Details of the Target

General Information of Target

Target ID LDTP04907
Target Name ADP-ribosylation factor 3 (ARF3)
Gene Name ARF3
Gene ID 377
Synonyms
ADP-ribosylation factor 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN
ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV
LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNK
K
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Arf family
Subcellular location
Golgi apparatus
Function
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Uniprot ID
P61204
Ensemble ID
ENST00000256682.9
HGNC ID
HGNC:654

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LNCaP clone FGC SNV: p.G163E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.51  LDD0402  [1]
C-Sul
 Probe Info  		3.10  LDD0066  [2]
STPyne
 Probe Info  		K142(8.19)  LDD0277  [3]
AZ-9
 Probe Info  		D141(0.84); D26(1.02); K73(0.41)  LDD2208  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
DBIA
 Probe Info  		C159(1.33)  LDD3332  [5]
HHS-482
 Probe Info  		Y35(0.86); Y58(1.10)  LDD0285  [6]
HHS-475
 Probe Info  		Y81(0.49); Y35(0.80); Y58(0.97)  LDD0264  [7]
HHS-465
 Probe Info  		Y35(7.78); Y58(7.97); Y81(6.70)  LDD2237  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
ATP probe
 Probe Info  		N.A.  LDD0035  [12]
NHS
 Probe Info  		K36(0.00); K142(0.00)  LDD0010  [13]
SF
 Probe Info  		K59(0.00); Y58(0.00)  LDD0028  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		K142(0.00); K127(0.00)  LDD0228  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
AOyne
 Probe Info  		5.70  LDD0443  [18]
MPP-AC
 Probe Info  		N.A.  LDD0428  [19]
NAIA_5
 Probe Info  		N.A.  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		10.68  LDD0472  [21]
FFF probe12
 Probe Info  		5.06  LDD0473  [21]
FFF probe13
 Probe Info  		8.55  LDD0476  [21]
FFF probe2
 Probe Info  		7.03  LDD0463  [21]
FFF probe3
 Probe Info  		5.29  LDD0465  [21]
JN0003
 Probe Info  		20.00  LDD0469  [21]
STS-1
 Probe Info  		N.A.  LDD0136  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [22]
BD-F
 Probe Info  		I46(0.00); Y58(0.00); T55(0.00); K59(0.00)  LDD0024  [23]
LD-F
 Probe Info  		E57(0.00); E41(0.00); I42(0.00); P47(0.00)  LDD0015  [23]
OEA-DA
 Probe Info  		4.71  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C159(0.90)  LDD1507  [25]
 LDCM0215  AC10 PaTu 8988t C159(0.65)  LDD1094  [26]
 LDCM0226  AC11 PaTu 8988t C159(0.95)  LDD1105  [26]
 LDCM0230  AC113 PaTu 8988t C159(2.01)  LDD1109  [26]
 LDCM0231  AC114 PaTu 8988t C159(1.07)  LDD1110  [26]
 LDCM0232  AC115 PaTu 8988t C159(1.80)  LDD1111  [26]
 LDCM0233  AC116 PaTu 8988t C159(1.57)  LDD1112  [26]
 LDCM0234  AC117 PaTu 8988t C159(1.55)  LDD1113  [26]
 LDCM0235  AC118 PaTu 8988t C159(0.70)  LDD1114  [26]
 LDCM0236  AC119 PaTu 8988t C159(2.08)  LDD1115  [26]
 LDCM0237  AC12 PaTu 8988t C159(0.74)  LDD1116  [26]
 LDCM0238  AC120 PaTu 8988t C159(1.34)  LDD1117  [26]
 LDCM0239  AC121 PaTu 8988t C159(1.28)  LDD1118  [26]
 LDCM0240  AC122 PaTu 8988t C159(0.73)  LDD1119  [26]
 LDCM0241  AC123 PaTu 8988t C159(1.14)  LDD1120  [26]
 LDCM0242  AC124 PaTu 8988t C159(1.71)  LDD1121  [26]
 LDCM0243  AC125 PaTu 8988t C159(1.07)  LDD1122  [26]
 LDCM0244  AC126 PaTu 8988t C159(1.11)  LDD1123  [26]
 LDCM0245  AC127 PaTu 8988t C159(1.55)  LDD1124  [26]
 LDCM0246  AC128 PaTu 8988t C159(0.64)  LDD1125  [26]
 LDCM0247  AC129 PaTu 8988t C159(1.16)  LDD1126  [26]
 LDCM0249  AC130 PaTu 8988t C159(0.95)  LDD1128  [26]
 LDCM0250  AC131 PaTu 8988t C159(0.87)  LDD1129  [26]
 LDCM0251  AC132 PaTu 8988t C159(1.04)  LDD1130  [26]
 LDCM0252  AC133 PaTu 8988t C159(0.56)  LDD1131  [26]
 LDCM0253  AC134 PaTu 8988t C159(0.82)  LDD1132  [26]
 LDCM0254  AC135 PaTu 8988t C159(0.54)  LDD1133  [26]
 LDCM0255  AC136 PaTu 8988t C159(0.75)  LDD1134  [26]
 LDCM0256  AC137 PaTu 8988t C159(0.72)  LDD1135  [26]
 LDCM0257  AC138 PaTu 8988t C159(0.62)  LDD1136  [26]
 LDCM0258  AC139 PaTu 8988t C159(0.99)  LDD1137  [26]
 LDCM0259  AC14 PaTu 8988t C159(1.28)  LDD1138  [26]
 LDCM0260  AC140 PaTu 8988t C159(0.88)  LDD1139  [26]
 LDCM0261  AC141 PaTu 8988t C159(0.98)  LDD1140  [26]
 LDCM0262  AC142 PaTu 8988t C159(0.92)  LDD1141  [26]
 LDCM0263  AC143 PaTu 8988t C159(0.75)  LDD1142  [26]
 LDCM0264  AC144 PaTu 8988t C159(0.92)  LDD1143  [26]
 LDCM0265  AC145 PaTu 8988t C159(0.67)  LDD1144  [26]
 LDCM0266  AC146 PaTu 8988t C159(0.96)  LDD1145  [26]
 LDCM0267  AC147 PaTu 8988t C159(0.85)  LDD1146  [26]
