Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C011  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 19.3
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 15.3
 LDTP01769  Dihydrofolate reductase (DHFR) 13.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 12.6
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 12.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 9.7
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 9.5
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 9.1
 LDTP02505  Lysosomal protective protein (CTSA) 8.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 8.8
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 8.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 8.2
 LDTP10329  Ceramide synthase 2 (CERS2) 7.9
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 7.7
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 7.4
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 7.1
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 7.1
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 6.7
 LDTP10966  Microsomal glutathione S-transferase 2 (MGST2) 6.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 6.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 6.2
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 5.9
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 5.7
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 5.6
 LDTP03537  Glycylpeptide N-tetradecanoyltransferase 1 (NMT1) 5.6
 LDTP00988  Protein O-GlcNAcase (OGA) 5.6
 LDTP12573  E3 ubiquitin-protein ligase RAD18 (RAD18) 5.5
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 5.4
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 5.2
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 5.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 5.2
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 5.2
 LDTP00910  Peroxisomal ATPase PEX1 (PEX1) 5.2
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 5.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.1
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 5.1
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 5.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.0
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 4.9
Transporter and channel
Click to Show/Hide to Show 29 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 27.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 27.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 19.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 16.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 14.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 13.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 11.5
 LDTP00592  Surfeit locus protein 4 (SURF4) 11.4
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 11.4
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 10.9
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 10.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 8.6
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 8.2
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 7.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 7.6
 LDTP03546  Translocator protein (TSPO) 7.1
 LDTP07236  Protein GPR107 (GPR107) 7.0
 LDTP16813  Tetraspanin-3 (TSPAN3) 6.5
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 6.4
 LDTP08881  Transmembrane protein 199 (TMEM199) 6.2
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 6.1
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 6.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 5.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.8
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 5.7
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 5.7
 LDTP12383  Protein GPR108 (GPR108) 5.5
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 5.1
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16717  Forkhead-associated domain-containing protein 1 (FHAD1) 9.8
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 12.9
Other
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 27.3
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 24.8
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 15.1
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 14.7
 LDTP11076  Apolipoprotein L2 (APOL2) 14.2
 LDTP05160  Nucleobindin-2 (NUCB2) 9.0
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 6.8
 LDTP00105  Protein unc-119 homolog B (UNC119B) 6.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 6.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 6.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 6.1
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 5.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 5.8
 LDTP05375  Nucleobindin-1 (NUCB1) 5.6
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 5.3
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587