Details of the Target

General Information of Target

Target ID	LDTP03257
Target Name	Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)
Gene Name	CPT2
Gene ID	1376
Synonyms	CPT1; Carnitine O-palmitoyltransferase 2, mitochondrial; EC 2.3.1.21; Carnitine palmitoyltransferase II; CPT II
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVPRLLLRAWPRGPAVGPGAPSRPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLEDT IRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFDMY LSARDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNP AKSDTITFKRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKA RHLLVLRKGNFYIFDVLDQDGNIVSPSEIQAHLKYILSDSSPAPEFPLAYLTSENRDIWA ELRQKLMSSGNEESLRKVDSAVFCLCLDDFPIKDLVHLSHNMLHGDGTNRWFDKSFNLII AKDGSTAVHFEHSWGDGVAVLRFFNEVFKDSTQTPAVTPQSQPATTDSTVTVQKLNFELT DALKTGITAAKEKFDATMKTLTIDCVQFQRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYG QTVATYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHG QLTKEAAMGQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNVLSTSTLSSPAVNLG GFAPVVSDGFGVGYAVHDNWIGCNVSSYPGRNAREFLQCVEKALEDMFDALEGKSIKS
Target Bioclass	Enzyme
Family	Carnitine/choline acetyltransferase family
Subcellular location	Mitochondrion inner membrane
Function	Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
Uniprot ID	P23786
Ensemble ID	ENST00000371486.4
HGNC ID	HGNC:2330
ChEMBL ID	CHEMBL3238

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 21 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
TH211 Probe Info	Y538(20.00); Y508(15.82)	LDD0260	[1]
BTD Probe Info	C84(0.76)	LDD2097	[2]
HPAP Probe Info	3.14	LDD0062	[3]
DBIA Probe Info	C84(4.64)	LDD0209	[4]
HHS-475 Probe Info	Y508(0.17)	LDD0264	[5]
AMP probe Probe Info	N.A.	LDD0200	[6]
ATP probe Probe Info	N.A.	LDD0199	[6]
4-Iodoacetamidophenylacetylene Probe Info	C535(0.00); C84(0.00); C445(0.00)	LDD0038	[7]
IA-alkyne Probe Info	N.A.	LDD0032	[8]
Lodoacetamide azide Probe Info	C512(0.00); C639(0.00); C535(0.00); C84(0.00)	LDD0037	[7]
JW-RF-010 Probe Info	N.A.	LDD0026	[9]
TFBX Probe Info	C489(0.00); C445(0.00)	LDD0027	[9]
IPM Probe Info	N.A.	LDD0147	[9]
NHS Probe Info	K69(0.00); K544(0.00)	LDD0010	[10]
STPyne Probe Info	N.A.	LDD0009	[10]
1c-yne Probe Info	N.A.	LDD0228	[11]
Acrolein Probe Info	C639(0.00); C84(0.00)	LDD0217	[12]
Crotonaldehyde Probe Info	C445(0.00); C639(0.00)	LDD0219	[12]
Methacrolein Probe Info	C445(0.00); C84(0.00)	LDD0218	[12]
NAIA_5 Probe Info	C512(0.00); C535(0.00); C445(0.00)	LDD2223	[13]
HHS-465 Probe Info	N.A.	LDD2240	[14]

PAL-AfBPP Probe

Click To Hide/Show 153 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
PARPYnD Probe Info	2.04	LDD0374	[15]
C004 Probe Info	15.35	LDD1714	[16]
C007 Probe Info	6.32	LDD1716	[16]
C011 Probe Info	5.62	LDD1720	[16]
C018 Probe Info	5.35	LDD1726	[16]
C022 Probe Info	11.24	LDD1728	[16]
C026 Probe Info	28.44	LDD1732	[16]
C027 Probe Info	6.28	LDD1733	[16]
C040 Probe Info	8.11	LDD1740	[16]
C041 Probe Info	14.32	LDD1741	[16]
C044 Probe Info	6.92	LDD1743	[16]
C055 Probe Info	24.93	LDD1752	[16]
C059 Probe Info	6.77	LDD1756	[16]
C064 Probe Info	6.28	LDD1761	[16]
C067 Probe Info	6.59	LDD1763	[16]
C070 Probe Info	26.17	LDD1766	[16]
C082 Probe Info	5.43	LDD1774	[16]
C085 Probe Info	6.23	LDD1777	[16]
C087 Probe Info	7.84	LDD1779	[16]
C091 Probe Info	13.45	LDD1782	[16]
C092 Probe Info	18.00	LDD1783	[16]
C106 Probe Info	31.56	LDD1793	[16]
C107 Probe Info	8.28	LDD1794	[16]
C108 Probe Info	22.32	LDD1795	[16]
C112 Probe Info	30.91	LDD1799	[16]
C117 Probe Info	4.92	LDD1804	[16]
C129 Probe Info	5.94	LDD1811	[16]
C130 Probe Info	20.68	LDD1812	[16]
C131 Probe Info	7.94	LDD1813	[16]
C134 Probe Info	37.53	LDD1816	[16]
C135 Probe Info	34.30	LDD1817	[16]
C139 Probe Info	15.03	LDD1821	[16]
C140 Probe Info	8.28	LDD1822	[16]
C143 Probe Info	62.25	LDD1825	[16]
C145 Probe Info	11.55	LDD1827	[16]
C153 Probe Info	21.26	LDD1834	[16]
C159 Probe Info	20.53	LDD1839	[16]
C160 Probe Info	18.64	LDD1840	[16]
C161 Probe Info	37.53	LDD1841	[16]
