Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C213  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 88 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 83.9
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) 61.8
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 55.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 54.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 53.4
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 45.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 39.4
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 38.6
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 38.3
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 37.0
 LDTP11199  DCN1-like protein 5 (DCUN1D5) 36.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 35.5
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 35.0
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 32.7
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 32.0
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 32.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 29.7
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 29.4
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 29.4
 LDTP01803  Adenosine deaminase (ADA) 27.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 26.9
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 26.9
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 26.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 26.4
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 25.5
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 25.3
 LDTP02359  Heme oxygenase 1 (HMOX1) 24.1
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 24.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 23.1
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 23.1
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 22.8
 LDTP02505  Lysosomal protective protein (CTSA) 22.2
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 22.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 21.1
 LDTP05905  Acid ceramidase (ASAH1) 21.0
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 21.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 20.5
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 20.3
 LDTP01518  NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7) 20.3
 LDTP03829  Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 20.0
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 19.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 19.8
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 19.7
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 19.4
 LDTP00988  Protein O-GlcNAcase (OGA) 19.4
 LDTP08933  Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) 19.3
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 18.9
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 18.8
 LDTP12610  Obg-like ATPase 1 (OLA1) 18.3
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 18.3
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 17.9
 LDTP04565  Methionine aminopeptidase 1 (METAP1) 17.8
 LDTP03787  Choline kinase alpha (CHKA) 17.5
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 17.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 17.4
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 17.1
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 17.1
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 17.0
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 16.9
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 16.8
 LDTP02837  Beta-galactosidase (GLB1) 16.4
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 16.2
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 16.2
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 16.1
 LDTP01769  Dihydrofolate reductase (DHFR) 16.0
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 15.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 15.9
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 15.8
 LDTP12233  Helicase MOV-10 (MOV10) 15.8
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 15.8
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 15.7
 LDTP11617  Myotubularin-related protein 12 (MTMR12) 15.6
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 15.6
 LDTP17633  Beta-galactosidase-1-like protein 2 (GLB1L2) 15.3
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 15.3
 LDTP02539  Lysosomal acid phosphatase (ACP2) 15.1
 LDTP16025  Ketosamine-3-kinase (FN3KRP) 15.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 14.9
 LDTP05446  Ubiquitin-protein ligase E3A (UBE3A) 14.8
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 14.7
 LDTP11127  ADP-dependent glucokinase (ADPGK) 14.6
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 14.6
 LDTP11708  ADP-ribosylation factor-like protein 6 (ARL6) 14.5
 LDTP01300  Cartilage-associated protein (CRTAP) 14.5
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 14.5
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 14.5
 LDTP05460  Elongation factor 1-alpha 2 (EEF1A2) 14.4
 LDTP04032  Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) 14.3
Transporter and channel
Click to Show/Hide to Show 56 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 99.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 84.4
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 72.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 67.2
 LDTP15948  Transmembrane protein 126A (TMEM126A) 49.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 46.5
 LDTP02215  Prosaposin (PSAP) 43.1
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 39.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 39.9
 LDTP20002  Transmembrane protein 160 (TMEM160) 38.3
 LDTP16190  Protein FAM8A1 (FAM8A1) 37.8
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 37.0
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 33.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 33.4
 LDTP11406  Transmembrane protein 59 (TMEM59) 31.8
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 31.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 30.7
 LDTP07236  Protein GPR107 (GPR107) 28.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 28.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 28.6
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 27.1
 LDTP16813  Tetraspanin-3 (TSPAN3) 26.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 26.7
 LDTP00501  Exportin-1 (XPO1) 25.3
