Details of the Target

General Information of Target

Target ID LDTP09288
Target Name Vang-like protein 1 (VANGL1)
Gene Name VANGL1
Gene ID 81839
Synonyms
STB2; Vang-like protein 1; Loop-tail protein 2 homolog; LPP2; Strabismus 2; Van Gogh-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGND
STRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLG
LLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMP
RVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVL
LELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKF
RAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKAR
LVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSM
ESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIV
FVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Vang family
Subcellular location
Cell membrane
TTD ID
T38183
Uniprot ID
Q8TAA9
DrugMap ID
TT18WJB
Ensemble ID
ENST00000310260.7
HGNC ID
HGNC:15512

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P437H .
HCT15 SNV: p.G205V; p.Q462Ter .
HT115 SNV: p.D60Y .
NCIH1793 Deletion: p.K19NfsTer104 .
NCIH1993 SNV: p.D389Y .
RH41 SNV: p.P498T .
RKO SNV: p.M99V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K407(5.88)  LDD0277  [1]
Probe 1
 Probe Info  		Y312(25.55)  LDD3495  [2]
DBIA
 Probe Info  		C485(1.15)  LDD1508  [3]
PAL-AfBPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.15  LDD1725  [4]
C040
 Probe Info  		12.91  LDD1740  [4]
C041
 Probe Info  		10.78  LDD1741  [4]
C055
 Probe Info  		15.35  LDD1752  [4]
C056
 Probe Info  		33.82  LDD1753  [4]
C070
 Probe Info  		17.39  LDD1766  [4]
C072
 Probe Info  		8.40  LDD1768  [4]
C087
 Probe Info  		7.21  LDD1779  [4]
C091
 Probe Info  		12.13  LDD1782  [4]
C106
 Probe Info  		18.64  LDD1793  [4]
C108
 Probe Info  		9.32  LDD1795  [4]
C130
 Probe Info  		7.26  LDD1812  [4]
C134
 Probe Info  		22.47  LDD1816  [4]
C135
 Probe Info  		13.27  LDD1817  [4]
C159
 Probe Info  		9.19  LDD1839  [4]
C160
 Probe Info  		7.62  LDD1840  [4]
C161
 Probe Info  		9.78  LDD1841  [4]
C163
 Probe Info  		14.42  LDD1843  [4]
C165
 Probe Info  		14.42  LDD1845  [4]
C166
 Probe Info  		7.21  LDD1846  [4]
C198
 Probe Info  		11.63  LDD1874  [4]
C208
 Probe Info  		5.43  LDD1883  [4]
C211
 Probe Info  		9.58  LDD1885  [4]
C213
 Probe Info  		15.67  LDD1887  [4]
C218
 Probe Info  		11.47  LDD1892  [4]
C219
 Probe Info  		6.50  LDD1893  [4]
C220
 Probe Info  		19.56  LDD1894  [4]
C229
 Probe Info  		7.67  LDD1902  [4]
C231
 Probe Info  		19.16  LDD1904  [4]
C233
 Probe Info  		11.71  LDD1906  [4]
C235
 Probe Info  		25.46  LDD1908  [4]
C243
 Probe Info  		12.30  LDD1916  [4]
C246
 Probe Info  		13.18  LDD1919  [4]
C264
 Probe Info  		16.91  LDD1935  [4]
C282
 Probe Info  		16.11  LDD1952  [4]
C287
 Probe Info  		13.36  LDD1957  [4]
C288
 Probe Info  		6.50  LDD1958  [4]
C307
 Probe Info  		5.46  LDD1975  [4]
C310
 Probe Info  		14.22  LDD1977  [4]
C349
 Probe Info  		10.41  LDD2010  [4]
C350
 Probe Info  		28.64  LDD2011  [4]
C362
 Probe Info  		29.24  LDD2023  [4]
C388
 Probe Info  		37.53  LDD2047  [4]
C390
 Probe Info  		61.82  LDD2049  [4]
C399
 Probe Info  		7.01  LDD2058  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C485(1.15)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C107(1.07)  LDD1509  [3]
 LDCM0277  AC18 HEK-293T C485(1.07)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C107(0.95)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C485(0.92)  LDD1518  [3]
 LDCM0286  AC26 HEK-293T C485(0.95)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C107(1.06)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C107(1.02)  LDD1529  [3]
 LDCM0295  AC34 HEK-293T C485(1.03)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C107(1.14)  LDD1535  [3]
 LDCM0304  AC42 HEK-293T C485(1.09)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C107(1.22)  LDD1544  [3]
 LDCM0313  AC50 HEK-293T C485(1.04)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C107(0.98)  LDD1553  [3]
 LDCM0321  AC58 HEK-293T C485(1.19)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C107(0.96)  LDD1561  [3]
 LDCM0369  CL100 HEK-293T C485(1.01)  LDD1573  [3]
 LDCM0373  CL104 HEK-293T C485(1.17)  LDD1577  [3]
 LDCM0377  CL108 HEK-293T C485(1.06)  LDD1581  [3]
 LDCM0382  CL112 HEK-293T C485(0.93)  LDD1586  [3]
 LDCM0386  CL116 HEK-293T C485(1.05)  LDD1590  [3]
 LDCM0391  CL120 HEK-293T C485(1.05)  LDD1595  [3]
 LDCM0395  CL124 HEK-293T C485(1.18)  LDD1599  [3]
 LDCM0399  CL128 HEK-293T C485(0.95)  LDD1603  [3]
 LDCM0403  CL16 HEK-293T C485(0.97)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C485(1.01)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C107(1.27)  LDD1610  [3]
 LDCM0416  CL28 HEK-293T C485(1.06)  LDD1620  [3]
 LDCM0419  CL30 HEK-293T C485(1.23)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C107(1.53)  LDD1624  [3]
 LDCM0429  CL4 HEK-293T C485(1.11)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C485(1.02)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C485(0.98)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C107(1.45)  LDD1637  [3]
 LDCM0443  CL52 HEK-293T C485(1.10)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C485(1.07)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C107(1.45)  LDD1649  [3]
 LDCM0451  CL6 HEK-293T C485(1.07)  LDD1654  [3]
 LDCM0456  CL64 HEK-293T C485(1.10)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C485(1.06)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C107(1.26)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C107(1.27)  LDD1665  [3]
 LDCM0469  CL76 HEK-293T C485(1.26)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C485(1.01)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C107(1.08)  LDD1675  [3]
 LDCM0482  CL88 HEK-293T C485(1.21)  LDD1685  [3]
 LDCM0485  CL90 HEK-293T C485(0.93)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C107(1.08)  LDD1689  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) Protein-tyrosine phosphatase family P26045
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD82 antigen (CD82) Tetraspanin (TM4SF) family P27701

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587