C165 Probe Info	13.83	LDD1845	[16]
C166 Probe Info	16.68	LDD1846	[16]
C167 Probe Info	9.92	LDD1847	[16]
C169 Probe Info	99.73	LDD1849	[16]
C170 Probe Info	13.36	LDD1850	[16]
C172 Probe Info	5.39	LDD1852	[16]
C173 Probe Info	11.24	LDD1853	[16]
C174 Probe Info	8.88	LDD1854	[16]
C176 Probe Info	6.63	LDD1855	[16]
C178 Probe Info	22.63	LDD1857	[16]
C183 Probe Info	6.19	LDD1861	[16]
C186 Probe Info	10.78	LDD1864	[16]
C191 Probe Info	9.51	LDD1868	[16]
C193 Probe Info	14.93	LDD1869	[16]
C194 Probe Info	12.47	LDD1870	[16]
C196 Probe Info	23.59	LDD1872	[16]
C197 Probe Info	7.31	LDD1873	[16]
C198 Probe Info	19.56	LDD1874	[16]
C201 Probe Info	26.35	LDD1877	[16]
C204 Probe Info	11.88	LDD1879	[16]
C206 Probe Info	15.35	LDD1881	[16]
C211 Probe Info	10.48	LDD1885	[16]
C214 Probe Info	39.95	LDD1888	[16]
C216 Probe Info	12.73	LDD1890	[16]
C217 Probe Info	18.77	LDD1891	[16]
C218 Probe Info	23.43	LDD1892	[16]
C219 Probe Info	6.92	LDD1893	[16]
C220 Probe Info	20.53	LDD1894	[16]
C222 Probe Info	23.10	LDD1896	[16]
C223 Probe Info	7.89	LDD1897	[16]
C225 Probe Info	9.00	LDD1898	[16]
C226 Probe Info	20.39	LDD1899	[16]
C228 Probe Info	19.03	LDD1901	[16]
C229 Probe Info	17.15	LDD1902	[16]
C231 Probe Info	12.91	LDD1904	[16]
C233 Probe Info	9.71	LDD1906	[16]
C234 Probe Info	5.66	LDD1907	[16]
C235 Probe Info	23.59	LDD1908	[16]
C238 Probe Info	19.43	LDD1911	[16]
C239 Probe Info	5.74	LDD1912	[16]
C243 Probe Info	12.73	LDD1916	[16]
C244 Probe Info	23.43	LDD1917	[16]
C246 Probe Info	15.14	LDD1919	[16]
C252 Probe Info	23.59	LDD1925	[16]
C260 Probe Info	5.21	LDD1932	[16]
C261 Probe Info	11.88	LDD1933	[16]
C264 Probe Info	20.97	LDD1935	[16]
C265 Probe Info	13.64	LDD1936	[16]
C270 Probe Info	8.34	LDD1940	[16]
C271 Probe Info	22.78	LDD1941	[16]
C282 Probe Info	32.22	LDD1952	[16]
C284 Probe Info	23.26	LDD1954	[16]
C285 Probe Info	22.94	LDD1955	[16]
C286 Probe Info	5.31	LDD1956	[16]
C287 Probe Info	11.47	LDD1957	[16]
C288 Probe Info	8.75	LDD1958	[16]
C289 Probe Info	37.79	LDD1959	[16]
C290 Probe Info	6.23	LDD1960	[16]
C293 Probe Info	27.47	LDD1963	[16]
C297 Probe Info	7.89	LDD1967	[16]
C299 Probe Info	7.62	LDD1968	[16]
C305 Probe Info	20.97	LDD1974	[16]
C310 Probe Info	8.51	LDD1977	[16]
C322 Probe Info	7.73	LDD1988	[16]
C338 Probe Info	22.01	LDD2001	[16]
C339 Probe Info	5.21	LDD2002	[16]
C342 Probe Info	5.06	LDD2004	[16]
C346 Probe Info	11.71	LDD2007	[16]
C348 Probe Info	14.83	LDD2009	[16]
C349 Probe Info	12.64	LDD2010	[16]
C350 Probe Info	99.73	LDD2011	[16]
C354 Probe Info	20.39	LDD2015	[16]
C355 Probe Info	32.67	LDD2016	[16]
C356 Probe Info	14.52	LDD2017	[16]
C357 Probe Info	9.99	LDD2018	[16]
C361 Probe Info	23.10	LDD2022	[16]
C366 Probe Info	14.22	LDD2027	[16]
C373 Probe Info	5.13	LDD2033	[16]
C378 Probe Info	6.68	LDD2037	[16]
C380 Probe Info	20.25	LDD2039	[16]
C382 Probe Info	24.25	LDD2041	[16]
C386 Probe Info	7.11	LDD2045	[16]
C388 Probe Info	47.84	LDD2047	[16]
C390 Probe Info	40.79	LDD2049	[16]
C391 Probe Info	15.03	LDD2050	[16]
C399 Probe Info	9.65	LDD2058	[16]
C403 Probe Info	16.22	LDD2061	[16]
C405 Probe Info	5.43	LDD2063	[16]
C416 Probe Info	5.86	LDD2071	[16]
C419 Probe Info	18.25	LDD2074	[16]
C420 Probe Info	16.00	LDD2075	[16]
C424 Probe Info	21.71	LDD2079	[16]
C426 Probe Info	14.22	LDD2081	[16]
C429 Probe Info	15.35	LDD2084	[16]
C430 Probe Info	5.70	LDD2085	[16]
C431 Probe Info	16.11	LDD2086	[16]
FFF probe11 Probe Info	20.00	LDD0471	[17]
FFF probe13 Probe Info	20.00	LDD0475	[17]
FFF probe14 Probe Info	20.00	LDD0477	[17]
FFF probe15 Probe Info	20.00	LDD0478	[17]
FFF probe2 Probe Info	20.00	LDD0463	[17]
FFF probe3 Probe Info	20.00	LDD0464	[17]
FFF probe4 Probe Info	18.05	LDD0466	[17]
FFF probe6 Probe Info	13.04	LDD0467	[17]
FFF probe7 Probe Info	20.00	LDD0483	[17]
FFF probe9 Probe Info	8.81	LDD0470	[17]
JN0003 Probe Info	20.00	LDD0469	[17]
VE-P Probe Info	N.A.	LDD0396	[18]
A-DA Probe Info	4.38	LDD0142	[19]
AEA-DA Probe Info	2.31	LDD0146	[19]
