Details of the Target

General Information of Target

Target ID LDTP11187
Target Name COP9 signalosome complex subunit 4 (COPS4)
Gene Name COPS4
Gene ID 51138
Synonyms
CSN4; COP9 signalosome complex subunit 4; SGN4; Signalosome subunit 4; JAB1-containing signalosome subunit 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALALAALAAVEPACGSRYQQLQNEEESGEPEQAAGDAPPPYSSISAESAAYFDYKDESG
FPKPPSYNVATTLPSYDEAERTKAEATIPLVPGRDEDFVGRDDFDDADQLRIGNDGIFML
TFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYFDGQYWL
WWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPRTRVLFIY
Target Bioclass
Enzyme
Family
CSN4 family
Subcellular location
Cytoplasm
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Uniprot ID
Q9BT78
Ensemble ID
ENST00000264389.7
HGNC ID
HGNC:16702

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.R193H DBIA    Probe Info 
CCK81 SNV: p.E219K DBIA    Probe Info 
EGI1 SNV: p.E177Ter DBIA    Probe Info 
FTC133 SNV: p.A335V DBIA    Probe Info 
HCT116 SNV: p.S376T DBIA    Probe Info 
HCT15 SNV: p.Q7P DBIA    Probe Info 
MFE319 SNV: p.R302G DBIA    Probe Info 
NCIH3122 SNV: p.L327F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K200(0.99)  LDD0277  [1]
Probe 1
 Probe Info  		Y114(24.83); Y167(11.90); Y208(43.16)  LDD3495  [2]
m-APA
 Probe Info  		12.08  LDD0403  [3]
BTD
 Probe Info  		C255(1.23)  LDD2099  [4]
Johansson_61
 Probe Info  		_(15.21)  LDD1485  [5]
AHL-Pu-1
 Probe Info  		C378(2.82)  LDD0169  [6]
DBIA
 Probe Info  		C378(3.38)  LDD0080  [7]
5E-2FA
 Probe Info  		H360(0.00); H19(0.00); H72(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C255(0.00); C232(0.00); C70(0.00); C378(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C255(0.00); C378(0.00); C70(0.00); C232(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
Compound 10
 Probe Info  		C255(0.00); C378(0.00); C70(0.00)  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
IPM
 Probe Info  		C70(0.00); C255(0.00); C378(0.00)  LDD0147  [15]
NHS
 Probe Info  		N.A.  LDD0010  [16]
TFBX
 Probe Info  		C232(0.00); C255(0.00)  LDD0148  [15]
1c-yne
 Probe Info  		K137(0.00); K372(0.00); K314(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C70(0.00); H218(0.00)  LDD0217  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		14.00  LDD0443  [20]
NAIA_5
 Probe Info  		C255(0.00); C378(0.00); C232(0.00); C70(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C059
 Probe Info  		5.39  LDD1756  [21]
C064
 Probe Info  		7.94  LDD1761  [21]
C067
 Probe Info  		7.31  LDD1763  [21]
C106
 Probe Info  		17.39  LDD1793  [21]
C107
 Probe Info  		6.45  LDD1794  [21]
C112
 Probe Info  		17.63  LDD1799  [21]
C134
 Probe Info  		99.73  LDD1816  [21]
C147
 Probe Info  		7.73  LDD1829  [21]
C160
 Probe Info  		7.67  LDD1840  [21]
C173
 Probe Info  		6.32  LDD1853  [21]
C177
 Probe Info  		7.46  LDD1856  [21]
C191
 Probe Info  		13.55  LDD1868  [21]
C201
 Probe Info  		31.56  LDD1877  [21]
C213
 Probe Info  		35.02  LDD1887  [21]
C216
 Probe Info  		12.91  LDD1890  [21]
C220
 Probe Info  		11.63  LDD1894  [21]
C228
 Probe Info  		21.56  LDD1901  [21]
C234
 Probe Info  		7.36  LDD1907  [21]
C252
 Probe Info  		14.22  LDD1925  [21]
C282
 Probe Info  		25.81  LDD1952  [21]
C285
 Probe Info  		20.53  LDD1955  [21]
C288
 Probe Info  		12.13  LDD1958  [21]
C310
 Probe Info  		12.47  LDD1977  [21]
C326
 Probe Info  		13.27  LDD1990  [21]
C343
 Probe Info  		16.80  LDD2005  [21]
C353
 Probe Info  		7.16  LDD2014  [21]
C355
 Probe Info  		27.28  LDD2016  [21]
C356
 Probe Info  		9.51  LDD2017  [21]
C363
 Probe Info  		18.64  LDD2024  [21]
C367
 Probe Info  		46.53  LDD2028  [21]
C388
 Probe Info  		36.76  LDD2047  [21]
C390
 Probe Info  		30.06  LDD2049  [21]
C419
 Probe Info  		10.78  LDD2074  [21]
FFF probe11
 Probe Info  		9.34  LDD0471  [22]
FFF probe13
 Probe Info  		16.14  LDD0475  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe15
 Probe Info  		5.05  LDD0478  [22]
FFF probe2
 Probe Info  		12.59  LDD0463  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
JN0003
 Probe Info  		12.45  LDD0469  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C255(1.71)  LDD2142  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C70(1.13)  LDD2117  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C378(2.82)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C255(1.14)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C255(0.96); C378(0.62)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C255(0.72); C378(0.62)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C255(0.63); C378(0.72)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C255(0.57); C378(0.67)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C255(0.46); C378(0.69)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C255(0.61); C378(0.79)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C255(0.52); C378(0.75)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C255(0.50); C378(0.65)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C255(0.55); C378(0.70)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C255(0.64); C378(0.71)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C255(0.83); C378(0.73)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C255(1.07); C378(0.73)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C255(0.62); C378(0.74)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C255(0.56); C378(0.75)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C255(0.54); C378(0.68)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C378(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C378(0.79)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C378(0.78)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C378(0.82)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C378(0.95)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C378(0.82)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C378(0.84)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C255(1.07); C378(0.77)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C378(0.83)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C378(0.82)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C378(0.83)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C378(0.98)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C378(1.02)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C378(0.76)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C378(0.67)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C378(0.73)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C378(0.92)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C378(1.84)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C378(0.98)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C378(1.25)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C378(1.02)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C378(1.02)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C378(1.13)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C378(1.11)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C378