Details of the Target

General Information of Target

Target ID LDTP14952
Target Name Mpv17-like protein 2 (MPV17L2)
Gene Name MPV17L2
Gene ID 84769
Synonyms
FKSG24; Mpv17-like protein 2
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTDNELSALVVDNGSGMCKAGFGGDDAPRAVFPSMIGRPRHQGVMVGMGQKDCYVGDEAQ
SKRGVLTLKYPIEHGVVTNWDDMEKIWYHTFYNELRVAPDEHPILLTEAPLNPKINREKM
TQIMFEAFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHIVPIYEGYALPHAILRLD
LAGRDLTDYLMKILTERGYNFTTTAEREIVRDVKEKLCYVALDFEQEMVRAAASSSPERS
YELPDGQVITIGNERFRCPEAIFQPSFLGIESSGIHETTFNSIMKCDVDIRKDLYANTVL
SGGSTMYPGIADRMQKEIITLAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISK
QEYDEAGPPIVHRKCF
Target Bioclass
Transporter and channel
Family
Peroxisomal membrane protein PXMP2/4 family
Subcellular location
Membrane
Function Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis.
Uniprot ID
Q567V2
Ensemble ID
ENST00000599612.3
HGNC ID
HGNC:28177

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.Q17H .
CHL1 SNV: p.V108L .
COLO320 SNV: p.V108L .
HEC1 SNV: p.A205S .
LS123 SNV: p.V108L .
LS180 SNV: p.L185S .
MEWO SNV: p.P196S .
SW1116 SNV: p.V108L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		6.36  LDD0196  [1]
Curcusone 37
 Probe Info  		3.09  LDD0188  [2]
AHL-Pu-1
 Probe Info  		C198(2.96)  LDD0169  [3]
Alkyne-RA190
 Probe Info  		6.79  LDD0299  [4]
EA-probe
 Probe Info  		C198(0.89)  LDD2210  [5]
DBIA
 Probe Info  		C198(0.98)  LDD0531  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
TFBX
 Probe Info  		C33(0.00); C198(0.00)  LDD0027  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 193 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.26  LDD1714  [15]
C006
 Probe Info  		8.17  LDD1715  [15]
C010
 Probe Info  		6.32  LDD1719  [15]
C011
 Probe Info  		5.78  LDD1720  [15]
C017
 Probe Info  		6.19  LDD1725  [15]
C018
 Probe Info  		7.36  LDD1726  [15]
C021
 Probe Info  		6.36  LDD1727  [15]
C022
 Probe Info  		78.25  LDD1728  [15]
C026
 Probe Info  		28.05  LDD1732  [15]
C027
 Probe Info  		12.64  LDD1733  [15]
C039
 Probe Info  		4.99  LDD1739  [15]
C040
 Probe Info  		17.63  LDD1740  [15]
C041
 Probe Info  		11.39  LDD1741  [15]
C044
 Probe Info  		6.19  LDD1743  [15]
C049
 Probe Info  		6.59  LDD1747  [15]
C055
 Probe Info  		18.77  LDD1752  [15]
C056
 Probe Info  		22.32  LDD1753  [15]
C063
 Probe Info  		44.32  LDD1760  [15]
C064
 Probe Info  		13.64  LDD1761  [15]
C065
 Probe Info  		7.36  LDD1762  [15]
C070
 Probe Info  		25.99  LDD1766  [15]
C071
 Probe Info  		14.22  LDD1767  [15]
C072
 Probe Info  		15.45  LDD1768  [15]
C082
 Probe Info  		16.68  LDD1774  [15]
C085
 Probe Info  		9.19  LDD1777  [15]
C087
 Probe Info  		16.80  LDD1779  [15]
C089
 Probe Info  		5.66  LDD1781  [15]
C091
 Probe Info  		36.00  LDD1782  [15]
C092
 Probe Info  		70.52  LDD1783  [15]
C094
 Probe Info  		74.03  LDD1785  [15]
C099
 Probe Info  		9.06  LDD1788  [15]
C100
 Probe Info  		5.70  LDD1789  [15]
C102
 Probe Info  		11.47  LDD1790  [15]
C106
 Probe Info  		24.93  LDD1793  [15]
C107
 Probe Info  		8.22  LDD1794  [15]
C108
 Probe Info  		14.72  LDD1795  [15]
C109
 Probe Info  		6.41  LDD1796  [15]
C111
 Probe Info  		13.09  LDD1798  [15]
C112
 Probe Info  		77.17  LDD1799  [15]
C129
 Probe Info  		10.70  LDD1811  [15]
C134
 Probe Info  		53.08  LDD1816  [15]
C135
 Probe Info  		18.90  LDD1817  [15]
C138
 Probe Info  		6.87  LDD1820  [15]
C139
 Probe Info  		36.76  LDD1821  [15]
C140
 Probe Info  		34.30  LDD1822  [15]
C141
 Probe Info  		12.13  LDD1823  [15]
C142
 Probe Info  		10.56  LDD1824  [15]
C143
 Probe Info  		30.48  LDD1825  [15]
C145
 Probe Info  		20.39  LDD1827  [15]
C147
 Probe Info  		22.63  LDD1829  [15]
C153
 Probe Info  		27.47  LDD1834  [15]
C157
 Probe Info  		5.82  LDD1837  [15]
C158
 Probe Info  		18.38  LDD1838  [15]
C159
 Probe Info  		28.25  LDD1839  [15]
C160
 Probe Info  		20.53  LDD1840  [15]
C161
 Probe Info  		47.18  LDD1841  [15]
C163
 Probe Info  		5.86  LDD1843  [15]
C166
 Probe Info  		7.01  LDD1846  [15]
C169
 Probe Info  		28.44  LDD1849  [15]
C173
 Probe Info  		10.56  LDD1853  [15]
C174
 Probe Info  		14.93  LDD1854  [15]
C176
 Probe Info  		10.13  LDD1855  [15]
C177
 Probe Info  		23.75  LDD1856  [15]
C178
 Probe Info  		41.64  LDD1857  [15]
C183
 Probe Info  		5.24  LDD1861  [15]
C185
 Probe Info  		4.92  LDD1863  [15]
C187
 Probe Info  		54.95  LDD1865  [15]
C191
 Probe Info  		17.27  LDD1868  [15]
C193
 Probe Info  		10.06  LDD1869  [15]
C194
 Probe Info  		24.42  LDD1870  [15]
C196
 Probe Info  		11.00  LDD1872  [15]
C197
 Probe Info  		9.78  LDD1873  [15]
C198
 Probe Info  		25.63  LDD1874  [15]
C199
 Probe Info  		9.71  LDD1875  [15]
C201
 Probe Info  		41.07  LDD1877  [15]
C203
 Probe Info  		6.96  LDD1878  [15]
C205
 Probe Info  		8.22  LDD1880  [15]
C206
 Probe Info  		24.59  LDD1881  [15]
C211
 Probe Info  		10.34  LDD1885  [15]
C212
 Probe Info  		5.62  LDD1886  [15]
C213
 Probe Info  		15.03  LDD1887  [15]
C216
 Probe Info  		19.70  LDD1890  [15]
C217
 Probe Info  		6.96  LDD1891  [15]
C218