BD-F Probe Info	Y202(0.00); Y486(0.00); A204(0.00); A209(0.00)	LDD0024	[20]
LD-F Probe Info	N.A.	LDD0015	[20]
DA-2 Probe Info	N.A.	LDD0072	[21]
OEA-DA Probe Info	20.00	LDD0046	[22]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C84(0.97)	LDD2117	[2]
LDCM0214	AC1	HCT 116	C84(0.96)	LDD0531	[23]
LDCM0215	AC10	HCT 116	C489(0.73); C535(1.16)	LDD0532	[23]
LDCM0216	AC100	HCT 116	C512(0.76); C445(0.47); C489(0.77); C535(0.46)	LDD0533	[23]
LDCM0217	AC101	HCT 116	C512(1.34); C445(0.53); C489(0.83); C535(0.78)	LDD0534	[23]
LDCM0218	AC102	HCT 116	C512(0.79); C445(0.37); C489(0.89); C535(0.57)	LDD0535	[23]
LDCM0219	AC103	HCT 116	C512(1.28); C445(0.19); C489(0.77); C535(0.43)	LDD0536	[23]
LDCM0220	AC104	HCT 116	C512(0.92); C445(0.22); C489(0.98); C535(0.45)	LDD0537	[23]
LDCM0221	AC105	HCT 116	C512(0.80); C445(0.21); C489(0.78); C535(0.44)	LDD0538	[23]
LDCM0222	AC106	HCT 116	C512(0.38); C445(0.22); C489(0.89); C535(0.40)	LDD0539	[23]
LDCM0223	AC107	HCT 116	C512(0.89); C445(0.30); C489(0.74); C535(0.55)	LDD0540	[23]
LDCM0224	AC108	HCT 116	C512(0.78); C445(0.45); C489(0.81); C535(0.59)	LDD0541	[23]
LDCM0225	AC109	HCT 116	C512(0.67); C445(0.39); C489(1.05); C535(0.50)	LDD0542	[23]
LDCM0226	AC11	HCT 116	C489(0.76); C535(1.13)	LDD0543	[23]
LDCM0227	AC110	HCT 116	C512(0.79); C445(0.35); C489(0.85); C535(0.81)	LDD0544	[23]
LDCM0228	AC111	HCT 116	C512(1.08); C445(0.33); C489(0.79); C535(0.49)	LDD0545	[23]
LDCM0229	AC112	HCT 116	C512(0.46); C445(0.30); C489(0.76); C535(0.60)	LDD0546	[23]
LDCM0230	AC113	HCT 116	C445(1.19); C489(1.18); C535(1.18); C84(0.85)	LDD0547	[23]
LDCM0231	AC114	HCT 116	C445(0.99); C489(1.02); C535(0.84); C84(0.61)	LDD0548	[23]
LDCM0232	AC115	HCT 116	C445(1.10); C489(1.12); C535(0.96); C84(0.68)	LDD0549	[23]
LDCM0233	AC116	HCT 116	C445(1.03); C489(0.91); C535(0.96); C84(0.79)	LDD0550	[23]
LDCM0234	AC117	HCT 116	C445(2.52); C489(0.85); C535(0.84); C84(0.96)	LDD0551	[23]
LDCM0235	AC118	HCT 116	C445(1.19); C489(0.83); C535(0.87); C84(0.93)	LDD0552	[23]
LDCM0236	AC119	HCT 116	C445(1.51); C489(0.92); C535(0.99); C84(0.83)	LDD0553	[23]
LDCM0237	AC12	HCT 116	C489(1.02); C535(1.19)	LDD0554	[23]
LDCM0238	AC120	HCT 116	C445(1.13); C489(0.91); C535(1.05); C84(0.93)	LDD0555	[23]
LDCM0239	AC121	HCT 116	C445(2.23); C489(0.84); C535(0.90); C84(1.26)	LDD0556	[23]
LDCM0240	AC122	HCT 116	C445(1.07); C489(0.86); C535(1.05); C84(0.99)	LDD0557	[23]
LDCM0241	AC123	HCT 116	C445(0.99); C489(1.21); C535(0.85); C84(1.18)	LDD0558	[23]
LDCM0242	AC124	HCT 116	C445(1.78); C489(0.91); C535(0.98); C84(1.19)	LDD0559	[23]
LDCM0243	AC125	HCT 116	C445(1.32); C489(1.11); C535(0.97); C84(1.11)	LDD0560	[23]
LDCM0244	AC126	HCT 116	C445(0.98); C489(1.14); C535(0.98); C84(1.17)	LDD0561	[23]
LDCM0245	AC127	HCT 116	C445(1.37); C489(1.02); C535(0.98); C84(1.08)	LDD0562	[23]
LDCM0246	AC128	HCT 116	C489(0.57); C639(0.96); C84(0.64)	LDD0563	[23]
LDCM0247	AC129	HCT 116	C489(1.38); C639(1.52); C84(1.22)	LDD0564	[23]
LDCM0249	AC130	HCT 116	C489(0.60); C639(1.14); C84(0.85)	LDD0566	[23]
LDCM0250	AC131	HCT 116	C489(1.57); C639(0.86); C84(0.85)	LDD0567	[23]
LDCM0251	AC132	HCT 116	C489(1.63); C639(1.08); C84(1.56)	LDD0568	[23]
LDCM0252	AC133	HCT 116	C489(0.66); C639(1.08); C84(0.78)	LDD0569	[23]
LDCM0253	AC134	HCT 116	C489(0.52); C639(1.28); C84(0.60)	LDD0570	[23]
LDCM0254	AC135	HCT 116	C489(0.48); C639(1.03); C84(0.71)	LDD0571	[23]
LDCM0255	AC136	HCT 116	C489(0.71); C639(0.91); C84(0.94)	LDD0572	[23]
LDCM0256	AC137	HCT 116	C489(1.05); C639(0.95); C84(1.52)	LDD0573	[23]
LDCM0257	AC138	HCT 116	C489(0.68); C639(1.19); C84(0.91)	LDD0574	[23]
LDCM0258	AC139	HCT 116	C489(0.65); C639(1.30); C84(0.84)	LDD0575	[23]
LDCM0259	AC14	HCT 116	C489(0.84); C535(0.97)	LDD0576	[23]
LDCM0260	AC140	HCT 116	C489(0.54); C639(1.34); C84(0.75)	LDD0577	[23]
LDCM0261	AC141	HCT 116	C489(0.70); C639(1.08); C84(0.94)	LDD0578	[23]
LDCM0262	AC142	HCT 116	C489(1.88); C639(0.92); C84(1.62)	LDD0579	[23]
