Details of the Target

General Information of Target

Target ID LDTP10281
Target Name Cytoplasmic dynein 2 intermediate chain 2 (DYNC2I2)
Gene Name DYNC2I2
Gene ID 89891
Synonyms
WDR34; Cytoplasmic dynein 2 intermediate chain 2; Dynein 2 intermediate chain 2; WD repeat-containing protein 34
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGSEATTPVIVAAGAGGEEGEHVKPFKPEKAKEIIMSLQQPAIFCNMVFDWPARHWNA
KYLSQVLHGKQIRFRMGMKSMSTVPQFETTCNYVEATLEEFLTWNCDQSSISGPFRDYDH
SKFWAYADYKYFVSLFEDKTDLFQDVKWSDFGFPGRNGQESTLWIGSLGAHTPCHLDSYG
CNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKAQRHA
VTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHLARVEEAITRMLVCALKTAEN
PQNTRAWLNPTEVEETSHAVNCCYLNAAVSAFFDRCRTSEVVEIQALRTDGEHMKKEELN
VCNHMEVGQTGSQNLTTGTDKPEAASPFGPDLVPVAQRSEEPPSERGGIFGSDGKDFVDK
DGEHFGKLHCAKRQQIMSNSENAIEEQIASNTTTTPQTFISTDDLLDCLVNPQVTRIVAQ
LLIQGRSL
Target Bioclass
Other
Family
Dynein light intermediate chain family
Subcellular location
Cytoplasm
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone.; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
Uniprot ID
Q96EX3
Ensemble ID
ENST00000372715.7
HGNC ID
HGNC:28296

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.26  LDD0403  [1]
DBIA
 Probe Info  		C196(0.46); C362(1.05); C65(0.92)  LDD0531  [2]
IA-alkyne
 Probe Info  		C362(0.00); C65(0.00); C400(0.00)  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		C65(0.00); C362(0.00)  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		C362(0.00); C65(0.00)  LDD0147  [6]
NPM
 Probe Info  		N.A.  LDD0016  [8]
AOyne
 Probe Info  		13.70  LDD0443  [9]
NAIA_5
 Probe Info  		C362(0.00); C400(0.00); C65(0.00)  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C156
 Probe Info  		9.25  LDD1836  [10]
C159
 Probe Info  		7.73  LDD1839  [10]
C160
 Probe Info  		9.25  LDD1840  [10]
C211
 Probe Info  		9.71  LDD1885  [10]
C212
 Probe Info  		6.32  LDD1886  [10]
C213
 Probe Info  		15.45  LDD1887  [10]
C214
 Probe Info  		6.54  LDD1888  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C196(0.46); C362(1.05); C65(0.92)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C196(1.74); C362(1.04); C65(0.78)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C362(1.16); C65(0.96)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C362(1.12); C65(0.85)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C362(0.83); C65(1.01)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C362(0.94); C65(1.23)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C362(0.58); C65(1.04)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C362(0.69); C65(1.05)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C362(0.92); C65(1.05)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C362(0.58); C65(0.87)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C362(0.66); C65(0.78)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C362(0.56); C65(0.82)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C196(1.12); C362(1.03); C65(0.95)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C362(0.55); C65(0.94)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C362(0.64); C65(0.99)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C362(0.80); C65(0.94)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C362(1.07); C65(0.90)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C362(0.91); C65(0.99)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C362(1.03); C65(1.47)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C362(1.19); C65(1.10)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C362(1.00); C65(1.37)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C362(0.99); C65(0.98)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C362(0.92); C65(0.86)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C196(1.07); C362(1.00); C65(0.84)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C362(1.16); C65(1.11)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C362(0.94); C65(0.96)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C362(1.20); C65(0.95)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C362(1.02); C65(1.22)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C362(1.18); C65(1.07)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C362(1.22); C65(0.99)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C362(1.17); C65(1.13)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C362(1.16); C65(1.54)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C362(0.90)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C362(0.90)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C362(0.84)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C362(0.88)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C362(1.00)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C362(0.60)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C362(0.80)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C362(0.83)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C362(0.93)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C362(0.93)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C362(0.87)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C362(0.79)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C196(1.34); C362(0.96); C65(1.17)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C362(1.04)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C362(1.01)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C362(0.81)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C362(1.00); C65(1.13)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C362(0.96); C65(1.46)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C362(1.03); C65(1.34)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C362(1.18); C65(1.34)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C362(0.99); C65(1.36)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C362(1.25); C65(1.88)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C362(1.15); C65(1.49)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C65(0.91); C362(0.98); C196(1.44)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C65(1.24); C362(1.26)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C362(1.03); C65(1.82)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C362(1.07); C65(1.45)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C362(1.20); C65(2.15)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C362(1.21); C65(1.82)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C362(1.32); C65(1.68)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C362(1.20); C65(1.39)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C362(1.03); C65(1.83)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C65(0.53); C362(1.05)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C65(0.66); C362(0.90)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C65(0.67); C362(1.07)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C196(0.93); C65(0.95); C362(1.12)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C65(0.57); C362(1.06)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C65(0.64); C362(0.96)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C65(0.48); C362(0.94)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C65(0.57); C362(0.96)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C65(0.66); C362(1.00)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C362(1.03)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C362(1.31)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C362(1.07)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C362(0.90)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C362(0.99)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C196(0.88); C65(0.90); C362(1.12)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C362(0.91)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C362(1.04)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C362(1.07)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C362(0.99)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C362(1.05)