Details of the Target

General Information of Target

Target ID LDTP13256
Target Name SUN domain-containing protein 2 (SUN2)
Gene Name SUN2
Gene ID 25777
Synonyms
FRIGG; KIAA0668; RAB5IP; UNC84B; SUN domain-containing protein 2; Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1/unc-84 protein-like 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCRED
SSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQE
AYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKT
IDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFN
VFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY
Target Bioclass
Transporter and channel
Subcellular location
Nucleus inner membrane
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
Uniprot ID
Q9UH99
Ensemble ID
ENST00000405018.5
HGNC ID
HGNC:14210

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 Substitution: p.A419V DBIA    Probe Info 
CAL62 SNV: p.G609A .
JURKAT SNV: p.S553L .
MCAS SNV: p.R338C DBIA    Probe Info 
SNGM SNV: p.A427T .
TOV21G SNV: p.G555V DBIA    Probe Info 
UACC257 SNV: p.V629L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K491(5.51); K533(10.00)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C563(3.26)  LDD0168  [2]
DBIA
 Probe Info  		C601(20.31)  LDD0204  [3]
5E-2FA
 Probe Info  		H495(0.00); H325(0.00)  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C563(0.00); C601(0.00); C705(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C563(0.00); C601(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C601(0.00); C563(0.00)  LDD0037  [5]
Ox-W18
 Probe Info  		N.A.  LDD2175  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
Crotonaldehyde
 Probe Info  		H269(0.00); H281(0.00)  LDD0219  [7]
PAL-AfBPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.28  LDD1725  [8]
C040
 Probe Info  		7.52  LDD1740  [8]
C094
 Probe Info  		27.67  LDD1785  [8]
C106
 Probe Info  		17.88  LDD1793  [8]
C112
 Probe Info  		24.08  LDD1799  [8]
C158
 Probe Info  		9.45  LDD1838  [8]
C201
 Probe Info  		24.93  LDD1877  [8]
C210
 Probe Info  		71.51  LDD1884  [8]
C211
 Probe Info  		10.78  LDD1885  [8]
C212
 Probe Info  		6.11  LDD1886  [8]
C213
 Probe Info  		19.16  LDD1887  [8]
C214
 Probe Info  		12.91  LDD1888  [8]
C228
 Probe Info  		15.35  LDD1901  [8]
C246
 Probe Info  		12.82  LDD1919  [8]
C285
 Probe Info  		19.56  LDD1955  [8]
C289
 Probe Info  		47.18  LDD1959  [8]
C348
 Probe Info  		10.34  LDD2009  [8]
C355
 Probe Info  		30.70  LDD2016  [8]
C356
 Probe Info  		8.82  LDD2017  [8]
C397
 Probe Info  		10.13  LDD2056  [8]
C400
 Probe Info  		8.34  LDD2059  [8]
C403
 Probe Info  		18.90  LDD2061  [8]
C407
 Probe Info  		11.88  LDD2064  [8]
FFF probe11
 Probe Info  		17.52  LDD0471  [9]
FFF probe13
 Probe Info  		13.43  LDD0475  [9]
FFF probe2
 Probe Info  		20.00  LDD0463  [9]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
STS-1
 Probe Info  		N.A.  LDD0136  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]
OEA-DA
 Probe Info  		18.12  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C563(3.26)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C563(2.03)  LDD0169  [2]
 LDCM0215  AC10 HEK-293T C705(0.99); C601(1.12)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C705(0.90)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C705(1.17)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C705(0.88)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C705(1.15)  LDD1513  [13]
 LDCM0277  AC18 HEK-293T C705(1.02); C601(1.14)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C705(1.08)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C705(1.04); C601(1.20)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C705(0.99)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C705(1.05)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C705(0.85)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C705(0.98)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C705(1.01); C601(1.38)  LDD1523  [13]
 LDCM0286  AC26 HEK-293T C705(1.02); C601(1.18)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C705(0.95)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C705(0.90)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C705(1.18)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C705(1.07)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C705(0.88)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C705(0.89)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C705(0.93); C601(1.43)  LDD1532  [13]
 LDCM0295  AC34 HEK-293T C705(1.17); C601(1.07)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C705(1.04)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C705(0.89)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C705(0.92)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C705(1.03)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C705(1.10)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C705(0.92)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C705(0.97); C601(1.10)  LDD1541  [13]
 LDCM0304  AC42 HEK-293T C705(0.91); C601(1.29)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C705(0.95)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C705(0.94)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C705(1.10)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C705(1.14)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C705(0.96)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C705(0.96); C601(1.47)  LDD1549  [13]
 LDCM0312  AC5 HEK-293T C705(0.81)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C705(0.97); C601(1.10)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C705(1.02)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C705(1.20)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C705(0.88)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C705(0.85)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C705(0.87)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C705(0.94); C601(1.47)  LDD1558  [13]
 LDCM0321  AC58 HEK-293T C705(1.07); C601(1.09)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C705(1.11)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C705(1.01)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C705(0.91)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C705(0.93)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C705(0.87)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C705(0.95)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C705(0.89); C601(1.66)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C705(0.99)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C705(0.93); C601(1.24)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C705(1.29)  LDD1511  [13]
 LDCM0275  AKOS034007705 HEK-293T C705(0.84); C601(1.14)  LDD1514  [13]
 LDCM0102  BDHI 8 Jurkat C601(20.31)  LDD0204  [3]
 LDCM0367  CL1 HEK-293T C705(0.89)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C705(0.98)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C705(0.89); C601(1.18)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C705(1.19)  LDD1574  [13]