(1.03)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C378(1.00)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C378(1.20)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C378(1.25)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C255(1.29); C378(0.66)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C378(0.91)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C378(1.17)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C378(1.07)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C255(0.78); C378(0.85)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C255(0.63); C378(0.76)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C378(0.78); C255(0.89)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C378(0.73); C255(0.83)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C255(0.73); C378(0.74)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C378(1.07); C255(1.70)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C378(0.76); C255(1.34)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C378(0.62); C255(1.09)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C378(0.65); C255(0.93)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C378(0.78); C255(0.85)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C255(0.61); C378(0.76)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C378(0.99); C255(1.07)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C255(0.67); C378(0.70)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C255(0.74); C378(0.77)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C255(0.95); C378(0.84)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C255(0.90); C378(0.81)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C378(0.93); C255(1.04)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C378(1.22); C255(1.42)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C378(0.99); C255(1.16)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C255(0.83)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C378(0.98); C255(1.12)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C378(0.87); C255(1.12)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C255(1.01); C378(1.07)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C378(0.95); C255(1.23)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C255(0.96); C378(1.04)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C378(0.88); C255(0.92)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C255(0.65); C378(0.83)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C255(0.76); C378(0.89)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C255(0.73); C378(0.76)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C255(0.60); C378(0.74)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C255(0.93)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C255(0.63); C378(1.04)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C255(0.70); C378(0.71)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C255(0.66); C378(0.80)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C378(0.76); C255(0.81)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C378(0.71); C255(0.77)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C378(1.00); C255(1.07)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C255(0.96); C378(1.08)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C378(0.96); C255(1.28)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C255(0.81); C378(0.99)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C255(0.88); C378(0.88)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C255(0.98)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C255(0.94); C378(1.10)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C255(0.92); C378(1.05)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C255(0.87); C378(1.05)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C255(0.69); C378(1.06)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C378(1.23); C255(1.32)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C378(1.02); C255(1.56)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C255(0.76); C378(0.91)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C255(0.82); C378(0.90)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C255(0.72); C378(0.77)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C255(0.69); C378(1.03)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C255(0.96)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C255(0.64); C378(0.93)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C378(0.92); C255(0.93)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C378(0.80); C255(0.88)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C378(0.97); C255(0.97)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C255(0.75); C378(1.02)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C255(0.87); C378(1.14)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C255(0.71); C378(1.10)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C255(0.47); C378(0.82)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C255(0.43); C378(1.05)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C255(0.43); C378(0.92)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C378(0.70); C255(0.79)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C255(0.41); C378(0.80)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C255(0.45); C378(0.81)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C255(0.40); C378(0.81)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C255(0.41); C378(0.65)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C255(0.35); C378(1.06)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C255(0.40); C378(0.93)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C255(0.43); C378(0.94)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C255(0.19); C378(0.97)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C255(0.78); C378(0.88)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C255(0.62); C378(1.02)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C378(0.70); C255(0.91)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C255(0.50); C378(0.89)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C255(1.13); C378(1.24)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C255(0.89); C378(1.02)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C255(0.46); C378(0.93)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C255(0.44); C378(0.99)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C255(0.45); C378(0.96)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C255(0.69); C378(0.96)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C255(0.63); C378(0.95)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C255(0.78); C378(0.87)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C255(0.94); C378(1.05)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C378(0.74); C255(0.96)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C255(0.71); C378(1.09)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C378(0.91); C255(1.01)