Details of the Target

General Information of Target

Target ID LDTP05767
Target Name TAR DNA-binding protein 43 (TARDBP)
Gene Name TARDBP
Gene ID 23435
Synonyms
TDP43; TAR DNA-binding protein 43; TDP-43
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGI
LHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDL
KEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNS
KQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIA
QSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLG
NNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQ
REPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Nucleus
Function
RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins. Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner. Negatively regulates the expression of CDK6. Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner.
TTD ID
T08014
Uniprot ID
Q13148
DrugMap ID
TT9RZ03
Ensemble ID
ENST00000240185.8
HGNC ID
HGNC:11571
ChEMBL ID
CHEMBL2362981

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.D236N; p.Q360H .
COLO792 SNV: p.P112L DBIA    Probe Info 
MFE319 SNV: p.D138G DBIA    Probe Info 
NCIH1155 SNV: p.G37R DBIA    Probe Info 
OVK18 SNV: p.A240V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.40  LDD0402  [1]
A-EBA
 Probe Info  		4.36  LDD0215  [2]
ILS-1
 Probe Info  		2.47  LDD0415  [3]
W1
 Probe Info  		11.77  LDD0235  [4]
TH211
 Probe Info  		Y374(20.00); Y73(13.73); Y77(10.34); Y214(10.12)  LDD0257  [5]
TH216
 Probe Info  		Y155(7.96)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
BTD
 Probe Info  		C50(3.53)  LDD1699  [7]
Probe 1
 Probe Info  		Y43(14.97); Y155(73.92)  LDD3495  [8]
THZ1-DTB
 Probe Info  		C39(1.05)  LDD0460  [9]
AHL-Pu-1
 Probe Info  		C198(2.01)  LDD0170  [10]
DBIA
 Probe Info  		C50(1.10)  LDD0078  [11]
5E-2FA
 Probe Info  		H256(0.00); H62(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K181(0.00); K263(0.00); K79(0.00); K82(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C244(0.00); C198(0.00); C50(0.00); C39(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C39(0.00); C198(0.00); C50(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		C39(0.00); C198(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C244(0.00); C198(0.00); C50(0.00); C39(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
aHNE
 Probe Info  		N.A.  LDD0001  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NHS
 Probe Info  		K84(0.00); K95(0.00); K181(0.00)  LDD0010  [19]
SF
 Probe Info  		K137(0.00); Y155(0.00)  LDD0028  [21]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
TFBX
 Probe Info  		N.A.  LDD0148  [17]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C244(0.00); C50(0.00); C39(0.00)  LDD0018  [22]
Ox-W18
 Probe Info  		W68(0.00); W172(0.00); W113(0.00)  LDD2175  [23]
1c-yne
 Probe Info  		K84(0.00); K95(0.00); K79(0.00); K121(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		H256(0.00); C198(0.00); H166(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		H166(0.00); C39(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C39(0.00); C50(0.00)  LDD0218  [25]
NAIA_5
 Probe Info  		C244(0.00); C198(0.00); C39(0.00); C50(0.00)  LDD2223  [18]
HHS-465
 Probe Info  		N.A.  LDD2240  [26]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		14.70  LDD0472  [27]
FFF probe13
 Probe Info  		6.25  LDD0475  [27]
FFF probe2
 Probe Info  		5.08  LDD0463  [27]
FFF probe3
 Probe Info  		5.92  LDD0464  [27]
STS-1
 Probe Info  		N.A.  LDD0136  [28]
STS-2
 Probe Info  		1.00  LDD0139  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C50(0.75)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C50(0.91)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C50(0.80)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C50(0.89)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C50(0.81)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C50(1.16)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C50(0.96)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C50(0.52)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C50(0.88)  LDD2131  [7]
 LDCM0025  4SU-RNA DM93 C198(2.01)  LDD0170  [10]
 LDCM0214  AC1 HCT 116 C198(2.07); C39(1.02); C50(1.41)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C198(0.72); C50(1.58)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C198(0.59); C50(1.05)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C198(0.56); C50(0.97)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C198(0.47); C50(0.98)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C198(0.37); C50(1.33)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C198(0.43); C50(1.00)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C198(0.44); C50(1.17)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C198(0.60); C50(1.36)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C198(0.40); C50(1.13)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C198(1.18); C50(1.13)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C198(0.58); C50(1.06)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C198(0.65); C50(1.39)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C198(0.58); C50(0.94)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C198(0.55); C50(0.94)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C198(0.50); C50(0.96)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C198(1.15); C50(0.97)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C198(0.93); C50(1.16)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C198(0.78); C50(1.25)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C198(0.81); C50(1.28)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C198(0.95); C50(1.26)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