Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C222 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03257 | Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) | 23.1 | ||||
| LDTP01769 | Dihydrofolate reductase (DHFR) | 18.5 | ||||
| LDTP09088 | Phospholipase A2 group XV (PLA2G15) | 13.0 | ||||
| LDTP03692 | Bifunctional epoxide hydrolase 2 (EPHX2) | 12.9 | ||||
| LDTP03787 | Choline kinase alpha (CHKA) | 12.8 | ||||
| LDTP11321 | Acetyl-CoA acetyltransferase, cytosolic (ACAT2) | 12.0 | ||||
| LDTP05758 | S-methyl-5'-thioadenosine phosphorylase (MTAP) | 11.2 | ||||
| LDTP06333 | Serum paraoxonase/arylesterase 2 (PON2) | 10.9 | ||||
| LDTP15484 | Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) | 9.4 | ||||
| LDTP16007 | Lipid droplet-associated hydrolase (LDAH) | 9.3 | ||||
| LDTP01982 | NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) | 9.1 | ||||
| LDTP02254 | ATP-dependent translocase ABCB1 (ABCB1) | 9.1 | ||||
| LDTP01039 | Protein-S-isoprenylcysteine O-methyltransferase (ICMT) | 9.1 | ||||
| LDTP01328 | CAAX prenyl protease 1 homolog (ZMPSTE24) | 8.7 | ||||
| LDTP13282 | Prenylcysteine oxidase 1 (PCYOX1) | 8.7 | ||||
| LDTP12013 | dCTP pyrophosphatase 1 (DCTPP1) | 8.2 | ||||
| LDTP04285 | Proteasome subunit beta type-2 (PSMB2) | 7.9 | ||||
| LDTP04004 | Lysosomal Pro-X carboxypeptidase (PRCP) | 7.8 | ||||
| LDTP02175 | Epoxide hydrolase 1 (EPHX1) | 7.7 | ||||
| LDTP12363 | Lysophosphatidic acid phosphatase type 6 (ACP6) | 7.6 | ||||
| LDTP10329 | Ceramide synthase 2 (CERS2) | 7.4 | ||||
| LDTP06375 | Delta(24)-sterol reductase (DHCR24) | 7.2 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 7.0 | ||||
| LDTP10550 | Dehydrogenase/reductase SDR family member 1 (DHRS1) | 6.9 | ||||
| LDTP05066 | Signal peptidase complex catalytic subunit SEC11A (SEC11A) | 6.7 | ||||
| LDTP09395 | Signal peptide peptidase-like 2A (SPPL2A) | 6.6 | ||||
| LDTP10188 | FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) | 6.6 | ||||
| LDTP06648 | Lanosterol 14-alpha demethylase (CYP51A1) | 6.4 | ||||
| LDTP04008 | Endothelin-converting enzyme 1 (ECE1) | 6.2 | ||||
| LDTP01389 | Delta(14)-sterol reductase TM7SF2 (TM7SF2) | 6.0 | ||||
| LDTP04712 | Puromycin-sensitive aminopeptidase (NPEPPS) | 5.9 | ||||
| LDTP08728 | Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) | 5.5 | ||||
| LDTP10182 | TLC domain-containing protein 1 (TLCD1) | 5.3 | ||||
| LDTP09256 | Putative phospholipase B-like 2 (PLBD2) | 5.3 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 32.7 | ||||
| LDTP07885 | Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) | 10.6 | ||||
| LDTP06945 | Sigma intracellular receptor 2 (TMEM97) | 8.6 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 8.2 | ||||
| LDTP06034 | Lysosome membrane protein 2 (SCARB2) | 7.2 | ||||
| LDTP15948 | Transmembrane protein 126A (TMEM126A) | 7.0 | ||||
| LDTP01804 | ATP synthase subunit a (MT-ATP6) | 6.7 | ||||
| LDTP16190 | Protein FAM8A1 (FAM8A1) | 6.3 | ||||
| LDTP16069 | Peroxisomal membrane protein 2 (PXMP2) | 6.1 | ||||
| LDTP06426 | Translocating chain-associated membrane protein 1 (TRAM1) | 6.1 | ||||
| LDTP00865 | Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) | 5.9 | ||||
| LDTP07236 | Protein GPR107 (GPR107) | 5.8 | ||||
| LDTP04071 | Voltage-dependent anion-selective channel protein 2 (VDAC2) | 5.5 | ||||
| LDTP03132 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 5.5 | ||||
| LDTP11162 | Solute carrier family 25 member 33 (SLC25A33) | 5.4 | ||||
| LDTP00592 | Surfeit locus protein 4 (SURF4) | 5.4 | ||||
| LDTP16813 | Tetraspanin-3 (TSPAN3) | 5.3 | ||||
| LDTP03277 | ER lumen protein-retaining receptor 1 (KDELR1) | 5.1 | ||||
| LDTP00541 | NPC intracellular cholesterol transporter 1 (NPC1) | 5.1 | ||||
GPCR
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP15303 | Membrane progestin receptor alpha (PAQR7) | 4.9 | ||||
Immunoglobulin
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP04720 | IgG receptor FcRn large subunit p51 (FCGRT) | 7.8 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03678 | ER lumen protein-retaining receptor 2 (KDELR2) | 12.8 | ||||
| LDTP00850 | ER lumen protein-retaining receptor 3 (KDELR3) | 8.9 | ||||
| LDTP13606 | Mammalian ependymin-related protein 1 (EPDR1) | 8.8 | ||||
| LDTP14486 | Clustered mitochondria protein homolog (CLUH) | 8.4 | ||||
| LDTP08130 | Rab9 effector protein with kelch motifs (RABEPK) | 7.9 | ||||
| LDTP05160 | Nucleobindin-2 (NUCB2) | 6.8 | ||||
| LDTP15623 | Neuferricin (CYB5D2) | 6.7 | ||||
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 6.5 | ||||
| LDTP05375 | Nucleobindin-1 (NUCB1) | 5.8 | ||||
| LDTP15067 | Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) | 5.7 | ||||
| LDTP05868 | Protein unc-119 homolog A (UNC119) | 5.2 | ||||
| LDTP08364 | Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) | 5.0 | ||||