Details of the Target

General Information of Target

Target ID LDTP04071
Target Name Voltage-dependent anion-selective channel protein 2 (VDAC2)
Gene Name VDAC2
Gene ID 7417
Synonyms
Voltage-dependent anion-selective channel protein 2; VDAC-2; hVDAC2; Outer mitochondrial membrane protein porin 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNT
DTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGK
KSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNF
AVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDP
TASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Eukaryotic mitochondrial porin family
Subcellular location
Mitochondrion outer membrane
Function
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway.
TTD ID
T35158
Uniprot ID
P45880
DrugMap ID
TTM1I7L
Ensemble ID
ENST00000313132.8
HGNC ID
HGNC:12672
ChEMBL ID
CHEMBL6190

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 73 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.08  LDD0402  [2]
Alkylaryl probe 1
 Probe Info  		6.00  LDD0387  [3]
Alkylaryl probe 3
 Probe Info  		6.41  LDD0381  [3]
HDSF-alk
 Probe Info  		2.55  LDD0197  [4]
P2
 Probe Info  		2.08  LDD0449  [5]
P3
 Probe Info  		10.00  LDD0450  [5]
P8
 Probe Info  		1.71  LDD0451  [5]
A-EBA
 Probe Info  		3.66  LDD0215  [6]
ILS-2
 Probe Info  		3.53  LDD0416  [7]
FBPP2
 Probe Info  		8.33  LDD0318  [8]
CHEMBL5175495
 Probe Info  		13.40  LDD0196  [9]
CY-1
 Probe Info  		5.69  LDD0243  [10]
CY4
 Probe Info  		10.61  LDD0244  [10]
N1
 Probe Info  		29.17  LDD0242  [10]
TG42
 Probe Info  		5.04  LDD0326  [11]
W1
 Probe Info  		68.06  LDD0235  [12]
TH211
 Probe Info  		Y184(20.00); Y236(20.00); Y78(11.36)  LDD0260  [13]
FBP2
 Probe Info  		3.91  LDD0317  [8]
IBr-1b
 Probe Info  		6.94  LDD0306  [14]
TH214
 Probe Info  		Y236(5.08)  LDD0258  [13]
TH216
 Probe Info  		Y78(20.00); Y236(8.96)  LDD0259  [13]
YN-1
 Probe Info  		48.81  LDD0444  [15]
YN-4
 Probe Info  		100.00  LDD0445  [15]
ONAyne
 Probe Info  		N.A.  LDD0273  [16]
P11
 Probe Info  		9.48  LDD0201  [17]
Alkylaryl probe 2
 Probe Info  		3.00  LDD0390  [3]
JZ128-DTB
 Probe Info  		C210(0.00); C47(0.00)  LDD0462  [18]
Sulforaphane-probe2
 Probe Info  		3.26  LDD0042  [19]
Jackson_14
 Probe Info  		2.56  LDD0123  [20]
Johansson_61
 Probe Info  		_(5.62)  LDD1490  [21]
YY4-yne
 Probe Info  		2.75  LDD0400  [22]
AHL-Pu-1
 Probe Info  		C76(2.03)  LDD0169  [23]
HPAP
 Probe Info  		6.44  LDD0062  [24]
EA-probe
 Probe Info  		N.A.  LDD0440  [25]
DBIA
 Probe Info  		C227(1.04); C210(1.02); C47(1.01); C76(0.97)  LDD0078  [26]
5E-2FA
 Probe Info  		N.A.  LDD2235  [27]
ATP probe
 Probe Info  		K74(0.00); K31(0.00); K72(0.00)  LDD0199  [28]
4-Iodoacetamidophenylacetylene
 Probe Info  		C13(0.00); C47(0.00); C76(0.00); C103(0.00)  LDD0038  [29]
IA-alkyne
 Probe Info  		C76(0.00); C103(0.00); C47(0.00)  LDD0032  [30]
IPIAA_L
 Probe Info  		C76(0.00); C47(0.00)  LDD0031  [31]
Lodoacetamide azide
 Probe Info  		C13(0.00); C47(0.00); C76(0.00); C103(0.00)  LDD0037  [29]
ATP probe
 Probe Info  		N.A.  LDD0035  [32]
AZ-9
 Probe Info  		N.A.  LDD0395  [33]
BTD
 Probe Info  		C76(0.00); C47(0.00)  LDD0004  [34]
JW-RF-010
 Probe Info  		C47(0.00); C210(0.00); C103(0.00); C8(0.00)  LDD0026  [35]
NAIA_4
 Probe Info  		C13(0.00); C47(0.00); C76(0.00); C103(0.00)  LDD2226  [36]
TFBX
 Probe Info  		C103(0.00); C13(0.00); C47(0.00); C8(0.00)  LDD0027  [35]
WYneC
 Probe Info  		N.A.  LDD0014  [34]
WYneN
 Probe Info  		C76(0.00); C47(0.00)  LDD0021  [34]
WYneO
 Probe Info  		C76(0.00); C210(0.00); C47(0.00)  LDD0022  [34]
aHNE
 Probe Info  		N.A.  LDD0001  [34]
Compound 10
 Probe Info  		C13(0.00); C210(0.00); C47(0.00); C76(0.00)  LDD2216  [37]
Compound 11
 Probe Info  		C13(0.00); C210(0.00); C47(0.00); C76(0.00)  LDD2213  [37]
ENE
 Probe Info  		C47(0.00); C210(0.00)  LDD0006  [34]
IPM
 Probe Info  		C47(0.00); C76(0.00); C210(0.00)  LDD0005  [34]
NHS
 Probe Info  		K277(0.00); K72(0.00); K235(0.00); K39(0.00)  LDD0010  [34]
PF-06672131
 Probe Info  		C47(0.00); C76(0.00)  LDD0017  [38]
PPMS
 Probe Info  		N.A.  LDD0008  [34]
SF
 Probe Info  		Y236(0.00); Y184(0.00)  LDD0028  [39]
STPyne
 Probe Info  		K120(0.00); K31(0.00)  LDD0009  [34]
VSF
 Probe Info  		C76(0.00); C210(0.00); C227(0.00); C47(0.00)  LDD0007  [34]
Phosphinate-6
 Probe Info  		C210(0.00); C103(0.00); C76(0.00); C227(0.00)  LDD0018  [40]
1c-yne
 Probe Info  		K74(0.00); K235(0.00); K267(0.00)  LDD0228  [41]
1d-yne
 Probe Info  		N.A.  LDD0357  [41]
Acrolein
 Probe Info  		C47(0.00); C103(0.00); C13(0.00); C76(0.00)  LDD0217  [42]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [42]
Crotonaldehyde
 Probe Info  		C47(0.00); C13(0.00); C76(0.00); H284(0.00)  LDD0219  [42]
Methacrolein
 Probe Info  		C47(0.00); C13(0.00); C76(0.00); H284(0.00)  LDD0218  [42]
AOyne
 Probe Info  		10.00  LDD0443  [43]
MPP-AC
 Probe Info  		N.A.  LDD0428  [44]
NAIA_5
 Probe Info  		C13(0.00); C47(0.00); C76(0.00); C103(0.00)  LDD2223  [36]
TER-AC
 Probe Info  		N.A.  LDD0426  [44]
TPP-AC
 Probe Info  		N.A.  LDD0427  [44]
PAL-AfBPP Probe
Click To Hide/Show 217 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		4.17  LDD0398  [45]
C001
 Probe Info  		9.45  LDD1711  [46]
C004
 Probe Info  		18.64  LDD1714  [46]
C007
 Probe Info  		13.00  LDD1716  [46]
C008
 Probe Info  		6.68  LDD1717  [46]
C010
 Probe Info  		8.51  LDD1719  [46]
C011
 Probe Info  		13.27  LDD1720  [46]
C022
 Probe Info  		24.25  LDD1728  [46]
C026
 Probe Info  		17.15  LDD1732  [46]
C027
 Probe Info  		5.74  LDD1733  [46]
C039
 Probe Info  		6.63  LDD1739  [46]
C040
 Probe Info  		28.44  LDD1740  [46]
C041
 Probe Info  		15.78  LDD1741  [46]
C044
 Probe Info  		9.85  LDD1743  [46]
C049
 Probe Info  		15.78  LDD1747  [46]
C055
 Probe Info  		64.00  LDD1752  [46]
C056
 Probe Info  		48.84  LDD1753  [46]
C059
 Probe Info  		5.39  LDD1756  [46]
C060
 Probe Info  		9.78  LDD1757  [46]
C063
 Probe Info  		45.25  LDD1760  [46]
C064
 Probe Info  		12.82  LDD1761  [46]
C067
 Probe Info  		9.06  LDD1763  [46]
C070
 Probe Info  		27.67  LDD1766  [46]
C071
 Probe Info  		10.63  LDD1767  [46]
C072
 Probe Info  		24.93  LDD1768  [46]
C082
 Probe Info  		16.11  LDD1774  [46]
C085
 Probe Info  		7.26  LDD1777  [46]
C087
 Probe Info  		10.20  LDD1779  [46]
C089
 Probe Info  		10.48  LDD1781  [46]
C091
 Probe Info  		73.01  LDD1782  [46]
C092
 Probe Info  		77.71  LDD1783  [46]
C094
 Probe Info  		83.87  LDD1785  [46]
C095
 Probe Info  		9.19  LDD1786  [46]
C099
 Probe Info  		5.21  LDD1788  [46]
C100
 Probe Info  		7.94  LDD1789  [46]
C106
 Probe Info  		36.50  LDD1793  [46]