 LDCM0268  AC148 PaTu 8988t C159(0.78)  LDD1147  [26]
 LDCM0269  AC149 PaTu 8988t C159(0.90)  LDD1148  [26]
 LDCM0270  AC15 PaTu 8988t C159(0.49)  LDD1149  [26]
 LDCM0271  AC150 PaTu 8988t C159(1.15)  LDD1150  [26]
 LDCM0272  AC151 PaTu 8988t C159(1.03)  LDD1151  [26]
 LDCM0273  AC152 PaTu 8988t C159(0.94)  LDD1152  [26]
 LDCM0274  AC153 PaTu 8988t C159(1.02)  LDD1153  [26]
 LDCM0621  AC154 PaTu 8988t C159(1.15)  LDD2166  [26]
 LDCM0622  AC155 PaTu 8988t C159(0.92)  LDD2167  [26]
 LDCM0623  AC156 PaTu 8988t C159(0.94)  LDD2168  [26]
 LDCM0624  AC157 PaTu 8988t C159(1.01)  LDD2169  [26]
 LDCM0276  AC17 PaTu 8988t C159(0.95)  LDD1155  [26]
 LDCM0277  AC18 PaTu 8988t C159(0.70)  LDD1156  [26]
 LDCM0278  AC19 PaTu 8988t C159(0.51)  LDD1157  [26]
 LDCM0279  AC2 HEK-293T C159(0.95)  LDD1518  [25]
 LDCM0280  AC20 PaTu 8988t C159(0.78)  LDD1159  [26]
 LDCM0281  AC21 PaTu 8988t C159(0.46)  LDD1160  [26]
 LDCM0282  AC22 PaTu 8988t C159(0.50)  LDD1161  [26]
 LDCM0283  AC23 PaTu 8988t C159(0.55)  LDD1162  [26]
 LDCM0284  AC24 PaTu 8988t C159(0.26)  LDD1163  [26]
 LDCM0285  AC25 HEK-293T C159(1.16)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C159(0.97)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C159(1.06)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C159(1.05)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C159(0.89)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C159(1.01)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C159(1.12)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C159(1.13)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C159(0.90)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C159(1.02)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C159(1.07)  LDD1534  [25]
 LDCM0296  AC35 PaTu 8988t C159(0.84)  LDD1175  [26]
 LDCM0297  AC36 PaTu 8988t C159(0.86)  LDD1176  [26]
 LDCM0298  AC37 PaTu 8988t C159(0.48)  LDD1177  [26]
 LDCM0299  AC38 PaTu 8988t C159(0.53)  LDD1178  [26]
 LDCM0300  AC39 PaTu 8988t C159(0.61)  LDD1179  [26]
 LDCM0301  AC4 HEK-293T C159(1.04)  LDD1540  [25]
 LDCM0302  AC40 PaTu 8988t C159(0.54)  LDD1181  [26]
 LDCM0303  AC41 PaTu 8988t C159(0.48)  LDD1182  [26]
 LDCM0304  AC42 PaTu 8988t C159(0.30)  LDD1183  [26]
 LDCM0305  AC43 PaTu 8988t C159(0.70)  LDD1184  [26]
 LDCM0306  AC44 PaTu 8988t C159(0.31)  LDD1185  [26]
 LDCM0307  AC45 PaTu 8988t C159(0.24)  LDD1186  [26]
 LDCM0308  AC46 HEK-293T C159(1.11)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C159(0.89)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C159(1.03)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C159(1.20)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C159(0.93)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C159(1.05)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C159(1.03)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C159(1.07)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C159(0.87)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C159(1.11)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C159(0.99)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C159(0.99)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C159(1.18)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C159(1.06)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C159(1.05)  LDD1561  [25]
 LDCM0323  AC6 PaTu 8988t C159(1.02)  LDD1202  [26]
 LDCM0324  AC60 HEK-293T C159(1.03)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C159(0.93)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C159(1.09)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C159(0.91)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C159(1.08)  LDD1567  [25]
 LDCM0334  AC7 PaTu 8988t C159(1.25)  LDD1213  [26]
 LDCM0345  AC8 PaTu 8988t C159(0.62)  LDD1224  [26]
 LDCM0248  AKOS034007472 PaTu 8988t C159(0.66)  LDD1127  [26]
 LDCM0356  AKOS034007680 PaTu 8988t C159(0.95)  LDD1235  [26]
 LDCM0275  AKOS034007705 PaTu 8988t C159(0.57)  LDD1154  [26]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0367  CL1 HEK-293T C159(1.08)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C159(1.20)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C159(1.03)  LDD1573  [25]
 LDCM0370  CL101 PaTu 8988t C159(1.18)  LDD1249  [26]
 LDCM0371  CL102 PaTu 8988t C159(1.06)  LDD1250  [26]
 LDCM0372  CL103 PaTu 8988t C159(0.65)  LDD1251  [26]