 Probe Info  		34.06  LDD1892  [15]
C219
 Probe Info  		10.34  LDD1893  [15]
C220
 Probe Info  		37.27  LDD1894  [15]
C221
 Probe Info  		10.85  LDD1895  [15]
C222
 Probe Info  		8.22  LDD1896  [15]
C225
 Probe Info  		13.09  LDD1898  [15]
C226
 Probe Info  		12.82  LDD1899  [15]
C228
 Probe Info  		30.27  LDD1901  [15]
C229
 Probe Info  		16.34  LDD1902  [15]
C231
 Probe Info  		21.56  LDD1904  [15]
C232
 Probe Info  		44.02  LDD1905  [15]
C233
 Probe Info  		25.63  LDD1906  [15]
C234
 Probe Info  		9.25  LDD1907  [15]
C235
 Probe Info  		39.40  LDD1908  [15]
C238
 Probe Info  		18.38  LDD1911  [15]
C239
 Probe Info  		9.58  LDD1912  [15]
C240
 Probe Info  		15.03  LDD1913  [15]
C243
 Probe Info  		19.43  LDD1916  [15]
C244
 Probe Info  		16.11  LDD1917  [15]
C246
 Probe Info  		22.32  LDD1919  [15]
C249
 Probe Info  		22.63  LDD1922  [15]
C252
 Probe Info  		9.78  LDD1925  [15]
C258
 Probe Info  		6.63  LDD1931  [15]
C264
 Probe Info  		39.95  LDD1935  [15]
C265
 Probe Info  		47.18  LDD1936  [15]
C266
 Probe Info  		23.10  LDD1937  [15]
C269
 Probe Info  		20.82  LDD1939  [15]
C270
 Probe Info  		14.52  LDD1940  [15]
C280
 Probe Info  		23.43  LDD1950  [15]
C282
 Probe Info  		36.76  LDD1952  [15]
C284
 Probe Info  		33.13  LDD1954  [15]
C287
 Probe Info  		11.08  LDD1957  [15]
C288
 Probe Info  		8.57  LDD1958  [15]
C289
 Probe Info  		26.35  LDD1959  [15]
C290
 Probe Info  		13.45  LDD1960  [15]
C293
 Probe Info  		23.75  LDD1963  [15]
C296
 Probe Info  		17.88  LDD1966  [15]
C297
 Probe Info  		8.00  LDD1967  [15]
C299
 Probe Info  		9.71  LDD1968  [15]
C300
 Probe Info  		5.66  LDD1969  [15]
C303
 Probe Info  		8.11  LDD1972  [15]
C305
 Probe Info  		16.80  LDD1974  [15]
C307
 Probe Info  		8.11  LDD1975  [15]
C310
 Probe Info  		11.08  LDD1977  [15]
C313
 Probe Info  		15.35  LDD1980  [15]
C314
 Probe Info  		17.75  LDD1981  [15]
C317
 Probe Info  		6.36  LDD1983  [15]
C322
 Probe Info  		9.58  LDD1988  [15]
C326
 Probe Info  		11.71  LDD1990  [15]
C327
 Probe Info  		4.96  LDD1991  [15]
C328
 Probe Info  		5.58  LDD1992  [15]
C333
 Probe Info  		9.71  LDD1996  [15]
C335
 Probe Info  		6.73  LDD1998  [15]
C336
 Probe Info  		6.19  LDD1999  [15]
C337
 Probe Info  		7.73  LDD2000  [15]
C338
 Probe Info  		46.53  LDD2001  [15]
C339
 Probe Info  		29.86  LDD2002  [15]
C340
 Probe Info  		6.15  LDD2003  [15]
C342
 Probe Info  		8.40  LDD2004  [15]
C343
 Probe Info  		18.64  LDD2005  [15]
C346
 Probe Info  		31.12  LDD2007  [15]
C347
 Probe Info  		22.32  LDD2008  [15]
C355
 Probe Info  		26.72  LDD2016  [15]
C356
 Probe Info  		9.00  LDD2017  [15]
C362
 Probe Info  		26.35  LDD2023  [15]
C363
 Probe Info  		15.56  LDD2024  [15]
C364
 Probe Info  		16.80  LDD2025  [15]
C366
 Probe Info  		5.98  LDD2027  [15]
C367
 Probe Info  		7.46  LDD2028  [15]
C370
 Probe Info  		5.03  LDD2031  [15]
C373
 Probe Info  		6.68  LDD2033  [15]
C374
 Probe Info  		5.39  LDD2034  [15]
C376
 Probe Info  		7.11  LDD2036  [15]
C378
 Probe Info  		6.02  LDD2037  [15]
C380
 Probe Info  		7.73  LDD2039  [15]
C382
 Probe Info  		11.63  LDD2041  [15]
C383
 Probe Info  		14.72  LDD2042  [15]
C386
 Probe Info  		11.31  LDD2045  [15]
C388
 Probe Info  		53.08  LDD2047  [15]
C389
 Probe Info  		10.63  LDD2048  [15]
C390
 Probe Info  		99.73  LDD2049  [15]
C391
 Probe Info  		62.25  LDD2050  [15]
C392
 Probe Info  		5.58  LDD2051  [15]
C393
 Probe Info  		5.98  LDD2052  [15]
C394
 Probe Info  		21.71  LDD2053  [15]
C395
 Probe Info  		7.62  LDD2054  [15]
C396
 Probe Info  		16.00  LDD2055  [15]
C397
 Probe Info  		10.34  LDD2056  [15]
C399
 Probe Info  		14.62  LDD2058  [15]
C403
 Probe Info  		26.72  LDD2061  [15]
C413
 Probe Info  		44.32  LDD2069  [15]
C416
 Probe Info  		7.01  LDD2071  [15]
C424
 Probe Info  		24.93  LDD2079  [15]
C425
 Probe Info  		5.28  LDD2080  [15]
C426
 Probe Info  		81.01  LDD2081  [15]
C427
 Probe Info  		16.22  LDD2082  [15]
C428
 Probe Info  		8.06  LDD2083  [15]
C429
 Probe Info  		20.25  LDD2084  [15]
C430
 Probe Info  		8.00  LDD2085  [15]
C431
 Probe Info  		24.08  LDD2086  [15]
C432
 Probe Info  		8.63  LDD2087  [15]
C433
 Probe Info  		14.03  LDD2088  [15]
FFF probe11
 Probe Info  		20.00  LDD0471  [16]
FFF probe13
 Probe Info  		20.00  LDD0476  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe15
 Probe Info  		16.59  LDD0478  [16]
FFF probe3
 Probe Info  		20.00  LDD0464  [16]
FFF probe6
 Probe Info  		20.00  LDD0467  [16]
JN0003
 Probe Info  		20.00  LDD0484  [16]
OEA-DA
 Probe Info  		20.00  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C198(2.96)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C198(0.98)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C198(1.05); C33(0.94); C70(0.71)  LDD1508  [18]