C198(1.02); C50(1.19)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C198(0.89); C50(1.19)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C198(0.77); C50(1.20)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C198(0.87); C50(0.87)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C198(1.13); C50(1.20)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C198(1.15); C50(1.25)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C198(0.90); C50(1.07)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C198(1.06); C50(1.05)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C198(1.02); C50(1.26)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C198(0.95); C50(1.23)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C198(1.02); C50(1.37)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C198(1.04); C50(1.29)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C198(2.37); C50(1.15)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C198(1.22); C50(1.42)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C198(1.15); C50(1.11)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C198(1.71); C50(1.44)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C198(1.31); C50(1.37)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C198(1.07); C50(1.51)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C198(1.22); C50(1.51)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C198(1.17); C50(1.37)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C198(1.42); C50(1.27)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C198(1.59); C50(1.55)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C198(1.69); C50(1.49)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C198(0.75); C50(1.53)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C198(1.84); C50(1.88)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C198(1.26); C50(1.70)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C198(2.54); C50(1.38)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C39(0.92); C198(1.12); C50(1.15)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C198(0.68); C39(0.82); C50(1.31)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C39(0.84); C198(0.85); C50(1.23)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C39(0.64); C198(0.84); C50(1.32)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C39(0.64); C198(0.66); C50(1.54)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C198(0.77); C39(0.78); C50(1.86)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C39(0.69); C198(0.82); C50(1.62)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C198(0.76); C50(1.41)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C39(0.76); C198(0.87); C50(1.17)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C198(0.89); C39(1.13); C50(1.17)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C198(0.61); C39(0.67); C50(1.35)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C39(0.71); C198(0.76); C50(1.91)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C198(0.65); C39(1.31); C50(1.33)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C198(0.77); C39(1.33); C50(1.30)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C198(0.96); C39(0.88); C50(1.14)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C198(1.01); C39(1.50); C50(1.17)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C198(1.02); C39(1.14); C50(1.16)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C198(0.42); C39(0.60); C50(0.96)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C198(0.61); C39(1.01); C50(1.16)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C39(1.12); C50(1.39); C198(1.66)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C198(0.78); C39(1.03); C50(1.10)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C198(0.71); C39(0.97); C50(1.00)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C39(0.99); C50(1.04); C198(1.06)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C39(0.80); C198(0.81); C50(1.06)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C198(1.00); C50(1.07); C39(1.30)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C198(0.91); C50(1.09); C39(1.34)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C198(0.84); C39(0.85); C50(1.33)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C198(0.67); C39(1.30); C50(1.65)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C198(0.73); C50(1.15); C39(1.18)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C198(0.76); C39(1.00); C50(1.47)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C39(0.92); C50(1.46); C198(2.32)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C198(0.62); C39(1.03); C50(1.23)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C198(0.65); C39(0.93); C50(1.46)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C198(0.60); C39(1.09); C50(1.64)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C198(0.62); C39(1.19); C50(1.34)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C198(0.53); C50(1.12); C39(1.33)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C50(0.79); C198(1.08)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C50(0.99); C198(1.01)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C198(0.65); C50(1.03)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C50(1.03); C198(1.22)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C50(1.06); C198(1.41)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C39(1.11); C50(1.58); C198(1.89)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C198(0.68); C50(1.02)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C198(0.87); C50(1.01)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C198(0.74); C50(0.99)