.81)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C184(0.79)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C184(1.74)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C184(1.31)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C184(7.34)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C184(0.96)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C184(1.84)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C184(3.89)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C184(0.84)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C184(20.00)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C184(1.09)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C184(5.37)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C184(12.39)  LDD2188  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C184(0.85)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C184(0.95)  LDD1497  [22]
 LDCM0024  KB05 HEK-293T C184(0.78)  LDD1502  [22]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C184(0.96)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C184(0.95)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C184(1.06)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C184(1.10)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C184(1.56)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C184(1.81)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C184(0.73)  LDD2104  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C184(0.90)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C184(1.16)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C184(0.96)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C184(0.86)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C184(1.25)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C184(0.84)  LDD2114  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C184(0.95)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C184(1.23)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C184(1.97)  LDD2119  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C184(0.89)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C184(1.00)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C184(1.11)  LDD2124  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C184(1.00)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C184(1.38)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C184(0.96)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C184(0.99)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C184(0.88)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C184(0.99)  LDD2141  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C184(0.91)  LDD2149  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C184(0.96)  LDD2151  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C184(0.99)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C184(0.71)  LDD2207  [24]
 LDCM0090  Rapamycin JHH-7 2.67  LDD0213  [19]
 LDCM0021  THZ1 HCT 116 C184(1.26)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) Adenosylhomocysteinase family O43865
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Huntingtin (HTT) Huntingtin family P42858
Cadherin-1 (CDH1) . P12830
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 5 activator 1 (CDK5R1) Cyclin-dependent kinase 5 activator family Q15078

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
20 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.