 LDTP00592  Surfeit locus protein 4 (SURF4) 24.3
 LDTP00310  Syntenin-1 (SDCBP) 24.3
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 23.9
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 21.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.5
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 19.8
 LDTP13256  SUN domain-containing protein 2 (SUN2) 19.2
 LDTP15481  Transmembrane protein 87A (TMEM87A) 19.2
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 19.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 18.0
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 17.8
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 17.4
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 17.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 17.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 17.1
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 17.0
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 16.8
 LDTP02071  Amyloid-beta precursor protein (APP) 16.7
 LDTP10036  BOS complex subunit NCLN (NCLN) 16.3
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 16.2
 LDTP11607  Exportin-4 (XPO4) 16.1
 LDTP09288  Vang-like protein 1 (VANGL1) 15.7
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 15.5
 LDTP05780  Syntaxin-5 (STX5) 15.2
 LDTP00810  Exportin-T (XPOT) 15.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 15.0
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 14.9
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 14.8
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 14.7
 LDTP05236  Phosphatidylinositol transfer protein alpha isoform (PITPNA) 14.5
 LDTP12451  Integral membrane protein 2C (ITM2C) 14.4
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 14.3
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05065  Y-box-binding protein 1 (YBX1) 15.5
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) 14.9
Other
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 92.4
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 88.6
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 77.7
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 52.3
 LDTP18883  Protein CEBPZOS (CEBPZOS) 49.2
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 44.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 42.2
 LDTP09813  CCR4-NOT transcription complex subunit 9 (CNOT9) 40.8
 LDTP10056  Protein FAM162A (FAM162A) 38.9
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 37.5
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 34.5
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 34.3
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 33.6
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 32.9
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 32.7
 LDTP11076  Apolipoprotein L2 (APOL2) 32.0
 LDTP08796  Protein SYS1 homolog (SYS1) 31.3
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 29.0
 LDTP14458  Tetraspanin-6 (TSPAN6) 28.6
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 25.6
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 25.6
 LDTP01075  Protein CutA (CUTA) 25.5
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 25.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 25.1
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 23.4
 LDTP05375  Nucleobindin-1 (NUCB1) 22.5
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 22.2
 LDTP02443  Calmodulin-3 (CALM3) 21.7
 LDTP13086  Syntaxin-18 (STX18) 21.1
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.4
 LDTP00887  Calumenin (CALU) 20.1
 LDTP05226  RNA-binding protein 3 (RBM3) 19.8
 LDTP02037  Tubulin beta-4A chain (TUBB4A) 19.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 19.3
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 19.0
 LDTP02297  Vimentin (VIM) 19.0
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 18.6
 LDTP02927  Ganglioside GM2 activator (GM2A) 18.5
 LDTP16006  Optic atrophy 3 protein (OPA3) 18.5
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 18.4
 LDTP02205  Tubulin beta chain (TUBB) 18.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 17.9
 LDTP01522  Reticulon-3 (RTN3) 17.9
 LDTP01652  Centrosomal protein 43 (CEP43) 17.8
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 17.8
 LDTP19924  Protein PBDC1 (PBDC1) 17.8
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 17.5
 LDTP14272  Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) 17.5
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 17.4
 LDTP10046  Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) 17.3
 LDTP13952  Intraflagellar transport protein 52 homolog (IFT52) 17.3
 LDTP18132  Protein FAM136A (FAM136A) 17.0
 LDTP00417  Programmed cell death protein 5 (PDCD5) 16.8
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 16.6
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 16.6
 LDTP13807  PRELI domain-containing protein 1, mitochondrial (PRELID1) 16.3
 LDTP04626  UV excision repair protein RAD23 homolog A (RAD23A) 16.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 16.2
 LDTP07132  Ubiquitin-associated protein 2 (UBAP2) 16.2
 LDTP05277  Protein SET (SET) 16.0
 LDTP14939  Membralin (TMEM259) 15.7
 LDTP08577  SURP and G-patch domain-containing protein 1 (SUGP1) 15.7
 LDTP01494  Protein YIF1A (YIF1A) 15.6
 LDTP11327  RNA polymerase II-associated protein 1 (RPAP1) 15.6
 LDTP05318  RNA-binding protein EWS (EWSR1) 15.6
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 15.5
 LDTP10281  Cytoplasmic dynein 2 intermediate chain 2 (DYNC2I2) 15.5
 LDTP06134  Protocadherin Fat 1 (FAT1) 15.5
 LDTP16577  DENN domain-containing protein 11 (DENND11) 15.3
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 15.3
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 15.2
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 15.1
 LDTP05960  Trophoblast glycoprotein (TPBG) 15.1
 LDTP13170  COP9 signalosome complex subunit 7a (COPS7A) 15.0
 LDTP11233  Tubulin beta-6 chain (TUBB6) 15.0
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) 14.8
 LDTP16156  Protein PALS2 (PALS2) 14.8
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 14.8
 LDTP05904  Tubulin beta-3 chain (TUBB3) 14.7
 LDTP11995  WD repeat and coiled-coil-containing protein (WDCP) 14.7
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 14.6
 LDTP00986  Syntaxin-10 (STX10) 14.5
 LDTP00859  Synaptogyrin-2 (SYNGR2) 14.4
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 14.4

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587