Details of the Target

General Information of Target

Target ID LDTP14272
Target Name Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
Gene Name IGF2BP2
Gene ID 10644
Synonyms
IMP2; VICKZ2; Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR
LWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF
VSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK
EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGG
PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLL
FFPLLWALPLLGPV
Target Bioclass
Other
Family
RRM IMP/VICKZ family
Subcellular location
Nucleus
Function
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD.
Uniprot ID
Q9Y6M1
Ensemble ID
ENST00000346192.7
HGNC ID
HGNC:28867

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
ONAyne
 Probe Info  		K292(5.88)  LDD0274  [2]
STPyne
 Probe Info  		K487(5.26); K495(1.01); K497(7.69)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BTD
 Probe Info  		C255(2.25)  LDD1700  [4]
DBIA
 Probe Info  		C255(0.79)  LDD0533  [5]
5E-2FA
 Probe Info  		H245(0.00); H181(0.00); H302(0.00); H143(0.00)  LDD2235  [6]
ATP probe
 Probe Info  		K232(0.00); K240(0.00); K67(0.00); K77(0.00)  LDD0199  [7]
m-APA
 Probe Info  		H181(0.00); H302(0.00); H143(0.00)  LDD2231  [6]
1d-yne
 Probe Info  		N.A.  LDD0358  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
1c-yne
 Probe Info  		K462(0.00); K530(0.00)  LDD0228  [8]
W1
 Probe Info  		N.A.  LDD0236  [3]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		8.82  LDD1779  [11]
C170
 Probe Info  		12.47  LDD1850  [11]
C213
 Probe Info  		17.51  LDD1887  [11]
FFF probe11
 Probe Info  		16.84  LDD0471  [12]
FFF probe12
 Probe Info  		9.75  LDD0473  [12]
FFF probe13
 Probe Info  		14.40  LDD0475  [12]
FFF probe14
 Probe Info  		12.77  LDD0477  [12]
FFF probe2
 Probe Info  		18.81  LDD0463  [12]
FFF probe3
 Probe Info  		9.70  LDD0464  [12]
FFF probe6
 Probe Info  		5.17  LDD0468  [12]
STS-2
 Probe Info  		N.A.  LDD0138  [13]
DA-2
 Probe Info  		N.A.  LDD0072  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C255(0.86)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C255(0.89)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C255(1.33)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C255(0.87)  LDD2130  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C255(1.40)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C255(1.01)  LDD2103  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C255(0.70)  LDD2131  [4]
 LDCM0215  AC10 PaTu 8988t C255(1.22)  LDD1094  [5]
 LDCM0216  AC100 HCT 116 C255(0.79)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C255(0.85)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C255(0.80)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C255(0.66)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C255(0.77)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C255(0.57)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C255(0.77)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C255(0.83)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C255(0.74)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C255(0.73)  LDD0542  [5]
 LDCM0226  AC11 PaTu 8988t C255(1.20)  LDD1105  [5]
 LDCM0227  AC110 HCT 116 C255(0.85)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C255(0.81)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C255(0.69)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C255(1.25)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C255(0.90)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C255(0.84)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C255(0.90)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C255(1.14)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C255(0.98)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C255(0.93)  LDD0553  [5]
 LDCM0237  AC12 PaTu 8988t C255(1.25)  LDD1116  [5]
 LDCM0238  AC120 HCT 116 C255(0.90)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C255(1.13)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C255(0.90)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C255(0.96)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C255(0.95)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C255(0.90)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C255(0.95)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C255(0.94)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C255(0.88)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C255(0.79)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C255(0.84)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C255(0.81)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C255(0.93)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C255(1.00)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C255(0.85)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C255(1.04)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C255(0.80)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C255(0.88)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C255(0.82)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C255(1.02)  LDD0575  [5]
 LDCM0259  AC14 PaTu 8988t C255(1.19)  LDD1138  [5]
 LDCM0260  AC140 HCT 116 C255(0.95)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C255(0.86)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C255(0.89)  LDD0579  [5]
 LDCM0270  AC15 PaTu 8988t C255(1.27)  LDD1149  [5]
 LDCM0276  AC17 PaTu 8988t C255(1.01)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C255(0.81)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C255(1.14)  LDD1157  [5]
 LDCM0279  AC2 HEK-293T C255(1.08)  LDD1518  [15]
 LDCM0280  AC20 PaTu 8988t C255(0.71)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C255(0.79)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C255(0.96)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C255(0.60)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C255(0.63)  LDD1163  [5]
 LDCM0285  AC25 PaTu 8988t C255(0.96)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C255(0.90)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C255(1.11)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C255(1.07)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C255(1.03)  LDD1168  [5]