LDCM0263	AC143	HCT 116	C512(1.37); C489(1.57); C84(1.09)	LDD0580	[23]
LDCM0264	AC144	HCT 116	C489(0.34); C84(0.37); C512(0.57)	LDD0581	[23]
LDCM0265	AC145	HCT 116	C84(0.79); C489(0.89); C512(1.87)	LDD0582	[23]
LDCM0266	AC146	HCT 116	C489(0.60); C84(0.61); C512(0.85)	LDD0583	[23]
LDCM0267	AC147	HCT 116	C489(0.31); C84(0.36); C512(0.50)	LDD0584	[23]
LDCM0268	AC148	HCT 116	C489(0.31); C84(0.34); C512(0.52)	LDD0585	[23]
LDCM0269	AC149	HCT 116	C489(0.30); C84(0.37); C512(0.67)	LDD0586	[23]
LDCM0270	AC15	HCT 116	C489(0.69); C535(1.14)	LDD0587	[23]
LDCM0271	AC150	HCT 116	C489(0.89); C84(0.93); C512(1.54)	LDD0588	[23]
LDCM0272	AC151	HCT 116	C489(0.92); C84(1.07); C512(1.20)	LDD0589	[23]
LDCM0273	AC152	HCT 116	C489(0.30); C84(0.33); C512(0.42)	LDD0590	[23]
LDCM0274	AC153	HCT 116	C489(0.37); C84(0.40); C512(0.62)	LDD0591	[23]
LDCM0621	AC154	HCT 116	C512(0.70); C489(0.45); C84(0.45)	LDD2158	[23]
LDCM0622	AC155	HCT 116	C512(0.63); C489(0.40); C84(0.48)	LDD2159	[23]
LDCM0623	AC156	HCT 116	C512(1.32); C489(0.87); C84(1.02)	LDD2160	[23]
LDCM0624	AC157	HCT 116	C512(1.37); C489(1.27); C84(0.99)	LDD2161	[23]
LDCM0276	AC17	HCT 116	C445(1.09); C489(1.39); C535(1.42)	LDD0593	[23]
LDCM0277	AC18	HCT 116	C445(0.32); C535(0.36); C489(0.42)	LDD0594	[23]
LDCM0278	AC19	HCT 116	C445(0.87); C489(1.05); C535(1.33)	LDD0595	[23]
LDCM0279	AC2	HCT 116	C84(1.00)	LDD0596	[23]
LDCM0280	AC20	HCT 116	C489(1.19); C445(1.38); C535(1.65)	LDD0597	[23]
LDCM0281	AC21	HCT 116	C535(0.88); C489(0.96); C445(1.01)	LDD0598	[23]
LDCM0282	AC22	HCT 116	C489(1.11); C535(1.41); C445(2.67)	LDD0599	[23]
LDCM0283	AC23	HCT 116	C445(0.70); C535(0.75); C489(1.04)	LDD0600	[23]
LDCM0284	AC24	HCT 116	C445(0.70); C489(1.18); C535(1.47)	LDD0601	[23]
LDCM0285	AC25	HCT 116	C84(0.85); C489(0.87); C445(0.89)	LDD0602	[23]
LDCM0286	AC26	HCT 116	C489(0.69); C445(0.71); C84(0.81)	LDD0603	[23]
LDCM0287	AC27	HCT 116	C445(0.60); C84(0.61); C489(0.80)	LDD0604	[23]
LDCM0288	AC28	HCT 116	C445(0.52); C84(0.52); C489(0.56)	LDD0605	[23]
LDCM0289	AC29	HCT 116	C445(0.64); C489(0.64); C84(0.77)	LDD0606	[23]
LDCM0290	AC3	HCT 116	C84(1.17)	LDD0607	[23]
LDCM0291	AC30	HCT 116	C84(0.52); C445(0.57); C489(0.58)	LDD0608	[23]
LDCM0292	AC31	HCT 116	C489(0.65); C445(0.70); C84(0.71)	LDD0609	[23]
LDCM0293	AC32	HCT 116	C84(0.27); C445(0.28); C489(0.54)	LDD0610	[23]
LDCM0294	AC33	HCT 116	C84(0.30); C445(0.35); C489(0.72)	LDD0611	[23]
LDCM0295	AC34	HCT 116	C84(0.22); C445(0.26); C489(1.04)	LDD0612	[23]
LDCM0296	AC35	HCT 116	C445(1.48); C639(1.90); C489(2.21); C84(2.46)	LDD0613	[23]
LDCM0297	AC36	HCT 116	C445(1.51); C489(1.63); C84(1.95); C639(1.97)	LDD0614	[23]
LDCM0298	AC37	HCT 116	C489(1.38); C445(1.49); C84(1.52); C639(1.68)	LDD0615	[23]
LDCM0299	AC38	HCT 116	C445(1.41); C489(1.55); C84(1.57); C639(1.66)	LDD0616	[23]
LDCM0300	AC39	HCT 116	C84(0.93); C445(1.02); C489(1.04); C639(1.47)	LDD0617	[23]
LDCM0301	AC4	HCT 116	C84(1.33)	LDD0618	[23]
LDCM0302	AC40	HCT 116	C84(0.82); C489(0.88); C445(0.90); C639(0.99)	LDD0619	[23]
LDCM0303	AC41	HCT 116	C489(1.03); C84(1.20); C445(1.21); C639(1.21)	LDD0620	[23]
LDCM0304	AC42	HCT 116	C84(0.92); C445(0.97); C489(1.06); C639(1.31)	LDD0621	[23]
LDCM0305	AC43	HCT 116	C84(1.16); C489(1.16); C445(1.31); C639(1.88)	LDD0622	[23]
LDCM0306	AC44	HCT 116	C84(0.85); C639(0.94); C445(0.94); C489(0.99)	LDD0623	[23]
LDCM0307	AC45	HCT 116	C84(0.90); C639(0.98); C445(0.99); C489(1.27)	LDD0624	[23]
LDCM0308	AC46	HCT 116	C535(1.09); C512(1.12); C84(1.19); C639(1.23)	LDD0625	[23]
LDCM0309	AC47	HCT 116	C489(0.83); C512(0.87); C445(0.90); C639(0.91)	LDD0626	[23]
LDCM0310	AC48	HCT 116	C639(1.35); C489(1.44); C535(1.64); C84(1.98)	LDD0627	[23]
LDCM0311	AC49	HCT 116	C512(0.50); C489(0.73); C535(0.85); C84(0.85)	LDD0628	[23]
LDCM0312	AC5	HCT 116	C84(1.13)	LDD0629	[23]
LDCM0313	AC50	HCT 116	C512(0.66); C489(0.71); C84(0.78); C639(0.84)	LDD0630	[23]
LDCM0314	AC51	HCT 116	C535(1.60); C639(1.80); C489(1.87); C84(2.32)	LDD0631	[23]