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C65(0.76); C362(0.90); C196(1.30)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C362(0.88); C65(0.99); C196(1.33)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C65(0.75); C362(0.90); C196(1.35)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C196(0.96); C362(1.10); C65(1.11)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C362(0.98); C65(1.02); C196(1.09)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C196(0.87); C65(0.92); C362(1.17)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C362(0.87); C65(1.04); C196(1.26)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C362(0.75); C65(0.76); C196(1.22)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C362(0.92); C65(0.98); C196(1.14)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C65(0.78); C362(0.98); C196(1.12)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C362(0.84); C65(0.91); C196(1.17)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C362(0.84); C65(1.05); C196(1.12)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C362(1.08)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C362(0.91)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C362(1.28)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C362(0.88)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C65(0.74); C196(0.75); C362(1.18)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C362(1.04)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C362(1.10)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C362(1.14)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C362(0.99)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C362(1.05)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C362(1.21)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C362(1.00)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C362(1.24); C65(1.29)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C362(1.14); C65(2.94)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C362(0.90); C65(1.37)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C65(0.90); C362(1.01); C196(1.54)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C362(0.95); C65(1.63)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C362(0.94); C65(1.35)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C362(0.87); C65(1.27)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C362(0.89); C65(1.94)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C362(0.78); C65(1.51)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C65(0.63); C362(0.91)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C65(0.72); C362(0.87)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C65(0.68); C362(0.90)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C196(1.01); C362(1.18)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C196(0.95); C362(1.34)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C362(0.94); C65(0.95); C196(1.70)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C196(0.89); C362(1.31)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C196(1.02); C362(1.38)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C196(1.11); C362(1.47)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C196(0.85); C362(1.31)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C196(0.79); C362(1.26)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C196(0.87); C362(1.23)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C196(0.89); C362(1.37)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C196(0.97); C362(1.42)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C196(0.99); C362(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C196(1.03); C362(1.03)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C65(0.77); C362(0.89); C196(1.28)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C196(1.03); C362(1.19)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C362(0.98); C196(1.00)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C196(0.88); C362(1.44)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C65(1.36); C362(1.41)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C362(1.21); C65(1.64)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C65(0.98); C362(1.15)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C65(1.09); C362(1.22)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C362(0.90); C65(1.02)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C65(1.14); C362(1.27)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C362(1.20); C65(1.34)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C362(1.31); C65(1.44)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C65(0.99); C362(1.12)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C65(1.01); C362(1.26)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C65(1.15); C362(1.20)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C65(0.95); C362(1.55)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C362(1.01); C65(1.17)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C65(0.94); C362(1.23)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C362(1.14); C65(1.19)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C362(1.11); C65(1.15)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C65(0.96); C362(1.07)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C196(1.30); C362(1.03); C65(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C65(1.00); C362(1.03); C196(1.60)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C65(0.83); C362(1.08); C196(1.35)  LDD0592  [2]
 LDCM0156  Aniline NCI-H1299 13.26  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C362(0.85); C65(0.58)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C65(0.90); C362(1.06)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C65(0.80); C362(1.38)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C196(0.87); C65(1.01); C362(1.12)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C65(0.82); C362(1.03); C196(1.30)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C362(1.15); C196(1.26); C65(1.35)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C362(1.06); C196(1.28); C65(1.30)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C362(0.96); C196(1.35); C65(1.37)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C65(0.53); C362(0.99)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C65(0.50); C362(1.11)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C65(0.51); C362(1.22)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C65(0.45); C362(1.15)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C65(0.56); C362(1.05)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C65(0.86); C362(0.99)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C65(0.44); C362(1.18)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C65(0.62); C362(0.99)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C362(0.86)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C362(0.98)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C362(0.93)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C362(0.89)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C362(1.03)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C362(0.86); C65(1.37); C196(1.39)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C65(0.78); C362(1.03); C196(1.28)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C362(1.04); C196(1.18); C65(1.21)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C65(0.72); C362(1.55)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C65(0.83); C362(0.93); C196(1.34)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C362(1.08)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C362(0.93)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C362(0.93)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C362(1.03)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C362(0.87); C65(0.98)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C362(0.83); C65(1.10)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C362(0.99); C65