Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name JN0003  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 20  Competitor Info 
Competitor Concentration 160 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 18.3
 LDTP02198  Cathepsin D (CTSD) 17.2
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 17.2
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 16.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 16.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 15.7
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 15.4
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 15.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 15.2
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 14.8
 LDTP02651  Gamma-interferon-inducible lysosomal thiol reductase (IFI30) 14.7
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 14.6
 LDTP02837  Beta-galactosidase (GLB1) 14.4
 LDTP03842  Squalene synthase (FDFT1) 14.4
 LDTP05192  ADP-ribosylation factor 1 (ARF1) 14.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 14.3
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 13.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 13.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 13.0
 LDTP02141  Alpha-galactosidase A (GLA) 12.9
 LDTP13751  Exonuclease 1 (EXO1) 12.2
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 12.1
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 12.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 12.0
 LDTP12610  Obg-like ATPase 1 (OLA1) 11.8
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 11.7
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 11.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 11.4
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 11.0
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 10.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 10.0
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 9.7
 LDTP04183  Lanosterol synthase (LSS) 9.3
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 9.3
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 9.1
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 8.5
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 7.9
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 7.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 6.3
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 5.9
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.8
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 16.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 16.1
 LDTP02215  Prosaposin (PSAP) 15.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 15.3
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 15.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.6
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 13.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 13.9
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 13.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 13.3
 LDTP00310  Syntenin-1 (SDCBP) 12.8
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 11.4
Other
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.2
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 11.4
 LDTP00105  Protein unc-119 homolog B (UNC119B) 10.2
 LDTP13630  Neudesin (NENF) 6.8
 LDTP12412  Reticulon-4 (RTN4) 6.6

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.