Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name JN0003  Probe Info 
Probe concentration Probe:20uM; negative probe:20uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 91 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 20.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 20.0
 LDTP11127  ADP-dependent glucokinase (ADPGK) 20.0
 LDTP04907  ADP-ribosylation factor 3 (ARF3) 20.0
 LDTP02942  ADP-ribosylation factor 4 (ARF4) 20.0
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 20.0
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 20.0
 LDTP02837  Beta-galactosidase (GLB1) 20.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 20.0
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 20.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 20.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 20.0
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 20.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 20.0
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 20.0
 LDTP05171  Dermcidin (DCD) 20.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 20.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.0
 LDTP13751  Exonuclease 1 (EXO1) 20.0
 LDTP02651  Gamma-interferon-inducible lysosomal thiol reductase (IFI30) 20.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.0
 LDTP04183  Lanosterol synthase (LSS) 20.0
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 20.0
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 20.0
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 20.0
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 20.0
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 20.0
 LDTP02539  Lysosomal acid phosphatase (ACP2) 20.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 20.0
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.0
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 20.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 20.0
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 20.0
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 20.0
 LDTP03842  Squalene synthase (FDFT1) 20.0
 LDTP12056  Thiol S-methyltransferase TMT1A (TMT1A) 20.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 20.0
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 20.0
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 19.4
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 19.2
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 18.7
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 18.7
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 18.6
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 18.6
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 18.5
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 18.4
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 18.3
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 17.9
 LDTP05192  ADP-ribosylation factor 1 (ARF1) 17.9
 LDTP07931  Heme A synthase COX15 (COX15) 17.8
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 17.8
 LDTP10329  Ceramide synthase 2 (CERS2) 17.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 17.7
 LDTP02141  Alpha-galactosidase A (GLA) 17.2
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 16.9
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 16.5
 LDTP12610  Obg-like ATPase 1 (OLA1) 15.6
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 15.0
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 14.5
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 14.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 13.9
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 13.7
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 13.6
 LDTP04581  Holocytochrome c-type synthase (HCCS) 12.6
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 12.5
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 11.9
 LDTP00886  Nardilysin (NRDC) 10.9
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 10.7
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) 10.4
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 9.9
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 9.5
 LDTP12163  Calcyclin-binding protein (CACYBP) 9.5
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 9.5
 LDTP04892  Ras-related protein Rab-2A (RAB2A) 9.4
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) 9.4
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 9.3
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 9.1
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 8.5
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 6.6
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 5.5
Transporter and channel
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10036  BOS complex subunit NCLN (NCLN) 20.0
 LDTP02815  Desmoplakin (DSP) 20.0
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 20.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 20.0
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 20.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 20.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 20.0
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 20.0
 LDTP11213  Nucleoporin NDC1 (NDC1) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP07236  Protein GPR107 (GPR107) 20.0
 LDTP11615  Protein tweety homolog 3 (TTYH3) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 20.0
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 20.0
 LDTP00310  Syntenin-1 (SDCBP) 20.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 20.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 20.0
 LDTP15481  Transmembrane protein 87A (TMEM87A) 20.0
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 19.8
 LDTP05900  Metaxin-1 (MTX1) 19.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 19.5
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 19.2
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 19.0
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 18.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 17.3
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 17.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 17.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 16.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 16.5
 LDTP04501  Importin subunit alpha-1 (KPNA2) 15.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 14.1
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 13.5
 LDTP09949  Transportin-1 (TNPO1) 13.4
 LDTP20002  Transmembrane protein 160 (TMEM160) 13.3
 LDTP12090  Sideroflexin-1 (SFXN1) 12.2
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 12.2
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 11.4
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 10.9
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 10.7
 LDTP00592  Surfeit locus protein 4 (SURF4) 10.3
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155) 9.6
 LDTP03405  Calnexin (CANX) 8.2
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 8.1
 LDTP04787  Transmembrane protein 33 (TMEM33) 7.9
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 7.5
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 7.3
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 9.1
Other
Click to Show/Hide to Show 35 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 20.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 20.0
 LDTP01652  Centrosomal protein 43 (CEP43) 20.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.0
 LDTP08425  Hornerin (HRNR) 20.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 20.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP08594  Negative elongation factor C/D (NELFCD) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP05160  Nucleobindin-2 (NUCB2) 20.0
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 20.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 20.0
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 20.0
 LDTP14458  Tetraspanin-6 (TSPAN6) 20.0
 LDTP00105  Protein unc-119 homolog B (UNC119B) 19.6
 LDTP10056  Protein FAM162A (FAM162A) 16.6
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 16.4
 LDTP13630  Neudesin (NENF) 16.1
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 16.0
 LDTP12412  Reticulon-4 (RTN4) 15.9
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 15.8
 LDTP10408  Far upstream element-binding protein 3 (FUBP3) 14.8
 LDTP08224  Protein LYRIC (MTDH) 12.6
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 10.7
 LDTP06097  Reticulocalbin-2 (RCN2) 9.6
 LDTP05400  Lamin-B2 (LMNB2) 9.4
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 9.2
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 8.7
 LDTP02297  Vimentin (VIM) 7.8
 LDTP10684  RNA-binding protein 14 (RBM14) 6.4
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 6.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 6.1
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 5.2
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 5.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.