Details of the Target

General Information of Target

Target ID LDTP02359
Target Name Heme oxygenase 1 (HMOX1)
Gene Name HMOX1
Gene ID 3162
Synonyms
HO; HO1; Heme oxygenase 1; HO-1; EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVA
LEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQ
LYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRA
SNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Heme oxygenase family
Subcellular location
Endoplasmic reticulum membrane
Function
[Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis.; [Heme oxygenase 1]: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy.; [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
TTD ID
T25703
Uniprot ID
P09601
DrugMap ID
TTI6V2A
Ensemble ID
ENST00000216117.9
HGNC ID
HGNC:5013
ChEMBL ID
CHEMBL2823

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1
 Probe Info  		2.58  LDD0415  [1]
TH211
 Probe Info  		Y134(12.06)  LDD0257  [2]
TH214
 Probe Info  		Y134(10.13)  LDD0258  [2]
TH216
 Probe Info  		Y134(20.00)  LDD0259  [2]
OPA-S-S-alkyne
 Probe Info  		K243(1.07); K39(1.45)  LDD3494  [3]
HPAP
 Probe Info  		3.37  LDD0062  [4]
HHS-475
 Probe Info  		Y134(1.08)  LDD0264  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
OSF
 Probe Info  		N.A.  LDD0029  [7]
SF
 Probe Info  		N.A.  LDD0028  [7]
STPyne
 Probe Info  		N.A.  LDD0009  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
Acrolein
 Probe Info  		H84(0.00); H25(0.00)  LDD0217  [10]
HHS-465
 Probe Info  		N.A.  LDD2240  [11]
HHS-482
 Probe Info  		Y134(1.74)  LDD2239  [12]
PAL-AfBPP Probe
Click To Hide/Show 184 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1 PP
 Probe Info  		2.53  LDD0417  [1]
C001
 Probe Info  		10.27  LDD1711  [13]
C003
 Probe Info  		12.82  LDD1713  [13]
C004
 Probe Info  		10.93  LDD1714  [13]
C007
 Probe Info  		11.63  LDD1716  [13]
C008
 Probe Info  		25.28  LDD1717  [13]
C010
 Probe Info  		9.45  LDD1719  [13]
C011
 Probe Info  		5.43  LDD1720  [13]
C017
 Probe Info  		6.15  LDD1725  [13]
C018
 Probe Info  		5.62  LDD1726  [13]
C022
 Probe Info  		41.36  LDD1728  [13]
C026
 Probe Info  		16.34  LDD1732  [13]
C027
 Probe Info  		13.18  LDD1733  [13]
C028
 Probe Info  		9.13  LDD1734  [13]
C038
 Probe Info  		10.56  LDD1738  [13]
C039
 Probe Info  		14.42  LDD1739  [13]
C040
 Probe Info  		66.72  LDD1740  [13]
C041
 Probe Info  		11.55  LDD1741  [13]
C042
 Probe Info  		6.77  LDD1742  [13]
C049
 Probe Info  		17.51  LDD1747  [13]
C052
 Probe Info  		4.92  LDD1750  [13]
C053
 Probe Info  		11.96  LDD1751  [13]
C055
 Probe Info  		38.05  LDD1752  [13]
C056
 Probe Info  		41.64  LDD1753  [13]
C063
 Probe Info  		30.91  LDD1760  [13]
C064
 Probe Info  		11.08  LDD1761  [13]
C065
 Probe Info  		6.92  LDD1762  [13]
C067
 Probe Info  		6.19  LDD1763  [13]
C070
 Probe Info  		39.95  LDD1766  [13]
C071
 Probe Info  		9.65  LDD1767  [13]
C072
 Probe Info  		13.09  LDD1768  [13]
C075
 Probe Info  		5.94  LDD1770  [13]
C082
 Probe Info  		11.31  LDD1774  [13]
C085
 Probe Info  		5.98  LDD1777  [13]
C087
 Probe Info  		20.39  LDD1779  [13]
C089
 Probe Info  		5.21  LDD1781  [13]
C091
 Probe Info  		99.73  LDD1782  [13]
C092
 Probe Info  		57.68  LDD1783  [13]
C094
 Probe Info  		99.73  LDD1785  [13]
C095
 Probe Info  		9.25  LDD1786  [13]
C100
 Probe Info  		14.03  LDD1789  [13]
C106
 Probe Info  		99.73  LDD1793  [13]
C107
 Probe Info  		6.68  LDD1794  [13]
C108
 Probe Info  		11.96  LDD1795  [13]
C112
 Probe Info  		79.34  LDD1799  [13]
C129
 Probe Info  		9.65  LDD1811  [13]
C130
 Probe Info  		30.06  LDD1812  [13]
C134
 Probe Info  		83.87  LDD1816  [13]
C135
 Probe Info  		38.32  LDD1817  [13]
C139
 Probe Info  		14.42  LDD1821  [13]
C140
 Probe Info  		20.53  LDD1822  [13]
C141
 Probe Info  		22.16  LDD1823  [13]
C143
 Probe Info  		40.79  LDD1825  [13]
C145
 Probe Info  		13.36  LDD1827  [13]
C147
 Probe Info  		25.63  LDD1829  [13]
C153
 Probe Info  		56.49  LDD1834  [13]
C156
 Probe Info  		9.32  LDD1836  [13]
C158
 Probe Info  		14.22  LDD1838  [13]
C159
 Probe Info  		45.57  LDD1839  [13]
C160
 Probe Info  		19.70  LDD1840  [13]
C161
 Probe Info  		26.72  LDD1841  [13]
C163
 Probe Info  		16.91  LDD1843  [13]
C165
 Probe Info  		13.45  LDD1845  [13]
C166
 Probe Info  		6.68  LDD1846  [13]
C169
 Probe Info  		60.13  LDD1849  [13]
C173
 Probe Info  		7.89  LDD1853  [13]
C177
 Probe Info  		11.08  LDD1856  [13]
C178
 Probe Info  		99.73  LDD1857  [13]
C183
 Probe Info  		11.63  LDD1861  [13]
C185
 Probe Info  		5.86  LDD1863  [13]
C186
 Probe Info  		12.55  LDD1864  [13]
C187
 Probe Info  		36.00  LDD1865  [13]
C191
 Probe Info  		11.08  LDD1868  [13]
C193
 Probe Info  		10.78  LDD1869  [13]
C194
 Probe Info  		15.78  LDD1870  [13]
C196
 Probe Info  		40.22  LDD1872  [13]
C198
 Probe Info  		11.31  LDD1874  [13]
C201
 Probe Info  		99.73  LDD1877  [13]
C204
 Probe Info  		5.50  LDD1879  [13]
C205
 Probe Info  		4.99  LDD1880  [13]
C206
 Probe Info  		79.34  LDD1881  [13]
C210
 Probe Info  		54.57  LDD1884  [13]
C211
 Probe Info  		12.55  LDD1885  [13]
C213
 Probe Info  		24.08  LDD1887  [13]
C214
 Probe Info  		6.77  LDD1888  [13]
C218
 Probe Info  		19.97  LDD1892  [13]
C219
 Probe Info  		7.73  LDD1893  [13]
C220
 Probe Info  		28.84  LDD1894  [13]
C225
 Probe Info  		11.96  LDD1898  [13]
C226
 Probe Info  		17.39  LDD1899  [13]
C228
 Probe Info  		99.73  LDD1901  [13]
C229
 Probe Info  		7.62  LDD1902  [13]
C231
 Probe Info  		24.42  LDD1904  [13]
C232
 Probe Info  		86.22  LDD1905  [13]
C233
 Probe Info  		14.03  LDD1906  [13]
C234
 Probe Info  		18.38  LDD1907  [13]
C235
 Probe Info  		35.51  LDD1908  [13]
C238
 Probe Info  		36.50  LDD1911  [13]
C239
 Probe Info  		6.36  LDD1912  [13]
C240
 Probe Info  		22.16  LDD1913  [13]
C243
 Probe Info  		17.75  LDD1916  [13]
C244
 Probe Info  		59.71  LDD1917  [13]
C245
 Probe Info  		6.19  LDD1918  [13]
C246
 Probe Info  		40.79  LDD1919  [13]
C249
 Probe Info  		32.22  LDD1922  [13]
C252
 Probe Info  		24.08  LDD1925  [13]
C255
 Probe Info  		10.70  LDD1928  [13]
C260
 Probe Info  		4.92  LDD1932  [13]
C264
 Probe Info  		61.82  LDD1935  [13]
C265
 Probe Info  		32.45  LDD1936  [13]
C266
 Probe Info  		9.65  LDD1937  [13]
C269
 Probe Info  		16.56  LDD1939  [13]
C270
 Probe Info  		7.84  LDD1940  [13]
C271
 Probe Info  		5.24  LDD1941  [13]
C273
 Probe Info  		12.73  LDD1943  [13]
C277
 Probe Info  		23.26  LDD1947  [13]
C278
 Probe Info  		91.14  LDD1948  [13]
C280
 Probe Info  		16.34  LDD1950  [13]
C282
 Probe Info  		40.50  LDD1952  [13]
C284
 Probe Info  		77.71  LDD1954  [13]
C285
 Probe Info  		25.11  LDD1955  [13]
C287
 Probe Info  		15.89  LDD1957  [13]
C289
 Probe Info  		33.13  LDD1959  [13]
C293
 Probe Info  		90.51  LDD1963  [13]
C296
 Probe Info  		30.70  LDD1966  [13]
C299
 Probe Info  		15.78  LDD1968  [13]
C301
 Probe Info  		24.76  LDD1970  [13]
C303
 Probe Info  		5.54  LDD1972  [13]
C305
 Probe Info  		21.41  LDD1974  [13]
C307
 Probe Info  		12.38  LDD1975  [13]
C310
 Probe Info  		17.15  LDD1977  [13]
C311
 Probe Info  		7.16  LDD1978  [13]
C313
 Probe Info  		36.76  LDD1980  [13]
C314
 Probe Info  		35.26  LDD1981  [13]
C317
 Probe Info  		7.57  LDD1983  [13]
C338
 Probe Info  		17.51  LDD2001  [13]
C339
 Probe Info  		22.47  LDD2002  [13]
C340
 Probe Info  		4.96  LDD2003  [13]
C342
 Probe Info  		6.06  LDD2004  [13]
C343
 Probe Info  		22.63  LDD2005  [13]
C346
 Probe Info  		13.36  LDD2007  [13]
C347
 Probe Info  		5.13  LDD2008  [13]
C348
 Probe Info  		31.12  LDD2009  [13]
C349
 Probe Info  		49.52  LDD2010  [13]
C350
 Probe Info  		99.73  LDD2011  [13]
C353
 Probe Info  		8.69  LDD2014  [13]
C354
 Probe Info  		9.45  LDD2015  [13]
C355
 Probe Info  		64.00  LDD2016  [13]
C356
 Probe Info  		23.26  LDD2017  [13]
C357
 Probe Info  		14.12  LDD2018  [13]
C362
 Probe Info  		99.73  LDD2023  [13]
C363
 Probe Info  		40.22  LDD2024  [13]
C364
 Probe Info  		68.59  LDD2025  [13]
C366
 Probe Info  		12.38  LDD2027  [13]
C373
 Probe Info  		4.99  LDD2033  [13]
C376
 Probe Info  		19.29  LDD2036  [13]
C378
 Probe Info  		15.56  LDD2037  [13]
C380
 Probe Info  		11.00  LDD2039  [13]
C382
 Probe Info  		22.01  LDD2041  [13]
C383
 Probe Info  		37.53  LDD2042  [13]
C386
 Probe Info  		9.19  LDD2045  [13]
C387
 Probe Info  		8.51  LDD2046  [13]
C388
 Probe Info  		99.73  LDD2047  [13]
C390
 Probe Info  		50.91  LDD2049  [13]
C397
 Probe Info  		9.51  LDD2056  [13]
C399
 Probe Info  		24.25  LDD2058  [13]
C403
 Probe Info  		70.03  LDD2061  [13]
C407
 Probe Info  		35.51  LDD2064  [13]
C408
 Probe Info  		5.31  LDD2065  [13]
C413
 Probe Info  		15.24  LDD2069  [13]
C419
 Probe Info  		14.72  LDD2074  [13]
C424
 Probe Info  		8.17  LDD2079  [13]
C426
 Probe Info  		34.06  LDD2081  [13]
C429
 Probe Info  		23.59  LDD2084  [13]
C431
 Probe Info  		70.52  LDD2086  [13]
C433
 Probe Info  		11.16  LDD2088  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe13
 Probe Info  		20.00  LDD0488  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe15
 Probe Info  		20.00  LDD0490  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
FFF probe3
 Probe Info  		20.00  LDD0464  [14]
JN0003
 Probe Info  		20.00  LDD0484  [14]
A-DA
 Probe Info  		2.51  LDD0141  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0116  HHS-0101 DM93 Y134(1.08)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y134(1.79)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y134(1.18)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y134(1.30)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y134(1.13)  LDD0268  [5]
 LDCM0107  IAA HeLa H84(0.00); H25(0.00)  LDD0221  [10]
 LDCM0109  NEM HeLa H25(0.00); H84(0.00); H119(0.00)  LDD0223  [10]
 LDCM0014  Panhematin HEK-293T 3.37  LDD0062  [4]
 LDCM0081  Rofecoxib A-549 2.51  LDD0141  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Very long chain fatty acid elongase 5 (ELOVL5) ELO family Q9NYP7
Very long chain fatty acid elongase 6 (ELOVL6) ELO family Q9H5J4
Signal peptidase complex catalytic subunit SEC11C (SEC11C) Peptidase S26B family Q9BY50
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Methylsterol monooxygenase 1 (MSMO1) Sterol desaturase family Q15800
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
Monocarboxylate transporter 2 (SLC16A7) Monocarboxylate porter (TC 2.A.1.13) family O60669
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Syntaxin-1A (STX1A) Syntaxin family Q16623
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) COQ9 family O75208
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Membrane protein FAM174A (FAM174A) FAM174 family Q8TBP5
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Protection of telomeres protein 1 (POT1) Telombin family Q9NUX5
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Vitamin E Small molecular drug DB00163
Alpha-tocopherol Succinate . DB14001
D-alpha-tocopherol Acetate . DB14002
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Stannsoporfin Small molecular drug D02JAY
Investigative
Click To Hide/Show 13 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-(Adamantan-1-yl)-2-(1h-imidazol-1-yl)Ethanone Small molecular drug D0K1NM
12-phenylheme Small molecular drug D0S8UN
2-phenylheme Small molecular drug D02AVZ
2-propanol, Isopropanol Small molecular drug D0W7LK
Biliverdine Ix Alpha Small molecular drug D06SCF
Biliverdine Ix Alpha Small molecular drug DB02073
Formic Acid Small molecular drug D06EWG
Formic Acid Small molecular drug DB01942
Heme Small molecular drug D0UU1I
Tin Protoporphyrin Small molecular drug D0HX0D
Verdoheme Small molecular drug D06UNX
1-({2-[2-(4-chlorophenyl)Ethyl]-13-dioxolan-2-yl}Methyl)-1h-imidazole . DB06914
Polaprezinc . DB09221

References

1 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD038010
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Mass spectrometry data entry: PXD041587
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