Details of the Target

General Information of Target

Target ID LDTP05400
Target Name Lamin-B2 (LMNB2)
Gene Name LMNB2
Gene ID 84823
Synonyms
LMN2; Lamin-B2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHY
IDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIE
IGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAEL
RAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERR
LVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAA
SAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEM
TEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSS
SSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEID
LEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAH
SPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGE
EDLFHQQGDPRTTSRGCYVM
Target Bioclass
Other
Family
Intermediate filament family
Subcellular location
Nucleus lamina
Function
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.
Uniprot ID
Q03252
Ensemble ID
ENST00000325327.4
HGNC ID
HGNC:6638

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1
 Probe Info  		2.44  LDD0415  [1]
AZ-9
 Probe Info  		5.49  LDD0393  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K123(10.00); K150(3.32); K195(7.23); K223(5.26)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
BTD
 Probe Info  		C212(0.96)  LDD2123  [5]
Jackson_1
 Probe Info  		2.14  LDD0120  [6]
DBIA
 Probe Info  		C192(1.11)  LDD0531  [7]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
IPM
 Probe Info  		N.A.  LDD0147  [12]
NHS
 Probe Info  		K285(0.00); K186(0.00); K275(0.00); K150(0.00)  LDD0010  [13]
NPM
 Probe Info  		N.A.  LDD0016  [13]
OSF
 Probe Info  		N.A.  LDD0029  [14]
SF
 Probe Info  		K47(0.00); Y319(0.00)  LDD0028  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
1c-yne
 Probe Info  		K489(0.00); K356(0.00); K150(0.00); K93(0.00)  LDD0228  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		14.83  LDD1713  [19]
C052
 Probe Info  		6.19  LDD1750  [19]
C087
 Probe Info  		7.06  LDD1779  [19]
C106
 Probe Info  		16.00  LDD1793  [19]
C210
 Probe Info  		44.94  LDD1884  [19]
C313
 Probe Info  		14.22  LDD1980  [19]
C338
 Probe Info  		12.21  LDD2001  [19]
C362
 Probe Info  		26.35  LDD2023  [19]
C391
 Probe Info  		13.93  LDD2050  [19]
FFF probe11
 Probe Info  		12.88  LDD0471  [20]
FFF probe12
 Probe Info  		12.01  LDD0473  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		17.16  LDD0477  [20]
FFF probe2
 Probe Info  		20.00  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
FFF probe6
 Probe Info  		20.00  LDD0467  [20]
FFF probe9
 Probe Info  		5.63  LDD0470  [20]
JN0003
 Probe Info  		14.59  LDD0469  [20]
OEA-DA
 Probe Info  		5.38  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C192(1.11)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C192(1.07)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C192(0.84)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C192(0.93)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C192(0.87)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C192(0.96)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C192(0.76)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C192(0.79)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C192(0.91)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C192(0.81)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C192(0.74)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C192(1.00)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C192(1.06)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C192(0.90)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C192(0.86)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C192(0.76)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C192(1.19)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C192(1.18)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C192(1.10)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C192(1.13)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C192(1.36)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C192(1.28)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C192(1.11)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C192(0.94)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C192(0.78)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C192(1.15)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C192(1.30)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C192(1.12)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C192(1.28)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C192(1.34)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C192(1.08)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C192(1.25)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C192(0.57)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C192(0.75)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C192(0.95)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C192(0.55)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C192(0.68)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C192(0.72)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C192(0.52)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C192(0.79)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C192(0.61)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C192(0.73)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C192(0.54)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C192(0.70)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C192(1.15)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C192(0.68)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C192(0.62)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C192(0.74)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C192(0.75)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C192(1.19)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C192(1.32)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C192(1.34)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C192(1.26)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C192(1.18)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C192(1.27)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C192(1.31)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C192(1.44)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C192(1.25)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C192(1.18)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C192(1.29)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C192(1.36)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C192(1.36)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C192(1.48)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C192(1.07)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C192(1.15)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C192(1.15)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C192(0.87)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C192(1.01)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C192(0.81)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C192(0.93)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C192(1.05)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C192(0.84)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C192(1.08)  LDD0601  [7]
 LDCM0285  AC25 PaTu 8988t C192(0.72)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C192(0.78)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C192(0.86)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C192(0.74)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C192(0.77)  LDD1168  [7]
 LDCM0290  AC3 HCT 116 C192(1.30)  LDD0607  [7]
 LDCM0291  AC30 PaTu 8988t C192(1.08)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C192(1.16)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C192(1.09)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C192(1.05)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C192(1.37)  LDD1174  [7]
 LDCM0296  AC35 HCT 116 C192(1.16)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C192(0.97)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C192(1.09)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C192(0.94)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C192(0.85)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C192(1.09)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C192(1.08)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C192(1.29)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C192(1.11)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C192(1.43)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C192(1.05)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C192(1.48)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C192(1.37)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C192(1.21)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C192(0.95)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C192(1.01)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C192(1.11)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C192(1.17)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C192(1.21)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C192(0.92)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C192(0.92)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C192(0.98)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C192(1.51)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C192(0.96)  LDD0636  [7]
 LDCM0320  AC57 PaTu 8988t C192(1.17)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C192(1.14)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C192(1.25)  LDD1201  [7]
 LDCM0323  AC6 HCT 116 C192(1.02)  LDD0640  [7]
 LDCM0324  AC60 PaTu 8988t C192(1.39)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C192(1.14)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C192(0.99)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C192(0.95)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C192(1.07)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C192(1.08)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C192(1.10)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C192(1.03)  LDD1210  [7]