LDCM0315	AC52	HCT 116	C512(0.67); C489(0.71); C535(0.82); C445(0.88)	LDD0632	[23]
LDCM0316	AC53	HCT 116	C512(0.57); C489(0.71); C445(0.77); C84(0.78)	LDD0633	[23]
LDCM0317	AC54	HCT 116	C512(0.44); C489(0.68); C639(0.80); C84(0.80)	LDD0634	[23]
LDCM0318	AC55	HCT 116	C512(0.62); C489(0.70); C84(0.76); C445(0.92)	LDD0635	[23]
LDCM0319	AC56	HCT 116	C512(0.67); C639(0.84); C489(0.85); C84(0.97)	LDD0636	[23]
LDCM0320	AC57	HCT 116	C445(0.41)	LDD0637	[23]
LDCM0321	AC58	HCT 116	C445(0.41)	LDD0638	[23]
LDCM0322	AC59	HCT 116	C445(0.34)	LDD0639	[23]
LDCM0323	AC6	HCT 116	C489(0.70); C535(1.07)	LDD0640	[23]
LDCM0324	AC60	HCT 116	C445(0.53)	LDD0641	[23]
LDCM0325	AC61	HCT 116	C445(1.07)	LDD0642	[23]
LDCM0326	AC62	HCT 116	C445(0.37)	LDD0643	[23]
LDCM0327	AC63	HCT 116	C445(0.41)	LDD0644	[23]
LDCM0328	AC64	HCT 116	C445(0.42)	LDD0645	[23]
LDCM0329	AC65	HCT 116	C445(0.48)	LDD0646	[23]
LDCM0330	AC66	HCT 116	C445(0.52)	LDD0647	[23]
LDCM0331	AC67	HCT 116	C445(0.53)	LDD0648	[23]
LDCM0332	AC68	HCT 116	C84(0.53); C445(0.66); C489(0.86); C639(0.97)	LDD0649	[23]
LDCM0333	AC69	HCT 116	C84(0.45); C445(0.66); C489(0.91); C639(1.14)	LDD0650	[23]
LDCM0334	AC7	HCT 116	C489(0.86); C535(0.90)	LDD0651	[23]
LDCM0335	AC70	HCT 116	C84(0.35); C445(0.52); C489(0.69); C639(1.25)	LDD0652	[23]
LDCM0336	AC71	HCT 116	C445(1.00); C84(1.02); C489(1.17); C639(1.17)	LDD0653	[23]
LDCM0337	AC72	HCT 116	C84(0.34); C445(0.55); C489(0.87); C639(1.25)	LDD0654	[23]
LDCM0338	AC73	HCT 116	C84(0.55); C445(0.83); C489(0.83); C639(1.12)	LDD0655	[23]
LDCM0339	AC74	HCT 116	C84(0.67); C445(0.93); C489(1.21); C639(1.36)	LDD0656	[23]
LDCM0340	AC75	HCT 116	C84(0.67); C489(0.81); C445(0.84); C639(1.28)	LDD0657	[23]
LDCM0341	AC76	HCT 116	C84(0.45); C445(0.63); C489(1.06); C639(1.12)	LDD0658	[23]
LDCM0342	AC77	HCT 116	C84(0.40); C445(0.65); C489(1.02); C639(1.02)	LDD0659	[23]
LDCM0343	AC78	HCT 116	C84(0.78); C489(1.06); C639(1.11); C445(1.18)	LDD0660	[23]
LDCM0344	AC79	HCT 116	C84(0.45); C445(0.64); C489(0.86); C639(1.29)	LDD0661	[23]
LDCM0345	AC8	HCT 116	C489(0.89); C535(1.20)	LDD0662	[23]
LDCM0346	AC80	HCT 116	C84(0.40); C445(0.55); C489(1.01); C639(1.12)	LDD0663	[23]
LDCM0347	AC81	HCT 116	C489(0.81); C445(0.92); C639(1.24); C84(1.46)	LDD0664	[23]
LDCM0348	AC82	HCT 116	C84(0.44); C445(0.77); C639(1.12); C489(1.15)	LDD0665	[23]
LDCM0349	AC83	HCT 116	C84(0.44); C489(0.59); C445(0.73); C512(4.22)	LDD0666	[23]
LDCM0350	AC84	HCT 116	C84(0.41); C489(0.58); C445(0.75); C512(4.26)	LDD0667	[23]
LDCM0351	AC85	HCT 116	C489(0.71); C84(0.82); C445(1.06); C512(4.18)	LDD0668	[23]
LDCM0352	AC86	HCT 116	C489(0.57); C84(0.73); C445(0.80); C512(4.28)	LDD0669	[23]
LDCM0353	AC87	HCT 116	C489(0.45); C84(0.94); C445(0.94); C512(4.27)	LDD0670	[23]
LDCM0354	AC88	HCT 116	C489(0.46); C445(0.74); C84(0.80); C512(4.86)	LDD0671	[23]
LDCM0355	AC89	HCT 116	C84(0.40); C489(0.57); C445(0.64); C512(5.23)	LDD0672	[23]
LDCM0357	AC90	HCT 116	C489(0.46); C445(1.04); C84(1.66); C512(4.36)	LDD0674	[23]
LDCM0358	AC91	HCT 116	C84(0.37); C445(0.72); C489(0.74); C512(3.50)	LDD0675	[23]
LDCM0359	AC92	HCT 116	C84(0.36); C489(0.54); C445(0.77); C512(6.31)	LDD0676	[23]
LDCM0360	AC93	HCT 116	C489(0.57); C84(0.61); C445(0.85); C512(3.26)	LDD0677	[23]
LDCM0361	AC94	HCT 116	C445(0.93); C489(0.98); C84(1.21); C512(4.28)	LDD0678	[23]
LDCM0362	AC95	HCT 116	C489(0.45); C84(0.98); C445(1.12); C512(5.25)	LDD0679	[23]
LDCM0363	AC96	HCT 116	C84(0.62); C489(0.70); C445(0.71); C512(2.38)	LDD0680	[23]
LDCM0364	AC97	HCT 116	C489(0.41); C84(0.41); C445(0.67); C512(5.12)	LDD0681	[23]
LDCM0365	AC98	HCT 116	C84(0.26); C445(0.28); C535(0.51); C489(0.70)	LDD0682	[23]
LDCM0366	AC99	HCT 116	C84(0.52); C445(0.64); C535(0.69); C489(0.83)	LDD0683	[23]
LDCM0248	AKOS034007472	HCT 116	C489(1.05); C535(1.19)	LDD0565	[23]
LDCM0356	AKOS034007680	HCT 116	C489(0.91); C535(0.98)	LDD0673	[23]
LDCM0275	AKOS034007705	HCT 116	C489(0.27); C535(1.15)	LDD0592	[23]
LDCM0020	ARS-1620	HCC44	C445(1.16)	LDD2171	[23]
