Details of the Target

General Information of Target

Target ID LDTP05192
Target Name ADP-ribosylation factor 1 (ARF1)
Gene Name ARF1
Gene ID 375
Synonyms
ADP-ribosylation factor 1; EC 3.6.5.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN
ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV
LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ
K
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Arf family
Subcellular location
Golgi apparatus membrane
Function
Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis. Plays also a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation.; (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
TTD ID
T47351
Uniprot ID
P84077
DrugMap ID
TT70KXY
Ensemble ID
ENST00000272102.10
HGNC ID
HGNC:652
ChEMBL ID
CHEMBL5985

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.51  LDD0402  [1]
N1
 Probe Info  		3.72  LDD0242  [2]
TH211
 Probe Info  		Y58(20.00); Y35(18.51); Y81(5.99)  LDD0260  [3]
ONAyne
 Probe Info  		K142(2.75)  LDD0274  [4]
STPyne
 Probe Info  		K36(10.00)  LDD0277  [4]
AZ-9
 Probe Info  		D141(0.84); D26(1.02); K73(0.41)  LDD2208  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
THZ1-DTB
 Probe Info  		C159(1.08)  LDD0460  [6]
HHS-482
 Probe Info  		Y35(0.86); Y58(1.10)  LDD0285  [7]
HHS-475
 Probe Info  		Y81(0.49); Y35(0.80); Y58(0.97)  LDD0264  [8]
HHS-465
 Probe Info  		Y35(7.78); Y58(7.97); Y81(6.70)  LDD2237  [9]
DBIA
 Probe Info  		C159(0.74)  LDD0532  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD2156  [12]
Ox-W18
 Probe Info  		W153(0.00); W172(0.00)  LDD2175  [13]
AOyne
 Probe Info  		5.70  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [16]
TPP-AC
 Probe Info  		N.A.  LDD0427  [16]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		7.66  LDD0471  [17]
FFF probe12
 Probe Info  		5.06  LDD0473  [17]
FFF probe13
 Probe Info  		10.16  LDD0475  [17]
FFF probe2
 Probe Info  		6.66  LDD0463  [17]
FFF probe3
 Probe Info  		5.29  LDD0465  [17]
JN0003
 Probe Info  		20.00  LDD0469  [17]
BD-F
 Probe Info  		L177(0.00); D164(0.00)  LDD0024  [18]
OEA-DA
 Probe Info  		3.68  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C159(1.07)  LDD0812  [10]
 LDCM0215  AC10 HCT 116 C159(0.74)  LDD0532  [10]
 LDCM0216  AC100 PaTu 8988t C159(1.07)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C159(0.97)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C159(0.66)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C159(0.86)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C159(0.64)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C159(1.07)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C159(1.07)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C159(1.19)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C159(1.18)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C159(0.76)  LDD1104  [10]
 LDCM0226  AC11 HCT 116 C159(0.51)  LDD0543  [10]
 LDCM0227  AC110 PaTu 8988t C159(0.70)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C159(0.97)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C159(0.89)  LDD1108  [10]
 LDCM0230  AC113 HCT 116 C159(1.14)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C159(1.31)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C159(1.03)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C159(0.80)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C159(1.20)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C159(1.61)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C159(0.78)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C159(0.74)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C159(0.60)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C159(1.25)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C159(0.87)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C159(0.83)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C159(1.15)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C159(1.33)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C159(0.84)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C159(0.93)  LDD0562  [10]
 LDCM0246  AC128 HEK-293T C159(1.02)  LDD0844  [10]
 LDCM0247  AC129 HEK-293T C159(1.09)  LDD0845  [10]
 LDCM0249  AC130 HEK-293T C159(1.03)  LDD0847  [10]
 LDCM0250  AC131 HEK-293T C159(1.04)  LDD0848  [10]
 LDCM0251  AC132 HEK-293T C159(1.19)  LDD0849  [10]
 LDCM0252  AC133 HEK-293T C159(1.35)  LDD0850  [10]
 LDCM0253  AC134 HEK-293T C159(1.24)  LDD0851  [10]
 LDCM0254  AC135 HEK-293T C159(1.36)  LDD0852  [10]
 LDCM0255  AC136 HEK-293T C159(1.36)  LDD0853  [10]
 LDCM0256  AC137 HEK-293T C159(1.56)  LDD0854  [10]
 LDCM0257  AC138 HEK-293T C159(1.95)  LDD0855  [10]
 LDCM0258  AC139 HEK-293T C159(1.51)  LDD0856  [10]
 LDCM0259  AC14 HCT 116 C159(0.74)  LDD0576  [10]
 LDCM0260  AC140 HEK-293T C159(1.35)  LDD0858  [10]
 LDCM0261  AC141 HEK-293T C159(1.66)  LDD0859  [10]
 LDCM0262  AC142 HEK-293T C159(1.25)  LDD0860  [10]