 LDCM0373  CL104 PaTu 8988t C159(1.27)  LDD1252  [26]
 LDCM0374  CL105 PaTu 8988t C159(0.67)  LDD1253  [26]
 LDCM0375  CL106 PaTu 8988t C159(0.55)  LDD1254  [26]
 LDCM0376  CL107 PaTu 8988t C159(0.93)  LDD1255  [26]
 LDCM0377  CL108 PaTu 8988t C159(0.59)  LDD1256  [26]
 LDCM0378  CL109 PaTu 8988t C159(1.06)  LDD1257  [26]
 LDCM0379  CL11 HEK-293T C159(0.95)  LDD1583  [25]
 LDCM0380  CL110 PaTu 8988t C159(0.56)  LDD1259  [26]
 LDCM0381  CL111 PaTu 8988t C159(0.53)  LDD1260  [26]
 LDCM0382  CL112 HEK-293T C159(0.96)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C159(0.98)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C159(1.01)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C159(1.00)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C159(1.08)  LDD1590  [25]
 LDCM0387  CL117 PaTu 8988t C159(0.71)  LDD1266  [26]
 LDCM0388  CL118 PaTu 8988t C159(0.24)  LDD1267  [26]
 LDCM0389  CL119 PaTu 8988t C159(0.48)  LDD1268  [26]
 LDCM0390  CL12 HEK-293T C159(0.90)  LDD1594  [25]
 LDCM0391  CL120 PaTu 8988t C159(0.89)  LDD1270  [26]
 LDCM0392  CL121 HEK-293T C159(0.91)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C159(1.11)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C159(1.04)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C159(1.13)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C159(0.99)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C159(1.05)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C159(1.13)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C159(1.05)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C159(1.09)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C159(1.09)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C159(1.03)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C159(1.11)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C159(0.94)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C159(1.06)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C159(1.24)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C159(1.02)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C159(1.06)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C159(1.02)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C159(1.14)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C159(0.88)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C159(1.00)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C159(0.98)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C159(1.03)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C159(1.22)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C159(1.04)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C159(0.99)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C159(0.98)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C159(1.09)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C159(1.05)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C159(1.01)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C159(1.14)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C159(1.06)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C159(1.11)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C159(1.09)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C159(1.06)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C159(1.02)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C159(1.01)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C159(1.04)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C159(0.97)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C159(1.00)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C159(1.02)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C159(1.10)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C159(1.04)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C159(1.04)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C159(1.00)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C159(0.88)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C159(1.12)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C159(1.16)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C159(0.95)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C159(1.09)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C159(1.11)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C159(1.05)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C159(1.15)