Details of the Target

General Information of Target

Target ID	LDTP04285
Target Name	Proteasome subunit beta type-2 (PSMB2)
Gene Name	PSMB2
Gene ID	5690
Synonyms	Proteasome subunit beta type-2; Macropain subunit C7-I; Multicatalytic endopeptidase complex subunit C7-I; Proteasome component C7-I
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV RIIDKNGIHDLDNISFPKQGS
Target Bioclass	Enzyme
Family	Peptidase T1B family
Subcellular location	Cytoplasm
Function	Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Uniprot ID	P49721
Ensemble ID	ENST00000373237.4
HGNC ID	HGNC:9539
ChEMBL ID	CHEMBL3492

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 46 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	9.35	LDD0402	[1]
A-EBA Probe Info	5.62	LDD0215	[2]
Jackson_1 Probe Info	10.27	LDD0122	[3]
CHEMBL5175495 Probe Info	8.50	LDD0196	[4]
CY-1 Probe Info	100.00	LDD0243	[5]
CY4 Probe Info	100.00	LDD0244	[5]
N1 Probe Info	100.00	LDD0242	[5]
TH211 Probe Info	Y134(17.89)	LDD0257	[6]
TH216 Probe Info	Y134(8.81)	LDD0259	[6]
YN-1 Probe Info	100.00	LDD0444	[7]
STPyne Probe Info	K185(5.48); K68(0.61)	LDD0277	[8]
BTD Probe Info	C163(2.26); C91(5.77)	LDD1699	[9]
Probe 1 Probe Info	Y146(9.10)	LDD3495	[10]
Cep-alkyne Probe Info	2.14	LDD0284	[11]
DA-P3 Probe Info	5.81	LDD0185	[12]
AHL-Pu-1 Probe Info	C91(3.06)	LDD0168	[13]
HHS-482 Probe Info	Y134(0.55); Y73(0.16)	LDD0285	[14]
HHS-475 Probe Info	Y146(0.05); Y116(1.54); Y120(1.59); Y134(1.67)	LDD0264	[15]
HHS-465 Probe Info	Y134(4.22); Y147(0.72)	LDD2237	[16]
DBIA Probe Info	C91(1.02)	LDD0078	[17]
5E-2FA Probe Info	H189(0.00); H32(0.00)	LDD2235	[18]
ATP probe Probe Info	N.A.	LDD0199	[19]
4-Iodoacetamidophenylacetylene Probe Info	C163(0.00); C46(0.00); C91(0.00)	LDD0038	[20]
IA-alkyne Probe Info	C163(0.00); C91(0.00); C46(0.00)	LDD0036	[20]
IPIAA_H Probe Info	N.A.	LDD0030	[21]
IPIAA_L Probe Info	N.A.	LDD0031	[21]
Lodoacetamide azide Probe Info	C163(0.00); C46(0.00); C91(0.00)	LDD0037	[20]
IPM Probe Info	C163(0.00); C91(0.00)	LDD0025	[22]
JW-RF-010 Probe Info	N.A.	LDD0026	[22]
NAIA_4 Probe Info	N.A.	LDD2226	[23]
TFBX Probe Info	C163(0.00); C91(0.00)	LDD0027	[22]
WYneN Probe Info	N.A.	LDD0021	[24]
WYneO Probe Info	N.A.	LDD0022	[24]
Compound 10 Probe Info	N.A.	LDD2216	[25]
ENE Probe Info	N.A.	LDD0006	[24]
NPM Probe Info	N.A.	LDD0016	[24]
SF Probe Info	Y146(0.00); Y134(0.00)	LDD0028	[26]
Phosphinate-6 Probe Info	N.A.	LDD0018	[27]
1c-yne Probe Info	N.A.	LDD0228	[28]
Acrolein Probe Info	N.A.	LDD0217	[29]
Crotonaldehyde Probe Info	N.A.	LDD0219	[29]
Methacrolein Probe Info	N.A.	LDD0218	[29]
W1 Probe Info	N.A.	LDD0236	[30]
AOyne Probe Info	13.20	LDD0443	[31]
MPP-AC Probe Info	N.A.	LDD0428	[32]
NAIA_5 Probe Info	C163(0.00); C91(0.00)	LDD2223	[23]