 LDCM0216  AC100 HCT 116 C198(0.85)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C198(0.87)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C198(0.88)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C198(0.94)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C198(1.01)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C198(0.98)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C198(0.99)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C198(0.75)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C198(1.20)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C198(0.98)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C198(1.08); C70(0.96)  LDD1509  [18]
 LDCM0227  AC110 HCT 116 C198(1.00)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C198(0.94)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C198(0.88)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C198(1.01)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C198(1.14)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C198(1.03)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C198(0.97)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C198(0.99)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C198(0.95)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C198(1.36)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C198(0.97)  LDD1510  [18]
 LDCM0238  AC120 HCT 116 C198(1.13)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C198(1.02)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C198(1.00)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C198(1.06)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C198(1.00)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C198(1.11)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C198(1.04)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C198(0.98)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C198(0.97)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C198(1.04)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C198(1.07)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C198(1.12)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C198(1.22)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C198(1.07)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C198(1.37)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C198(1.08)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C198(1.35)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C198(1.12)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C198(1.48)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C198(1.38)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C198(0.97)  LDD1512  [18]
 LDCM0260  AC140 HCT 116 C198(1.65)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C198(1.64)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C198(1.24)  LDD0579  [6]
 LDCM0263  AC143 HEK-293T C198(1.04)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C198(1.10)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C198(1.12)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C198(1.04)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C198(1.10)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C198(1.24)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C198(1.19)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C198(0.93); C70(1.01)  LDD1513  [18]
 LDCM0271  AC150 HEK-293T C198(1.16)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C198(1.09)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C198(1.09)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C198(1.04)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C198(1.02)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C198(1.10)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C198(1.14)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C198(1.33)  LDD2165  [6]
 LDCM0276  AC17 HCT 116 C198(0.90)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C198(1.33)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C198(0.88)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C198(1.10)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C198(0.92)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C198(0.92)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C198(0.82)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C198(0.90)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C198(0.91)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C198(1.11)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C198(1.54)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C198(1.61)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C198(1.37)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C198(1.68)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C198(0.95)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C198(2.02)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C198(1.35)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C198(1.50)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C198(1.82)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C198(1.77)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C198(0.93)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C198(0.93)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C198(0.85)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C198