 LDCM0290  AC3 HEK-293T C255(1.11)  LDD1529  [15]
 LDCM0291  AC30 PaTu 8988t C255(0.95)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C255(0.95)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C255(0.95)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C255(1.12)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C255(0.92)  LDD1174  [5]
 LDCM0296  AC35 HEK-293T C255(1.04)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C255(0.99)  LDD1536  [15]
 LDCM0300  AC39 HEK-293T C255(1.05)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C255(0.86)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C255(1.31)  LDD1541  [15]
 LDCM0304  AC42 HEK-293T C255(0.92)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C255(1.10)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C255(1.01)  LDD1545  [15]
 LDCM0308  AC46 HCT 116 C255(1.02)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C255(0.90)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C255(1.04)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C255(1.21)  LDD0628  [5]
 LDCM0313  AC50 HCT 116 C255(1.16)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C255(0.93)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C255(0.94)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C255(1.06)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C255(1.07)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C255(0.98)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C255(1.17)  LDD0636  [5]
 LDCM0321  AC58 HEK-293T C255(0.91)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C255(1.17)  LDD1561  [15]
 LDCM0323  AC6 PaTu 8988t C255(1.18)  LDD1202  [5]
 LDCM0324  AC60 HEK-293T C255(0.98)  LDD1563  [15]
 LDCM0327  AC63 HEK-293T C255(1.03)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C255(1.13)  LDD1567  [15]
 LDCM0334  AC7 PaTu 8988t C255(1.20)  LDD1213  [5]
 LDCM0345  AC8 PaTu 8988t C255(0.86)  LDD1224  [5]
 LDCM0349  AC83 HCT 116 C255(0.97)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C255(1.04)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C255(1.13)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C255(1.07)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C255(0.97)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C255(1.01)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C255(1.14)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C255(0.86)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C255(1.01)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C255(0.97)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C255(0.97)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C255(1.00)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C255(1.04)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C255(0.75)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C255(0.95)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C255(0.70)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C255(0.66)  LDD0683  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C255(1.29)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C255(1.12)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C255(0.93)  LDD1154  [5]
 LDCM0498  BS-3668 MDA-MB-231 C255(0.78)  LDD2091  [4]
 LDCM0367  CL1 HEK-293T C255(1.22)  LDD1571  [15]
 LDCM0369  CL100 HEK-293T C255(0.80)  LDD1573  [15]
 LDCM0370  CL101 PaTu 8988t C255(1.14)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C255(1.09)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C255(1.46)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C255(1.10)  LDD1252  [5]
 LDCM0374  CL105 PaTu 8988t C255(0.78)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C255(0.85)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C255(0.80)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C255(0.76)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C255(0.89)  LDD1257  [5]
 LDCM0379  CL11 HEK-293T C255(1.19)  LDD1583  [15]
 LDCM0380  CL110 PaTu 8988t C255(0.78)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C255(0.57)  LDD1260  [5]
 LDCM0382  CL112 PaTu 8988t C255(0.94)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C255(0.99)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C255(0.83)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C255(0.83)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C255(1.02)  LDD1265  [5]
 LDCM0387  CL117 HEK-293T C255(1.15)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C255(0.95)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C255(0.99)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C255(1.61)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C255(0.86)  LDD1595  [15]
 LDCM0392  CL121 HCT 116 C255(0.92)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C255(1.14)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C255(1.06)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C255(1.11)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C255(0.95)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C255(0.92)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C255(1.05)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C255(0.91)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C255(1.24)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C255(1.04)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C255(1.08)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C255(0.96)  LDD1607  [15]
 LDCM0405  CL18 HEK-293T C255(1.07)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C255(1.08)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C255(0.89)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C255(1.17)  LDD1612  [15]
 LDCM0411  CL23 HEK-293T C255(1.35)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C255(1.50)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C255(0.80)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C255(0.96)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C255(1.00)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C255(0.83)  LDD1620  [15]
 LDCM0418  CL3 HEK-293T C255(0.98)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C255(1.12)  LDD1623  [15]
