Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name JN0003  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 17  Competitor Info 
Competitor Concentration 160 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 36 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 34.5
 LDTP13751  Exonuclease 1 (EXO1) 34.5
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 24.3
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 24.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 22.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 20.6
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 19.2
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 18.7
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 15.7
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 13.1
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 12.9
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 12.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.4
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 11.2
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 10.9
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 10.1
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 9.3
 LDTP05192  ADP-ribosylation factor 1 (ARF1) 9.0
 LDTP02141  Alpha-galactosidase A (GLA) 9.0
 LDTP02198  Cathepsin D (CTSD) 8.9
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 8.9
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 8.1
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 7.9
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 7.5
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 6.6
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 6.4
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 6.0
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.9
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 5.7
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 5.4
 LDTP02837  Beta-galactosidase (GLB1) 5.4
 LDTP12610  Obg-like ATPase 1 (OLA1) 5.1
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 4.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 3.3
Transporter and channel
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 16.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 13.2
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 11.5
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 9.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 6.6
 LDTP02215  Prosaposin (PSAP) 5.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 3.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 3.0
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13630  Neudesin (NENF) 11.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 4.1

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.