PAL-AfBPP Probe

Click To Hide/Show 192 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C001 Probe Info	16.22	LDD1711	[33]
C004 Probe Info	7.57	LDD1714	[33]
C006 Probe Info	4.99	LDD1715	[33]
C007 Probe Info	6.77	LDD1716	[33]
C010 Probe Info	8.00	LDD1719	[33]
C011 Probe Info	4.99	LDD1720	[33]
C017 Probe Info	6.92	LDD1725	[33]
C022 Probe Info	24.42	LDD1728	[33]
C039 Probe Info	5.74	LDD1739	[33]
C040 Probe Info	21.86	LDD1740	[33]
C041 Probe Info	18.00	LDD1741	[33]
C042 Probe Info	7.26	LDD1742	[33]
C044 Probe Info	6.68	LDD1743	[33]
C055 Probe Info	24.93	LDD1752	[33]
C058 Probe Info	5.90	LDD1755	[33]
C059 Probe Info	15.67	LDD1756	[33]
C060 Probe Info	7.89	LDD1757	[33]
C063 Probe Info	18.64	LDD1760	[33]
C064 Probe Info	10.70	LDD1761	[33]
C067 Probe Info	7.11	LDD1763	[33]
C070 Probe Info	11.71	LDD1766	[33]
C071 Probe Info	8.34	LDD1767	[33]
C082 Probe Info	9.25	LDD1774	[33]
C085 Probe Info	14.03	LDD1777	[33]
C087 Probe Info	29.24	LDD1779	[33]
C088 Probe Info	9.38	LDD1780	[33]
C089 Probe Info	7.26	LDD1781	[33]
C092 Probe Info	21.41	LDD1783	[33]
C094 Probe Info	24.08	LDD1785	[33]
C106 Probe Info	25.63	LDD1793	[33]
C107 Probe Info	25.28	LDD1794	[33]
C108 Probe Info	14.42	LDD1795	[33]
C112 Probe Info	20.39	LDD1799	[33]
C130 Probe Info	9.38	LDD1812	[33]
C134 Probe Info	27.28	LDD1816	[33]
C135 Probe Info	13.27	LDD1817	[33]
C139 Probe Info	12.91	LDD1821	[33]
C140 Probe Info	15.24	LDD1822	[33]
C141 Probe Info	29.04	LDD1823	[33]
C143 Probe Info	25.46	LDD1825	[33]
C145 Probe Info	12.30	LDD1827	[33]
C147 Probe Info	13.83	LDD1829	[33]
C153 Probe Info	19.29	LDD1834	[33]
C156 Probe Info	8.40	LDD1836	[33]
C159 Probe Info	12.21	LDD1839	[33]
C160 Probe Info	27.47	LDD1840	[33]
C161 Probe Info	26.72	LDD1841	[33]
C163 Probe Info	19.29	LDD1843	[33]
C169 Probe Info	20.25	LDD1849	[33]
C173 Probe Info	6.06	LDD1853	[33]
C177 Probe Info	11.00	LDD1856	[33]
C178 Probe Info	21.56	LDD1857	[33]
C179 Probe Info	6.32	LDD1858	[33]
C182 Probe Info	6.36	LDD1860	[33]
C183 Probe Info	7.89	LDD1861	[33]
C185 Probe Info	8.40	LDD1863	[33]
C186 Probe Info	14.32	LDD1864	[33]
C187 Probe Info	21.86	LDD1865	[33]
C191 Probe Info	18.25	LDD1868	[33]
C193 Probe Info	8.40	LDD1869	[33]
C194 Probe Info	31.12	LDD1870	[33]
C195 Probe Info	6.41	LDD1871	[33]
C196 Probe Info	9.99	LDD1872	[33]
C197 Probe Info	9.65	LDD1873	[33]
C198 Probe Info	15.45	LDD1874	[33]
C201 Probe Info	57.68	LDD1877	[33]
C204 Probe Info	8.63	LDD1879	[33]
C205 Probe Info	7.62	LDD1880	[33]
C206 Probe Info	24.08	LDD1881	[33]
C208 Probe Info	6.23	LDD1883	[33]
C211 Probe Info	24.93	LDD1885	[33]
C212 Probe Info	7.73	LDD1886	[33]
C213 Probe Info	29.65	LDD1887	[33]
C214 Probe Info	5.66	LDD1888	[33]
C215 Probe Info	4.92	LDD1889	[33]
C216 Probe Info	9.13	LDD1890	[33]
C217 Probe Info	5.28	LDD1891	[33]
C218 Probe Info	30.27	LDD1892	[33]
C219 Probe Info	13.45	LDD1893	[33]
C220 Probe Info	39.67	LDD1894	[33]
C222 Probe Info	7.94	LDD1896	[33]
C225 Probe Info	8.06	LDD1898	[33]
C226 Probe Info	6.23	LDD1899	[33]
C228 Probe Info	29.65	LDD1901	[33]
C229 Probe Info	15.24	LDD1902	[33]
C231 Probe Info	31.78	LDD1904	[33]
C233 Probe Info	24.08	LDD1906	[33]
C234 Probe Info	10.13	LDD1907	[33]
C238 Probe Info	11.47	LDD1911	[33]
C240 Probe Info	11.47	LDD1913	[33]
C242 Probe Info	6.11	LDD1915	[33]
C243 Probe Info	16.00	LDD1916	[33]
C244 Probe Info	17.15	LDD1917	[33]
C246 Probe Info	26.17	LDD1919	[33]
C249 Probe Info	16.22	LDD1922	[33]
C252 Probe Info	9.32	LDD1925	[33]
C258 Probe Info	5.13	LDD1931	[33]
C264 Probe Info	24.59	LDD1935	[33]
C265 Probe Info	28.44	LDD1936	[33]
C270 Probe Info	19.84	LDD1940	[33]
C273 Probe Info	10.85	LDD1943	[33]
C277 Probe Info	18.25	LDD1947	[33]
C278 Probe Info	96.34	LDD1948	[33]
C280 Probe Info	18.64	LDD1950	[33]
C281 Probe Info	5.70	LDD1951	[33]
C282 Probe Info	44.32	LDD1952	[33]
C284 Probe Info	37.27	LDD1954	[33]
C285 Probe Info	29.24	LDD1955	[33]
C286 Probe Info	10.56	LDD1956	[33]
C287 Probe Info	12.04	LDD1957	[33]
C288 Probe Info	18.77	LDD1958	[33]
C289 Probe Info	38.05	LDD1959	[33]
C290 Probe Info	15.03	LDD1960	[33]
C292 Probe Info	5.66	LDD1962	[33]
C293 Probe Info	18.77	LDD1963	[33]
C296 Probe Info	13.00	LDD1966	[33]
C299 Probe Info	9.45	LDD1968	[33]
C300 Probe Info	7.57	LDD1969	[33]
C301 Probe Info	5.86	LDD1970	[33]
C303 Probe Info	13.27	LDD1972	[33]
C305 Probe Info	9.85	LDD1974	[33]
C307 Probe Info	7.52	LDD1975	[33]
C310 Probe Info	9.58	LDD1977	[33]
C322 Probe Info	9.19	LDD1988	[33]
C326 Probe Info	7.41	LDD1990	[33]
C327 Probe Info	5.21	LDD1991	[33]
C333 Probe Info	9.71	LDD1996	[33]
C337 Probe Info	6.15	LDD2000	[33]
C340 Probe Info	7.36	LDD2003	[33]
C342 Probe Info	5.94	LDD2004	[33]
C343 Probe Info	19.29	LDD2005	[33]
C344 Probe Info	5.24	LDD2006	[33]
C349 Probe Info	13.55	LDD2010	[33]
C350 Probe Info	32.90	LDD2011	[33]
C353 Probe Info	8.94	LDD2014	[33]
C354 Probe Info	8.63	LDD2015	[33]
C355 Probe Info	27.28	LDD2016	[33]
C356 Probe Info	19.84	LDD2017	[33]
C357 Probe Info	7.11	LDD2018	[33]
C360 Probe Info	6.11	LDD2021	[33]