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C198(0.96); C50(1.16)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C198(0.78); C50(1.03)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C198(0.84); C50(1.08)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C39(1.03); C50(1.15)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C39(0.68); C50(1.18)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C39(0.63); C50(1.42)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C39(0.91); C50(1.30)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C39(0.79); C198(1.45); C50(1.72)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C39(0.91); C50(1.31)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C39(0.63); C50(1.03)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C39(1.00); C50(1.19)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C39(0.73); C50(1.14)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C39(0.84); C50(1.06)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C39(0.99); C50(1.34)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C39(1.20); C50(1.60)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C198(0.70); C50(1.40)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C198(0.83); C50(1.60)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C198(0.85); C50(1.57)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C198(0.69); C50(1.48)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C198(0.85); C50(1.46)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C198(1.25); C50(1.43)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C198(0.78); C50(1.75)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C198(1.00); C50(1.44)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C198(0.83); C50(1.52)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C198(0.89); C50(1.72)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C198(1.05); C50(1.78)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C198(0.78); C50(1.85)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C50(0.91)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C50(0.95)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C198(0.68); C50(1.27)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C50(1.35)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C50(0.96)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C50(1.09)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C50(1.50)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C50(1.17)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C50(1.41)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C50(1.12)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C50(1.34)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C50(1.48)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C50(1.07)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C198(0.66); C50(1.23)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C50(1.10)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C50(0.96)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C50(1.66)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C198(0.43); C50(1.46)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C198(0.36); C50(1.42)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C198(0.52); C50(1.40)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C198(0.61); C50(1.40)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C198(0.74); C50(1.22)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C198(0.68); C50(1.29)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C198(0.62); C50(1.56)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C198(0.79); C50(1.31)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C198(0.44); C50(1.58)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C198(0.37); C50(1.57)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C198(0.49); C50(1.29)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C198(0.56); C50(1.18)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C198(0.72); C50(1.36)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C198(0.62); C50(1.47)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C198(0.38); C50(1.52)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C198(0.36); C50(1.43)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C198(0.72); C50(0.89)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C50(0.42)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C50(0.88)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C198(1.22); C50(1.24)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C198(0.93); C50(1.29)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C198(0.55); C50(1.90)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C50(1.10)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C50(0.87)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C39(0.00); H256(0.00); C50(0.00); H166(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C50(0.79)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C39(0.84); C50(0.91)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C39(1.15); C50(1.31)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C39(0.88); C50(1.54); C198(1.87)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C198(0.79); C50(1.39)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C198(0.99); C50(1.21)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C198(0.67); C50(1.14)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C198(0.97); C50(1.17)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C198(0.60); C39(0.97); C50(1.19)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C198(0.51); C39(0.95); C50(1.30)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