C107
 Probe Info  		18.64  LDD1794  [46]
C108
 Probe Info  		24.08  LDD1795  [46]
C112
 Probe Info  		51.98  LDD1799  [46]
C129
 Probe Info  		14.72  LDD1811  [46]
C130
 Probe Info  		25.99  LDD1812  [46]
C134
 Probe Info  		75.58  LDD1816  [46]
C135
 Probe Info  		37.27  LDD1817  [46]
C139
 Probe Info  		38.05  LDD1821  [46]
C140
 Probe Info  		19.03  LDD1822  [46]
C141
 Probe Info  		42.81  LDD1823  [46]
C143
 Probe Info  		63.56  LDD1825  [46]
C145
 Probe Info  		18.13  LDD1827  [46]
C147
 Probe Info  		15.03  LDD1829  [46]
C153
 Probe Info  		50.21  LDD1834  [46]
C156
 Probe Info  		7.78  LDD1836  [46]
C159
 Probe Info  		35.51  LDD1839  [46]
C160
 Probe Info  		38.59  LDD1840  [46]
C161
 Probe Info  		55.72  LDD1841  [46]
C163
 Probe Info  		28.64  LDD1843  [46]
C165
 Probe Info  		30.27  LDD1845  [46]
C166
 Probe Info  		16.00  LDD1846  [46]
C169
 Probe Info  		99.73  LDD1849  [46]
C170
 Probe Info  		17.27  LDD1850  [46]
C173
 Probe Info  		6.28  LDD1853  [46]
C174
 Probe Info  		16.00  LDD1854  [46]
C177
 Probe Info  		22.63  LDD1856  [46]
C178
 Probe Info  		49.52  LDD1857  [46]
C183
 Probe Info  		12.64  LDD1861  [46]
C186
 Probe Info  		21.56  LDD1864  [46]
C187
 Probe Info  		60.97  LDD1865  [46]
C191
 Probe Info  		17.51  LDD1868  [46]
C193
 Probe Info  		26.35  LDD1869  [46]
C194
 Probe Info  		24.93  LDD1870  [46]
C195
 Probe Info  		6.06  LDD1871  [46]
C196
 Probe Info  		18.00  LDD1872  [46]
C197
 Probe Info  		11.08  LDD1873  [46]
C198
 Probe Info  		38.32  LDD1874  [46]
C201
 Probe Info  		99.73  LDD1877  [46]
C204
 Probe Info  		5.94  LDD1879  [46]
C205
 Probe Info  		5.43  LDD1880  [46]
C206
 Probe Info  		79.89  LDD1881  [46]
C207
 Probe Info  		35.02  LDD1882  [46]
C210
 Probe Info  		72.50  LDD1884  [46]
C211
 Probe Info  		37.27  LDD1885  [46]
C212
 Probe Info  		6.32  LDD1886  [46]
C213
 Probe Info  		39.95  LDD1887  [46]
C217
 Probe Info  		7.84  LDD1891  [46]
C218
 Probe Info  		38.32  LDD1892  [46]
C219
 Probe Info  		16.80  LDD1893  [46]
C220
 Probe Info  		59.71  LDD1894  [46]
C222
 Probe Info  		5.54  LDD1896  [46]
C225
 Probe Info  		22.78  LDD1898  [46]
C226
 Probe Info  		21.56  LDD1899  [46]
C228
 Probe Info  		72.50  LDD1901  [46]
C229
 Probe Info  		31.78  LDD1902  [46]
C231
 Probe Info  		60.13  LDD1904  [46]
C232
 Probe Info  		69.55  LDD1905  [46]
C233
 Probe Info  		44.32  LDD1906  [46]
C234
 Probe Info  		18.13  LDD1907  [46]
C235
 Probe Info  		70.03  LDD1908  [46]
C238
 Probe Info  		47.18  LDD1911  [46]
C239
 Probe Info  		7.57  LDD1912  [46]
C240
 Probe Info  		28.25  LDD1913  [46]
C243
 Probe Info  		59.71  LDD1916  [46]
C244
 Probe Info  		28.84  LDD1917  [46]
C245
 Probe Info  		16.80  LDD1918  [46]
C246
 Probe Info  		47.18  LDD1919  [46]
C249
 Probe Info  		20.82  LDD1922  [46]
C252
 Probe Info  		18.13  LDD1925  [46]
C255
 Probe Info  		20.39  LDD1928  [46]
C258
 Probe Info  		11.31  LDD1931  [46]
C264
 Probe Info  		36.76  LDD1935  [46]
C265
 Probe Info  		30.70  LDD1936  [46]
C269
 Probe Info  		8.28  LDD1939  [46]
C270
 Probe Info  		13.45  LDD1940  [46]
C272
 Probe Info  		7.01  LDD1942  [46]
C273
 Probe Info  		15.89  LDD1943  [46]
C275
 Probe Info  		6.92  LDD1945  [46]
C277
 Probe Info  		32.22  LDD1947  [46]
C278
 Probe Info  		79.34  LDD1948  [46]
C280
 Probe Info  		32.45  LDD1950  [46]
C282
 Probe Info  		48.84  LDD1952  [46]
C284
 Probe Info  		31.78  LDD1954  [46]
C285
 Probe Info  		44.94  LDD1955  [46]
C286
 Probe Info  		10.06  LDD1956  [46]
C287
 Probe Info  		30.70  LDD1957  [46]
C288
 Probe Info  		15.14  LDD1958  [46]
C289
 Probe Info  		56.10  LDD1959  [46]
C290
 Probe Info  		15.03  LDD1960  [46]
C293
 Probe Info  		49.18  LDD1963  [46]
C296
 Probe Info  		21.11  LDD1966  [46]
C297
 Probe Info  		11.63  LDD1967  [46]
C299
 Probe Info  		25.28  LDD1968  [46]
C301
 Probe Info  		5.78  LDD1970  [46]
C303
 Probe Info  		7.46  LDD1972  [46]
C304
 Probe Info  		9.78  LDD1973  [46]
C305
 Probe Info  		21.71  LDD1974  [46]
C307
 Probe Info  		14.52  LDD1975  [46]
C310
 Probe Info  		17.03  LDD1977  [46]
C313
 Probe Info  		13.27  LDD1980  [46]
C314
 Probe Info  		38.32  LDD1981  [46]
C320
 Probe Info  		6.54  LDD1986  [46]
C322
 Probe Info  		9.71  LDD1988  [46]
C326
 Probe Info  		15.89  LDD1990  [46]
C337
 Probe Info  		9.13  LDD2000  [46]
C338
 Probe Info  		18.90  LDD2001  [46]
C339
 Probe Info  		21.11  LDD2002  [46]
C342
 Probe Info  		5.46  LDD2004  [46]
C343
 Probe Info  		32.67  LDD2005  [46]
C346
 Probe Info  		19.97  LDD2007  [46]
C348
 Probe Info  		52.71  LDD2009  [46]
C349
 Probe Info  		72.00  LDD2010  [46]
C350
 Probe Info  		99.73  LDD2011  [46]
C353
 Probe Info  		10.27  LDD2014  [46]
C354
 Probe Info  		22.78  LDD2015  [46]
C355
 Probe Info  		99.73  LDD2016  [46]
C356
 Probe Info  		42.81  LDD2017  [46]
C357
 Probe Info  		28.05  LDD2018  [46]
C361
 Probe Info  		22.94  LDD2022  [46]
C362
 Probe Info  		82.14  LDD2023  [46]
C363
 Probe Info  		31.12  LDD2024  [46]
C364
 Probe Info  		36.50  LDD2025  [46]
C366
 Probe Info  		16.00  LDD2027  [46]
C367
 Probe Info  		6.19  LDD2028  [46]
C373
 Probe Info  		17.15  LDD2033  [46]
C376
 Probe Info  		27.10  LDD2036  [46]
C378
 Probe Info  		20.25  LDD2037  [46]
C380
 Probe Info  		17.39  LDD2039  [46]
C382
 Probe Info  		36.50  LDD2041  [46]
C383
 Probe Info  		27.86  LDD2042  [46]
C385
 Probe Info  		7.46  LDD2044  [46]
C386
 Probe Info  		28.64  LDD2045  [46]
C387
 Probe Info  		11.55  LDD2046  [46]
C388
 Probe Info  		99.73  LDD2047  [46]
C390
 Probe Info  		99.73  LDD2049  [46]
C391
 Probe Info  		27.10  LDD2050  [46]
C397
 Probe Info  		9.92  LDD2056  [46]
C399
 Probe Info  		25.63  LDD2058  [46]
C403
 Probe Info  		39.67  LDD2061  [46]
C405
 Probe Info  		9.25  LDD2063  [46]
C407
 Probe Info  		23.43  LDD2064  [46]
C409
 Probe Info  		6.15  LDD2066  [46]
C413
 Probe Info  		38.85  LDD2069  [46]
C419
 Probe Info  		40.79  LDD2074  [46]
C420
 Probe Info  		28.44  LDD2075  [46]
C422
 Probe Info  		13.64  LDD2077  [46]
C423
 Probe Info  		11.47  LDD2078  [46]
C424
 Probe Info  		18.77  LDD2079  [46]
C426
 Probe Info  		54.95  LDD2081  [46]
C428
 Probe Info  		8.63  LDD2083  [46]
C429
 Probe Info  		71.51  LDD2084  [46]
C430
 Probe Info  		5.28  LDD2085  [46]
C431
 Probe Info  		65.34  LDD2086  [46]
C433
 Probe Info  		15.24  LDD2088  [46]
FFF probe11
 Probe Info  		20.00  LDD0471  [47]
FFF probe12
 Probe Info  		7.23  LDD0487  [47]
FFF probe13
 Probe Info  		20.00  LDD0475  [47]
FFF probe14
 Probe Info  		20.00  LDD0477  [47]
FFF probe15
 Probe Info  		20.00  LDD0478  [47]
FFF probe2
 Probe Info  		20.00  LDD0463  [47]