C361 Probe Info	21.86	LDD2022	[33]
C362 Probe Info	34.78	LDD2023	[33]
C363 Probe Info	18.51	LDD2024	[33]
C364 Probe Info	18.00	LDD2025	[33]
C366 Probe Info	7.16	LDD2027	[33]
C367 Probe Info	5.74	LDD2028	[33]
C369 Probe Info	5.58	LDD2030	[33]
C376 Probe Info	10.63	LDD2036	[33]
C378 Probe Info	6.28	LDD2037	[33]
C380 Probe Info	6.41	LDD2039	[33]
C382 Probe Info	9.32	LDD2041	[33]
C383 Probe Info	14.72	LDD2042	[33]
C385 Probe Info	9.71	LDD2044	[33]
C386 Probe Info	18.51	LDD2045	[33]
C387 Probe Info	10.13	LDD2046	[33]
C388 Probe Info	39.95	LDD2047	[33]
C390 Probe Info	46.21	LDD2049	[33]
C391 Probe Info	17.15	LDD2050	[33]
C392 Probe Info	7.01	LDD2051	[33]
C393 Probe Info	8.28	LDD2052	[33]
C399 Probe Info	11.39	LDD2058	[33]
C403 Probe Info	20.39	LDD2061	[33]
C405 Probe Info	5.46	LDD2063	[33]
C407 Probe Info	12.82	LDD2064	[33]
C408 Probe Info	5.10	LDD2065	[33]
C413 Probe Info	12.91	LDD2069	[33]
C414 Probe Info	7.21	LDD2070	[33]
C419 Probe Info	25.99	LDD2074	[33]
C420 Probe Info	15.35	LDD2075	[33]
C424 Probe Info	9.13	LDD2079	[33]
C428 Probe Info	8.63	LDD2083	[33]
C429 Probe Info	27.47	LDD2084	[33]
C430 Probe Info	7.78	LDD2085	[33]
C431 Probe Info	21.11	LDD2086	[33]
C433 Probe Info	6.36	LDD2088	[33]
FFF probe11 Probe Info	14.77	LDD0471	[34]
FFF probe12 Probe Info	6.45	LDD0473	[34]
FFF probe13 Probe Info	20.00	LDD0475	[34]
FFF probe14 Probe Info	20.00	LDD0477	[34]
FFF probe15 Probe Info	10.88	LDD0478	[34]
FFF probe2 Probe Info	20.00	LDD0463	[34]
FFF probe3 Probe Info	14.66	LDD0464	[34]
FFF probe4 Probe Info	20.00	LDD0466	[34]
FFF probe6 Probe Info	8.31	LDD0468	[34]
FFF probe7 Probe Info	10.63	LDD0483	[34]
JN0003 Probe Info	20.00	LDD0469	[34]
STS-2 Probe Info	N.A.	LDD0139	[35]
BD-F Probe Info	G133(0.00); Y134(0.00)	LDD0024	[36]
LD-F Probe Info	D108(0.00); E109(0.00)	LDD0015	[36]
DA-2 Probe Info	N.A.	LDD0070	[37]
OEA-DA Probe Info	20.00	LDD0046	[38]
STS-1 Probe Info	N.A.	LDD0068	[39]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0548	1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one	MDA-MB-231	C163(0.35); C91(0.30)	LDD2142	[9]
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C91(0.47)	LDD2112	[9]
LDCM0502	1-(Cyanoacetyl)piperidine	MDA-MB-231	C163(0.71); C91(0.57)	LDD2095	[9]
LDCM0537	2-Cyano-N,N-dimethylacetamide	MDA-MB-231	C163(0.89); C91(0.96)	LDD2130	[9]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C163(1.12); C91(1.05)	LDD2117	[9]
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C163(1.64); C91(1.05)	LDD2152	[9]
LDCM0539	3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C163(0.57); C91(0.60)	LDD2132	[9]
LDCM0538	4-(Cyanoacetyl)morpholine	MDA-MB-231	C163(0.60)	LDD2131	[9]
LDCM0025	4SU-RNA	HEK-293T	C91(3.06)	LDD0168	[13]
LDCM0026	4SU-RNA+native RNA	HEK-293T	C91(5.04)	LDD0169	[13]
LDCM0214	AC1	HCT 116	C91(1.21)	LDD0531	[17]
LDCM0215	AC10	HCT 116	C163(0.91); C91(1.08)	LDD0532	[17]
LDCM0216	AC100	HCT 116	C91(1.07)	LDD0533	[17]
LDCM0217	AC101	HCT 116	C91(1.03)	LDD0534	[17]
LDCM0218	AC102	HCT 116	C91(1.11)	LDD0535	[17]
LDCM0219	AC103	HCT 116	C91(1.13)	LDD0536	[17]
LDCM0220	AC104	HCT 116	C91(0.96)	LDD0537	[17]
LDCM0221	AC105	HCT 116	C91(1.05)	LDD0538	[17]
LDCM0222	AC106	HCT 116	C91(1.10)	LDD0539	[17]
LDCM0223	AC107	HCT 116	C91(1.16)	LDD0540	[17]
LDCM0224	AC108	HCT 116	C91(1.10)	LDD0541	[17]
LDCM0225	AC109	HCT 116	C91(0.96)	LDD0542	[17]
LDCM0226	AC11	HCT 116	C163(0.87); C91(1.12)	LDD0543	[17]
LDCM0227	AC110	HCT 116	C91(1.19)	LDD0544	[17]
LDCM0228	AC111	HCT 116	C91(1.20)	LDD0545	[17]
LDCM0229	AC112	HCT 116	C91(1.12)	LDD0546	[17]
LDCM0230	AC113	HCT 116	C91(1.13)	LDD0547	[17]
LDCM0231	AC114	HCT 116	C91(1.24)	LDD0548	[17]
LDCM0232	AC115	HCT 116	C91(0.98)	LDD0549	[17]
LDCM0233	AC116	HCT 116	C91(1.05)	LDD0550	[17]
LDCM0234	AC117	HCT 116	C91(1.11)	LDD0551	[17]
LDCM0235	AC118	HCT 116	C91(1.20)	LDD0552	[17]
LDCM0236	AC119	HCT 116	C91(1.30)	LDD0553	[17]
LDCM0237	AC12	HCT 116	C163(0.93); C91(1.07)	LDD0554	[17]
LDCM0238	AC120	HCT 116	C91(1.21)	LDD0555	[17]
LDCM0239	AC121	HCT 116	C91(1.18)	LDD0556	[17]
LDCM0240	AC122	HCT 116	C91(1.27)	LDD0557	[17]
LDCM0241	AC123	HCT 116	C91(1.32)	LDD0558	[17]
LDCM0242	AC124	HCT 116	C91(1.25)	LDD0559	[17]
LDCM0243	AC125	HCT 116	C91(1.22)	LDD0560	[17]
LDCM0244	AC126	HCT 116	C91(1.16)	LDD0561	[17]
LDCM0245	AC127	HCT 116	C91(1.19)	LDD0562	[17]
LDCM0246	AC128	HCT 116	C91(0.81)	LDD0563	[17]
LDCM0247	AC129	HCT 116	C91(0.90)	LDD0564	[17]
LDCM0249	AC130	HCT 116	C91(1.04)	LDD0566	[17]
LDCM0250	AC131	HCT 116	C91(0.95)	LDD0567	[17]
LDCM0251	AC132	HCT 116	C91(1.08)	LDD0568	[17]
LDCM0252	AC133	HCT 116	C91(0.95)	LDD0569	[17]
LDCM0253	AC134	HCT 116	C91(1.05)	LDD0570	[17]
LDCM0254	AC135	HCT 116	C91(0.93)	LDD0571	[17]
LDCM0255	AC136	HCT 116	C91(1.05)	LDD0572	[17]
LDCM0256	AC137	HCT 116	C91(1.05)	LDD0573	[17]
LDCM0257	AC138	HCT 116	C91(1.33)	LDD0574	[17]
LDCM0258	AC139	HCT 116	C91(1.16)	LDD0575	[17]
LDCM0259	AC14	HCT 116	C163(0.88); C91(1.09)	LDD0576	[17]
LDCM0260	AC140	HCT 116	C91(1.23)	LDD0577	[17]
LDCM0261	AC141	HCT 116	C91(1.27)	LDD0578	[17]