C198(0.56); C39(0.86); C50(1.32)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C198(0.51); C39(0.94); C50(1.27)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C198(0.69); C50(1.24); C39(1.31)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C39(1.14); C50(1.38)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C198(0.55); C39(0.95); C50(1.26)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C198(0.68); C39(0.90); C50(1.14)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C50(0.72); C39(0.76); C198(0.92)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C198(0.57); C39(0.89); C50(1.01)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C198(0.81); C39(0.94); C50(1.06)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C39(0.78); C198(0.80); C50(1.03)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C39(0.78); C198(0.81); C50(1.42)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C198(0.96); C50(1.24)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C198(0.95); C50(1.06)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C198(0.76); C50(1.12)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C39(1.07); C50(1.67)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C50(1.16); C198(1.30)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C39(0.89); C50(1.04)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C39(0.64); C50(1.17)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C39(0.96); C50(1.15)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C39(0.76); C50(1.26)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C50(1.07); C198(1.29)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C198(1.05); C50(1.12)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C198(0.87); C50(1.22)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C198(0.82); C50(1.50)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C50(1.24); C39(1.35)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C50(1.11); C39(1.34)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C39(1.12); C50(1.21)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C198(0.80); C39(1.08); C50(1.15)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C198(0.82); C39(0.89); C50(1.17)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C198(0.67); C39(1.21); C50(1.38)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C198(0.50); C39(1.30); C50(1.31)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C50(0.94); C39(1.04)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C198(0.57); C39(1.17); C50(1.58)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C198(0.54); C39(1.16); C50(1.48)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C198(0.55); C39(1.75); C50(1.87)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C198(0.60); C50(1.20); C39(1.21)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C198(0.59); C39(1.38); C50(1.64)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C198(0.48); C39(1.10); C50(1.68)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C198(0.73); C39(1.30); C50(1.54)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C198(0.87); C39(1.09); C50(1.38)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C198(0.62); C39(1.63); C50(1.37)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C198(0.82); C39(1.47); C50(1.79)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C39(1.07); C50(0.98)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C198(0.60); C39(0.98); C50(1.31)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C198(0.74); C50(1.02)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C198(0.85); C50(1.05)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C198(0.85); C50(0.99)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C198(0.69); C50(1.24)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C198(0.49); C50(1.10)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C198(0.58); C50(1.21)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C198(0.62); C50(1.23)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C198(0.61); C50(1.05)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C39(1.18); C50(0.99)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C198(0.49); C50(1.15)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C198(0.65); C50(1.18)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C198(0.61); C50(1.52)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C198(0.68); C50(1.31)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C198(0.71); C50(1.17)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C198(0.60); C50(1.24)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C198(1.77); C50(0.95)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C198(1.63); C50(0.92)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C198(1.84); C50(0.93)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C198(1.25); C50(0.95)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C39(1.23); C50(1.07)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C198(1.80); C50(0.97)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C198(1.63); C50(1.01)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C198(1.93); C50(1.10)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C198(1.50); C50(0.89)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C198(1.53); C50(0.90)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C198(1.35); C50(1.06)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C198(1.20); C50(1.08)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C198(1.40); C50(0.92)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C198(1.60); C50(0.96)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C198(1.27); C50(1.01)