FFF probe3
 Probe Info  		20.00  LDD0464  [47]
FFF probe4
 Probe Info  		19.11  LDD0466  [47]
FFF probe6
 Probe Info  		18.94  LDD0467  [47]
FFF probe7
 Probe Info  		20.00  LDD0483  [47]
FFF probe9
 Probe Info  		20.00  LDD0470  [47]
JN0003
 Probe Info  		20.00  LDD0469  [47]
STS-2
 Probe Info  		1.99  LDD0138  [48]
AX-1
 Probe Info  		4.25  LDD0441  [49]
A-DA
 Probe Info  		3.35  LDD0145  [50]
Kambe_26
 Probe Info  		2.06  LDD0134  [51]
Kambe_3
 Probe Info  		2.48  LDD0130  [51]
Kambe_8
 Probe Info  		3.46  LDD0131  [51]
Alk-rapa
 Probe Info  		6.67  LDD0213  [52]
Diazir
 Probe Info  		C210(0.00); E84(0.00); C47(0.00)  LDD0011  [34]
BD-F
 Probe Info  		E211(0.00); T215(0.00); C47(0.00); T88(0.00)  LDD0024  [53]
LD-F
 Probe Info  		K45(0.00); C47(0.00); V217(0.00); S216(0.00)  LDD0015  [53]
TM-F
 Probe Info  		Y236(0.00); D214(0.00); V217(0.00); L238(0.00)  LDD0020  [53]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [54]
DA-2
 Probe Info  		N.A.  LDD0070  [55]
OEA-DA
 Probe Info  		19.61  LDD0046  [56]
STS-1
 Probe Info  		N.A.  LDD0068  [57]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C47(0.69); C13(0.87)  LDD2142  [58]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C47(0.85); C13(0.85)  LDD2112  [58]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C47(0.72)  LDD2095  [58]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C47(0.90); C13(0.93)  LDD2130  [58]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C47(0.93); C13(0.81); C76(1.05)  LDD2117  [58]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C47(1.33)  LDD2152  [58]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C47(1.38)  LDD2103  [58]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C47(0.62)  LDD2132  [58]
 LDCM0025  4SU-RNA DM93 C76(2.40); C47(2.46); C103(2.13)  LDD0170  [23]
 LDCM0026  4SU-RNA+native RNA HEK-293T C76(2.03)  LDD0169  [23]
 LDCM0176  9im MDA-MB-231 4.25  LDD0441  [49]
 LDCM0214  AC1 HCT 116 C210(1.07); C227(1.08); C103(0.84); C13(1.01)  LDD0531  [26]
 LDCM0215  AC10 HCT 116 C210(1.18); C227(1.11); C103(0.68); C13(1.26)  LDD0532  [26]
 LDCM0216  AC100 HCT 116 C210(1.16); C227(1.11); C103(0.28); C13(1.18)  LDD0533  [26]
 LDCM0217  AC101 HCT 116 C210(1.09); C227(1.09); C103(0.30); C13(1.29)  LDD0534  [26]
 LDCM0218  AC102 HCT 116 C210(1.13); C227(1.11); C103(0.24); C13(1.11)  LDD0535  [26]
 LDCM0219  AC103 HCT 116 C210(1.42); C227(1.36); C103(0.19); C13(1.31)  LDD0536  [26]
 LDCM0220  AC104 HCT 116 C210(1.30); C227(1.27); C103(0.21); C13(1.02)  LDD0537  [26]
 LDCM0221  AC105 HCT 116 C210(1.22); C227(1.19); C103(0.20); C13(1.15)  LDD0538  [26]
 LDCM0222  AC106 HCT 116 C210(1.30); C227(1.26); C103(0.18); C13(1.29)  LDD0539  [26]
 LDCM0223  AC107 HCT 116 C210(1.17); C227(1.15); C103(0.16); C13(1.29)  LDD0540  [26]
 LDCM0224  AC108 HCT 116 C210(1.09); C227(1.03); C103(0.34); C13(1.15)  LDD0541  [26]
 LDCM0225  AC109 HCT 116 C210(1.16); C227(1.14); C103(0.29); C13(1.00)  LDD0542  [26]
 LDCM0226  AC11 HCT 116 C210(1.31); C227(1.22); C103(0.71); C13(1.27)  LDD0543  [26]
 LDCM0227  AC110 HCT 116 C210(1.19); C227(1.15); C103(0.27); C13(1.26)  LDD0544  [26]
 LDCM0228  AC111 HCT 116 C210(1.14); C227(1.05); C103(0.29); C13(1.40)  LDD0545  [26]
 LDCM0229  AC112 HCT 116 C210(1.17); C227(1.09); C103(0.21); C13(1.21)  LDD0546  [26]
 LDCM0230  AC113 HCT 116 C210(0.93); C227(0.99); C13(1.10); C47(1.21)  LDD0547  [26]
 LDCM0231  AC114 HCT 116 C210(1.09); C227(1.27); C13(1.24); C47(1.30)  LDD0548  [26]
 LDCM0232  AC115 HCT 116 C210(1.31); C227(1.37); C13(1.31); C47(1.35)  LDD0549  [26]
 LDCM0233  AC116 HCT 116 C210(1.30); C227(1.31); C13(1.26); C47(1.43)  LDD0550  [26]
 LDCM0234  AC117 HCT 116 C210(1.10); C227(1.13); C13(1.07); C47(1.16)  LDD0551  [26]
 LDCM0235  AC118 HCT 116 C210(0.99); C227(1.02); C13(1.16); C47(1.09)  LDD0552  [26]
 LDCM0236  AC119 HCT 116 C210(1.22); C227(1.27); C13(1.17); C47(1.27)  LDD0553  [26]
 LDCM0237  AC12 HCT 116 C210(1.04); C227(1.03); C103(0.85); C13(0.99)  LDD0554  [26]
 LDCM0238  AC120 HCT 116 C210(1.20); C227(1.24); C13(1.28); C47(1.34)  LDD0555  [26]
 LDCM0239  AC121 HCT 116 C210(1.01); C227(1.04); C13(1.06); C47(1.17)  LDD0556  [26]
 LDCM0240  AC122 HCT 116 C210(1.14); C227(1.23); C13(1.29); C47(1.17)  LDD0557  [26]
 LDCM0241  AC123 HCT 116 C210(1.02); C227(1.05); C13(1.03); C47(1.07)  LDD0558  [26]
 LDCM0242  AC124 HCT 116 C210(0.99); C227(1.06); C13(1.05); C47(0.98)  LDD0559  [26]
 LDCM0243  AC125 HCT 116 C210(1.01); C227(1.18); C13(1.13); C47(1.07)  LDD0560  [26]
 LDCM0244  AC126 HCT 116 C210(1.20); C227(1.28); C13(1.38); C47(1.27)  LDD0561  [26]
 LDCM0245  AC127 HCT 116 C210(1.21); C227(1.33); C13(1.36); C47(1.35)  LDD0562  [26]
 LDCM0246  AC128 HCT 116 C210(1.01); C227(0.96); C103(0.80); C13(1.17)  LDD0563  [26]
 LDCM0247  AC129 HCT 116 C210(1.20); C227(1.02); C103(1.08); C13(1.06)  LDD0564  [26]
 LDCM0249  AC130 HCT 116 C210(1.20); C227(1.00); C103(0.71); C13(1.19)  LDD0566  [26]
 LDCM0250  AC131 HCT 116 C210(1.17); C227(1.07); C103(1.05); C13(1.05)  LDD0567  [26]
 LDCM0251  AC132 HCT 116 C210(1.27); C227(1.11); C103(1.20); C13(1.09)  LDD0568  [26]
 LDCM0252  AC133 HCT 116 C210(1.09); C227(0.85); C103(0.86); C13(1.16)  LDD0569  [26]
 LDCM0253  AC134 HCT 116 C210(1.50); C227(1.77); C103(0.84); C13(1.35)  LDD0570  [26]
 LDCM0254  AC135 HCT 116 C210(1.22); C227(1.28); C103(0.87); C13(1.20)  LDD0571  [26]
 LDCM0255  AC136 HCT 116 C210(1.33); C227(1.14); C103(0.88); C13(1.23)  LDD0572  [26]
 LDCM0256  AC137 HCT 116 C210(1.27); C227(0.94); C103(1.04); C13(1.35)  LDD0573  [26]
 LDCM0257  AC138 HCT 116 C210(1.40); C227(1.06); C103(0.94); C13(1.40)  LDD0574  [26]
 LDCM0258  AC139 HCT 116 C210(1.74); C227(1.23); C103(1.07); C13(1.40)  LDD0575  [26]
 LDCM0259  AC14 HCT 116 C210(1.17); C227(1.06); C103(0.67); C13(1.08)  LDD0576  [26]
 LDCM0260  AC140 HCT 116 C210(1.64); C227(1.11); C103(0.88); C13(1.53)  LDD0577  [26]
 LDCM0261  AC141 HCT 116 C210(1.70); C227(1.38); C103(1.02); C13(1.52)  LDD0578  [26]
 LDCM0262  AC142 HCT 116 C210(1.32); C227(1.03); C103(1.07); C13(1.18)  LDD0579  [26]
 LDCM0263  AC143 HCT 116 C210(1.20); C227(1.22); C76(1.10); C13(1.18)  LDD0580  [26]
 LDCM0264  AC144 HCT 116 C13(0.91); C76(1.00); C227(1.24); C210(1.37)  LDD0581  [26]
 LDCM0265  AC145 HCT 116 C13(0.79); C76(1.07); C227(1.14); C210(1.21)  LDD0582  [26]
 LDCM0266  AC146 HCT 116 C13(0.86); C76(0.89); C227(1.21); C210(1.26)  LDD0583  [26]
 LDCM0267  AC147 HCT 116 C13(0.82); C76(1.11); C227(1.23); C210(1.27)  LDD0584  [26]
 LDCM0268  AC148 HCT 116 C13(0.82); C76(0.92); C227(1.70); C47(1.81)  LDD0585  [26]