LDCM0262	AC142	HCT 116	C91(1.14)	LDD0579	[17]
LDCM0263	AC143	HCT 116	C91(1.04)	LDD0580	[17]
LDCM0264	AC144	HCT 116	C91(1.14)	LDD0581	[17]
LDCM0265	AC145	HCT 116	C91(1.08)	LDD0582	[17]
LDCM0266	AC146	HCT 116	C91(1.04)	LDD0583	[17]
LDCM0267	AC147	HCT 116	C91(1.18)	LDD0584	[17]
LDCM0268	AC148	HCT 116	C91(1.07)	LDD0585	[17]
LDCM0269	AC149	HCT 116	C91(1.07)	LDD0586	[17]
LDCM0270	AC15	HCT 116	C163(0.92); C91(1.15)	LDD0587	[17]
LDCM0271	AC150	HCT 116	C91(1.02)	LDD0588	[17]
LDCM0272	AC151	HCT 116	C91(1.09)	LDD0589	[17]
LDCM0273	AC152	HCT 116	C91(1.06)	LDD0590	[17]
LDCM0274	AC153	HCT 116	C91(1.09)	LDD0591	[17]
LDCM0621	AC154	HCT 116	C91(1.08)	LDD2158	[17]
LDCM0622	AC155	HCT 116	C91(1.04)	LDD2159	[17]
LDCM0623	AC156	HCT 116	C91(0.94)	LDD2160	[17]
LDCM0624	AC157	HCT 116	C91(0.91)	LDD2161	[17]
LDCM0276	AC17	HCT 116	C91(0.98)	LDD0593	[17]
LDCM0277	AC18	HCT 116	C91(1.10)	LDD0594	[17]
LDCM0278	AC19	HCT 116	C91(0.99)	LDD0595	[17]
LDCM0279	AC2	HCT 116	C91(1.22)	LDD0596	[17]
LDCM0280	AC20	HCT 116	C91(0.91)	LDD0597	[17]
LDCM0281	AC21	HCT 116	C91(0.86)	LDD0598	[17]
LDCM0282	AC22	HCT 116	C91(0.98)	LDD0599	[17]
LDCM0283	AC23	HCT 116	C91(1.00)	LDD0600	[17]
LDCM0284	AC24	HCT 116	C91(0.97)	LDD0601	[17]
LDCM0285	AC25	HCT 116	C91(1.10)	LDD0602	[17]
LDCM0286	AC26	HCT 116	C91(1.18)	LDD0603	[17]
LDCM0287	AC27	HCT 116	C91(1.16)	LDD0604	[17]
LDCM0288	AC28	HCT 116	C91(1.18)	LDD0605	[17]
LDCM0289	AC29	HCT 116	C91(1.21)	LDD0606	[17]
LDCM0290	AC3	HCT 116	C91(1.19)	LDD0607	[17]
LDCM0291	AC30	HCT 116	C91(1.29)	LDD0608	[17]
LDCM0292	AC31	HCT 116	C91(1.17)	LDD0609	[17]
LDCM0293	AC32	HCT 116	C91(1.34)	LDD0610	[17]
LDCM0294	AC33	HCT 116	C91(1.22)	LDD0611	[17]
LDCM0295	AC34	HCT 116	C91(1.28)	LDD0612	[17]
LDCM0296	AC35	HCT 116	C91(0.89); C163(1.00)	LDD0613	[17]
LDCM0297	AC36	HCT 116	C91(0.97); C163(1.01)	LDD0614	[17]
LDCM0298	AC37	HCT 116	C91(0.95); C163(1.09)	LDD0615	[17]
LDCM0299	AC38	HCT 116	C91(0.97); C163(1.01)	LDD0616	[17]
LDCM0300	AC39	HCT 116	C91(1.06); C163(1.10)	LDD0617	[17]
LDCM0301	AC4	HCT 116	C91(1.20)	LDD0618	[17]
LDCM0302	AC40	HCT 116	C163(0.87); C91(1.08)	LDD0619	[17]
LDCM0303	AC41	HCT 116	C163(0.95); C91(0.97)	LDD0620	[17]
LDCM0304	AC42	HCT 116	C163(0.98); C91(1.00)	LDD0621	[17]
LDCM0305	AC43	HCT 116	C163(0.96); C91(1.06)	LDD0622	[17]
LDCM0306	AC44	HCT 116	C163(0.95); C91(1.05)	LDD0623	[17]
LDCM0307	AC45	HCT 116	C163(0.86); C91(1.06)	LDD0624	[17]
LDCM0308	AC46	HCT 116	C91(1.03); C163(1.07)	LDD0625	[17]
LDCM0309	AC47	HCT 116	C163(0.94); C91(1.05)	LDD0626	[17]
LDCM0310	AC48	HCT 116	C163(0.93); C91(1.05)	LDD0627	[17]
LDCM0311	AC49	HCT 116	C163(0.75); C91(1.03)	LDD0628	[17]
LDCM0312	AC5	HCT 116	C91(1.22)	LDD0629	[17]
LDCM0313	AC50	HCT 116	C163(0.73); C91(0.93)	LDD0630	[17]
LDCM0314	AC51	HCT 116	C91(0.91); C163(0.95)	LDD0631	[17]
LDCM0315	AC52	HCT 116	C163(0.97); C91(1.01)	LDD0632	[17]
LDCM0316	AC53	HCT 116	C163(0.87); C91(1.05)	LDD0633	[17]
LDCM0317	AC54	HCT 116	C163(0.91); C91(1.00)	LDD0634	[17]
LDCM0318	AC55	HCT 116	C163(0.74); C91(1.27)	LDD0635	[17]
LDCM0319	AC56	HCT 116	C163(0.58); C91(1.19)	LDD0636	[17]
LDCM0320	AC57	HCT 116	C91(0.97)	LDD0637	[17]
LDCM0321	AC58	HCT 116	C91(0.90)	LDD0638	[17]
LDCM0322	AC59	HCT 116	C91(1.02)	LDD0639	[17]
LDCM0323	AC6	HCT 116	C163(1.00); C91(1.19)	LDD0640	[17]
LDCM0324	AC60	HCT 116	C91(0.99)	LDD0641	[17]
LDCM0325	AC61	HCT 116	C91(1.00)	LDD0642	[17]
LDCM0326	AC62	HCT 116	C91(0.99)	LDD0643	[17]
LDCM0327	AC63	HCT 116	C91(1.00)	LDD0644	[17]
LDCM0328	AC64	HCT 116	C91(1.02)	LDD0645	[17]
LDCM0329	AC65	HCT 116	C91(1.13)	LDD0646	[17]
LDCM0330	AC66	HCT 116	C91(0.94)	LDD0647	[17]
LDCM0331	AC67	HCT 116	C91(1.06)	LDD0648	[17]
LDCM0332	AC68	HCT 116	C91(1.05)	LDD0649	[17]
LDCM0333	AC69	HCT 116	C91(1.05)	LDD0650	[17]
LDCM0334	AC7	HCT 116	C163(0.89); C91(1.08)	LDD0651	[17]
LDCM0335	AC70	HCT 116	C91(1.05)	LDD0652	[17]
LDCM0336	AC71	HCT 116	C91(0.96)	LDD0653	[17]
LDCM0337	AC72	HCT 116	C91(1.05)	LDD0654	[17]
LDCM0338	AC73	HCT 116	C91(1.05)	LDD0655	[17]
LDCM0339	AC74	HCT 116	C91(0.99)	LDD0656	[17]
LDCM0340	AC75	HCT 116	C91(1.04)	LDD0657	[17]
LDCM0341	AC76	HCT 116	C91(1.04)	LDD0658	[17]
LDCM0342	AC77	HCT 116	C91(1.04)	LDD0659	[17]
LDCM0343	AC78	HCT 116	C91(0.98)	LDD0660	[17]
LDCM0344	AC79	HCT 116	C91(1.09)	LDD0661	[17]
LDCM0345	AC8	HCT 116	C163(0.81); C91(1.13)	LDD0662	[17]
LDCM0346	AC80	HCT 116	C91(1.07)	LDD0663	[17]
LDCM0347	AC81	HCT 116	C91(0.97)	LDD0664	[17]
LDCM0348	AC82	HCT 116	C91(1.03)	LDD0665	[17]
LDCM0349	AC83	HCT 116	C91(1.00)	LDD0666	[17]
LDCM0350	AC84	HCT 116	C91(1.08)	LDD0667	[17]
LDCM0351	AC85	HCT 116	C91(1.08)	LDD0668	[17]
LDCM0352	AC86	HCT 116	C91(1.04)	LDD0669	[17]
LDCM0353	AC87	HCT 116	C91(1.08)	LDD0670	[17]
LDCM0354	AC88	HCT 116	C91(1.16)	LDD0671	[17]
LDCM0355	AC89	HCT 116	C91(1.10)	LDD0672	[17]
LDCM0357	AC90	HCT 116	C91(1.18)	LDD0674	[17]
LDCM0358	AC91	HCT 116	C91(1.25)	LDD0675	[17]
LDCM0359	AC92	HCT 116	C91(1.13)	LDD0676	[17]
LDCM0360	AC93	HCT 116	C91(1.14)	LDD0677	[17]
LDCM0361	AC94	HCT 116	C91(1.09)	LDD0678	[17]
LDCM0362	AC95	HCT 116	C91(1.12)	LDD0679	[17]