(1.07)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C198(1.10)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C198(1.11)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C198(1.06)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C198(0.91)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C198(1.16)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C198(0.98)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C198(1.03)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C198(1.03)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C198(1.17)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C198(1.08)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C198(1.17)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C198(1.28)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C198(1.05)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C198(1.36)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C198(1.02)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C198(1.09)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C198(1.22)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C198(1.18)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C198(1.23)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C198(1.44)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C198(0.94)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C198(0.89)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C198(1.00)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C198(0.93)  LDD1562  [18]
 LDCM0324  AC60 HCT 116 C198(1.12)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C198(1.07)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C198(1.22)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C198(1.30)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C198(1.25)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C198(0.98)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C198(1.06)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C198(1.08)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C198(0.93)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C198(0.92)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C198(0.99); C70(0.97)  LDD1568  [18]
 LDCM0335  AC70 HCT 116 C198(0.86)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C198(0.92)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C198(1.06)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C198(1.04)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C198(0.95)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C198(1.10)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C198(1.04)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C198(1.06)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C198(0.93)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C198(1.06)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C70(0.89)  LDD1569  [18]
 LDCM0346  AC80 HCT 116 C198(1.10)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C198(0.92)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C198(0.92)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C198(1.80)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C198(1.89)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C198(1.34)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C198(1.63)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C198(1.41)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C198(1.27)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C198(1.45)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C198(1.36)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C198(1.60)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C198(1.93)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C198(1.38)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C198(1.38)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C198(1.44)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C198(1.29)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C198(1.68)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C198(1.25)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C198(0.81)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C198(0.99)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C198(1.13); C33(0.97)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C70(0.94)  LDD1514  [18]
 LDCM0367  CL1 HCT 116 C198(1.22)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C198(1.21)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C198(1.11)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C198(0.91); C33(0.97)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C198(0.93); C70(0.99)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C198(0.90); C33(1.14); C70(1.23)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C198(1.08); C33(0.94)  LDD1577  [18]