 LDCM0269  AC149 HCT 116 C13(0.84); C76(1.12); C227(1.35); C210(1.51)  LDD0586  [26]
 LDCM0270  AC15 HCT 116 C103(0.67); C227(1.07); C210(1.12); C76(1.22)  LDD0587  [26]
 LDCM0271  AC150 HCT 116 C13(0.89); C227(1.12); C76(1.14); C47(1.21)  LDD0588  [26]
 LDCM0272  AC151 HCT 116 C227(0.96); C76(0.96); C13(1.02); C210(1.15)  LDD0589  [26]
 LDCM0273  AC152 HCT 116 C13(0.82); C227(1.20); C76(1.23); C47(1.44)  LDD0590  [26]
 LDCM0274  AC153 HCT 116 C13(0.77); C76(0.92); C227(1.92); C210(2.14)  LDD0591  [26]
 LDCM0621  AC154 HCT 116 C210(1.44); C227(1.28); C13(0.81); C47(1.38)  LDD2158  [26]
 LDCM0622  AC155 HCT 116 C210(1.23); C227(1.07); C13(0.85); C47(1.28)  LDD2159  [26]
 LDCM0623  AC156 HCT 116 C210(1.11); C227(0.97); C13(0.89); C47(1.04)  LDD2160  [26]
 LDCM0624  AC157 HCT 116 C210(1.00); C227(0.91); C13(0.77); C47(1.05)  LDD2161  [26]
 LDCM0276  AC17 HCT 116 C76(0.99); C13(1.02); C210(1.04); C103(1.15)  LDD0593  [26]
 LDCM0277  AC18 HCT 116 C103(0.59); C76(0.97); C13(1.07); C227(1.15)  LDD0594  [26]
 LDCM0278  AC19 HCT 116 C103(0.81); C13(1.02); C76(1.04); C210(1.07)  LDD0595  [26]
 LDCM0279  AC2 HCT 116 C76(1.03); C210(1.08); C103(1.09); C227(1.12)  LDD0596  [26]
 LDCM0280  AC20 HCT 116 C103(0.82); C76(1.02); C47(1.08); C13(1.09)  LDD0597  [26]
 LDCM0281  AC21 HCT 116 C76(0.99); C103(1.02); C13(1.07); C210(1.13)  LDD0598  [26]
 LDCM0282  AC22 HCT 116 C47(0.99); C76(0.99); C210(1.02); C103(1.17)  LDD0599  [26]
 LDCM0283  AC23 HCT 116 C103(0.98); C76(1.08); C13(1.13); C47(1.14)  LDD0600  [26]
 LDCM0284  AC24 HCT 116 C103(0.90); C76(0.92); C47(0.96); C13(1.02)  LDD0601  [26]
 LDCM0285  AC25 HCT 116 C227(0.79); C210(0.90); C103(0.90); C13(1.02)  LDD0602  [26]
 LDCM0286  AC26 HCT 116 C103(0.68); C227(1.02); C13(1.09); C210(1.26)  LDD0603  [26]
 LDCM0287  AC27 HCT 116 C103(0.76); C227(0.94); C210(1.14); C76(1.19)  LDD0604  [26]
 LDCM0288  AC28 HCT 116 C103(0.76); C227(0.91); C13(1.12); C76(1.16)  LDD0605  [26]
 LDCM0289  AC29 HCT 116 C103(0.77); C227(0.98); C13(1.20); C47(1.22)  LDD0606  [26]
 LDCM0290  AC3 HCT 116 C103(1.06); C76(1.06); C210(1.10); C47(1.12)  LDD0607  [26]
 LDCM0291  AC30 HCT 116 C103(0.72); C227(1.01); C13(1.18); C76(1.25)  LDD0608  [26]
 LDCM0292  AC31 HCT 116 C103(0.63); C227(1.01); C13(1.11); C210(1.22)  LDD0609  [26]
 LDCM0293  AC32 HCT 116 C103(0.66); C227(1.05); C210(1.34); C13(1.41)  LDD0610  [26]
 LDCM0294  AC33 HCT 116 C103(0.69); C227(0.91); C210(1.18); C76(1.35)  LDD0611  [26]
 LDCM0295  AC34 HCT 116 C103(0.64); C227(1.05); C210(1.34); C76(1.36)  LDD0612  [26]
 LDCM0296  AC35 HCT 116 C76(0.62); C13(0.87); C210(1.00); C227(1.04)  LDD0613  [26]
 LDCM0297  AC36 HCT 116 C76(0.82); C47(0.96); C227(1.08); C210(1.11)  LDD0614  [26]
 LDCM0298  AC37 HCT 116 C227(0.87); C76(0.87); C210(0.90); C47(0.91)  LDD0615  [26]
 LDCM0299  AC38 HCT 116 C76(0.90); C47(1.02); C227(1.04); C210(1.07)  LDD0616  [26]
 LDCM0300  AC39 HCT 116 C103(0.88); C13(0.95); C76(1.06); C47(1.09)  LDD0617  [26]
 LDCM0301  AC4 HCT 116 C103(0.83); C76(1.08); C210(1.16); C47(1.17)  LDD0618  [26]
 LDCM0302  AC40 HCT 116 C76(0.96); C13(1.04); C103(1.12); C47(1.24)  LDD0619  [26]
 LDCM0303  AC41 HCT 116 C47(1.01); C13(1.04); C76(1.04); C227(1.06)  LDD0620  [26]
 LDCM0304  AC42 HCT 116 C76(1.01); C13(1.05); C103(1.07); C47(1.17)  LDD0621  [26]
 LDCM0305  AC43 HCT 116 C103(0.94); C13(1.07); C227(1.12); C76(1.12)  LDD0622  [26]
 LDCM0306  AC44 HCT 116 C76(1.07); C227(1.08); C103(1.09); C13(1.11)  LDD0623  [26]
 LDCM0307  AC45 HCT 116 C103(0.88); C13(1.00); C227(1.08); C76(1.10)  LDD0624  [26]
 LDCM0308  AC46 HCT 116 C103(0.81); C76(0.93); C210(1.01); C227(1.07)  LDD0625  [26]
 LDCM0309  AC47 HCT 116 C103(0.81); C13(1.03); C210(1.06); C76(1.09)  LDD0626  [26]
 LDCM0310  AC48 HCT 116 C103(0.80); C76(1.04); C227(1.04); C210(1.05)  LDD0627  [26]
 LDCM0311  AC49 HCT 116 C103(0.71); C13(1.21); C47(1.24); C227(1.27)  LDD0628  [26]
 LDCM0312  AC5 HCT 116 C103(0.90); C76(1.04); C210(1.15); C47(1.20)  LDD0629  [26]
 LDCM0313  AC50 HCT 116 C103(0.68); C13(1.15); C227(1.27); C76(1.29)  LDD0630  [26]
 LDCM0314  AC51 HCT 116 C210(0.87); C76(0.89); C47(0.89); C227(0.93)  LDD0631  [26]
 LDCM0315  AC52 HCT 116 C103(0.90); C210(0.98); C76(1.00); C227(1.02)  LDD0632  [26]
 LDCM0316  AC53 HCT 116 C103(0.73); C13(0.96); C76(1.14); C227(1.32)  LDD0633  [26]
 LDCM0317  AC54 HCT 116 C103(0.79); C13(0.98); C227(1.11); C210(1.17)  LDD0634  [26]
 LDCM0318  AC55 HCT 116 C103(0.70); C13(1.14); C227(1.25); C47(1.32)  LDD0635  [26]
 LDCM0319  AC56 HCT 116 C103(0.59); C13(1.10); C227(1.46); C47(1.52)  LDD0636  [26]
 LDCM0320  AC57 HCT 116 C13(0.95); C103(1.11); C76(1.32); C210(1.39)  LDD0637  [26]
 LDCM0321  AC58 HCT 116 C103(0.97); C13(1.09); C76(1.40); C210(1.48)  LDD0638  [26]
 LDCM0322  AC59 HCT 116 C13(1.05); C103(1.35); C76(1.36); C210(1.60)  LDD0639  [26]
 LDCM0323  AC6 HCT 116 C103(0.75); C227(1.20); C13(1.23); C76(1.24)  LDD0640  [26]
 LDCM0324  AC60 HCT 116 C13(1.02); C103(1.12); C76(1.42); C210(1.45)  LDD0641  [26]
 LDCM0325  AC61 HCT 116 C13(0.95); C103(1.03); C210(1.34); C76(1.39)  LDD0642  [26]
 LDCM0326  AC62 HCT 116 C13(1.23); C103(1.25); C76(1.36); C210(1.55)  LDD0643  [26]
 LDCM0327  AC63 HCT 116 C13(1.01); C76(1.38); C210(1.39); C47(1.56)  LDD0644  [26]
 LDCM0328  AC64 HCT 116 C13(1.01); C76(1.43); C103(1.47); C210(1.63)  LDD0645  [26]
 LDCM0329  AC65 HCT 116 C103(0.90); C13(1.13); C76(1.71); C210(1.73)  LDD0646  [26]
 LDCM0330  AC66 HCT 116 C103(1.06); C13(1.12); C210(1.62); C76(1.68)  LDD0647  [26]
 LDCM0331  AC67 HCT 116 C103(1.00); C13(1.03); C76(1.75); C210(1.90)  LDD0648  [26]
 LDCM0332  AC68 HCT 116 C103(0.89); C76(1.02); C13(1.03); C227(1.09)  LDD0649  [26]
 LDCM0333  AC69 HCT 116 C103(0.71); C13(0.97); C76(1.09); C227(1.16)  LDD0650  [26]
 LDCM0334  AC7 HCT 116 C103(0.89); C13(1.13); C76(1.15); C47(1.24)  LDD0651  [26]
 LDCM0335  AC70 HCT 116 C103(0.75); C13(1.04); C210(1.11); C76(1.25)  LDD0652  [26]
 LDCM0336  AC71 HCT 116 C13(0.86); C103(0.91); C210(0.98); C76(1.00)  LDD0653  [26]
 LDCM0337  AC72 HCT 116 C13(0.93); C76(1.03); C103(1.05); C210(1.06)  LDD0654  [26]
 LDCM0338  AC73 HCT 116 C210(1.44); C227(1.51); C103(0.80); C13(1.06)  LDD0655  [26]
 LDCM0339  AC74 HCT 116 C103(0.74); C13(1.04); C76(1.38); C227(1.51)  LDD0656  [26]
 LDCM0340  AC75 HCT 116 C103(0.74); C13(1.07); C76(1.38); C227(1.68)  LDD0657  [26]
 LDCM0341  AC76 HCT 116 C103(0.77); C13(0.95); C76(1.08); C227(1.20)  LDD0658  [26]
 LDCM0342  AC77 HCT 116 C103(0.82); C76(0.98); C13(1.09); C210(1.13)  LDD0659  [26]
 LDCM0343  AC78 HCT 116 C13(0.89); C103(0.92); C76(0.99); C210(1.05)  LDD0660  [26]