LDCM0108	Chloroacetamide	HeLa	C445(0.00); C84(0.00)	LDD0222	[12]
LDCM0367	CL1	HCT 116	C84(0.79); C489(0.92)	LDD0684	[23]
LDCM0368	CL10	HCT 116	C489(0.32); C84(0.55)	LDD0685	[23]
LDCM0369	CL100	HCT 116	C84(0.86)	LDD0686	[23]
LDCM0370	CL101	HCT 116	C489(0.52); C535(1.21)	LDD0687	[23]
LDCM0371	CL102	HCT 116	C489(0.95); C535(1.08)	LDD0688	[23]
LDCM0372	CL103	HCT 116	C535(1.08); C489(1.09)	LDD0689	[23]
LDCM0373	CL104	HCT 116	C489(1.14); C535(1.29)	LDD0690	[23]
LDCM0374	CL105	HCT 116	C445(0.52); C489(0.70); C535(0.94)	LDD0691	[23]
LDCM0375	CL106	HCT 116	C535(0.36); C445(0.36); C489(0.40)	LDD0692	[23]
LDCM0376	CL107	HCT 116	C445(0.24); C489(0.33); C535(0.34)	LDD0693	[23]
LDCM0377	CL108	HCT 116	C445(0.28); C535(0.34); C489(0.37)	LDD0694	[23]
LDCM0378	CL109	HCT 116	C445(0.64); C489(0.75); C535(0.87)	LDD0695	[23]
LDCM0379	CL11	HCT 116	C489(0.34); C84(0.55)	LDD0696	[23]
LDCM0380	CL110	HCT 116	C445(0.46); C489(0.49); C535(0.58)	LDD0697	[23]
LDCM0381	CL111	HCT 116	C445(0.77); C489(1.00); C535(1.00)	LDD0698	[23]
LDCM0382	CL112	HCT 116	C489(0.77); C445(0.80); C84(1.20)	LDD0699	[23]
LDCM0383	CL113	HCT 116	C84(0.28); C445(0.32); C489(0.59)	LDD0700	[23]
LDCM0384	CL114	HCT 116	C489(0.62); C445(0.99); C84(1.13)	LDD0701	[23]
LDCM0385	CL115	HCT 116	C84(0.66); C445(0.70); C489(0.74)	LDD0702	[23]
LDCM0386	CL116	HCT 116	C84(0.63); C445(0.88); C489(1.00)	LDD0703	[23]
LDCM0387	CL117	HCT 116	C639(0.99); C84(1.03); C489(1.10); C445(1.25)	LDD0704	[23]
LDCM0388	CL118	HCT 116	C445(0.94); C84(0.98); C489(0.99); C639(1.28)	LDD0705	[23]
LDCM0389	CL119	HCT 116	C84(0.80); C445(0.88); C489(1.02); C639(1.05)	LDD0706	[23]
LDCM0390	CL12	HCT 116	C489(0.29); C84(0.61)	LDD0707	[23]
LDCM0391	CL120	HCT 116	C489(1.12); C84(1.17); C445(1.25); C639(1.50)	LDD0708	[23]
LDCM0392	CL121	HCT 116	C512(0.46); C84(0.57); C489(0.59); C445(0.60)	LDD0709	[23]
LDCM0393	CL122	HCT 116	C512(0.83); C489(0.94); C535(1.02); C84(1.05)	LDD0710	[23]
LDCM0394	CL123	HCT 116	C512(0.58); C489(0.62); C445(0.73); C84(0.76)	LDD0711	[23]
LDCM0395	CL124	HCT 116	C512(0.68); C489(0.72); C84(0.75); C445(0.85)	LDD0712	[23]
LDCM0396	CL125	HCT 116	C445(1.06)	LDD0713	[23]
LDCM0397	CL126	HCT 116	C445(0.93)	LDD0714	[23]
LDCM0398	CL127	HCT 116	C445(0.82)	LDD0715	[23]
LDCM0399	CL128	HCT 116	C445(0.38)	LDD0716	[23]
LDCM0400	CL13	HCT 116	C489(0.38); C84(0.61)	LDD0717	[23]
LDCM0401	CL14	HCT 116	C489(0.53); C84(0.73)	LDD0718	[23]
LDCM0402	CL15	HCT 116	C489(0.49); C84(0.78)	LDD0719	[23]
LDCM0403	CL16	HCT 116	C84(0.76); C489(0.87)	LDD0720	[23]
LDCM0404	CL17	HCT 116	C489(0.77); C84(0.86)	LDD0721	[23]
LDCM0405	CL18	HCT 116	C84(0.84); C489(0.86)	LDD0722	[23]
LDCM0406	CL19	HCT 116	C489(0.82); C84(0.97)	LDD0723	[23]
LDCM0407	CL2	HCT 116	C489(0.79); C84(0.95)	LDD0724	[23]
LDCM0408	CL20	HCT 116	C84(0.49); C489(0.52)	LDD0725	[23]
LDCM0409	CL21	HCT 116	C489(0.48); C84(0.72)	LDD0726	[23]
LDCM0410	CL22	HCT 116	C489(0.63); C84(0.68)	LDD0727	[23]
LDCM0411	CL23	HCT 116	C489(0.52); C84(0.82)	LDD0728	[23]
LDCM0412	CL24	HCT 116	C489(0.49); C84(0.64)	LDD0729	[23]
LDCM0413	CL25	HCT 116	C489(0.51); C84(0.64)	LDD0730	[23]
LDCM0414	CL26	HCT 116	C489(0.55); C84(0.77)	LDD0731	[23]
LDCM0415	CL27	HCT 116	C489(0.60); C84(0.78)	LDD0732	[23]
LDCM0416	CL28	HCT 116	C489(0.56); C84(0.66)	LDD0733	[23]
LDCM0417	CL29	HCT 116	C489(0.60); C84(0.59)	LDD0734	[23]
LDCM0418	CL3	HCT 116	C489(0.63); C84(0.86)	LDD0735	[23]
LDCM0419	CL30	HCT 116	C489(0.95); C84(0.82)	LDD0736	[23]
LDCM0420	CL31	HCT 116	C512(1.21); C489(0.78); C84(0.85)	LDD0737	[23]
LDCM0421	CL32	HCT 116	C512(1.13); C489(0.83); C84(0.78)	LDD0738	[23]
LDCM0422	CL33	HCT 116	C512(0.97); C489(0.88); C84(0.75)	LDD0739	[23]
LDCM0423	CL34	HCT 116	C512(0.75); C489(0.35); C84(0.42)	LDD0740	[23]
LDCM0424	CL35	HCT 116	C512(0.95); C489(0.34); C84(0.37)	LDD0741	[23]
LDCM0425	CL36	HCT 116	C512(1.03); C489(0.30); C84(0.38)	LDD0742	[23]
LDCM0426	CL37	HCT 116	C512(1.20); C489(0.36); C84(0.42)	LDD0743	[23]
LDCM0428	CL39	HCT 116	C512(1.05); C489(0.30); C84(0.39)	LDD0745	[23]