LDCM0363	AC96	HCT 116	C91(1.13)	LDD0680	[17]
LDCM0364	AC97	HCT 116	C91(1.25)	LDD0681	[17]
LDCM0365	AC98	HCT 116	C91(1.11)	LDD0682	[17]
LDCM0366	AC99	HCT 116	C91(1.13)	LDD0683	[17]
LDCM0545	Acetamide	MDA-MB-231	C91(0.68)	LDD2138	[9]
LDCM0520	AKOS000195272	MDA-MB-231	C163(0.59); C91(0.62)	LDD2113	[9]
LDCM0248	AKOS034007472	HCT 116	C163(0.93); C91(1.09)	LDD0565	[17]
LDCM0356	AKOS034007680	HCT 116	C163(0.89); C91(1.11)	LDD0673	[17]
LDCM0275	AKOS034007705	HCT 116	C163(1.02); C91(1.35)	LDD0592	[17]
LDCM0156	Aniline	NCI-H1299	12.08	LDD0403	[1]
LDCM0020	ARS-1620	HCC44	C91(1.02)	LDD0078	[17]
LDCM0498	BS-3668	MDA-MB-231	C163(0.93); C91(0.79)	LDD2091	[9]
LDCM0087	Capsaicin	HEK-293T	5.81	LDD0185	[12]
LDCM0122	Cepafungin 1	RPMI-8226	2.14	LDD0284	[11]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[29]
LDCM0632	CL-Sc	Hep-G2	C91(0.62)	LDD2227	[23]
LDCM0367	CL1	HCT 116	C163(0.75); C91(0.92)	LDD0684	[17]
LDCM0368	CL10	HCT 116	C163(1.00); C91(1.03)	LDD0685	[17]
LDCM0369	CL100	HCT 116	C91(1.21)	LDD0686	[17]
LDCM0370	CL101	HCT 116	C163(1.00); C91(1.16)	LDD0687	[17]
LDCM0371	CL102	HCT 116	C163(0.96); C91(1.10)	LDD0688	[17]
LDCM0372	CL103	HCT 116	C163(0.95); C91(0.97)	LDD0689	[17]
LDCM0373	CL104	HCT 116	C163(1.04); C91(1.07)	LDD0690	[17]
LDCM0374	CL105	HCT 116	C91(0.96)	LDD0691	[17]
LDCM0375	CL106	HCT 116	C91(1.09)	LDD0692	[17]
LDCM0376	CL107	HCT 116	C91(1.15)	LDD0693	[17]
LDCM0377	CL108	HCT 116	C91(1.12)	LDD0694	[17]
LDCM0378	CL109	HCT 116	C91(1.12)	LDD0695	[17]
LDCM0379	CL11	HCT 116	C163(0.94); C91(1.07)	LDD0696	[17]
LDCM0380	CL110	HCT 116	C91(1.06)	LDD0697	[17]
LDCM0381	CL111	HCT 116	C91(1.07)	LDD0698	[17]
LDCM0382	CL112	HCT 116	C91(1.06)	LDD0699	[17]
LDCM0383	CL113	HCT 116	C91(1.22)	LDD0700	[17]
LDCM0384	CL114	HCT 116	C91(1.22)	LDD0701	[17]
LDCM0385	CL115	HCT 116	C91(1.11)	LDD0702	[17]
LDCM0386	CL116	HCT 116	C91(1.19)	LDD0703	[17]
LDCM0387	CL117	HCT 116	C163(0.71); C91(0.99)	LDD0704	[17]
LDCM0388	CL118	HCT 116	C163(0.96); C91(1.00)	LDD0705	[17]
LDCM0389	CL119	HCT 116	C163(0.96); C91(1.07)	LDD0706	[17]
LDCM0390	CL12	HCT 116	C163(1.08); C91(1.13)	LDD0707	[17]
LDCM0391	CL120	HCT 116	C91(1.03); C163(1.11)	LDD0708	[17]
LDCM0392	CL121	HCT 116	C91(0.96); C163(1.13)	LDD0709	[17]
LDCM0393	CL122	HCT 116	C163(0.91); C91(0.98)	LDD0710	[17]
LDCM0394	CL123	HCT 116	C163(0.92); C91(1.15)	LDD0711	[17]
LDCM0395	CL124	HCT 116	C163(0.80); C91(1.18)	LDD0712	[17]
LDCM0396	CL125	HCT 116	C91(1.07)	LDD0713	[17]
LDCM0397	CL126	HCT 116	C91(0.77)	LDD0714	[17]
LDCM0398	CL127	HCT 116	C91(0.95)	LDD0715	[17]
LDCM0399	CL128	HCT 116	C91(0.97)	LDD0716	[17]
LDCM0400	CL13	HCT 116	C163(1.01); C91(1.02)	LDD0717	[17]
LDCM0401	CL14	HCT 116	C163(0.90); C91(0.96)	LDD0718	[17]
LDCM0402	CL15	HCT 116	C163(0.94); C91(0.98)	LDD0719	[17]
LDCM0403	CL16	HCT 116	C91(1.09)	LDD0720	[17]
LDCM0404	CL17	HCT 116	C91(1.09)	LDD0721	[17]
LDCM0405	CL18	HCT 116	C91(1.13)	LDD0722	[17]
LDCM0406	CL19	HCT 116	C91(1.11)	LDD0723	[17]
LDCM0407	CL2	HCT 116	C163(0.95); C91(0.98)	LDD0724	[17]
LDCM0408	CL20	HCT 116	C91(1.26)	LDD0725	[17]
LDCM0409	CL21	HCT 116	C91(1.25)	LDD0726	[17]
LDCM0410	CL22	HCT 116	C91(1.22)	LDD0727	[17]
LDCM0411	CL23	HCT 116	C91(1.18)	LDD0728	[17]
LDCM0412	CL24	HCT 116	C91(1.30)	LDD0729	[17]
LDCM0413	CL25	HCT 116	C91(1.31)	LDD0730	[17]
LDCM0414	CL26	HCT 116	C91(1.18)	LDD0731	[17]
LDCM0415	CL27	HCT 116	C91(1.24)	LDD0732	[17]
LDCM0416	CL28	HCT 116	C91(1.19)	LDD0733	[17]
LDCM0417	CL29	HCT 116	C91(1.28)	LDD0734	[17]
LDCM0418	CL3	HCT 116	C163(0.93); C91(0.96)	LDD0735	[17]
LDCM0419	CL30	HCT 116	C91(1.13)	LDD0736	[17]
LDCM0420	CL31	HCT 116	C91(0.99)	LDD0737	[17]
LDCM0421	CL32	HCT 116	C91(1.03)	LDD0738	[17]
LDCM0422	CL33	HCT 116	C91(1.02)	LDD0739	[17]
LDCM0423	CL34	HCT 116	C91(0.88)	LDD0740	[17]
LDCM0424	CL35	HCT 116	C91(1.01)	LDD0741	[17]
LDCM0425	CL36	HCT 116	C91(0.96)	LDD0742	[17]
LDCM0426	CL37	HCT 116	C91(1.08)	LDD0743	[17]
LDCM0428	CL39	HCT 116	C91(1.04)	LDD0745	[17]
LDCM0429	CL4	HCT 116	C163(1.03); C91(0.89)	LDD0746	[17]
LDCM0430	CL40	HCT 116	C91(1.06)	LDD0747	[17]
LDCM0431	CL41	HCT 116	C91(1.00)	LDD0748	[17]
LDCM0432	CL42	HCT 116	C91(1.06)	LDD0749	[17]
LDCM0433	CL43	HCT 116	C91(1.06)	LDD0750	[17]
LDCM0434	CL44	HCT 116	C91(1.05)	LDD0751	[17]
LDCM0435	CL45	HCT 116	C91(1.06)	LDD0752	[17]
LDCM0436	CL46	HCT 116	C91(1.12)	LDD0753	[17]
LDCM0437	CL47	HCT 116	C91(1.08)	LDD0754	[17]
LDCM0438	CL48	HCT 116	C91(1.06)	LDD0755	[17]
LDCM0439	CL49	HCT 116	C91(1.03)	LDD0756	[17]
LDCM0440	CL5	HCT 116	C163(1.02); C91(0.94)	LDD0757	[17]
LDCM0441	CL50	HCT 116	C91(1.02)	LDD0758	[17]
LDCM0442	CL51	HCT 116	C91(1.02)	LDD0759	[17]
LDCM0443	CL52	HCT 116	C91(1.07)	LDD0760	[17]
LDCM0444	CL53	HCT 116	C91(1.06)	LDD0761	[17]
LDCM0445	CL54	HCT 116	C91(1.00)	LDD0762	[17]
LDCM0446	CL55	HCT 116	C91(1.09)	LDD0763	[17]
LDCM0447	CL56	HCT 116	C91(1.05)	LDD0764	[17]
LDCM0448	CL57	HCT 116	C91(0.96)	LDD0765	[17]
LDCM0449	CL58	HCT 116	C91(1.09)	LDD0766	[17]
LDCM0450	CL59	HCT 116	C91(1.05)	LDD0767	[17]
LDCM0451	CL6	HCT 116	C163(0.94); C91(0.97)	LDD0768	[17]