 LDCM0344  AC79 HCT 116 C103(0.95); C13(0.96); C76(1.01); C210(1.05)  LDD0661  [26]
 LDCM0345  AC8 HCT 116 C103(0.73); C76(1.09); C227(1.14); C13(1.18)  LDD0662  [26]
 LDCM0346  AC80 HCT 116 C13(0.96); C47(1.07); C210(1.12); C227(1.13)  LDD0663  [26]
 LDCM0347  AC81 HCT 116 C13(0.99); C76(1.07); C210(1.11); C47(1.12)  LDD0664  [26]
 LDCM0348  AC82 HCT 116 C103(0.50); C13(1.11); C227(1.56); C210(1.62)  LDD0665  [26]
 LDCM0349  AC83 HCT 116 C103(0.52); C13(1.42); C227(1.51); C76(1.52)  LDD0666  [26]
 LDCM0350  AC84 HCT 116 C103(0.52); C227(1.31); C13(1.40); C76(1.50)  LDD0667  [26]
 LDCM0351  AC85 HCT 116 C103(0.76); C76(1.28); C13(1.29); C227(1.37)  LDD0668  [26]
 LDCM0352  AC86 HCT 116 C103(0.82); C76(1.14); C47(1.19); C13(1.25)  LDD0669  [26]
 LDCM0353  AC87 HCT 116 C103(0.82); C76(1.05); C47(1.13); C227(1.16)  LDD0670  [26]
 LDCM0354  AC88 HCT 116 C103(0.79); C76(1.09); C13(1.18); C47(1.22)  LDD0671  [26]
 LDCM0355  AC89 HCT 116 C103(0.77); C13(1.17); C76(1.17); C47(1.19)  LDD0672  [26]
 LDCM0357  AC90 HCT 116 C76(1.00); C47(1.11); C227(1.15); C13(1.18)  LDD0674  [26]
 LDCM0358  AC91 HCT 116 C103(0.54); C13(1.10); C76(1.38); C227(1.58)  LDD0675  [26]
 LDCM0359  AC92 HCT 116 C103(0.58); C76(1.36); C13(1.38); C47(1.45)  LDD0676  [26]
 LDCM0360  AC93 HCT 116 C103(0.83); C227(1.11); C76(1.18); C210(1.21)  LDD0677  [26]
 LDCM0361  AC94 HCT 116 C103(0.68); C47(1.07); C13(1.15); C76(1.15)  LDD0678  [26]
 LDCM0362  AC95 HCT 116 C103(0.68); C47(1.00); C76(1.12); C227(1.14)  LDD0679  [26]
 LDCM0363  AC96 HCT 116 C103(0.61); C76(1.17); C13(1.24); C47(1.25)  LDD0680  [26]
 LDCM0364  AC97 HCT 116 C103(0.67); C76(1.30); C13(1.31); C47(1.36)  LDD0681  [26]
 LDCM0365  AC98 HCT 116 C103(0.08); C13(1.45); C227(1.62); C76(1.64)  LDD0682  [26]
 LDCM0366  AC99 HCT 116 C103(0.26); C76(1.01); C227(1.07); C47(1.09)  LDD0683  [26]
 LDCM0545  Acetamide MDA-MB-231 C47(0.48)  LDD2138  [58]
 LDCM0520  AKOS000195272 MDA-MB-231 C47(0.53); C13(0.89)  LDD2113  [58]
 LDCM0248  AKOS034007472 HCT 116 C210(1.06); C227(1.02); C103(0.89); C13(1.15)  LDD0565  [26]
 LDCM0356  AKOS034007680 HCT 116 C103(0.74); C13(1.06); C47(1.14); C227(1.14)  LDD0673  [26]
 LDCM0275  AKOS034007705 HCT 116 C103(0.52); C227(1.61); C47(1.63); C76(1.63)  LDD0592  [26]
 LDCM0156  Aniline NCI-H1299 11.92  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C227(1.04); C210(1.02); C47(1.01); C76(0.97)  LDD0078  [26]
 LDCM0199  BPK-21 T cell C210, C227(5.31)  LDD0517  [59]
 LDCM0200  BPK-25 T cell C210, C227(5.07)  LDD0516  [59]
 LDCM0089  C30 HEK-293T 1.14  LDD0210  [17]
 LDCM0088  C45 HEK-293T 9.48  LDD0201  [17]
 LDCM0108  Chloroacetamide HeLa C103(0.00); C47(0.00); C13(0.00); C76(0.00)  LDD0222  [42]
 LDCM0632  CL-Sc Hep-G2 C76(3.84); C76(1.19); C47(0.91); C47(0.76)  LDD2227  [36]
 LDCM0367  CL1 HCT 116 C76(0.82); C47(0.95); C13(1.27); C227(1.43)  LDD0684  [26]
 LDCM0368  CL10 HCT 116 C103(0.77); C76(1.23); C13(1.26); C47(1.31)  LDD0685  [26]
 LDCM0369  CL100 HCT 116 C103(0.90); C76(1.16); C210(1.23); C227(1.31)  LDD0686  [26]
 LDCM0370  CL101 HCT 116 C103(0.68); C13(1.18); C76(1.24); C47(1.41)  LDD0687  [26]
 LDCM0371  CL102 HCT 116 C103(0.88); C76(1.09); C13(1.09); C47(1.16)  LDD0688  [26]
 LDCM0372  CL103 HCT 116 C103(0.80); C13(0.99); C76(1.04); C47(1.09)  LDD0689  [26]
 LDCM0373  CL104 HCT 116 C103(0.76); C13(0.96); C76(1.08); C47(1.12)  LDD0690  [26]
 LDCM0374  CL105 HCT 116 C103(0.85); C13(1.10); C76(1.14); C47(1.18)  LDD0691  [26]
 LDCM0375  CL106 HCT 116 C103(0.49); C13(1.10); C76(1.34); C47(1.54)  LDD0692  [26]
 LDCM0376  CL107 HCT 116 C103(0.61); C13(1.10); C47(1.35); C76(1.35)  LDD0693  [26]
 LDCM0377  CL108 HCT 116 C103(0.78); C13(1.02); C76(1.23); C210(1.46)  LDD0694  [26]
 LDCM0378  CL109 HCT 116 C103(0.65); C76(1.09); C47(1.11); C13(1.15)  LDD0695  [26]
 LDCM0379  CL11 HCT 116 C103(0.84); C76(1.28); C13(1.34); C47(1.43)  LDD0696  [26]
 LDCM0380  CL110 HCT 116 C103(0.66); C76(1.17); C47(1.23); C13(1.24)  LDD0697  [26]
 LDCM0381  CL111 HCT 116 C103(0.83); C76(1.09); C47(1.20); C13(1.21)  LDD0698  [26]
 LDCM0382  CL112 HCT 116 C76(0.95); C227(0.99); C210(1.05); C103(1.11)  LDD0699  [26]
 LDCM0383  CL113 HCT 116 C103(0.69); C227(0.96); C210(1.16); C76(1.27)  LDD0700  [26]
 LDCM0384  CL114 HCT 116 C103(0.75); C47(1.22); C76(1.24); C13(1.30)  LDD0701  [26]
 LDCM0385  CL115 HCT 116 C103(0.82); C227(1.15); C76(1.22); C13(1.29)  LDD0702  [26]
 LDCM0386  CL116 HCT 116 C103(0.83); C227(0.89); C210(1.06); C13(1.16)  LDD0703  [26]
 LDCM0387  CL117 HCT 116 C103(0.81); C13(1.03); C76(1.31); C227(1.41)  LDD0704  [26]
 LDCM0388  CL118 HCT 116 C76(0.98); C13(1.05); C103(1.06); C47(1.09)  LDD0705  [26]
 LDCM0389  CL119 HCT 116 C76(0.94); C13(1.02); C103(1.03); C227(1.10)  LDD0706  [26]
 LDCM0390  CL12 HCT 116 C103(0.85); C76(1.24); C13(1.27); C47(1.35)  LDD0707  [26]
 LDCM0391  CL120 HCT 116 C227(1.05); C47(1.09); C76(1.10); C210(1.14)  LDD0708  [26]
 LDCM0392  CL121 HCT 116 C47(0.95); C76(0.95); C103(0.99); C13(1.04)  LDD0709  [26]
 LDCM0393  CL122 HCT 116 C103(0.72); C13(1.08); C76(1.09); C47(1.43)  LDD0710  [26]
 LDCM0394  CL123 HCT 116 C103(0.70); C13(1.06); C76(1.09); C47(1.38)  LDD0711  [26]
 LDCM0395  CL124 HCT 116 C103(0.66); C13(1.09); C76(1.28); C47(1.37)  LDD0712  [26]
 LDCM0396  CL125 HCT 116 C76(1.13); C103(1.17); C210(1.18); C13(1.22)  LDD0713  [26]
 LDCM0397  CL126 HCT 116 C103(0.93); C210(1.13); C13(1.24); C76(1.27)  LDD0714  [26]
 LDCM0398  CL127 HCT 116 C103(0.97); C13(1.06); C210(1.12); C227(1.23)  LDD0715  [26]
 LDCM0399  CL128 HCT 116 C103(0.86); C13(0.99); C76(1.33); C210(1.45)  LDD0716  [26]
 LDCM0400  CL13 HCT 116 C103(0.81); C76(1.07); C13(1.16); C47(1.19)  LDD0717  [26]
 LDCM0401  CL14 HCT 116 C47(1.02); C76(1.03); C103(1.10); C13(1.27)  LDD0718  [26]
 LDCM0402  CL15 HCT 116 C103(0.76); C76(1.02); C47(1.15); C13(1.26)  LDD0719  [26]
 LDCM0403  CL16 HCT 116 C76(1.03); C227(1.04); C47(1.10); C13(1.10)  LDD0720  [26]
 LDCM0404  CL17 HCT 116 C76(1.01); C47(1.06); C13(1.16); C227(3.05)  LDD0721  [26]
 LDCM0405  CL18 HCT 116 C13(0.93); C227(1.04); C76(1.04); C210(1.09)  LDD0722  [26]
 LDCM0406  CL19 HCT 116 C13(0.94); C47(1.05); C227(1.08); C76(1.12)  LDD0723  [26]
 LDCM0407  CL2 HCT 116 C76(0.94); C210(1.00); C47(1.04); C227(1.08)  LDD0724  [26]
 LDCM0408  CL20 HCT 116 C13(0.99); C76(1.11); C227(1.13); C210(1.23)  LDD0725  [26]
 LDCM0409  CL21 HCT 116 C13(1.09); C76(1.28); C47(1.32); C227(3.28)  LDD0726  [26]
 LDCM0410  CL22 HCT 116 C13(0.93); C47(1.75); C227(1.80); C76(2.01)  LDD0727  [26]
 LDCM0411  CL23 HCT 116 C13(0.94); C227(1.13); C76(1.18); C47(1.21)  LDD0728  [26]
 LDCM0412  CL24 HCT 116 C227(1.32); C210(1.46); C13(0.94); C47(1.44)  LDD0729  [26]
 LDCM0413  CL25 HCT 116 C210(2.04); C227(1.77); C13(1.12); C47(1.45)  LDD0730  [26]
 LDCM0414  CL26 HCT 116 C210(1.22); C227(1.11); C13(1.02); C47(1.24)  LDD0731  [26]
 LDCM0415  CL27 HCT 116 C210(1.27); C227(1.15); C13(0.91); C47(1.07)  LDD0732  [26]
 LDCM0416  CL28 HCT 116 C210(1.75); C227(1.56); C13(0.96); C47(1.21)  LDD0733  [26]
 LDCM0417  CL29 HCT 116 C210(1.33); C227(1.19); C13(1.05); C47(1.26)  LDD0734  [26]
 LDCM0418  CL3 HCT 116 C210(1.19); C227(1.18); C103(1.22); C13(1.05)  LDD0735  [26]
 LDCM0419  CL30 HCT 116 C210(1.09); C227(1.00); C13(1.00); C47(1.06)  LDD0736  [26]
 LDCM0420  CL31 HCT 116 C210(1.37); C227(1.34); C103(0.76); C13(1.09)  LDD0737  [26]
 LDCM0421  CL32 HCT 116 C210(1.38); C227(1.33); C103(0.61); C13(1.30)  LDD0738  [26]
 LDCM0422  CL33 HCT 116 C210(4.37); C227(3.91); C103(0.54); C13(1.27)  LDD0739  [26]
 LDCM0423  CL34 HCT 116 C210(2.26); C227(2.11); C103(0.57); C13(1.01)  LDD0740  [26]
 LDCM0424  CL35 HCT 116 C210(1.62); C227(1.52); C103(0.60); C13(1.03)  LDD0741  [26]
 LDCM0425  CL36 HCT 116 C210(1.70); C227(1.57); C103(0.76); C13(1.02)  LDD0742  [26]
 LDCM0426  CL37 HCT 116 C210(2.13); C227(2.05); C103(0.63); C13(1.08)  LDD0743  [26]
 LDCM0428  CL39 HCT 116 C210(1.62); C227(1.55); C103(0.67); C13(1.03)  LDD0745  [26]
 LDCM0429  CL4 HCT 116 C210(2.71); C227(2.16); C103(1.19); C13(1.13)  LDD0746  [26]
 LDCM0430  CL40 HCT 116 C210(1.94); C227(1.73); C103(0.74); C13(1.38)  LDD0747  [26]
 LDCM0431  CL41 HCT 116 C210(1.45); C227(1.40); C103(0.72); C13(0.99)  LDD0748  [26]
 LDCM0432  CL42 HCT 116 C210(3.49); C227(3.21); C103(0.49); C13(0.99)  LDD0749  [26]
 LDCM0433  CL43 HCT 116 C210(1.64); C227(1.58); C103(0.54); C13(1.00)  LDD0750  [26]
 LDCM0434  CL44 HCT 116 C210(1.76); C227(1.69); C103(0.53); C13(1.13)  LDD0751  [26]
 LDCM0435  CL45 HCT 116 C210(2.44); C227(2.33); C103(0.47); C13(1.10)  LDD0752  [26]
 LDCM0436  CL46 HCT 116 C210(1.01); C227(1.15); C13(1.09); C47(0.90)  LDD0753  [26]
 LDCM0437  CL47 HCT 116 C210(0.87); C227(0.95); C13(1.09); C47(0.88)  LDD0754  [26]
 LDCM0438  CL48 HCT 116 C210(0.90); C227(0.99); C13(0.95); C47(0.87)  LDD0755  [26]
 LDCM0439  CL49 HCT 116 C210(0.99); C227(1.10); C13(0.99); C47(0.87)  LDD0756  [26]
 LDCM0440  CL5 HCT 116 C210(1.08); C227(1.11); C103(1.13); C13(1.07)  LDD0757  [26]
 LDCM0441  CL50 HCT 116 C210(1.46); C227(1.55); C13(0.97); C47(0.86)  LDD0758  [26]
 LDCM0442  CL51 HCT 116 C210(1.12); C227(1.24); C13(0.98); C47(0.93)  LDD0759  [26]
 LDCM0443  CL52 HCT 116 C210(1.06); C227(1.12); C13(1.04); C47(0.91)  LDD0760  [26]
 LDCM0444  CL53 HCT 116 C210(1.13); C227(1.24); C13(0.95); C47(0.94)  LDD0761  [26]
 LDCM0445  CL54 HCT 116 C210(2.45); C227(2.37); C13(0.81); C47(0.81)  LDD0762  [26]
 LDCM0446  CL55 HCT 116 C210(1.00); C227(1.08); C13(0.92); C47(0.82)  LDD0763  [26]
 LDCM0447  CL56 HCT 116 C210(0.92); C227(1.03); C13(1.05); C47(0.99)  LDD0764  [26]
 LDCM0448  CL57 HCT 116 C210(1.05); C227(1.08); C13(0.86); C47(0.83)  LDD0765  [26]
 LDCM0449  CL58 HCT 116 C210(0.86); C227(0.96); C13(0.87); C47(0.82)  LDD0766  [26]
 LDCM0450  CL59 HCT 116 C210(0.90); C227(1.01); C13(0.97); C47(0.85)  LDD0767  [26]
 LDCM0451  CL6 HCT 116 C210(2.42); C227(1.80); C103(0.85); C13(1.19)  LDD0768  [26]
 LDCM0452  CL60 HCT 116 C210(0.93); C227(1.06); C13(1.05); C47(0.90)  LDD0769  [26]
 LDCM0453  CL61 HCT 116 C210(1.03); C227(1.19); C103(0.99); C13(1.17)  LDD0770  [26]
 LDCM0454  CL62 HCT 116 C210(1.10); C227(1.17); C103(0.96); C13(1.24)  LDD0771  [26]
 LDCM0455  CL63 HCT 116 C210(1.40); C227(1.46); C103(0.84); C13(1.14)  LDD0772  [26]
 LDCM0456  CL64 HCT 116 C210(2.21); C227(2.28); C103(0.70); C13(1.28)  LDD0773  [26]
 LDCM0457  CL65 HCT 116 C210(1.11); C227(1.21); C103(0.80); C13(1.08)  LDD0774  [26]
 LDCM0458  CL66 HCT 116 C210(1.63); C227(1.61); C103(0.63); C13(1.46)  LDD0775  [26]
 LDCM0459  CL67 HCT 116 C210(1.30); C227(1.34); C103(0.70); C13(1.20)  LDD0776  [26]
 LDCM0460  CL68 HCT 116 C210(1.43); C227(1.47); C103(0.68); C13(1.22)  LDD0777  [26]
 LDCM0461  CL69 HCT 116 C210(1.65); C227(1.66); C103(0.63); C13(1.05)  LDD0778  [26]
 LDCM0462  CL7 HCT 116 C210(1.58); C227(1.42); C103(0.90); C13(1.18)  LDD0779  [26]
 LDCM0463  CL70 HCT 116 C210(1.22); C227(1.22); C103(0.63); C13(1.10)  LDD0780  [26]
 LDCM0464  CL71 HCT 116 C210(1.45); C227(1.58); C103(0.78); C13(1.30)  LDD0781  [26]
 LDCM0465  CL72 HCT 116 C210(1.09); C227(1.12); C103(0.95); C13(1.14)  LDD0782  [26]
 LDCM0466  CL73 HCT 116 C210(2.08); C227(2.13); C103(0.77); C13(1.19)  LDD0783  [26]
 LDCM0467  CL74 HCT 116 C210(1.24); C227(1.31); C103(0.74); C13(1.25)  LDD0784  [26]
 LDCM0469  CL76 HCT 116 C210(1.02); C227(1.03); C103(1.13); C13(1.05)  LDD0786  [26]
 LDCM0470  CL77 HCT 116 C210(2.14); C227(1.98); C103(1.37); C13(1.30)  LDD0787  [26]
 LDCM0471  CL78 HCT 116 C210(1.20); C227(1.16); C103(0.93); C13(1.12)  LDD0788  [26]
 LDCM0472  CL79 HCT 116 C210(1.31); C227(1.32); C103(0.96); C13(0.98)  LDD0789  [26]
 LDCM0473  CL8 HCT 116 C210(7.73); C227(1.65); C103(0.84); C13(1.73)  LDD0790  [26]
 LDCM0474  CL80 HCT 116 C210(0.94); C227(0.98); C103(0.98); C13(0.92)  LDD0791  [26]
 LDCM0475  CL81 HCT 116 C210(1.11); C227(1.14); C103(1.06); C13(0.93)  LDD0792  [26]
 LDCM0476  CL82 HCT 116 C210(1.60); C227(1.61); C103(0.70); C13(0.91)  LDD0793  [26]
 LDCM0477  CL83 HCT 116 C210(1.80); C227(1.71); C103(0.68); C13(1.01)  LDD0794  [26]
 LDCM0478  CL84 HCT 116 C210(4.49); C227(4.32); C103(0.80); C13(0.88)  LDD0795  [26]
 LDCM0479  CL85 HCT 116 C210(1.15); C227(1.20); C103(0.90); C13(1.00)  LDD0796  [26]
 LDCM0480  CL86 HCT 116 C210(1.02); C227(1.08); C103(1.32); C13(0.98)  LDD0797  [26]
 LDCM0481  CL87 HCT 116 C210(1.43); C227(1.44); C103(0.97); C13(0.97)  LDD0798  [26]
 LDCM0482  CL88 HCT 116 C210(1.78); C227(1.81); C103(0.77); C13(0.90)  LDD0799  [26]
 LDCM0483  CL89 HCT 116 C210(1.99); C227(2.06); C103(0.72); C13(0.87)  LDD0800  [26]
 LDCM0484  CL9 HCT 116 C210(1.19); C227(1.11); C103(1.02); C13(1.26)  LDD0801  [26]
 LDCM0485  CL90 HCT 116 C210(2.79); C227(2.44); C103(1.53); C13(1.25)  LDD0802  [26]
 LDCM0486  CL91 HCT 116 C210(0.93); C227(1.01); C103(1.08); C13(1.30)  LDD0803  [26]
 LDCM0487  CL92 HCT 116 C210(1.69); C227(1.68); C103(1.16); C13(1.21)  LDD0804  [26]
 LDCM0488  CL93 HCT 116 C210(1.29); C227(1.32); C103(1.09); C13(0.98)  LDD0805  [26]
 LDCM0489  CL94 HCT 116 C210(1.39); C227(1.61); C103(0.86); C13(1.32)  LDD0806  [26]
 LDCM0490  CL95 HCT 116 C210(1.95); C227(2.11); C103(0.78); C13(1.22)  LDD0807  [26]
 LDCM0491  CL96 HCT 116 C210(2.06); C227(1.82); C103(0.92); C13(1.12)  LDD0808  [26]
