Details of the Target

General Information of Target

Target ID LDTP09155
Target Name Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)
Gene Name PIK3C3
Gene ID 5289
Synonyms
VPS34; Phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; EC 2.7.1.137; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family
Subcellular location
Midbody
Function
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes.; (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication.
Uniprot ID
Q8NEB9
Ensemble ID
ENST00000262039.9
HGNC ID
HGNC:8974
ChEMBL ID
CHEMBL1075165

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K557(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C336(1.17)  LDD0613  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C336(0.00); C476(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C336(0.00); C476(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		20.11  LDD1733  [7]
C130
 Probe Info  		6.68  LDD1812  [7]
C163
 Probe Info  		5.94  LDD1843  [7]
C166
 Probe Info  		33.36  LDD1846  [7]
C249
 Probe Info  		13.55  LDD1922  [7]
C293
 Probe Info  		33.36  LDD1963  [7]
C349
 Probe Info  		9.85  LDD2010  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C336(0.97); C476(1.00); C501(1.04); C54(1.09)  LDD1507  [8]
 LDCM0215  AC10 PaTu 8988t C54(0.56); C61(0.56)  LDD1094  [2]
 LDCM0216  AC100 HEK-293T C336(0.88)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C336(0.82)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C336(0.77)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C336(0.82)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C336(0.87)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C336(0.95)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C336(1.19)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C336(0.88)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C336(0.89)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C336(0.92)  LDD0823  [2]
 LDCM0226  AC11 PaTu 8988t C54(0.57); C61(0.57)  LDD1105  [2]
 LDCM0227  AC110 HEK-293T C336(0.85)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C336(1.05)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C336(0.98)  LDD0827  [2]
 LDCM0237  AC12 PaTu 8988t C54(0.52); C61(0.52)  LDD1116  [2]
 LDCM0259  AC14 PaTu 8988t C54(0.99); C61(0.99)  LDD1138  [2]
 LDCM0263  AC143 HEK-293T C336(1.07)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C336(1.04)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C336(1.15)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C336(1.16)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C336(1.14)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C336(1.16)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C336(1.08)  LDD0867  [2]
 LDCM0270  AC15 PaTu 8988t C54(0.59); C61(0.59)  LDD1149  [2]
 LDCM0271  AC150 HEK-293T C336(1.12)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C336(1.22)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C336(1.19)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C336(1.25)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C336(1.00)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C336(1.29)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C336(1.10)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C336(1.40)  LDD2165  [2]
 LDCM0276  AC17 PaTu 8988t C336(1.35)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C336(0.73)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C336(0.94)  LDD1157  [2]
 LDCM0279  AC2 HEK-293T C476(0.98); C501(1.11)  LDD1518  [8]
 LDCM0280  AC20 PaTu 8988t C336(0.96)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C336(1.21)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C336(1.08)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C336(0.62)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C336(0.67)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C336(1.28)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C336(0.82)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C336(0.87)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C336(0.73)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C336(0.80)  LDD1168  [2]
 LDCM0290  AC3 HEK-293T C336(1.00); C476(1.04)  LDD1529  [8]
 LDCM0291  AC30 PaTu 8988t C336(0.88)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C336(1.17)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C336(0.84)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C336(0.69)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C336(0.92)  LDD1174  [2]
 LDCM0296  AC35 HCT 116 C336(1.17)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C336(1.04)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C336(1.08)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C336(1.16)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C336(1.10)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C336(1.03); C476(1.01)  LDD1540  [8]
 LDCM0302  AC40 HCT 116 C336(1.00)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C336(0.98)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C336(1.01)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C336(0.96)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C336(1.10)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C336(0.89)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C336(0.69)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C336(0.93)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C336(0.66)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C336(0.74)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C476(1.14); C501(1.04); C54(0.92)  LDD1551  [8]
 LDCM0313  AC50 HCT 116 C336(0.74)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C336(0.84)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C336(0.76)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C336(1.21)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C336(0.81)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C336(1.13)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C336(0.93)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C336(0.87)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C336(0.83)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C336(0.87)  LDD0639  [2]
 LDCM0323  AC6 PaTu 8988t C54(0.72); C61(0.72)  LDD1202  [2]
 LDCM0324  AC60 HCT 116 C336(0.87)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C336(0.76)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C336(0.85)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C336(0.91)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C336(1.01)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C336(0.88)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C336(0.91)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C336(0.78)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C336(1.19)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C336(0.82)  LDD0650  [2]
 LDCM0334  AC7 PaTu 8988t C54(0.68); C61(0.68)  LDD1213  [2]
 LDCM0335  AC70 HCT 116 C336(1.18)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C336(1.32)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C336(1.16)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C336(1.01)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C336(1.28)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C336(0.87)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C336(0.99)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C336(0.96)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C336(0.79)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C336(1.43)  LDD0661  [2]
 LDCM0345  AC8 PaTu 8988t C54(0.68); C61(0.68)  LDD1224  [2]
 LDCM0346  AC80 HCT 116 C336(0.92)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C336(1.29)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C336(1.29)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C336(0.88)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C336(0.89)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C336(0.92)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C336(0.98)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C336(0.91)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C336(0.88)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C336(0.94)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C336(0.78)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C336(1.04)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C336(0.95)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C336(0.89)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C336(1.61)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C336(0.90)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C336(1.40)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C336(0.82)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C336(0.87)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C336(0.88)  LDD0964  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C54(1.30); C61(1.30)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C54(0.46); C61(0.46)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C54(0.50); C61(0.50)  LDD1154  [2]
 LDCM0367  CL1 HCT 116 C336(0.96)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C336(0.92)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C336(1.00); C476(1.05); C501(1.01)  LDD1573  [8]
 LDCM0370  CL101 PaTu 8988t C54(0.65); C61(0.65)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C54(0.54); C61(0.54)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C54(0.61); C61(0.61)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C54(0.69); C61(0.69)  LDD1252  [2]
 LDCM0374  CL105 PaTu 8988t C336(0.85)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C336(0.83)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C336(0.80)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C336(0.87)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C336(0.82)  LDD1257  [2]
 LDCM0379  CL11 HCT 116 C336(0.91)  LDD0696  [2]
 LDCM0380  CL110 PaTu 8988t C336(0.66)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C336(0.64)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C336(0.86)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C336(0.92)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C336(0.86)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C336(1.01)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C336(0.74)  LDD1265  [2]
 LDCM0387  CL117 HCT 116 C336(0.89)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C336(1.06)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C336(0.90)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C336(0.93)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C336(1.11)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C336(0.78)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C336(0.72)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C336(0.60)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C336(0.78)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C336(1.17)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C336(0.91)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C336(0.95)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C336(0.94)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C336(0.84)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C336(0.85)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C336(1.06)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C336(0.99)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C336(1.10)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C336(1.09)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C336(1.11)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C336(0.86)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C336(1.01)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C336(1.07)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C336(0.88)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C336(0.93)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C336(1.20)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C336(1.01)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C336(0.86)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C336(1.10)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C336(1.02)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C336(1.10)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C336(0.95)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C336(0.96)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C336(0.87)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C336(0.62)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C336(0.62)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C336(0.79)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C336(0.81)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C336(0.81)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C336(0.89)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C336(0.83)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C336(0.91)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C336(0.75)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C336(0.85)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C336(0.86)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C336(0.74)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C336(0.77)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C336(0.79)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C336(0.96)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C336(1.19)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C336(0.85)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C336(0.91)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C336(1.13)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C336(1.18)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C336(0.92)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C336(0.92)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C336(1.26)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C336(1.04)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C336(1.04)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C336(0.93)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C336(1.31)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C336(0.99)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C336(0.89)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C336(1.04)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C336(1.41)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C336(0.97)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C336(0.80)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C336(0.85)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C336(0.93)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C336(0.87)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C336(0.82)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C336(0.84)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C336(0.71)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C336(0.81)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C336(0.89)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C336(0.91)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C336(0.75)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C336(0.85)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C336(0.75)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C336(0.68)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C336(1.10)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C336(0.99)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C336(1.00)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C336(1.23)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C336(0.86)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C336(0.92)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C336(1.35)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C336(1.56)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C336(1.33)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C336(0.85)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C336(1.11)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C336(1.22)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C336(1.56)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C336(1.41)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C336(1.12)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C336(0.81)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C336(1.21)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C336(1.09); C476(1.32)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C336(1.04); C476(1.01)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C476(1.01); C501(0.90); C54(0.87)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C476(0.86); C501(0.94); C54(1.25)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C336(0.87); C476(0.57); C501(1.01); C54(0.66)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C336(1.13); C476(1.18); C501(0.92); C802(1.07)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C336(0.96); C476(1.01); C501(1.06); C54(0.78)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C476(0.98); C501(1.00)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C476(1.20)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C476(1.13)  LDD1698  [8]
 LDCM0625  F8 Ramos C336(0.90)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C336(0.75)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C336(1.14)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C336(1.03)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C336(1.01)  LDD2192  [9]
 LDCM0579  Fragment20 Ramos C336(1.01)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C336(1.05)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C336(0.79)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C336(0.91)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C336(0.94)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C336(1.19)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C336(1.09)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C336(0.87)  LDD2201  [9]
 LDCM0468  Fragment33 HEK-293T C336(0.68)  LDD1066  [2]
 LDCM0596  Fragment38 Ramos C336(0.88)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C336(0.99)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C336(0.97)  LDD0744  [2]
 LDCM0614  Fragment56 Ramos C336(1.27)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C336(0.99)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C336(0.98)  LDD2188  [9]
 LDCM0022  KB02 HEK-293T C476(1.05)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C476(1.05)  LDD1497  [8]
 LDCM0024  KB05 UACC257 C336(2.27)  LDD3325  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin 1-associated autophagy-related key regulator (ATG14) ATG14 family Q6ZNE5
Beclin-1 (BECN1) Beclin family Q14457
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor-binding factor 2 (NRBF2) . Q96F24
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) . Q92622
UV radiation resistance-associated gene protein (UVRAG) . Q9P2Y5

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk-1059615 Small molecular drug DB11962
N-(5-{4-chloro-3-[(2-hydroxyethyl)Sulfamoyl]Phenyl}-4-methyl-13-thiazol-2-yl)Acetamide Small molecular drug DB06836

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840