 LDCM0263  AC143 HCT 116 C159(0.66)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C159(0.64)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C159(0.62)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C159(0.36)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C159(0.42)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C159(0.38)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C159(0.48)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C159(0.78)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C159(0.58)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C159(0.84)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C159(0.44)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C159(0.45)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C159(0.54)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C159(0.49)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C159(0.71)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C159(1.38)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C159(1.45)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C159(0.66)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C159(1.22)  LDD0595  [10]
 LDCM0279  AC2 HEK-293T C159(1.40)  LDD0877  [10]
 LDCM0280  AC20 HCT 116 C159(1.30)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C159(0.71)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C159(0.84)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C159(1.21)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C159(1.48)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C159(0.99)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C159(0.69)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C159(0.84)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C159(0.77)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C159(1.25)  LDD0606  [10]
 LDCM0290  AC3 HEK-293T C159(1.07)  LDD0888  [10]
 LDCM0291  AC30 HCT 116 C159(0.60)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C159(0.68)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C159(0.91)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C159(0.82)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C159(0.80)  LDD0612  [10]
 LDCM0296  AC35 HEK-293T C159(1.01)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C159(1.00)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C159(1.00)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C159(0.91)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C159(0.99)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C159(1.09)  LDD0899  [10]
 LDCM0302  AC40 HEK-293T C159(0.96)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C159(0.91)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C159(1.03)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C159(1.06)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C159(1.10)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C159(1.02)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C159(0.93)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C159(1.02)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C159(1.02)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C159(0.88)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C159(1.11)  LDD0910  [10]
 LDCM0313  AC50 HEK-293T C159(1.03)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C159(1.04)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C159(1.13)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C159(1.10)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C159(1.14)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C159(1.14)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C159(1.03)  LDD1558  [20]
 LDCM0320  AC57 PaTu 8988t C159(1.29)  LDD1199  [10]
 LDCM0321  AC58 PaTu 8988t C159(1.26)  LDD1200  [10]
 LDCM0322  AC59 PaTu 8988t C159(1.33)  LDD1201  [10]
 LDCM0323  AC6 HCT 116 C159(0.78)  LDD0640  [10]
 LDCM0324  AC60 PaTu 8988t C159(1.67)  LDD1203  [10]
 LDCM0325  AC61 PaTu 8988t C159(1.88)  LDD1204  [10]
 LDCM0326  AC62 PaTu 8988t C159(1.24)  LDD1205  [10]
 LDCM0327  AC63 PaTu 8988t C159(1.17)  LDD1206  [10]
 LDCM0328  AC64 PaTu 8988t C159(0.95)  LDD1207  [10]
 LDCM0329  AC65 PaTu 8988t C159(1.08)  LDD1208  [10]
 LDCM0330  AC66 PaTu 8988t C159(1.04)  LDD1209  [10]
 LDCM0331  AC67 PaTu 8988t C159(1.49)  LDD1210  [10]
 LDCM0334  AC7 HCT 116 C159(0.96)  LDD0651  [10]
 LDCM0345  AC8 HCT 116 C159(1.02)  LDD0662  [10]
 LDCM0349  AC83 HEK-293T C159(1.38)  LDD0947  [10]
 LDCM0350  AC84 HEK-293T C159(1.14)  LDD0948  [10]
 LDCM0351  AC85 HEK-293T C159(1.78)  LDD0949  [10]
 LDCM0352  AC86 HEK-293T C159(1.61)  LDD0950  [10]
 LDCM0353  AC87 HEK-293T C159(1.45)  LDD0951  [10]
 LDCM0354  AC88 HEK-293T C159(1.41)  LDD0952  [10]
 LDCM0355  AC89 HEK-293T C159(1.91)  LDD0953  [10]
 LDCM0357  AC90 HEK-293T C159(1.50)  LDD0955  [10]
 LDCM0358  AC91 HEK-293T C159(1.57)  LDD0956  [10]
 LDCM0359  AC92 HEK-293T C159(2.48)  LDD0957  [10]
 LDCM0360  AC93 HEK-293T C159(1.11)  LDD0958  [10]
 LDCM0361  AC94 HEK-293T C159(1.32)  LDD0959  [10]
 LDCM0362  AC95 HEK-293T C159(1.55)  LDD0960  [10]
 LDCM0363  AC96 HEK-293T C159(1.36)  LDD0961  [10]
 LDCM0364  AC97 HEK-293T C159(1.80)  LDD0962  [10]
 LDCM0365  AC98 PaTu 8988t C159(0.60)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C159(1.03)  LDD1245  [10]