 LDCM0492  CL97 HCT 116 C210(2.11); C227(1.75); C103(0.99); C13(1.10)  LDD0809  [26]
 LDCM0493  CL98 HCT 116 C210(1.32); C227(1.39); C103(0.99); C13(1.18)  LDD0810  [26]
 LDCM0494  CL99 HCT 116 C210(1.13); C227(1.12); C103(0.97); C13(1.16)  LDD0811  [26]
 LDCM0189  Compound 16 HEK-293T 15.50  LDD0492  [47]
 LDCM0185  Compound 17 HEK-293T 16.67  LDD0504  [47]
 LDCM0182  Compound 18 HEK-293T 11.11  LDD0501  [47]
 LDCM0184  Compound 20 HEK-293T 16.13  LDD0503  [47]
 LDCM0191  Compound 21 HEK-293T 11.17  LDD0493  [47]
 LDCM0186  Compound 31 HEK-293T 10.00  LDD0506  [47]
 LDCM0187  Compound 32 HEK-293T 20.62  LDD0507  [47]
 LDCM0188  Compound 33 HEK-293T 10.36  LDD0505  [47]
 LDCM0190  Compound 34 HEK-293T 18.02  LDD0497  [47]
 LDCM0192  Compound 35 HEK-293T 12.66  LDD0491  [47]
 LDCM0193  Compound 36 HEK-293T 10.93  LDD0494  [47]
 LDCM0194  Compound 37 HEK-293T 11.43  LDD0498  [47]
 LDCM0195  Compound 38 HEK-293T 16.26  LDD0499  [47]
 LDCM0196  Compound 39 HEK-293T 11.36  LDD0496  [47]
 LDCM0197  Compound 40 HEK-293T 14.39  LDD0495  [47]
 LDCM0181  Compound 41 HEK-293T 10.87  LDD0502  [47]
 LDCM0183  Compound 42 HEK-293T 5.87  LDD0500  [47]
 LDCM0495  E2913 HEK-293T C47(0.83); C13(1.02); C76(1.08); C103(1.00)  LDD1698  [60]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C103(4.58); C76(2.96); C210(1.44); C13(1.01)  LDD1702  [58]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [25]
 LDCM0202  EV-93 T cell C210, C227(18.13)  LDD0527  [59]
 LDCM0625  F8 Ramos C13(0.78); C47(1.28); C103(0.37); C76(1.76)  LDD2187  [61]
 LDCM0572  Fragment10 Ramos C13(5.75); C47(2.96); C103(0.92); 2.71  LDD2189  [61]
 LDCM0573  Fragment11 Ramos C13(0.24); C47(0.42); C103(0.91); C76(0.44)  LDD2190  [61]
 LDCM0574  Fragment12 Ramos C13(3.17); C47(2.95); C103(0.91); 1.13  LDD2191  [61]
 LDCM0575  Fragment13 Ramos C13(1.26); C47(0.96); C103(0.56); 0.83  LDD2192  [61]
 LDCM0576  Fragment14 Ramos C13(1.35); C47(8.70); C103(2.11); C76(2.01)  LDD2193  [61]
 LDCM0579  Fragment20 Ramos C13(2.02); C47(3.29); C103(1.52); 3.09  LDD2194  [61]
 LDCM0580  Fragment21 Ramos C13(0.92); C47(1.00); C103(1.16); 0.64  LDD2195  [61]
 LDCM0582  Fragment23 Ramos C13(0.94); C47(0.43); C103(0.78); 0.89  LDD2196  [61]
 LDCM0578  Fragment27 Ramos C13(1.11); C47(0.85); C103(0.72); 1.54  LDD2197  [61]
 LDCM0586  Fragment28 Ramos C13(0.40); C47(0.50); C103(0.45); C76(1.73)  LDD2198  [61]
 LDCM0588  Fragment30 Ramos C13(0.94); C47(1.25); C103(0.93); 0.60  LDD2199  [61]
 LDCM0589  Fragment31 Ramos C13(1.35); C47(1.16); C103(0.93); 1.01  LDD2200  [61]
 LDCM0590  Fragment32 Ramos C13(6.11); C47(3.41); C103(0.60)  LDD2201  [61]
 LDCM0468  Fragment33 HCT 116 C210(1.16); C227(1.20); C103(0.82); C13(1.17)  LDD0785  [26]
 LDCM0596  Fragment38 Ramos C13(1.02); C47(2.92); C103(0.73); 2.70  LDD2203  [61]
 LDCM0566  Fragment4 Ramos C13(0.69); C47(2.48); C103(0.61); C76(0.88)  LDD2184  [61]
 LDCM0427  Fragment51 HCT 116 C210(4.85); C227(2.00); C103(0.52); C13(2.56)  LDD0744  [26]
 LDCM0610  Fragment52 Ramos C13(0.86); C47(1.55); C103(0.58); 1.12  LDD2204  [61]
 LDCM0614  Fragment56 Ramos C13(1.25); C47(0.93); C103(0.84); 0.69  LDD2205  [61]
 LDCM0617  Fragment63-S Jurkat _(5.62)  LDD1490  [21]
 LDCM0569  Fragment7 Ramos C13(1.43); C47(3.31); C103(0.86); C76(1.37)  LDD2186  [61]
 LDCM0571  Fragment9 Ramos C13(2.25); C47(3.25); C103(1.37); 0.69  LDD2188  [61]
 LDCM0015  HNE MDA-MB-231 C47(1.95); C76(0.99)  LDD0346  [61]
 LDCM0107  IAA HeLa C103(0.00); H284(0.00)  LDD0221  [42]
 LDCM0179  JZ128 PC-3 C210(0.00); C47(0.00)  LDD0462  [18]
 LDCM0075  kambe_cp62 PC-3 3.46  LDD0131  [51]
 LDCM0074  Kambe_cp66 PC-3 2.48  LDD0130  [51]
 LDCM0078  kambe_cp70 PC-3 2.06  LDD0134  [51]
 LDCM0022  KB02 HCT 116 C210(20.00); C227(6.43); C47(1.43); C103(1.50)  LDD0080  [26]
 LDCM0023  KB03 HCT 116 C210(20.00); C227(10.73); C47(2.08); C103(1.14)  LDD0081  [26]
 LDCM0024  KB05 HCT 116 C210(20.00); C227(11.60); C47(2.05); C103(1.73)  LDD0082  [26]
 LDCM0169  KB63 Ramos 20.00  LDD0432  [62]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C47(3.79); C13(0.59)  LDD2102  [58]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C47(0.47); C13(0.87)  LDD2121  [58]
 LDCM0109  NEM HeLa N.A.  LDD0223  [42]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C47(0.76); C13(1.04)  LDD2089  [58]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C47(1.25); C13(0.58)  LDD2092  [58]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C47(0.98); C13(1.13)  LDD2093  [58]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C47(0.38)  LDD2096  [58]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C47(0.93)  LDD2097  [58]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C47(3.30); C13(0.83)  LDD2098  [58]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C47(0.96); C13(1.04)  LDD2099  [58]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C47(0.87); C13(0.65)  LDD2100  [58]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C47(0.68); C13(0.86)  LDD2101  [58]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C13(0.86)  LDD2104  [58]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C47(0.91); C13(0.96)  LDD2105  [58]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C47(0.95); C13(0.90)  LDD2107  [58]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C13(0.85)  LDD2108  [58]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C47(1.12); C13(1.30)  LDD2109  [58]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C47(0.99); C13(0.94)  LDD2111  [58]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C13(0.63)  LDD2114  [58]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C13(1.10)  LDD2115  [58]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C47(0.52)  LDD2116  [58]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C47(0.65); C13(1.10)  LDD2118  [58]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C47(2.02); C13(0.94)  LDD2119  [58]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C47(0.91)  LDD2122  [58]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C47(0.84); C13(1.17)  LDD2123  [58]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C47(0.54)  LDD2124  [58]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C47(0.91); C13(0.97)  LDD2125  [58]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C47(0.77)  LDD2126  [58]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C47(1.02); C13(0.98)  LDD2127  [58]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C47(1.37); C13(1.00)  LDD2129  [58]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C47(0.63); C13(1.03)  LDD2134  [58]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C47(1.02); C13(1.19)  LDD2135  [58]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C47(1.16); C13(1.25)  LDD2136  [58]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C47(0.86); C13(1.03)  LDD2137  [58]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C47(2.23)  LDD1700  [58]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C47(0.61); C13(0.86)  LDD2140  [58]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C47(0.85); C13(0.76)  LDD2141  [58]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C47(3.17); C13(1.32)  LDD2144  [58]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C47(0.97); C13(1.01)  LDD2146  [58]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C47(0.64); C13(0.96)  LDD2148  [58]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C47(0.51)  LDD2149  [58]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C47(0.62)  LDD2150  [58]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C47(1.42)  LDD2151  [58]
 LDCM0627  NUDT7-COV-1 HEK-293T C76(2.84); C47(1.11); C76(0.78); C8(0.70)  LDD2206  [63]
 LDCM0628  OTUB2-COV-1 HEK-293T C8(1.24); C8(0.90); C47(0.84); C76(0.76)  LDD2207  [63]
 LDCM0014  Panhematin HEK-293T 6.44  LDD0062  [24]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0388  [3]
 LDCM0131  RA190 MM1.R C103(3.05); C13(1.71); C47(1.32); C76(1.10)  LDD0304  [64]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.56  LDD0123  [20]
 LDCM0090  Rapamycin JHH-7 6.67  LDD0213  [52]
 LDCM0084  Ro 48-8071 A-549 3.35  LDD0145  [50]
 LDCM0170  Structure8 Ramos 16.09; 7.04; 5.65; 4.82  LDD0433  [62]
 LDCM0003  Sulforaphane MCF-7 3.26  LDD0042  [19]
 LDCM0021  THZ1 HCT 116 C210(1.02); C227(1.02); C76(0.97); C47(0.95)  LDD2173  [26]
 LDCM0112  W16 Hep-G2 C13(0.52)  LDD0239  [12]
 LDCM0154  YY4 T cell 2.75  LDD0400  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal ATPase PEX1 (PEX1) AAA ATPase family O43933
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) Complex I 51 kDa subunit family P49821
Cathepsin D (CTSD) Peptidase A1 family P07339
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Tubulin polymerization-promoting protein (TPPP) TPPP family O94811
Transthyretin (TTR) Transthyretin family P02766
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent anion-selective channel protein 1 (VDAC1) Eukaryotic mitochondrial porin family P21796
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 5 (ICAM5) ICAM family Q9UMF0
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Progranulin (GRN) Granulin family P28799
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
T-complex protein 1 subunit epsilon (CCT5) TCP-1 chaperonin family P48643
Protein FAM162A (FAM162A) UPF0389 family Q96A26
Zona pellucida sperm-binding protein 2 (ZP2) ZP domain family Q05996
Zona pellucida sperm-binding protein 3 (ZP3) ZP domain family P21754
RING finger protein 11 (RNF11) . Q9Y3C5

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aluminium Monostearate Small molecular drug DB01375
Prlx 93936 . DB06098

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
4 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
5 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
6 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
7 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
8 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
9 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
10 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
11 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry. J Am Chem Soc. 2021 Dec 8;143(48):20095-20108. doi: 10.1021/jacs.1c06167. Epub 2021 Nov 24.
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
17 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
18 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
19 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
20 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
21 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
22 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
23 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
24 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
25 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
26 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
27 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
28 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
29 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
30 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
31 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
32 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
33 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
34 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
35 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
36 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
37 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
38 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
39 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
40 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
41 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
42 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
43 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
44 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
45 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
46 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
47 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
48 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
49 Cell- and Tissue-Based Proteome Profiling and Bioimaging with Probes Derived from a Potent AXL Kinase Inhibitor. Chem Asian J. 2018 Sep 17;13(18):2601-2605. doi: 10.1002/asia.201800605. Epub 2018 Aug 7.
50 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
51 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
52 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
53 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
54 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
55 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
56 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
57 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
58 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
59 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
60 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
61 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
62 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
63 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
64 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.