 LDCM0420  CL31 HCT 116 C255(0.82)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C255(0.82)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C255(0.62)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C255(0.68)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C255(0.96)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C255(0.50)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C255(0.87)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C255(1.05)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C255(1.02)  LDD1633  [15]
 LDCM0430  CL40 HCT 116 C255(0.84)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C255(0.74)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C255(0.76)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C255(0.60)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C255(0.85)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C255(0.86)  LDD0752  [5]
 LDCM0437  CL47 HEK-293T C255(1.57)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C255(1.89)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C255(0.99)  LDD1643  [15]
 LDCM0441  CL50 HEK-293T C255(1.09)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C255(0.93)  LDD1646  [15]
 LDCM0445  CL54 HEK-293T C255(1.17)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C255(1.13)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C255(0.99)  LDD1650  [15]
 LDCM0450  CL59 HEK-293T C255(1.24)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C255(1.25)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C255(1.35)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C255(1.14)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C255(1.05)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C255(0.99)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C255(0.89)  LDD1659  [15]
 LDCM0458  CL66 HEK-293T C255(0.98)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C255(1.22)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C255(1.09)  LDD1663  [15]
 LDCM0462  CL7 HEK-293T C255(1.02)  LDD1665  [15]
 LDCM0464  CL71 HEK-293T C255(1.19)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C255(1.38)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C255(1.03)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C255(0.89)  LDD1670  [15]
 LDCM0469  CL76 PaTu 8988t C255(1.16)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C255(1.12)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C255(1.20)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C255(1.29)  LDD1351  [5]
 LDCM0473  CL8 HEK-293T C255(0.99)  LDD1676  [15]
 LDCM0474  CL80 PaTu 8988t C255(1.35)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C255(1.22)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C255(1.45)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C255(1.57)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C255(1.08)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C255(1.14)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C255(1.39)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C255(1.03)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C255(1.30)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C255(1.04)  LDD1362  [5]
 LDCM0485  CL90 PaTu 8988t C255(1.17)  LDD1364  [5]
 LDCM0486  CL91 HEK-293T C255(1.15)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C255(1.08)  LDD1690  [15]
 LDCM0490  CL95 HEK-293T C255(1.09)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C255(1.28)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C255(0.99)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C255(0.97)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C255(0.92)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C255(1.12)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C255(1.54)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C255(1.14)  LDD1671  [15]
 LDCM0427  Fragment51 HCT 116 C255(0.68)  LDD0744  [5]
 LDCM0022  KB02 A-549 C255(2.05)  LDD2260  [16]
 LDCM0023  KB03 ABC-1 C255(5.80)  LDD2679  [16]
 LDCM0024  KB05 ABC-1 C255(4.92)  LDD3096  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C255(0.97)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C255(0.81)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C255(0.78)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C255(1.16)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C255(0.92)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C255(1.06)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C255(1.25)  LDD2094  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C255(1.65)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C255(1.00)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C255(0.68)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C255(0.83)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C255(1.24)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C255(0.60)  LDD2106  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C255(0.55)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C255(0.67)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C255(1.18)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C255(0.52)  LDD2114  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C255(0.82)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C255(0.89)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C255(1.19)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C255(1.11)  LDD2127  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C255(1.29)  LDD2135  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C255(2.25)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C255(0.95)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C255(0.88)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C255(0.91)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C255(2.49)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C255(1.12)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C255(0.42)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C255(0.46)  LDD2150  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C255(1.82)  LDD2153  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein 3 (RBM3) . P98179
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840