LDCM0452	CL60	HCT 116	C91(1.05)	LDD0769	[17]
LDCM0453	CL61	HCT 116	C91(1.05)	LDD0770	[17]
LDCM0454	CL62	HCT 116	C91(1.03)	LDD0771	[17]
LDCM0455	CL63	HCT 116	C91(1.09)	LDD0772	[17]
LDCM0456	CL64	HCT 116	C91(0.99)	LDD0773	[17]
LDCM0457	CL65	HCT 116	C91(0.92)	LDD0774	[17]
LDCM0458	CL66	HCT 116	C91(1.03)	LDD0775	[17]
LDCM0459	CL67	HCT 116	C91(0.84)	LDD0776	[17]
LDCM0460	CL68	HCT 116	C91(0.94)	LDD0777	[17]
LDCM0461	CL69	HCT 116	C91(1.06)	LDD0778	[17]
LDCM0462	CL7	HCT 116	C163(1.15); C91(1.06)	LDD0779	[17]
LDCM0463	CL70	HCT 116	C91(0.91)	LDD0780	[17]
LDCM0464	CL71	HCT 116	C91(1.09)	LDD0781	[17]
LDCM0465	CL72	HCT 116	C91(1.01)	LDD0782	[17]
LDCM0466	CL73	HCT 116	C91(0.99)	LDD0783	[17]
LDCM0467	CL74	HCT 116	C91(0.98)	LDD0784	[17]
LDCM0469	CL76	HCT 116	C91(0.90)	LDD0786	[17]
LDCM0470	CL77	HCT 116	C91(1.02)	LDD0787	[17]
LDCM0471	CL78	HCT 116	C91(0.98)	LDD0788	[17]
LDCM0472	CL79	HCT 116	C91(1.04)	LDD0789	[17]
LDCM0473	CL8	HCT 116	C163(0.95); C91(1.08)	LDD0790	[17]
LDCM0474	CL80	HCT 116	C91(1.01)	LDD0791	[17]
LDCM0475	CL81	HCT 116	C91(0.95)	LDD0792	[17]
LDCM0476	CL82	HCT 116	C91(0.91)	LDD0793	[17]
LDCM0477	CL83	HCT 116	C91(1.02)	LDD0794	[17]
LDCM0478	CL84	HCT 116	C91(0.99)	LDD0795	[17]
LDCM0479	CL85	HCT 116	C91(1.03)	LDD0796	[17]
LDCM0480	CL86	HCT 116	C91(0.97)	LDD0797	[17]
LDCM0481	CL87	HCT 116	C91(0.90)	LDD0798	[17]
LDCM0482	CL88	HCT 116	C91(1.02)	LDD0799	[17]
LDCM0483	CL89	HCT 116	C91(1.02)	LDD0800	[17]
LDCM0484	CL9	HCT 116	C163(1.07); C91(1.03)	LDD0801	[17]
LDCM0485	CL90	HCT 116	C91(1.04)	LDD0802	[17]
LDCM0486	CL91	HCT 116	C91(1.13)	LDD0803	[17]
LDCM0487	CL92	HCT 116	C91(1.05)	LDD0804	[17]
LDCM0488	CL93	HCT 116	C91(1.05)	LDD0805	[17]
LDCM0489	CL94	HCT 116	C91(1.12)	LDD0806	[17]
LDCM0490	CL95	HCT 116	C91(1.15)	LDD0807	[17]
LDCM0491	CL96	HCT 116	C91(1.19)	LDD0808	[17]
LDCM0492	CL97	HCT 116	C91(1.17)	LDD0809	[17]
LDCM0493	CL98	HCT 116	C91(1.18)	LDD0810	[17]
LDCM0494	CL99	HCT 116	C91(1.19)	LDD0811	[17]
LDCM0189	Compound 16	HEK-293T	13.13	LDD0492	[34]
LDCM0185	Compound 17	HEK-293T	9.52	LDD0504	[34]
LDCM0182	Compound 18	HEK-293T	4.42	LDD0501	[34]
LDCM0184	Compound 20	HEK-293T	14.29	LDD0503	[34]
LDCM0191	Compound 21	HEK-293T	8.57	LDD0493	[34]
LDCM0186	Compound 31	HEK-293T	4.48	LDD0506	[34]
LDCM0187	Compound 32	HEK-293T	17.70	LDD0507	[34]
LDCM0188	Compound 33	HEK-293T	3.72	LDD0505	[34]
LDCM0190	Compound 34	HEK-293T	14.28	LDD0497	[34]
LDCM0192	Compound 35	HEK-293T	6.70	LDD0491	[34]
LDCM0193	Compound 36	HEK-293T	5.81	LDD0494	[34]
LDCM0194	Compound 37	HEK-293T	9.69	LDD0498	[34]
LDCM0195	Compound 38	HEK-293T	7.17	LDD0499	[34]
LDCM0196	Compound 39	HEK-293T	9.52	LDD0496	[34]
LDCM0197	Compound 40	HEK-293T	8.61	LDD0495	[34]
LDCM0181	Compound 41	HEK-293T	3.92	LDD0502	[34]
LDCM0634	CY-0357	Hep-G2	C91(0.74)	LDD2228	[23]
LDCM0495	E2913	HEK-293T	C91(0.89); C163(1.05); C46(1.07)	LDD1698	[40]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C91(1.55)	LDD1702	[9]
LDCM0625	F8	Ramos	C91(1.50); C163(0.96)	LDD2187	[41]
LDCM0572	Fragment10	Ramos	C91(0.76); C163(0.50)	LDD2189	[41]
LDCM0573	Fragment11	Ramos	C91(0.01); C163(0.13)	LDD2190	[41]
LDCM0574	Fragment12	Ramos	C91(0.59); C163(0.64)	LDD2191	[41]
LDCM0575	Fragment13	Ramos	C91(0.90); C163(0.88)	LDD2192	[41]
LDCM0576	Fragment14	Ramos	C91(0.92); C163(0.67)	LDD2193	[41]
LDCM0579	Fragment20	Ramos	C91(0.58); C163(0.49)	LDD2194	[41]
LDCM0580	Fragment21	Ramos	C91(0.80); C163(0.77)	LDD2195	[41]
LDCM0582	Fragment23	Ramos	C91(1.02); C163(0.94)	LDD2196	[41]
LDCM0578	Fragment27	Ramos	C91(0.93); C163(0.80)	LDD2197	[41]
LDCM0586	Fragment28	Ramos	C91(0.67); C163(0.62)	LDD2198	[41]
LDCM0588	Fragment30	Ramos	C91(1.12); C163(1.02)	LDD2199	[41]
LDCM0589	Fragment31	Ramos	C91(0.96); C163(0.76)	LDD2200	[41]
LDCM0590	Fragment32	Ramos	C91(0.58); C163(0.51)	LDD2201	[41]
LDCM0468	Fragment33	HCT 116	C91(1.01)	LDD0785	[17]
LDCM0596	Fragment38	Ramos	C91(0.90); C163(1.00)	LDD2203	[41]
LDCM0566	Fragment4	Ramos	C91(1.22); C163(0.72)	LDD2184	[41]
LDCM0427	Fragment51	HCT 116	C91(0.94)	LDD0744	[17]
LDCM0610	Fragment52	Ramos	C91(0.92); C163(1.21)	LDD2204	[41]
LDCM0614	Fragment56	Ramos	C91(1.11); C163(1.14)	LDD2205	[41]
LDCM0569	Fragment7	Ramos	C91(0.68); C163(0.62)	LDD2186	[41]
LDCM0571	Fragment9	Ramos	C91(0.71); C163(0.43)	LDD2188	[41]
LDCM0116	HHS-0101	DM93	Y146(0.05); Y116(1.54); Y120(1.59); Y134(1.67)	LDD0264	[15]
LDCM0117	HHS-0201	DM93	Y146(0.07); Y116(1.07); Y120(2.10); Y134(2.64)	LDD0265	[15]
LDCM0118	HHS-0301	DM93	Y146(0.07); Y116(0.63); Y120(2.01); Y134(2.48)	LDD0266	[15]
LDCM0119	HHS-0401	DM93	Y146(0.30); Y116(1.58); Y120(1.89); Y134(3.14)	LDD0267	[15]
LDCM0120	HHS-0701	DM93	Y146(0.29); Y120(2.45); Y116(3.27); Y134(8.70)	LDD0268	[15]
LDCM0107	IAA	HeLa	N.A.	LDD0221	[29]
LDCM0123	JWB131	DM93	Y134(0.55); Y73(0.16)	LDD0285	[14]
LDCM0124	JWB142	DM93	Y134(0.38); Y73(0.30)	LDD0286	[14]
LDCM0125	JWB146	DM93	Y134(1.12); Y73(1.25)	LDD0287	[14]
LDCM0126	JWB150	DM93	Y134(3.14); Y73(0.31)	LDD0288	[14]
LDCM0127	JWB152	DM93	Y134(0.81); Y73(1.39)	LDD0289	[14]