 LDCM0374  CL105 HCT 116 C198(1.01)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C198(1.29)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C198(1.24)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C198(1.30)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C198(1.07)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C198(1.18)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C198(1.24)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C198(0.91)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C198(1.32)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C198(1.58)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C198(1.55)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C198(1.80)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C198(1.99)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C198(1.34)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C198(1.18)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C198(1.13)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C198(1.24)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C198(0.96)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C198(0.97)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C198(1.19)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C198(1.33)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C198(1.27)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C198(1.03)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C198(1.06)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C198(1.06)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C198(1.09)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C198(1.09)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C198(1.22)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C198(0.92)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C198(1.37)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C198(1.53)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C198(1.13)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C198(1.51)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C198(0.94)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C198(1.51)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C198(1.46)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C198(2.50)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C198(1.37)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C198(1.59)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C198(1.43)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C198(1.53)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C198(1.49)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C198(1.51)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C198(1.84)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C198(1.07)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C198(0.99)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C198(1.27)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C198(1.89)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C198(1.47)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C198(1.58)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C198(1.88)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C198(1.58)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C198(1.70)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C198(2.91)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C198(0.89)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C198(1.71)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C198(1.74)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C198(2.27)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C198(1.98)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C198(2.06)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C198(3.67)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C198(1.00)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C198(0.89)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C198(0.79)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C198(0.95)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C198(0.80)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C198(0.87)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C198(0.87)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C198(0.86)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C198(0.86)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C198(0.93)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C198(0.81)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C198(0.99)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C198(0.82)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C198(0.90)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C198(0.96)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C198(0.93)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C198(0.98)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C198(0.91)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C198(0.86)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C198(0.76)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C198(0.81)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C198(0.81)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C198(0.86)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C198(0.88)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C198(0.80)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C198(0.83)  LDD1059  [6]
