Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name JN0003  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 32  Competitor Info 
Competitor Concentration 160 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 36 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 87.7
 LDTP13751  Exonuclease 1 (EXO1) 71.4
 LDTP02837  Beta-galactosidase (GLB1) 52.6
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 48.8
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 44.4
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 43.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 38.5
 LDTP12610  Obg-like ATPase 1 (OLA1) 38.0
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 34.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 31.7
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 28.4
 LDTP02198  Cathepsin D (CTSD) 25.6
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 21.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 21.3
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 19.2
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 19.2
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 18.6
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 17.8
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 17.7
 LDTP05192  ADP-ribosylation factor 1 (ARF1) 17.7
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 17.2
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 16.9
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 16.9
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 16.7
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 16.3
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 15.8
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 15.6
 LDTP02141  Alpha-galactosidase A (GLA) 12.9
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 11.4
 LDTP03842  Squalene synthase (FDFT1) 10.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 9.8
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 9.7
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 7.4
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.2
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02215  Prosaposin (PSAP) 55.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 51.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 45.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 19.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 19.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 19.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 19.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 17.0
 LDTP11213  Nucleoporin NDC1 (NDC1) 14.0
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12412  Reticulon-4 (RTN4) 132.3
 LDTP13630  Neudesin (NENF) 27.7
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 11.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.