LDCM0128	JWB198	DM93	Y134(2.12); Y73(0.84)	LDD0290	[14]
LDCM0129	JWB202	DM93	Y73(0.42)	LDD0291	[14]
LDCM0130	JWB211	DM93	Y134(0.77); Y73(0.10)	LDD0292	[14]
LDCM0022	KB02	HCT 116	C91(1.23)	LDD0080	[17]
LDCM0023	KB03	HCT 116	C91(1.19)	LDD0081	[17]
LDCM0024	KB05	HCT 116	C91(1.15)	LDD0082	[17]
LDCM0509	N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide	MDA-MB-231	C163(1.53); C91(1.55)	LDD2102	[9]
LDCM0528	N-(4-bromophenyl)-2-cyano-N-phenylacetamide	MDA-MB-231	C163(1.06); C91(1.01)	LDD2121	[9]
LDCM0109	NEM	HeLa	N.A.	LDD0223	[29]
LDCM0496	Nucleophilic fragment 11a	MDA-MB-231	C163(1.13); C91(0.94)	LDD2089	[9]
LDCM0497	Nucleophilic fragment 11b	MDA-MB-231	C91(1.30)	LDD2090	[9]
LDCM0499	Nucleophilic fragment 12b	MDA-MB-231	C163(1.26); C91(1.18)	LDD2092	[9]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C163(1.33); C91(1.30)	LDD2093	[9]
LDCM0501	Nucleophilic fragment 13b	MDA-MB-231	C163(2.89); C91(2.64)	LDD2094	[9]
LDCM0503	Nucleophilic fragment 14b	MDA-MB-231	C163(0.17); C91(1.09)	LDD2096	[9]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C163(0.75); C91(0.72)	LDD2097	[9]
LDCM0505	Nucleophilic fragment 15b	MDA-MB-231	C163(1.00)	LDD2098	[9]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C163(1.89); C91(1.18)	LDD2099	[9]
LDCM0507	Nucleophilic fragment 16b	MDA-MB-231	C163(0.49); C91(0.29)	LDD2100	[9]
LDCM0508	Nucleophilic fragment 17a	MDA-MB-231	C163(0.81); C91(0.91)	LDD2101	[9]
LDCM0511	Nucleophilic fragment 18b	MDA-MB-231	C163(0.26)	LDD2104	[9]
LDCM0512	Nucleophilic fragment 19a	MDA-MB-231	C163(1.47); C91(1.12)	LDD2105	[9]
LDCM0513	Nucleophilic fragment 19b	MDA-MB-231	C163(0.24); C91(0.44)	LDD2106	[9]
LDCM0514	Nucleophilic fragment 20a	MDA-MB-231	C163(1.19); C91(0.86)	LDD2107	[9]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C163(0.56); C91(0.29)	LDD2108	[9]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C163(0.59); C91(0.65)	LDD2109	[9]
LDCM0517	Nucleophilic fragment 21b	MDA-MB-231	C163(0.22); C91(1.15)	LDD2110	[9]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C163(1.18); C91(1.01)	LDD2111	[9]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C91(0.93)	LDD2114	[9]
LDCM0522	Nucleophilic fragment 24a	MDA-MB-231	C163(0.35); C91(0.53)	LDD2115	[9]
LDCM0523	Nucleophilic fragment 24b	MDA-MB-231	C91(0.83)	LDD2116	[9]
LDCM0525	Nucleophilic fragment 25b	MDA-MB-231	C163(0.39)	LDD2118	[9]
LDCM0526	Nucleophilic fragment 26a	MDA-MB-231	C163(1.68); C91(1.61)	LDD2119	[9]
LDCM0527	Nucleophilic fragment 26b	MDA-MB-231	C163(0.57); C91(0.73)	LDD2120	[9]
LDCM0529	Nucleophilic fragment 27b	MDA-MB-231	C163(0.25); C91(0.97)	LDD2122	[9]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C163(0.91); C91(0.92)	LDD2123	[9]
LDCM0531	Nucleophilic fragment 28b	MDA-MB-231	C163(0.21); C91(0.59)	LDD2124	[9]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C163(1.03); C91(0.97)	LDD2125	[9]
LDCM0533	Nucleophilic fragment 29b	MDA-MB-231	C163(0.31); C91(0.57)	LDD2126	[9]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C163(1.43); C91(1.11)	LDD2127	[9]
LDCM0535	Nucleophilic fragment 30b	MDA-MB-231	C163(0.60); C91(0.41)	LDD2128	[9]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C163(1.51); C91(1.07)	LDD2129	[9]
LDCM0540	Nucleophilic fragment 35	MDA-MB-231	C91(0.50)	LDD2133	[9]
LDCM0541	Nucleophilic fragment 36	MDA-MB-231	C163(0.46); C91(0.39)	LDD2134	[9]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C163(1.66); C91(1.04)	LDD2135	[9]
LDCM0543	Nucleophilic fragment 38	MDA-MB-231	C163(1.65); C91(1.37)	LDD2136	[9]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C163(1.08); C91(0.95)	LDD2137	[9]
LDCM0211	Nucleophilic fragment 3b	MDA-MB-231	C163(3.22); C91(2.35)	LDD1700	[9]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C163(1.18); C91(0.86)	LDD2140	[9]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C163(0.62); C91(0.26)	LDD2141	[9]
LDCM0549	Nucleophilic fragment 43	MDA-MB-231	C163(0.70)	LDD2143	[9]
LDCM0550	Nucleophilic fragment 5a	MDA-MB-231	C163(1.85); C91(2.02)	LDD2144	[9]
LDCM0551	Nucleophilic fragment 5b	MDA-MB-231	C163(0.05); C91(0.79)	LDD2145	[9]
LDCM0552	Nucleophilic fragment 6a	MDA-MB-231	C163(1.08); C91(0.80)	LDD2146	[9]
LDCM0553	Nucleophilic fragment 6b	MDA-MB-231	C163(1.44); C91(1.16)	LDD2147	[9]
LDCM0554	Nucleophilic fragment 7a	MDA-MB-231	C163(0.39); C91(1.35)	LDD2148	[9]
LDCM0556	Nucleophilic fragment 8a	MDA-MB-231	C91(0.62)	LDD2150	[9]
LDCM0557	Nucleophilic fragment 8b	MDA-MB-231	C163(0.25); C91(1.08)	LDD2151	[9]
LDCM0559	Nucleophilic fragment 9b	MDA-MB-231	C163(1.66); C91(1.29)	LDD2153	[9]
LDCM0627	NUDT7-COV-1	HEK-293T	C91(0.81)	LDD2206	[42]
LDCM0628	OTUB2-COV-1	HEK-293T	C91(1.38); C91(0.74)	LDD2207	[42]
LDCM0131	RA190	MM1.R	C91(1.42)	LDD0304	[43]
LDCM0021	THZ1	HCT 116	C91(1.17)	LDD2173	[17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Proteasome subunit alpha type-1 (PSMA1)	Peptidase T1A family	P25786
Proteasome subunit beta type-1 (PSMB1)	Peptidase T1B family	P20618
Proteasome subunit beta type-3 (PSMB3)	Peptidase T1B family	P49720