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C39(1.07); C50(1.11)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C198(1.21); C50(1.13)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C198(0.86); C39(0.91); C50(1.07)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C198(0.93); C39(0.76); C50(1.19)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C198(0.97); C39(0.79); C50(1.17)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C198(0.66); C39(0.86); C50(1.40)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C198(0.78); C39(0.86); C50(1.22)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C198(0.63); C39(0.88); C50(1.43)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C198(0.58); C39(0.70); C50(1.18)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C198(0.74); C39(0.68); C50(1.18)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C198(0.97); C39(1.10); C50(1.05)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C39(1.02); C50(1.16)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C198(0.77); C39(0.77); C50(1.28)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C198(0.70); C39(0.71); C50(1.07)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C198(0.92); C39(0.55); C50(1.10)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C198(0.61); C39(0.99); C50(1.17)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C198(0.73); C39(0.85); C50(1.25)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C198(0.60); C50(1.12)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C198(0.53); C50(0.88)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C198(0.69); C50(1.33)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C198(0.53); C50(1.60)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C39(1.17); C50(1.45)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C198(0.45); C50(1.12)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C198(0.57); C50(1.23)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C198(0.50); C50(1.71)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C198(0.50); C50(1.60)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C198(0.56); C50(1.90)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C198(0.93); C50(1.44)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C198(0.76); C50(1.24)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C198(0.63); C50(1.34)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C198(0.58); C50(1.69)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C198(0.50); C50(2.10)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C39(1.34); C50(1.15)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C198(0.70); C50(1.11)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C198(1.07); C39(0.99); C50(1.37)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C198(0.85); C39(0.81); C50(1.27)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C198(1.21); C39(0.93); C50(1.27)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C198(1.35); C39(0.83); C50(1.29)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C198(0.91); C39(0.79); C50(1.40)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C198(1.11); C39(0.89); C50(1.39)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C198(1.16); C39(1.00); C50(1.37)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C198(1.98); C39(0.94); C50(1.50)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C198(2.22); C39(1.00); C50(1.43)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C50(0.92); C198(1.06); C39(0.81); C244(1.01)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C50(2.21)  LDD1702  [7]
 LDCM0625  F8 Ramos C50(1.43); 1.25; C39(0.31)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C50(0.57); 0.41; C39(0.34)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C50(0.01); 0.52; C39(0.83)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C50(0.46); 0.41; C39(0.31)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C50(1.19); 1.16; C39(0.58)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C50(1.06); 0.42; C39(1.35)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C50(0.46); 0.45; C39(0.59)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C50(1.42); 0.59; C39(0.25)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C50(0.72); 0.44; C39(0.78)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C50(1.34); 1.17; C39(0.39)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C50(0.51); 2.53  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C50(1.10); 0.36; C39(0.77)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C50(0.77); 0.38  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C50(0.55); 0.26; C39(0.45)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C198(0.65); C39(0.60); C50(1.17)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C50(1.11); 0.21; C39(0.70)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C50(0.87); 1.05; C39(0.14)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C198(0.48); C50(1.62)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C50(0.86); 0.91; C39(0.30)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C50(0.74); 0.65  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C50(0.78); 0.90; C39(0.33)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C50(0.44); 0.33; C39(0.54)  LDD2188  [30]
 LDCM0107  IAA HeLa H256(0.00); C39(0.00)  LDD0221  [25]
 LDCM0022  KB02 HCT 116 C50(1.59); C198(1.66)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C50(1.37); C198(1.75)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C50(1.97); C198(1.42)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C50(1.30)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C50(0.77)  LDD2121  [7]