 LDCM0462  CL7 HCT 116 C198(0.97)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C198(0.82)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C198(0.70)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C198(0.99)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C198(0.73)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C198(0.70)  LDD1065  [6]
 LDCM0469  CL76 HCT 116 C198(0.94)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C198(0.85)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C198(1.14)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C198(1.06)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C198(1.56)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C198(0.82)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C198(0.88)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C198(1.06)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C198(1.11)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C198(1.09)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C198(0.85)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C198(1.19)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C198(1.25)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C198(1.12)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C198(1.33)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C198(1.25)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C198(0.84)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C198(1.04)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C198(0.85)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C198(0.91)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C198(0.98)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C198(1.08)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C198(0.98)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C198(1.01)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C198(1.02)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C198(1.01)  LDD0811  [6]
 LDCM0189  Compound 16 HEK-293T 23.81  LDD0492  [16]
 LDCM0191  Compound 21 HEK-293T 5.54  LDD0508  [16]
 LDCM0186  Compound 31 HEK-293T 15.75  LDD0506  [16]
 LDCM0188  Compound 33 HEK-293T 16.39  LDD0505  [16]
 LDCM0190  Compound 34 HEK-293T 32.79  LDD0497  [16]
 LDCM0192  Compound 35 HEK-293T 7.84  LDD0491  [16]
 LDCM0193  Compound 36 HEK-293T 11.56  LDD0511  [16]
 LDCM0194  Compound 37 HEK-293T 8.30  LDD0498  [16]
 LDCM0196  Compound 39 HEK-293T 9.57  LDD0496  [16]
 LDCM0197  Compound 40 HEK-293T 19.05  LDD0495  [16]
 LDCM0181  Compound 41 HEK-293T 13.79  LDD0502  [16]
 LDCM0033  Curcusone1d MCF-7 3.09  LDD0188  [2]
 LDCM0495  E2913 HEK-293T C198(0.88); C33(1.18); C70(1.16)  LDD1698  [18]
 LDCM0175  Ethacrynic acid HeLa C198(0.89)  LDD2210  [5]
 LDCM0625  F8 Ramos C198(0.90)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C198(1.74)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C198(0.11); C33(1.37)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C198(2.16); C33(0.35)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C198(0.96); C33(0.67)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C198(1.70); C33(1.77)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C33(0.34)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C198(0.98); C33(0.44)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C198(0.71); C33(0.37)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C198(0.82); C33(0.87)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C198(0.37); C33(1.17)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C198(1.04); C33(0.63)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C198(0.45); C33(0.76)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C198(2.82); C33(0.43)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C198(0.70)  LDD1066  [6]
 LDCM0596  Fragment38 Ramos C198(1.26); C33(0.39)  LDD2203  [19]
 LDCM0427  Fragment51 HCT 116 C198(3.75)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C198(0.91); C33(0.37)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C198(1.01); C33(0.36)  LDD2205  [19]
 LDCM0571  Fragment9 Ramos C33(0.39)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C33(0.96)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C33(0.92)  LDD1497  [18]
 LDCM0024  KB05 NCI-H1975 C198(2.20)  LDD3352  [20]
 LDCM0627  NUDT7-COV-1 HEK-293T C198(1.16); C33(1.11)  LDD2206  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C33(0.80); C198(0.45)  LDD2207  [21]
 LDCM0131  RA190 MM1.R 6.79  LDD0299  [4]
 LDCM0170  Structure8 Ramos 4.03  LDD0433  [22]

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
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7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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