LDCM0429	CL4	HCT 116	C489(0.47); C84(0.87)	LDD0746	[23]
LDCM0430	CL40	HCT 116	C512(1.24); C489(0.32); C84(0.33)	LDD0747	[23]
LDCM0431	CL41	HCT 116	C512(1.19); C489(0.33); C84(0.42)	LDD0748	[23]
LDCM0432	CL42	HCT 116	C512(1.14); C489(0.38); C84(0.46)	LDD0749	[23]
LDCM0433	CL43	HCT 116	C512(1.05); C489(0.42); C84(0.45)	LDD0750	[23]
LDCM0434	CL44	HCT 116	C512(1.05); C489(0.45); C84(0.46)	LDD0751	[23]
LDCM0435	CL45	HCT 116	C512(1.21); C489(0.34); C84(0.43)	LDD0752	[23]
LDCM0436	CL46	HCT 116	C489(1.06)	LDD0753	[23]
LDCM0437	CL47	HCT 116	C489(1.55)	LDD0754	[23]
LDCM0438	CL48	HCT 116	C489(0.96)	LDD0755	[23]
LDCM0439	CL49	HCT 116	C489(1.25)	LDD0756	[23]
LDCM0440	CL5	HCT 116	C489(0.40); C84(0.62)	LDD0757	[23]
LDCM0441	CL50	HCT 116	C489(1.35)	LDD0758	[23]
LDCM0442	CL51	HCT 116	C489(1.55)	LDD0759	[23]
LDCM0443	CL52	HCT 116	C489(1.26)	LDD0760	[23]
LDCM0444	CL53	HCT 116	C489(1.04)	LDD0761	[23]
LDCM0445	CL54	HCT 116	C489(1.23)	LDD0762	[23]
LDCM0446	CL55	HCT 116	C489(1.73)	LDD0763	[23]
LDCM0447	CL56	HCT 116	C489(1.29)	LDD0764	[23]
LDCM0448	CL57	HCT 116	C489(1.46)	LDD0765	[23]
LDCM0449	CL58	HCT 116	C489(1.11)	LDD0766	[23]
LDCM0450	CL59	HCT 116	C489(1.08)	LDD0767	[23]
LDCM0451	CL6	HCT 116	C489(0.74); C84(0.82)	LDD0768	[23]
LDCM0452	CL60	HCT 116	C489(0.86)	LDD0769	[23]
LDCM0453	CL61	HCT 116	C512(1.29)	LDD0770	[23]
LDCM0454	CL62	HCT 116	C512(0.95)	LDD0771	[23]
LDCM0455	CL63	HCT 116	C512(0.65)	LDD0772	[23]
LDCM0456	CL64	HCT 116	C512(0.38)	LDD0773	[23]
LDCM0457	CL65	HCT 116	C512(0.90)	LDD0774	[23]
LDCM0458	CL66	HCT 116	C512(0.21)	LDD0775	[23]
LDCM0459	CL67	HCT 116	C512(0.27)	LDD0776	[23]
LDCM0460	CL68	HCT 116	C512(0.77)	LDD0777	[23]
LDCM0461	CL69	HCT 116	C512(1.40)	LDD0778	[23]
LDCM0462	CL7	HCT 116	C489(0.32); C84(0.62)	LDD0779	[23]
LDCM0463	CL70	HCT 116	C512(0.92)	LDD0780	[23]
LDCM0464	CL71	HCT 116	C512(0.47)	LDD0781	[23]
LDCM0465	CL72	HCT 116	C512(0.94)	LDD0782	[23]
LDCM0466	CL73	HCT 116	C512(0.61)	LDD0783	[23]
LDCM0467	CL74	HCT 116	C512(0.50)	LDD0784	[23]
LDCM0469	CL76	HCT 116	C84(0.62)	LDD0786	[23]
LDCM0470	CL77	HCT 116	C84(0.81)	LDD0787	[23]
LDCM0471	CL78	HCT 116	C84(0.57)	LDD0788	[23]
LDCM0472	CL79	HCT 116	C84(0.39)	LDD0789	[23]
LDCM0473	CL8	HCT 116	C489(0.28); C84(0.45)	LDD0790	[23]
LDCM0474	CL80	HCT 116	C84(0.76)	LDD0791	[23]
LDCM0475	CL81	HCT 116	C84(0.63)	LDD0792	[23]
LDCM0476	CL82	HCT 116	C84(0.42)	LDD0793	[23]
LDCM0477	CL83	HCT 116	C84(0.35)	LDD0794	[23]
LDCM0478	CL84	HCT 116	C84(0.49)	LDD0795	[23]
LDCM0479	CL85	HCT 116	C84(0.52)	LDD0796	[23]
LDCM0480	CL86	HCT 116	C84(0.72)	LDD0797	[23]
LDCM0481	CL87	HCT 116	C84(0.42)	LDD0798	[23]
LDCM0482	CL88	HCT 116	C84(0.35)	LDD0799	[23]
LDCM0483	CL89	HCT 116	C84(0.43)	LDD0800	[23]
LDCM0484	CL9	HCT 116	C489(0.31); C84(0.49)	LDD0801	[23]
LDCM0485	CL90	HCT 116	C84(0.91)	LDD0802	[23]
LDCM0486	CL91	HCT 116	C84(1.25)	LDD0803	[23]
LDCM0487	CL92	HCT 116	C84(1.00)	LDD0804	[23]
LDCM0488	CL93	HCT 116	C84(1.22)	LDD0805	[23]
LDCM0489	CL94	HCT 116	C84(0.91)	LDD0806	[23]
LDCM0490	CL95	HCT 116	C84(1.32)	LDD0807	[23]
LDCM0491	CL96	HCT 116	C84(1.07)	LDD0808	[23]
LDCM0492	CL97	HCT 116	C84(1.31)	LDD0809	[23]
LDCM0493	CL98	HCT 116	C84(0.85)	LDD0810	[23]
LDCM0494	CL99	HCT 116	C84(1.01)	LDD0811	[23]
LDCM0189	Compound 16	HEK-293T	36.36	LDD0492	[17]
LDCM0185	Compound 17	HEK-293T	34.48	LDD0504	[17]
LDCM0182	Compound 18	HEK-293T	6.33	LDD0501	[17]
LDCM0184	Compound 20	HEK-293T	12.05	LDD0503	[17]
LDCM0191	Compound 21	HEK-293T	8.73	LDD0493	[17]
LDCM0186	Compound 31	HEK-293T	6.54	LDD0506	[17]
LDCM0188	Compound 33	HEK-293T	10.99	LDD0505	[17]
LDCM0190	Compound 34	HEK-293T	43.48	LDD0497	[17]
LDCM0192	Compound 35	HEK-293T	9.85	LDD0491	[17]
LDCM0193	Compound 36	HEK-293T	7.38	LDD0494	[17]
LDCM0194	Compound 37	HEK-293T	14.60	LDD0498	[17]
LDCM0195	Compound 38	HEK-293T	12.35	LDD0499	[17]
LDCM0196	Compound 39	HEK-293T	9.13	LDD0496	[17]
LDCM0197	Compound 40	HEK-293T	9.95	LDD0495	[17]
LDCM0181	Compound 41	HEK-293T	5.97	LDD0502	[17]