 LDCM0109  NEM HeLa H256(0.00); H166(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C50(0.56)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C50(1.21)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C50(0.79)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C50(1.04)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C50(1.13)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C50(0.69)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C50(1.18)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C50(0.92)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C50(0.92)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C50(0.87)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C50(1.06)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C50(0.74)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C50(1.07)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C50(0.64)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C50(0.90)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C50(0.83)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C50(0.69)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C50(1.07)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C50(0.97)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C50(0.63)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C50(0.45)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C50(0.97)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C50(1.15)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C50(2.03)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C50(0.68)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C50(1.07)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C50(0.79)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C50(1.00)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C50(0.69)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C50(1.27)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C50(0.89)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C50(0.86)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C50(0.97)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C50(1.44)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C50(0.56)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C50(1.18)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C50(1.18)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C50(0.84)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C50(1.67)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C50(0.67)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C50(0.81)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C50(0.97)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C50(1.90)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C50(6.63)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C50(1.12)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C50(1.54)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C50(0.46)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C50(1.23)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C50(0.44)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C50(1.44)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C50(2.18)  LDD2153  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C50(0.36)  LDD2207  [31]
 LDCM0131  RA190 MM1.R C198(1.26); C39(1.21); C50(1.16)  LDD0304  [32]
 LDCM0021  THZ1 HeLa S3 C39(1.05)  LDD0460  [9]
 LDCM0110  W12 Hep-G2 C50(4.47)  LDD0237  [4]
 LDCM0113  W17 Hep-G2 C50(1.38)  LDD0240  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 53 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-3' exoribonuclease 2 (XRN2) 5'-3' exonuclease family Q9H0D6
Cell division cycle protein 16 homolog (CDC16) APC6/CDC16 family Q13042
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
ATP-dependent RNA helicase DDX3X (DDX3X) DEAD box helicase family O00571
Probable ATP-dependent RNA helicase DDX17 (DDX17) DEAD box helicase family Q92841
Probable ATP-dependent RNA helicase DDX5 (DDX5) DEAD box helicase family P17844
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Adenylyltransferase and sulfurtransferase MOCS3 (MOCS3) HesA/MoeB/ThiF family O95396
Histone deacetylase 6 (HDAC6) Histone deacetylase family Q9UBN7
L-lactate dehydrogenase A-like 6B (LDHAL6B) LDH family Q9BYZ2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 (PCMTD2) L-isoaspartyl/D-aspartyl protein methyltransferase family Q9NV79
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Ubiquitin carboxyl-terminal hydrolase 13 (USP13) Peptidase C19 family Q92995
Ubiquitin carboxyl-terminal hydrolase 48 (USP48) Peptidase C19 family Q86UV5
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
MPN domain-containing protein (MPND) Peptidase M67 family Q8N594
STAM-binding protein (STAMBP) Peptidase M67C family O95630
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Proteasome subunit beta type-4 (PSMB4) Peptidase T1B family P28070
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) Proteasome subunit S2 family Q13200
Mitogen-activated protein kinase 11 (MAPK11) CMGC Ser/Thr protein kinase family Q15759
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) TKL Ser/Thr protein kinase family O43187
E3 ubiquitin-protein ligase RAD18 (RAD18) RAD18 family Q9NS91
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) RBR family Q9BYM8
E3 ubiquitin-protein ligase RNF14 (RNF14) RBR family Q9UBS8
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
E3 ubiquitin-protein ligase RNF10 (RNF10) RNF10 family Q8N5U6
ADP-ribosylation factor-like protein 16 (ARL16) Arf family Q0P5N6
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
SPRY domain-containing SOCS box protein 1 (SPSB1) SPSB family Q96BD6