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C255(0.42); C378(0.99)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C255(0.33)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C255(0.34)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C255(0.51)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C255(0.83)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C255(0.79)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C255(0.74)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C255(0.54)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C255(1.24)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C255(0.39)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C255(0.43)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C255(0.66)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C255(0.70)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C255(0.73)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C255(0.48)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C255(0.51)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C255(0.30); C378(0.73)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C378(0.76); C255(0.82)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C255(1.05); C378(0.73)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C378(0.65); C255(1.13)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C378(0.65); C255(0.78)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.08  LDD0403  [3]
 LDCM0108  Chloroacetamide HeLa C70(0.00); C232(0.00); H307(0.00); H218(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C255(1.10)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C378(1.16)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C378(0.86)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C255(0.90)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C378(0.68); C255(0.88)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C378(0.74); C255(0.81)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C378(0.62); C255(1.11)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C378(0.74); C255(0.86)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C378(0.92); C255(1.30)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C378(0.85); C255(1.81)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C378(0.84); C255(1.42)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C378(0.93); C255(1.29)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C378(0.93); C255(1.13)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C378(1.03)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C378(0.76); C255(0.83)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C378(0.79); C255(0.87)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C255(0.86); C378(0.89)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C255(0.65); C378(0.74)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C255(0.66); C378(0.88)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C255(0.73); C378(0.76)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C378(0.79); C255(0.91)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C255(0.81); C378(1.43)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C255(0.76); C378(0.96)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C255(0.88); C378(0.99)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C378(1.28)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C255(0.88); C378(1.08)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C378(0.79); C255(0.92)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C255(0.84); C378(0.91)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C255(0.71); C378(0.81)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C255(0.76); C378(0.97)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C378(0.72); C255(0.94)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C255(0.74); C378(0.95)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C255(0.85); C378(1.26)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C255(0.48); C378(1.05)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C378(0.94)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C378(0.88)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C378(0.78)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C255(0.74); C378(0.86)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C255(0.72); C378(0.81)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C255(0.61); C378(0.75)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C255(0.59); C378(0.76)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C378(1.06)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C255(0.60); C378(0.91)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C255(0.41); C378(0.78)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C255(0.34); C378(1.08)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C255(0.74); C378(0.80)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C255(0.40); C378(0.96)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C255(0.42); C378(0.79)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C255(0.74); C378(0.88)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C255(0.68); C378(0.78)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C255(0.52); C378(0.77)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C255(0.55); C378(0.83)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C378(0.90)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C255(0.71); C378(0.86)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C255(0.90); C378(0.97)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C255(0.89); C378(0.78)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C255(0.87); C378(0.64)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C255(0.73); C378(0.89)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C255(0.87); C378(1.06)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C255(0.83); C378(1.01)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C255(0.90); C378(0.97)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C255(0.89); C378(0.93)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C378(0.99)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C255(0.69); C378(0.88)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C255(1.08); C378(0.91)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C255(0.96); C378(1.13)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C255(1.03); C378(1.02)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C255(1.03); C378(0.78)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C255(0.87); C378(0.86)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C255(0.90); C378(1.11)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C255(0.89); C378(1.02)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C255(1.04); C378(1.06)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C255(1.10); C378(1.07)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C378(1.09)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C255(1.13); C378(1.14)