 LDCM0248  AKOS034007472 HCT 116 C159(0.90)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C159(1.16)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C159(0.59)  LDD0592  [10]
 LDCM0630  CCW28-3 231MFP C159(1.09)  LDD2214  [21]
 LDCM0367  CL1 HCT 116 C159(1.01)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C159(0.48)  LDD0685  [10]
 LDCM0369  CL100 HEK-293T C159(1.19)  LDD0967  [10]
 LDCM0370  CL101 HCT 116 C159(0.81)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C159(0.93)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C159(1.37)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C159(2.56)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C159(0.98)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C159(0.34)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C159(0.67)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C159(0.80)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C159(0.84)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C159(0.58)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C159(0.57)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C159(1.33)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C159(0.99)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C159(0.78)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C159(0.91)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C159(0.58)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C159(0.85)  LDD0703  [10]
 LDCM0387  CL117 HEK-293T C159(1.04)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C159(1.18)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C159(1.21)  LDD1593  [20]
 LDCM0390  CL12 HCT 116 C159(1.14)  LDD0707  [10]
 LDCM0391  CL120 HEK-293T C159(0.98)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C159(1.07)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C159(1.16)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C159(1.07)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C159(1.01)  LDD1599  [20]
 LDCM0396  CL125 PaTu 8988t C159(1.36)  LDD1275  [10]
 LDCM0397  CL126 PaTu 8988t C159(0.90)  LDD1276  [10]
 LDCM0398  CL127 PaTu 8988t C159(1.52)  LDD1277  [10]
 LDCM0399  CL128 PaTu 8988t C159(1.74)  LDD1278  [10]
 LDCM0400  CL13 HCT 116 C159(0.52)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C159(1.04)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C159(0.38)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C159(0.98)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C159(0.83)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C159(0.43)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C159(0.77)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C159(1.02)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C159(1.35)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C159(0.56)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C159(0.53)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C159(1.28)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C159(0.78)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C159(0.65)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C159(1.10)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C159(1.05)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C159(0.68)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C159(0.81)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C159(0.99)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C159(0.66)  LDD0736  [10]
 LDCM0420  CL31 HEK-293T C159(1.01)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C159(0.90)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C159(0.93)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C159(0.94)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C159(1.02)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C159(0.97)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C159(1.28)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C159(1.28)  LDD1632  [20]
 LDCM0429  CL4 HCT 116 C159(0.95)  LDD0746  [10]
 LDCM0430  CL40 HEK-293T C159(0.95)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C159(0.75)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C159(1.12)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C159(1.08)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C159(0.97)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C159(0.98)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C159(1.06)  LDD1034  [10]
 LDCM0437  CL47 HEK-293T C159(0.91)  LDD1035  [10]
 LDCM0438  CL48 HEK-293T C159(0.94)  LDD1036  [10]
 LDCM0439  CL49 HEK-293T C159(1.04)  LDD1037  [10]
 LDCM0440  CL5 HCT 116 C159(0.86)  LDD0757  [10]
 LDCM0441  CL50 HEK-293T C159(1.33)  LDD1039  [10]
 LDCM0442  CL51 HEK-293T C159(1.19)  LDD1040  [10]
 LDCM0443  CL52 HEK-293T C159(0.97)  LDD1041  [10]
 LDCM0444  CL53 HEK-293T C159(1.31)  LDD1042  [10]
 LDCM0445  CL54 HEK-293T C159(1.27)  LDD1043  [10]
 LDCM0446  CL55 HEK-293T C159(1.09)  LDD1044  [10]
 LDCM0447  CL56 HEK-293T C159(1.03)  LDD1045  [10]
 LDCM0448  CL57 HEK-293T C159(1.13)  LDD1046  [10]
 LDCM0449  CL58 HEK-293T C159(0.99)  LDD1047  [10]
 LDCM0450  CL59 HEK-293T C159(1.28)  LDD1048  [10]
 LDCM0451  CL6 HCT 116 C159(0.41)  LDD0768  [10]
 LDCM0452  CL60 HEK-293T C159(1.39)  LDD1050  [10]
 LDCM0453  CL61 PaTu 8988t C159(0.76)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C159(0.60)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C159(0.82)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C159(0.97)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C159(0.88)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C159(0.76)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C159(0.80)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C159(0.85)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C159(0.71)  LDD1340  [10]
 LDCM0462  CL7 HCT 116 C159(0.57)  LDD0779  [10]
 LDCM0463  CL70 PaTu 8988t C159(0.74)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C159(0.94)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C159(0.77)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C159(0.56)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C159(0.87)  LDD1346  [10]
 LDCM0469  CL76 HCT 116 C159(0.55)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C159(1.03)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C159(1.01)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C159(0.75)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C159(0.66)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C159(0.52)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C159(0.70)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C159(0.47)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C159(0.59)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C159(0.45)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C159(0.71)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C159(0.98)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C159(1.02)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C159(0.55)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C159(0.31)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C159(0.95)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C159(0.79)  LDD0802  [10]
 LDCM0486  CL91 HEK-293T C159(0.94)  LDD1084  [10]
 LDCM0487  CL92 HEK-293T C159(1.21)  LDD1085  [10]
 LDCM0488  CL93 HEK-293T C159(1.14)  LDD1086  [10]
 LDCM0489  CL94 HEK-293T C159(1.28)  LDD1087  [10]
 LDCM0490  CL95 HEK-293T C159(1.54)  LDD1088  [10]
 LDCM0491  CL96 HEK-293T C159(1.04)  LDD1089  [10]
 LDCM0492  CL97 HEK-293T C159(1.07)  LDD1090  [10]
 LDCM0493  CL98 HEK-293T C159(1.21)  LDD1091  [10]
 LDCM0494  CL99 HEK-293T C159(1.07)  LDD1092  [10]
 LDCM0185  Compound 17 HEK-293T 9.03  LDD0504  [17]
 LDCM0184  Compound 20 HEK-293T 14.30  LDD0503  [17]
 LDCM0186  Compound 31 HEK-293T 9.66  LDD0506  [17]
 LDCM0187  Compound 32 HEK-293T 17.69  LDD0507  [17]
 LDCM0188  Compound 33 HEK-293T 5.92  LDD0505  [17]
 LDCM0495  E2913 HEK-293T C159(1.35)  LDD1698  [20]
 LDCM0468  Fragment33 PaTu 8988t C159(0.77)  LDD1347  [10]
 LDCM0427  Fragment51 HEK-293T C159(0.92)  LDD1631  [20]
 LDCM0116  HHS-0101 DM93 Y81(0.49); Y35(0.80); Y58(0.97)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y81(0.65); Y35(0.80); Y58(0.84)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y35(0.78); Y58(0.89); Y81(1.31)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y35(0.84); Y58(0.90); Y81(1.04)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y35(1.11); Y81(2.44); Y58(3.05)  LDD0268  [8]
 LDCM0123  JWB131 DM93 Y35(0.86); Y58(1.10)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y35(0.72); Y58(1.04); Y81(0.92)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y35(1.05); Y58(0.87); Y81(0.64)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y35(3.18); Y58(3.37); Y81(3.46)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y35(2.08); Y58(2.44); Y81(0.17)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y35(1.55); Y58(1.29)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y35(1.07); Y58(0.74)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y35(1.06); Y58(1.40)  LDD0292  [7]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HEK-293T C159(1.05)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C159(1.01)  LDD1497  [20]
 LDCM0024  KB05 HMCB C159(1.22)  LDD3312  [22]
 LDCM0627  NUDT7-COV-1 HEK-293T C159(2.44)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C159(0.33)  LDD2207  [23]
 LDCM0021  THZ1 HeLa S3 C159(1.08)  LDD0460  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) JIP scaffold family O60271
Arfaptin-1 (ARFIP1) . P53367
Cytohesin-2 (CYTH2) . Q99418

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Chlortetracycline . DB09093
Glycerin . DB09462
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315
Guanosine-5'-triphosphate Small molecular drug DB04137
Myristic Acid Small molecular drug DB08231
13-propanediol . DB02774
Brefeldin A . DB07348
Guanosine-3'-monophosphate-5'-diphosphate . DB04121

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
13 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
19 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.