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C159(1.06)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C159(1.00)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C159(1.12)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C159(0.99)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C159(1.06)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C159(0.97)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C159(0.99)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C159(1.06)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C159(1.01)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C159(1.03)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C159(1.02)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C159(0.96)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C159(1.09)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C159(1.04)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C159(1.05)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C159(1.05)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C159(0.94)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C159(1.00)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C159(1.03)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C159(0.99)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C159(1.01)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C159(0.98)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C159(1.08)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C159(1.11)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C159(1.15)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C159(1.07)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C159(1.04)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C159(1.09)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C159(1.09)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C159(0.99)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C159(0.89)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C159(1.06)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C159(1.03)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C159(1.09)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C159(1.01)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C159(1.09)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C159(0.96)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C159(1.02)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C159(1.11)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C159(1.01)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C159(1.03)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C159(1.01)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C159(0.91)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C159(0.90)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C159(0.99)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C159(1.05)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C159(0.94)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C159(1.01)  LDD1698  [25]
 LDCM0468  Fragment33 HEK-293T C159(1.05)  LDD1671  [25]
 LDCM0427  Fragment51 HEK-293T C159(0.93)  LDD1631  [25]
 LDCM0116  HHS-0101 DM93 Y81(0.49); Y35(0.80); Y58(0.97)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y81(0.65); Y35(0.80); Y58(0.84)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y35(0.78); Y58(0.89); Y81(1.31)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y35(0.84); Y58(0.90); Y81(1.04)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y35(1.11); Y81(2.44); Y58(3.05)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0123  JWB131 DM93 Y35(0.86); Y58(1.10)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y35(0.72); Y58(1.04); Y81(0.92)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y35(1.05); Y58(0.87); Y81(0.64)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y35(3.18); Y58(3.37); Y81(3.46)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y35(2.08); Y58(2.44); Y81(0.17)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y35(1.55); Y58(1.29)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y35(1.07); Y58(0.74)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y35(1.06); Y58(1.40)  LDD0292  [6]
 LDCM0022  KB02 BRX142 C159(1.36)  LDD2267  [5]
 LDCM0023  KB03 A-172 C159(0.93)  LDD2668  [5]
 LDCM0024  KB05 MKN45 C159(1.33)  LDD3332  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.