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C255(1.04); C378(0.98)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C255(1.05); C378(0.91)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C255(1.03); C378(1.08)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C255(0.99); C378(0.96)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C255(1.04); C378(1.03)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C255(1.04); C378(1.00)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C255(1.08); C378(1.04)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C255(1.29); C378(1.18)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C255(1.04); C378(1.05)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C378(0.89)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C255(1.00); C378(1.09)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C378(0.92)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C378(0.86)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C378(0.76)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C378(0.81)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C378(0.89)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C378(0.85)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C378(0.81)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C378(0.73)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C378(0.73)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C378(0.93)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C378(0.79)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C378(0.79)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C378(0.98)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C378(0.75)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C378(0.80)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C255(0.59)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C255(1.16)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C255(0.79)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C255(0.56)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C378(1.07)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C255(0.80)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C255(0.58)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C255(0.33)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C255(0.42)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C255(0.29)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C255(0.72)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C255(0.85)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C255(0.74)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C255(0.42)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C255(0.25)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C378(1.03)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C255(0.97)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C255(0.90)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C255(1.03)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C255(1.13)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C255(1.19)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C255(1.02)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C255(0.88)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C255(0.89)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C255(0.81)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C255(0.87)  LDD0811  [7]
 LDCM0185  Compound 17 HEK-293T 3.71  LDD0512  [22]
 LDCM0191  Compound 21 HEK-293T 9.76  LDD0508  [22]
 LDCM0190  Compound 34 HEK-293T 8.44  LDD0510  [22]
 LDCM0192  Compound 35 HEK-293T 7.12  LDD0509  [22]
 LDCM0193  Compound 36 HEK-293T 8.66  LDD0511  [22]
 LDCM0495  E2913 HEK-293T C255(1.09); C70(1.01); C378(0.89)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C70(0.64)  LDD1702  [4]
 LDCM0625  F8 Ramos C255(1.00)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C255(0.90)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C255(0.70)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C255(1.21)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C255(1.08)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C255(1.59)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C255(1.26)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C255(1.25)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C255(1.18)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C255(1.10)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C255(0.93)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C255(1.04)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C255(1.63)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C255(0.77)  LDD2201  [24]
 LDCM0468  Fragment33 HCT 116 C378(0.84)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C255(0.92)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C255(0.93)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C255(0.78); C378(0.99)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C255(0.99)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C255(1.00)  LDD2205  [24]
 LDCM0615  Fragment63-R Jurkat _(5.57)  LDD1487  [5]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [5]
 LDCM0569  Fragment7 Jurkat _(15.21)  LDD1485  [5]
 LDCM0571  Fragment9 Ramos C255(0.96)  LDD2188  [24]
 LDCM0107  IAA HeLa C70(0.00); H218(0.00); H307(0.00); H228(0.00)  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C378(3.38)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C378(2.40)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C378(2.34)  LDD0082  [7]
 LDCM0109  NEM HeLa H307(0.00); H218(0.00)  LDD0223  [18]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C255(1.23)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C255(0.71)  LDD2100  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C70(0.34); C255(0.68)  LDD2106  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C70(0.72)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C70(0.56)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C70(0.34); C255(0.57)  LDD2110  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C255(0.99)  LDD2122  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C255(0.91)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C255(1.10)  LDD2127  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C70(0.87)  LDD2137  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C70(0.57)  LDD2141  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C70(0.36)  LDD2148  [4]
 LDCM0131  RA190 MM1.R C378(1.68)  LDD0304  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 6 (COPS6) Peptidase M67A family Q7L5N1
Serine/threonine-protein kinase STK11 (STK11) CAMK Ser/Thr protein kinase family Q15831
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Peroxisomal membrane protein PEX14 (PEX14) Peroxin-14 family O75381
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein c-Fos (FOS) BZIP family P01100
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
Protocadherin beta-12 (PCDHB12) . Q9Y5F1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.