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Huntingtin (HTT)				Huntingtin family	P42858

Other

Click To Hide/Show 7 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Protein INCA1 (INCA1)	INCA family	Q0VD86
Keratin-associated protein 19-1 (KRTAP19-1)	KRTAP type 19 family	Q8IUB9
Keratin-associated protein 19-5 (KRTAP19-5)	KRTAP type 19 family	Q3LI72
Keratin-associated protein 19-6 (KRTAP19-6)	KRTAP type 19 family	Q3LI70
Keratin-associated protein 19-7 (KRTAP19-7)	KRTAP type 19 family	Q3SYF9
Axin-2 (AXIN2)	.	Q9Y2T1
BTB/POZ domain-containing protein KCTD9 (KCTD9)	.	Q7L273

The Drug(s) Related To This Target

Approved

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Carfilzomib				Small molecular drug	DB08889

Investigative

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
(3ar6r6as)-6-((S)-((S)-cyclohex-2-enyl)(Hydroxy)Methyl)-6a-methyl-4-oxo-hexahydro-2h-furo[32-c]Pyrrole-6-carbaldehyde				.	DB08515

References

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3	Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
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21	SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25. Mass spectrometry data entry: PXD029500 , PXD031647
22	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
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28	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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33	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
34	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
35	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
36	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
37	Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
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Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni