Details of the Probe

General Information of Probe

Probe ID
LDPC0214
Probe Name
ILS-1
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 358.434
Lipid-water partition coefficient (xlogp) 2.0707
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C21H26O5
Canonical SMILES
C#CCCCC(=O)OCC1(C)C=C2C(=O)C(C)(O)C3(CC3)C(C)=C2C1O
InChI
InChI=1S/C21H26O5/c1-5-6-7-8-15(22)26-12-19(3)11-14-16(18(19)24)13(2)21(9-10-21)20(4,25)17(14)23/h1,11,18,24-25H,6-10,12H2,2-4H3/t18-,19+,20+/m1/s1
InChIKey
JSVGPGSGTTXNED-AABGKKOBSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

4 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 9.39  LDD0415 
Heme oxygenase 1 (HMOX1) LDTP02359 2.58  LDD0415 
Squalene synthase (FDFT1) LDTP03842 3.60  LDD0415 
Transcription intermediary factor 1-beta (TRIM28) LDTP05808 2.13  LDD0415 
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3 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 2.40  LDD0415 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 2.15  LDD0415 
THO complex subunit 4 (ALYREF) LDTP08274 2.04  LDD0415 
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1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Splicing factor, proline- and glutamine-rich (SFPQ) LDTP03212 2.01; 2.40  LDD0415 
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14 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Elongation factor 1-delta (EEF1D) LDTP03499 2.16  LDD0415 
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) LDTP04495 2.78  LDD0415 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 2.76  LDD0415 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 2.29; 4.29  LDD0415 
Histone H2A type 1-D (H2AC7) LDTP03063 4.16  LDD0415 
Histone H2B type 1-H (H2BC9) LDTP09975 2.19  LDD0415 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 3.44  LDD0415 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 4.78; 6.61  LDD0415 
Lamin-B2 (LMNB2) LDTP05400 2.44  LDD0415 
Nucleolysin TIAR (TIAL1) LDTP05274 2.18  LDD0415 
Small ribosomal subunit protein eS7 (RPS7) LDTP04958 2.06  LDD0415 
Small ribosomal subunit protein uS2 (RPSA) LDTP02312 2.04  LDD0415 
Splicing factor U2AF 65 kDa subunit (U2AF2) LDTP03352 3.26  LDD0415 
TAR DNA-binding protein 43 (TARDBP) LDTP05767 2.47  LDD0415 
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⏷ Show the Full List of 14 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
3 uM
Quantitative Method
SILAC
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Lung
Disease Model
Lung adenocarcinoma [ICD-11:2C25]
Model Name
Human lung adenocarcinoma cells (A-549)
Interaction Atlas ID
 LDD0415 
Download The Altas

References

1 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175