(1.52)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C362(0.89); C65(1.18)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C65(0.85); C362(0.97)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C65(0.79); C362(1.17)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C65(0.76); C362(1.07)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C362(0.80); C196(0.85); C65(1.06)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C362(0.94); C65(1.06)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C362(0.82); C65(1.14)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C362(0.86); C65(1.04)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C65(0.80); C362(0.98)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C362(0.83); C65(0.95)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C65(0.95); C362(1.05)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C65(0.92); C362(0.94)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C362(0.89); C65(1.18)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C362(0.92); C65(0.97)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C362(0.95); C65(0.86)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C362(0.86); C65(0.91)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C362(1.08); C65(0.85)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C362(0.91); C65(1.12)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C362(0.85); C65(1.03)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C362(0.99); C65(0.77)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C362(0.94); C65(1.08)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C362(1.00)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C196(0.76); C362(1.22); C65(0.90)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C196(0.73); C362(1.46); C65(1.23)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C196(1.06); C362(1.01); C65(0.93)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C196(1.12); C362(1.24); C65(0.81)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C196(1.16); C362(1.32); C65(1.20)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C196(1.13); C362(1.31); C65(0.88)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C196(0.79); C362(1.08); C65(0.91)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C362(0.91); C65(0.89)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C196(0.73); C362(1.19); C65(1.18)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C196(1.15); C362(1.03); C65(1.24)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C196(0.91); C362(0.94); C65(0.96)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C196(1.02); C362(1.07); C65(1.27)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C196(0.99); C362(1.05); C65(0.79)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C196(1.13); C362(1.59); C65(0.80)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C362(0.95); C65(1.07)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C362(0.99); C65(0.91)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C362(1.02); C65(0.99)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C362(0.94); C65(1.12)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C362(1.16); C65(0.78)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C362(1.14); C65(0.88)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C362(1.29); C65(0.96)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C362(1.19); C65(1.23)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C362(1.18); C65(1.05)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C362(1.06); C65(0.92)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C362(0.98); C65(1.01)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C362(1.02); C65(1.03)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C362(1.06); C65(1.13)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C362(0.92); C65(1.09)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C362(1.05); C65(0.84)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C362(0.99); C65(0.87)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C362(0.93); C65(0.98)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C362(1.34); C65(0.91)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C362(1.23); C65(1.02)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C362(1.44); C65(0.78)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C362(1.54); C65(0.62)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C362(1.31); C65(0.64)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C362(1.32); C65(0.78)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C362(1.18); C65(0.80)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C362(1.23); C65(0.90)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C362(1.38); C65(0.92)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C362(1.05); C65(0.83)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C362(1.12); C65(1.03)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C362(1.18); C65(1.11)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C362(1.06); C65(0.75)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C362(1.23); C65(0.77)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C362(1.48); C65(0.81)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C362(1.07); C65(0.95)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C362(0.98); C65(0.82)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C362(1.03); C65(0.82)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C362(1.19); C65(0.81)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C362(1.84); C65(1.02)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C362(1.01); C65(0.90)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C362(1.16); C65(0.84)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C362(1.18); C65(0.84)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C362(1.14); C65(1.21)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C362(0.99); C65(0.96)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C362(0.99); C65(0.86)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C362(1.22); C65(0.83)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C362(1.15); C65(1.03)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C362(1.10); C65(0.98)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C362(1.36); C65(0.82)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C362(1.03); C65(0.79)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C362(1.33); C65(0.95)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C196(0.68); C362(1.09); C65(1.26)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C196(0.53); C362(1.12); C65(1.14)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C196(0.68); C362(1.08); C65(0.87)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C196(1.00); C362(1.18); C65(1.09)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C196(1.12); C362(1.36); C65(1.41)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C196(0.77); C362(1.07); C65(0.89)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C196(0.56); C362(1.14); C65(1.03)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C196(0.67); C362(1.16); C65(1.22)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C196(0.85); C362(1.06); C65(0.98)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C65(1.29); C362(1.05)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C65(2.31)  LDD1702  [12]
 LDCM0468  Fragment33 HCT 116 C362(1.16); C65(0.75)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C196(1.36); C362(1.38); C65(1.00)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C65(0.97); C362(0.95)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C65(1.14); C362(0.97)  LDD1497  [11]
 LDCM0024  KB05 NCI-H1155 C65(3.04)  LDD3342  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C362(0.07)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C362(0.27)  LDD2207  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coilin (COIL) Coilin family P38432

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.