 LDCM0372  CL103 HEK-293T C705(0.95)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C705(1.00); C601(1.13)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C705(1.41)  LDD1578  [13]
 LDCM0376  CL107 HEK-293T C705(0.92)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C705(1.08); C601(1.41)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C705(1.17)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C705(1.09)  LDD1583  [13]
 LDCM0381  CL111 HEK-293T C705(1.11)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C705(1.17); C601(1.11)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C705(1.09)  LDD1587  [13]
 LDCM0385  CL115 HEK-293T C705(1.07)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C705(1.05); C601(1.10)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C705(0.84)  LDD1591  [13]
 LDCM0389  CL119 HEK-293T C705(1.02)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C705(0.95); C601(1.29)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C705(1.09); C601(1.03)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C705(1.07)  LDD1596  [13]
 LDCM0394  CL123 HEK-293T C705(0.85)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C705(1.06); C601(1.92)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C705(1.21)  LDD1600  [13]
 LDCM0398  CL127 HEK-293T C705(1.03)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C705(1.11); C601(1.34)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C705(1.00)  LDD1604  [13]
 LDCM0402  CL15 HEK-293T C705(0.79)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C705(0.94); C601(1.10)  LDD1607  [13]
 LDCM0405  CL18 HEK-293T C705(1.01); C601(0.95)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C705(1.03)  LDD1610  [13]
 LDCM0408  CL20 HEK-293T C705(0.94)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C705(0.99)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C705(1.19)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C705(1.20)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C705(0.94); C601(1.10)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C705(1.09)  LDD1617  [13]
 LDCM0415  CL27 HEK-293T C705(1.00)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C705(0.95); C601(0.95)  LDD1620  [13]
 LDCM0418  CL3 HEK-293T C705(0.96)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C705(1.02); C601(1.00)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C705(1.09)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C705(0.93)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C705(0.74)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C705(0.72)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C705(0.77)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C705(0.90); C601(1.18)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C705(1.02)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C705(1.05)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C705(1.12); C601(1.00)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C705(1.11); C601(1.07)  LDD1634  [13]
 LDCM0432  CL42 HEK-293T C705(1.06); C601(0.94)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C705(0.90)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C705(0.73)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C705(0.90)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C705(1.01)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C705(1.03)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C705(0.90); C601(1.37)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C705(0.85)  LDD1643  [13]
 LDCM0443  CL52 HEK-293T C705(0.98); C601(1.37)  LDD1646  [13]
 LDCM0445  CL54 HEK-293T C705(0.90); C601(1.01)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C705(1.22)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C705(0.99)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C705(1.02)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C705(0.89)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C705(1.05)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C705(1.05); C601(0.86)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C705(0.96); C601(1.26)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C705(0.96)  LDD1656  [13]
 LDCM0455  CL63 HEK-293T C705(1.06)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C705(0.97); C601(1.35)  LDD1659  [13]
 LDCM0458  CL66 HEK-293T C705(0.90); C601(1.12)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C705(1.17)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C705(1.08)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C705(0.76)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C705(1.21)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C705(1.03)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C705(1.07)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C705(0.95); C601(1.11)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C705(1.02)  LDD1669  [13]
 LDCM0469  CL76 HEK-293T C705(1.12); C601(0.97)  LDD1672  [13]
 LDCM0471  CL78 HEK-293T C705(0.94); C601(1.03)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C705(1.24)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C705(0.86)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C705(0.93)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C705(0.86)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C705(0.97)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C705(1.10)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C705(0.96); C601(1.16)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C705(1.16)  LDD1682  [13]
 LDCM0481  CL87 HEK-293T C705(1.03)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C705(1.26); C601(1.44)  LDD1685  [13]
 LDCM0484  CL9 HEK-293T C705(1.01)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C705(0.80); C601(1.11)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C705(1.17)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C705(0.83)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C705(0.82)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C705(1.12)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C705(0.89)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C705(1.01); C601(1.43)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C705(0.88)  LDD1695  [13]
 LDCM0494  CL99 HEK-293T C705(0.94)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C705(1.02)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C705(0.99)  LDD1671  [13]
 LDCM0022  KB02 22RV1 C761(1.94)  LDD2243  [14]
 LDCM0023  KB03 22RV1 C761(1.63)  LDD2660  [14]
 LDCM0024  KB05 COLO792 C726(1.98); C622(2.36)  LDD3310  [14]
 LDCM0109  NEM HeLa N.A.  LDD0224  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-5A (RAB5A) Rab family P20339
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
SUN domain-containing protein 2 (SUN2) . Q9UH99
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prelamin-A/C (LMNA) Intermediate filament family P02545
Nesprin-1 (SYNE1) Nesprin family Q8NF91
Nesprin-2 (SYNE2) Nesprin family Q8WXH0
Nurim (NRM) Nurim family Q8IXM6
Coatomer subunit beta (COPB1) . P53618
Emerin (EMD) . P50402

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840