RING finger protein 112 (RNF112) GB1/RHD3 GTPase family Q9ULX5
tRNA modification GTPase GTPBP3, mitochondrial (GTPBP3) TrmE GTPase family Q969Y2
Mannose-1-phosphate guanyltransferase alpha (GMPPA) Transferase hexapeptide repeat family Q96IJ6
E3 ubiquitin-protein ligase TRIM8 (TRIM8) TRIM/RBCC family Q9BZR9
E3 ubiquitin-protein ligase TRIM9 (TRIM9) TRIM/RBCC family Q9C026
Ubiquitin-like modifier-activating enzyme 7 (UBA7) Ubiquitin-activating E1 family P41226
Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) Ubiquitin-conjugating enzyme family Q13404
BTB/POZ domain-containing protein 1 (BTBD1) . Q9H0C5
Double-stranded RNA-specific adenosine deaminase (ADAR) . P55265
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
E3 ubiquitin-protein ligase CBL-C (CBLC) . Q9ULV8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase makorin-2 (MKRN2) . Q9H000
E3 ubiquitin-protein ligase RNF138 (RNF138) . Q8WVD3
E3 ubiquitin-protein ligase RNF166 (RNF166) . Q96A37
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
E3 ubiquitin-protein transferase RMND5A (RMND5A) . Q9H871
E3 ubiquitin-protein transferase RMND5B (RMND5B) . Q96G75
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) . Q1L5Z9
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
RING finger protein 37 (UBOX5) . O94941
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
V-type proton ATPase subunit B, kidney isoform (ATP6V1B1) ATPase alpha/beta chains family P15313
Choline transporter-like protein 5 (SLC44A5) CTL (choline transporter-like) family Q8NCS7
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) WD repeat G protein beta family P62879
Membrane protein MLC1 (MLC1) . Q15049
Nucleoporin Nup43 (NUP43) . Q8NFH3
Transcription factor
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
Protein Jade-3 (JADE3) JADE family Q92613
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Y-box-binding protein 1 (YBX1) YBX1 family P67809
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) . O75398
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
Myc proto-oncogene protein (MYC) . P01106
T-box transcription factor TBX22 (TBX22) . Q9Y458
THAP domain-containing protein 3 (THAP3) . Q8WTV1
Transcription factor HES-4 (HES4) . Q9HCC6
Transcription factor p65 (RELA) . Q04206
Zinc finger and BTB domain-containing protein 25 (ZBTB25) . P24278
Zinc finger protein 366 (ZNF366) . Q8N895
Zinc finger protein 581 (ZNF581) . Q9P0T4
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 64 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 13 (ASB13) Ankyrin SOCS box (ASB) family Q8WXK3
Ankyrin repeat and SOCS box protein 9 (ASB9) Ankyrin SOCS box (ASB) family Q96DX5
Annexin A8 (ANXA8) Annexin family P13928
Ataxin-2 (ATXN2) Ataxin-2 family Q99700
Protein BEX5 (BEX5) BEX family Q5H9J7
Protein Tob1 (TOB1) BTG family P50616
Epithelial splicing regulatory protein 1 (ESRP1) ESRP family Q6NXG1
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Protein FAM98C (FAM98C) FAM98 family Q17RN3
Baculoviral IAP repeat-containing protein 5 (BIRC5) IAP family O15392
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
NSFL1 cofactor p47 (NSFL1C) NSFL1C family Q9UNZ2
Phosphofurin acidic cluster sorting protein 1 (PACS1) PACS family Q6VY07
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) PPP1R15 family O75807
ELAV-like protein 1 (ELAVL1) RRM elav family Q15717
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) RRM IMP/VICKZ family Q9Y6M1
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) RRM IMP/VICKZ family O00425
RNA-binding protein FUS (FUS) RRM TET family P35637
Splicing factor 3B subunit 3 (SF3B3) RSE1 family Q15393
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
U6 snRNA-associated Sm-like protein LSm8 (LSM8) SnRNP Sm proteins family O95777
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Vacuolar protein sorting-associated protein 37A (VPS37A) VPS37 family Q8NEZ2
DDB1- and CUL4-associated factor 7 (DCAF7) WD repeat DCAF7 family P61962
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028
Ribosome biogenesis protein WDR12 (WDR12) WD repeat WDR12/YTM1 family Q9GZL7
Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1) . Q969K4
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Calicin (CCIN) . Q13939
CDK-activating kinase assembly factor MAT1 (MNAT1) . P51948
Enkurin (ENKUR) . Q8TC29
F-box only protein 4 (FBXO4) . Q9UKT5
F-box/LRR-repeat protein 5 (FBXL5) . Q9UKA1
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Galectin-9C (LGALS9C) . Q6DKI2
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) . O14979
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) . Q9BUJ2
Kelch-like protein 17 (KLHL17) . Q6TDP4
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Kelch-like protein 22 (KLHL22) . Q53GT1
Kelch-like protein 26 (KLHL26) . Q53HC5
Kelch-like protein 32 (KLHL32) . Q96NJ5
Ligand of Numb protein X 2 (LNX2) . Q8N448
Matrin-3 (MATR3) . P43243
Pre-mRNA-processing-splicing factor 8 (PRPF8) . Q6P2Q9
Probable RNA-binding protein 46 (RBM46) . Q8TBY0
Protein FAM117B (FAM117B) . Q6P1L5
Protein MGARP (MGARP) . Q8TDB4
Putative insulin-like growth factor 2-associated protein . P09565
RING1 and YY1-binding protein (RYBP) . Q8N488
RNA-binding motif protein, X chromosome (RBMX) . P38159
RNA-binding protein 10 (RBM10) . P98175
Spermatogenesis-associated protein 22 (SPATA22) . Q8NHS9
Superkiller complex protein 8 (SKIC8) . Q9GZS3
Suppressor of cytokine signaling 6 (SOCS6) . O14544
TAR DNA-binding protein 43 (TARDBP) . Q13148
Ubiquilin-like protein (UBQLNL) . Q8IYU4
Uncharacterized protein C6orf141 (C6orf141) . Q5SZD1
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lmt-x . D05XDZ

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.