Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name ILS-1  Probe Info 
Probe concentration 3 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lung
Disease Model Lung adenocarcinoma [ICD-11:2C25]
Model Name Human lung adenocarcinoma cells (A-549)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 9.4
 LDTP03842  Squalene synthase (FDFT1) 3.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 2.6
 LDTP05808  Transcription intermediary factor 1-beta (TRIM28) 2.1
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02262  Heat shock protein HSP 90-beta (HSP90AB1) 2.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 2.2
 LDTP08274  THO complex subunit 4 (ALYREF) 2.0
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ) 2.4
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ) 2.0
Other
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 6.6
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 4.8
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 4.3
 LDTP03063  Histone H2A type 1-D (H2AC7) 4.2
 LDTP05004  Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) 3.4
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 3.3
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 2.8
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 2.8
 LDTP05767  TAR DNA-binding protein 43 (TARDBP) 2.5
 LDTP05400  Lamin-B2 (LMNB2) 2.4
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 2.3
 LDTP09975  Histone H2B type 1-H (H2BC9) 2.2
 LDTP05274  Nucleolysin TIAR (TIAL1) 2.2
 LDTP03499  Elongation factor 1-delta (EEF1D) 2.2
 LDTP04958  Small ribosomal subunit protein eS7 (RPS7) 2.1
 LDTP02312  Small ribosomal subunit protein uS2 (RPSA) 2.0

References

1 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175