LDCM0495	E2913	HEK-293T	C512(1.02); C535(0.94); C639(1.06); C445(0.99)	LDD1698	[24]
LDCM0625	F8	Ramos	C84(6.51)	LDD2187	[25]
LDCM0082	FK866	A-549	4.38	LDD0142	[19]
LDCM0572	Fragment10	Ramos	C84(0.31)	LDD2189	[25]
LDCM0574	Fragment12	Ramos	C84(0.53)	LDD2191	[25]
LDCM0575	Fragment13	Ramos	C84(1.25)	LDD2192	[25]
LDCM0576	Fragment14	Ramos	C84(0.45)	LDD2193	[25]
LDCM0579	Fragment20	Ramos	C84(0.39)	LDD2194	[25]
LDCM0578	Fragment27	Ramos	C84(1.09)	LDD2197	[25]
LDCM0586	Fragment28	Ramos	C84(0.82)	LDD2198	[25]
LDCM0588	Fragment30	Ramos	C84(1.08)	LDD2199	[25]
LDCM0590	Fragment32	Ramos	C84(0.46)	LDD2201	[25]
LDCM0468	Fragment33	HCT 116	C512(0.45)	LDD0785	[23]
LDCM0566	Fragment4	Ramos	C84(2.74)	LDD2184	[25]
LDCM0427	Fragment51	HCT 116	C512(0.91); C489(0.36); C84(0.44)	LDD0744	[23]
LDCM0569	Fragment7	Ramos	C84(3.94)	LDD2186	[25]
LDCM0571	Fragment9	Ramos	C84(0.43)	LDD2188	[25]
LDCM0116	HHS-0101	DM93	Y508(0.17)	LDD0264	[5]
LDCM0117	HHS-0201	DM93	Y508(0.40)	LDD0265	[5]
LDCM0118	HHS-0301	DM93	Y508(0.05)	LDD0266	[5]
LDCM0119	HHS-0401	DM93	Y508(0.24)	LDD0267	[5]
LDCM0120	HHS-0701	DM93	Y508(0.31)	LDD0268	[5]
LDCM0107	IAA	HeLa	C445(0.00); C639(0.00)	LDD0221	[12]
LDCM0022	KB02	HEK-293T	C489(0.96); C445(1.18); C326(0.92)	LDD1492	[24]
LDCM0023	KB03	Jurkat	C84(4.64)	LDD0209	[4]
LDCM0024	KB05	COLO792	C489(1.11)	LDD3310	[26]
LDCM0109	NEM	HeLa	N.A.	LDD0227	[12]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C84(0.76)	LDD2097	[2]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C84(1.04)	LDD2099	[2]
LDCM0514	Nucleophilic fragment 20a	MDA-MB-231	C84(0.91)	LDD2107	[2]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C84(0.63)	LDD2109	[2]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C512(0.57)	LDD2114	[2]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C84(0.92)	LDD2123	[2]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C84(0.71)	LDD2125	[2]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C84(0.94)	LDD2127	[2]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C512(1.68); C84(0.90)	LDD2129	[2]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C84(1.51)	LDD2135	[2]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C84(1.10)	LDD2137	[2]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C84(1.05)	LDD2140	[2]
LDCM0014	Panhematin	HEK-293T	3.14	LDD0062	[3]
LDCM0084	Ro 48-8071	A-549	2.23	LDD0145	[19]
LDCM0021	THZ1	HCT 116	C445(1.16)	LDD2173	[23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Homeobox protein OTX1 (OTX1)				Paired homeobox family	P32242

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1)				CYSRT1 family	A8MQ03

The Drug(s) Related To This Target

Approved

Click To Hide/Show 2 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Levocarnitine				Small molecular drug	DB00583
Perhexiline				Small molecular drug	DB01074

References

1	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
3	A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12. Mass spectrometry data entry: PXD034651
4	Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5	Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
8	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
10	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
14	Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6. Mass spectrometry data entry: PXD038010
15	Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
16	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
17	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18	Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
20	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
21	Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
22	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
23	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
24	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
25	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
26	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni