Details of the Target

General Information of Target

Target ID LDTP13170
Target Name COP9 signalosome complex subunit 7a (COPS7A)
Gene Name COPS7A
Gene ID 50813
Synonyms
CSN7A; DERP10; COP9 signalosome complex subunit 7a; SGN7a; Signalosome subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDV
VFIEPVQPPPPSVPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVID
DEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDS
EIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVN
IQTYTPSLTSQTKTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPG
VDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCL
SSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGAL
NKSRCTICGKLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAG
NNVLVIDGQQKRFCCQSCVSEYKQVGSHPSFLKEVRDHMQDSFLMQPEKYGKLTTCTGCR
TQCRFFDMTQCIGPNGYMEPYCSTACMNSHKTKYAKSQSLGIICHFCKRNSLPQYQATMP
DGKLYNFCNSSCVAKFQALSMQSSPNGQFVAPSDIQLKCNYCKNSFCSKPEILEWENKVH
QFCSKTCSDDYKKLHCIVTYCEYCQEEKTLHETVNFSGVKRPFCSEGCKLLYKQDFARRL
GLRCVTCNYCSQLCKKGATKELDGVVRDFCSEDCCKKFQDWYYKAARCDCCKSQGTLKER
VQWRGEMKHFCDQHCLLRFYCQQNEPNMTTQKGPENLHYDQGCQTSRTKMTGSAPPPSPT
PNKEMKNKAVLCKPLTMTKATYCKPHMQTKSCQTDDTWRTEYVPVPIPVPVYIPVPMHMY
SQNIPVPTTVPVPVPVPVFLPAPLDSSEKIPAAIEELKSKVSSDALDTELLTMTDMMSED
EGKTETTNINSVIIETDIIGSDLLKNSDPETQSSMPDVPYEPDLDIEIDFPRAAEELDME
NEFLLPPVFGEEYEEQPRPRSKKKGAKRKAVSGYQSHDDSSDNSECSFPFKYTYGVNAWK
HWVKTRQLDEDLLVLDELKSSKSVKLKEDLLSHTTAELNYGLAHFVNEIRRPNGENYAPD
SIYYLCLGIQEYLCGSNRKDNIFIDPGYQTFEQELNKILRSWQPSILPDGSIFSRVEEDY
LWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMENKACL
RYQVSSLCGTDNEDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQ
RMDVFYLQPECSSSTDSPVWYTSTSLDRNTLENMLVRVLLVKDIYDKDNYELDEDTD
Target Bioclass
Other
Family
CSN7/EIF3M family, CSN7 subfamily
Subcellular location
Cytoplasm
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Uniprot ID
Q9UBW8
Ensemble ID
ENST00000229251.7
HGNC ID
HGNC:16758

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K217(5.63); K269(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y137(15.09)  LDD3495  [4]
EA-probe
 Probe Info  		C110(0.98)  LDD2210  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
DBIA
 Probe Info  		C110(1.24)  LDD0080  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
IPM
 Probe Info  		N.A.  LDD0147  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C211
 Probe Info  		9.13  LDD1885  [14]
C212
 Probe Info  		5.24  LDD1886  [14]
C213
 Probe Info  		15.03  LDD1887  [14]
C278
 Probe Info  		61.39  LDD1948  [14]
C280
 Probe Info  		9.06  LDD1950  [14]
C282
 Probe Info  		16.56  LDD1952  [14]
C284
 Probe Info  		28.25  LDD1954  [14]
C423
 Probe Info  		5.58  LDD2078  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C110(1.42)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C110(0.99)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C110(0.72)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C110(0.87)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C110(0.86)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C110(0.88)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C110(0.72)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C110(1.06)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C110(0.89)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C110(0.76)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C110(0.70)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C110(0.91)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C110(0.85)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C110(0.88)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C110(0.74)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C110(0.78)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C110(1.02)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C110(1.25)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C110(1.27)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C110(1.33)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C110(1.21)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C110(1.25)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C110(1.10)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C110(0.97)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C110(1.22)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C110(0.97)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C110(0.80)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C110(1.13)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C110(0.92)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C110(1.09)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C110(1.14)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C110(1.25)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C110(1.18)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C110(1.21)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C110(1.19)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C110(1.38)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C110(1.02)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C110(1.00)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C110(1.53)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C110(1.27)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C110(0.91)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C110(0.99)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C110(1.03)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C110(1.23)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C110(1.04)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C110(1.29)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C110(0.97)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C110(1.12)  LDD0579  [7]
 LDCM0270  AC15 HCT 116 C110(1.04)  LDD0587  [7]
 LDCM0276  AC17 HCT 116 C110(1.15)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C110(1.09)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C110(1.06)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C110(1.47)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C110(1.16)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C110(1.05)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C110(1.03)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C110(1.05)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C110(1.09)  LDD0601  [7]
 LDCM0285  AC25 HEK-293T C178(0.64); C181(0.64)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C178(0.52); C181(0.52)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C178(0.67); C181(0.67)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C178(0.62); C181(0.62)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C178(0.72); C181(0.72)  LDD0887  [7]
 LDCM0290  AC3 HCT 116 C110(1.30)  LDD0607  [7]
 LDCM0291  AC30 HEK-293T C178(0.71); C181(0.71)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C178(0.87); C181(0.87)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C178(0.63); C181(0.63)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C178(0.62); C181(0.62)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C178(0.60); C181(0.60)  LDD0893  [7]
 LDCM0296  AC35 HCT 116 C110(1.03)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C110(1.11)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C110(1.05)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C110(1.19)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C110(1.04)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C110(1.61)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C110(1.17)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C110(1.11)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C110(1.12)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C110(1.26)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C110(1.13)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C110(1.38)  LDD0624  [7]
 LDCM0308  AC46 HEK-293T C178(0.79); C181(0.79)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C178(0.88); C181(0.88)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C178(0.71); C181(0.71)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C178(0.63); C181(0.63)  LDD0909  [7]
 LDCM0312  AC5 HCT 116 C110(1.82)  LDD0629  [7]
 LDCM0313  AC50 HEK-293T C178(0.68); C181(0.68)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C178(0.75); C181(0.75)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C178(0.68); C181(0.68)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C178(0.79); C181(0.79)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C178(0.62); C181(0.62)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C178(0.68); C181(0.68)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C178(0.69); C181(0.69)  LDD0917  [7]
 LDCM0320  AC57 HCT 116 C110(1.02)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C110(1.07)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C110(1.25)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C110(1.12)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C110(1.10)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C110(0.96)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C110(1.34)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C110(1.08)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C110(1.11)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C110(1.21)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C110(1.15)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C110(1.09)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C110(0.77)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C110(0.94)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C110(0.93)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C110(0.92)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C110(0.96)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C110(0.70)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C110(1.08)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C110(1.16)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C110(1.11)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C110(1.05)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C110(1.06)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C110(1.39)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C110(1.22)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C110(1.13)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C110(1.14)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C110(0.13)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C110(0.67)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C110(1.29)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C110(1.29)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C110(0.93)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C110(1.14)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C110(1.06)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C110(1.00)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C110(1.22)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C110(1.03)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C110(1.21)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C110(1.27)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C110(1.11)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C110(1.09)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C110(0.98)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C110(1.22)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C110(1.37)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C110(0.73)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C110(0.70)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C110(1.07)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C110(0.91)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C110(1.20)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.68  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HCT 116 C110(1.03)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C110(0.94)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C110(1.81)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C110(0.96)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C110(0.84)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C110(0.84)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C110(1.07)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C110(1.29)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C110(1.23)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C110(1.19)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C110(1.35)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C110(1.03)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C110(1.37)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C110(1.11)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C110(1.00)  LDD0698  [7]
 LDCM0382  CL112 HEK-293T C178(0.62); C181(0.62)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C178(0.72); C181(0.72)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C178(0.49); C181(0.49)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C178(0.48); C181(0.48)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C178(0.49); C181(0.49)  LDD0984  [7]
 LDCM0387  CL117 HCT 116 C110(1.44)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C110(1.14)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C110(1.19)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C110(1.45)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C110(1.16)  LDD0708  [7]
 LDCM0392  CL121 HEK-293T C178(0.58); C181(0.58)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C178(0.66); C181(0.66)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C178(0.82); C181(0.82)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C178(0.63); C181(0.63)  LDD0993  [7]
 LDCM0396  CL125 HCT 116 C110(0.86)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C110(0.78)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C110(1.05)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C110(1.21)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C110(1.14)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C110(0.87)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C110(1.10)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C110(1.08)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C110(1.06)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C110(1.10)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C110(1.15)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C110(0.85)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C110(1.30)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C110(1.25)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C110(1.62)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C110(1.34)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C110(1.43)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C110(1.26)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C110(1.15)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C110(1.11)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C110(1.14)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C110(1.28)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C110(0.87)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C110(1.10)  LDD0736  [7]
 LDCM0420  CL31 HEK-293T C178(0.70); C181(0.70)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C178(0.77); C181(0.77)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C178(0.97); C181(0.97)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C178(0.87); C181(0.87)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C178(0.54); C181(0.54)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C178(0.90); C181(0.90)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C178(0.62); C181(0.62)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C178(0.52); C181(0.52)  LDD1026  [7]
 LDCM0429  CL4 HCT 116 C110(1.37)  LDD0746  [7]
 LDCM0430  CL40 HEK-293T C178(0.72); C181(0.72)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C178(0.50); C181(0.50)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C178(0.49); C181(0.49)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C178(0.54); C181(0.54)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C178(0.70); C181(0.70)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C178(0.56); C181(0.56)  LDD1033  [7]
 LDCM0436  CL46 HCT 116 C110(1.04)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C110(0.93)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C110(0.90)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C110(1.05)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C110(1.07)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C110(0.99)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C110(1.03)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C110(1.11)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C110(1.08)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C110(0.96)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C110(1.09)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C110(0.98)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C110(1.04)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C110(0.91)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C110(0.98)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C110(0.87)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C110(1.12)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C110(1.19)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C110(1.23)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C110(1.42)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C110(0.93)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C110(1.15)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C110(1.59)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C110(1.42)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C110(1.33)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C110(1.00)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C110(1.02)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C110(1.14)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C110(1.37)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C110(1.30)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C110(1.40)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C110(1.14)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C110(1.12)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C110(1.28)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C110(1.10)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C110(1.50)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C110(1.14)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C110(1.25)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C110(1.30)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C110(1.31)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C110(1.41)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C110(1.62)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C110(1.38)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C110(1.18)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C110(1.27)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C110(1.41)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C110(1.76)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C110(1.09)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C110(1.01)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C110(1.71)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C110(1.89)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C110(1.35)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C110(1.43)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C110(1.31)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C110(2.20)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C110(1.75)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C110(1.36)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C110(1.34)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C110(1.10)  LDD1698  [15]
 LDCM0175  Ethacrynic acid HeLa C110(0.98)  LDD2210  [5]
 LDCM0625  F8 Ramos C110(0.79)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C110(0.56)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C110(13.91)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C110(0.96)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C110(2.03)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C110(1.68)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C110(0.94)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C110(1.04)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C110(1.20)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C110(1.23)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C110(2.27)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C110(1.72)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C110(1.31)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C110(1.52)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C110(1.40)  LDD0785  [7]
 LDCM0566  Fragment4 Ramos C110(0.65)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C178(1.47); C181(1.47)  LDD1025  [7]
 LDCM0614  Fragment56 Ramos C110(0.70)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C110(1.25)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C110(0.83)  LDD2188  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HCT 116 C110(1.24)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C110(1.23)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C110(1.95)  LDD0082  [7]
 LDCM0109  NEM HeLa H238(0.00); H98(0.00)  LDD0223  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578