 LDCM0332  AC68 HCT 116 C192(1.25)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C192(1.11)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C192(1.09)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C192(1.02)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C192(1.28)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C192(0.95)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C192(0.97)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C192(0.96)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C192(1.11)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C192(1.13)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C192(1.30)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C192(1.21)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C192(1.24)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C192(1.14)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C192(1.04)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C192(0.90)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C192(0.84)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C192(0.79)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C192(1.21)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C192(0.94)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C192(1.18)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C192(0.89)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C192(0.92)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C192(1.00)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C192(1.40)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C192(0.98)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C192(0.93)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C192(0.89)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C192(0.89)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C192(1.33)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C192(1.10)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C192(0.75)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C192(0.68)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C192(0.75)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C192(0.95)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C192(0.98)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C192(1.23)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.14  LDD0120  [6]
 LDCM0367  CL1 HCT 116 C192(1.16)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C192(1.24)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C192(1.01)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C192(0.89)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C192(0.90)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C192(1.11)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C192(1.04)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C192(1.08)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C192(1.13)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C192(1.29)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C192(1.12)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C192(1.11)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C192(1.31)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C192(0.80)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C192(0.79)  LDD0698  [7]
 LDCM0382  CL112 PaTu 8988t C192(0.93)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C192(0.97)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C192(0.85)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C192(0.79)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C192(1.55)  LDD1265  [7]
 LDCM0387  CL117 HCT 116 C192(1.02)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C192(1.30)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C192(1.34)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C192(1.68)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C192(0.94)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C192(1.05)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C192(0.94)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C192(0.82)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C192(0.89)  LDD0712  [7]
 LDCM0396  CL125 PaTu 8988t C192(1.02)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C192(0.97)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C192(1.03)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C192(1.10)  LDD1278  [7]
 LDCM0400  CL13 HCT 116 C192(1.49)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C192(1.25)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C192(1.50)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C192(1.22)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C192(1.29)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C192(3.00)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C192(2.01)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C192(1.22)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C192(1.35)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C192(1.32)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C192(1.45)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C192(1.46)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C192(2.03)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C192(1.72)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C192(1.24)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C192(1.65)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C192(1.60)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C192(1.71)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C192(1.27)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C192(1.89)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C192(0.83)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C192(1.11)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C192(1.03)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C192(1.13)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C192(1.00)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C192(0.95)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C192(1.10)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C192(1.04)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C192(1.56)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C192(1.00)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C192(0.97)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C192(0.93)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C192(1.05)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C192(1.11)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C192(1.14)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C192(0.75)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C192(0.87)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C192(0.92)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C192(0.96)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C192(1.49)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C192(0.97)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C192(1.11)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C192(0.71)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C192(0.68)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C192(0.67)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C192(0.91)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C192(0.84)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C192(1.01)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C192(0.78)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C192(1.05)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C192(1.37)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C192(1.00)  LDD0769  [7]
 LDCM0453  CL61 PaTu 8988t C192(1.23)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C192(0.90)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C192(1.00)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C192(1.09)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C192(1.10)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C192(1.06)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C192(1.11)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C192(1.68)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C192(1.36)  LDD1340  [7]
 LDCM0462  CL7 HCT 116 C192(1.40)  LDD0779  [7]
 LDCM0463  CL70 PaTu 8988t C192(1.06)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C192(0.78)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C192(1.20)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C192(0.99)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C192(1.59)  LDD1346  [7]
 LDCM0469  CL76 HCT 116 C192(1.40)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C192(1.07)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C192(1.30)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C192(1.26)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C192(1.22)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C192(1.20)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C192(1.28)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C192(1.23)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C192(1.24)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C192(1.74)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C192(1.00)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C192(1.38)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C192(5.45)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C192(1.35)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C192(1.28)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C192(1.33)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C192(1.75)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C192(1.30)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C192(1.02)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C192(0.95)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C192(1.02)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C192(0.99)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C192(1.00)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C192(0.92)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C192(1.02)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C192(1.03)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C212(1.02)  LDD1698  [22]
 LDCM0468  Fragment33 PaTu 8988t C192(1.22)  LDD1347  [7]
 LDCM0427  Fragment51 HCT 116 C192(1.06)  LDD0744  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C212(1.01)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C212(1.01)  LDD1497  [22]
 LDCM0024  KB05 G361 C212(1.50)  LDD3311  [23]
 LDCM0109  NEM HeLa H267(0.00); H157(0.00)  LDD0223  [17]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C212(0.96)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C212(0.73)  LDD2125  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carbonic anhydrase-related protein (CA8) Alpha-carbonic anhydrase family P35219
Fumarate hydratase, mitochondrial (FH) Class-II fumarase/aspartase family P07954
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Putative transcription factor Ovo-like 1 (OVOL1) . O14753
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Coiled-coil domain-containing protein 88B (CCDC88B) CCDC88 family A6NC98
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Lamin-B1 (LMNB1) Intermediate filament family P20700
Lamin-B2 (LMNB2) Intermediate filament family Q03252
Prelamin-A/C (LMNA) Intermediate filament family P02545
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840