Details of the Target

General Information of Target

Target ID LDTP05558
Target Name Galectin-3-binding protein (LGALS3BP)
Gene Name LGALS3BP
Gene ID 3959
Synonyms
M2BP; Galectin-3-binding protein; Basement membrane autoantigen p105; Lectin galactoside-binding soluble 3-binding protein; Mac-2-binding protein; MAC2BP; Mac-2 BP; Tumor-associated antigen 90K
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASV
VCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAG
VVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANL
EAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQ
GYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVP
TDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQ
FNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTD
SSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSL
VYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGW
KAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD
Target Bioclass
Other
Subcellular location
Secreted
Function Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Uniprot ID
Q08380
Ensemble ID
ENST00000262776.8
HGNC ID
HGNC:6564

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		7.00  LDD0387  [1]
Alkylaryl probe 2
 Probe Info  		7.00  LDD0391  [1]
FBPP2
 Probe Info  		16.83  LDD0318  [2]
DA-P2
 Probe Info  		4.39  LDD0348  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K427(2.98)  LDD0277  [5]
OPA-S-S-alkyne
 Probe Info  		K110(0.20); K427(2.98)  LDD3494  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
DBIA
 Probe Info  		C561(0.74)  LDD0531  [8]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
IA-alkyne
 Probe Info  		C49(0.00); C561(0.00); C123(0.00); C93(0.00)  LDD0162  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
IPM
 Probe Info  		N.A.  LDD0147  [11]
Acrolein
 Probe Info  		H131(0.00); H336(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C011
 Probe Info  		5.13  LDD1720  [14]
C022
 Probe Info  		8.34  LDD1728  [14]
C045
 Probe Info  		9.45  LDD1744  [14]
C063
 Probe Info  		10.63  LDD1760  [14]
C073
 Probe Info  		6.28  LDD1769  [14]
C087
 Probe Info  		7.78  LDD1779  [14]
C106
 Probe Info  		18.00  LDD1793  [14]
C108
 Probe Info  		8.28  LDD1795  [14]
C115
 Probe Info  		7.89  LDD1802  [14]
C140
 Probe Info  		8.00  LDD1822  [14]
C149
 Probe Info  		7.94  LDD1830  [14]
C159
 Probe Info  		7.62  LDD1839  [14]
C161
 Probe Info  		10.41  LDD1841  [14]
C164
 Probe Info  		6.19  LDD1844  [14]
C170
 Probe Info  		36.25  LDD1850  [14]
C171
 Probe Info  		9.25  LDD1851  [14]
C184
 Probe Info  		6.02  LDD1862  [14]
C186
 Probe Info  		25.28  LDD1864  [14]
C197
 Probe Info  		12.30  LDD1873  [14]
C206
 Probe Info  		15.89  LDD1881  [14]
C208
 Probe Info  		16.80  LDD1883  [14]
C211
 Probe Info  		9.19  LDD1885  [14]
C220
 Probe Info  		13.64  LDD1894  [14]
C221
 Probe Info  		12.04  LDD1895  [14]
C223
 Probe Info  		12.55  LDD1897  [14]
C281
 Probe Info  		6.87  LDD1951  [14]
C302
 Probe Info  		8.34  LDD1971  [14]
C310
 Probe Info  		14.83  LDD1977  [14]
C334
 Probe Info  		8.28  LDD1997  [14]
C336
 Probe Info  		5.66  LDD1999  [14]
C346
 Probe Info  		13.09  LDD2007  [14]
C355
 Probe Info  		29.65  LDD2016  [14]
C363
 Probe Info  		16.00  LDD2024  [14]
C376
 Probe Info  		7.06  LDD2036  [14]
C383
 Probe Info  		11.24  LDD2042  [14]
C386
 Probe Info  		7.31  LDD2045  [14]
C390
 Probe Info  		51.27  LDD2049  [14]
C391
 Probe Info  		14.93  LDD2050  [14]
C420
 Probe Info  		14.72  LDD2075  [14]
C425
 Probe Info  		22.63  LDD2080  [14]
C429
 Probe Info  		16.45  LDD2084  [14]
C431
 Probe Info  		15.78  LDD2086  [14]
FFF probe12
 Probe Info  		20.00  LDD0473  [15]
FFF probe9
 Probe Info  		20.00  LDD0470  [15]
STS-1
 Probe Info  		N.A.  LDD0136  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C561(0.74)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C561(0.79)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C561(0.71)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C561(0.74)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C561(0.77)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C561(0.88)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C561(0.89)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C561(0.69)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C561(0.76)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C561(0.62)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C561(0.72)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C561(0.85)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C561(0.82)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C561(0.76)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C561(0.76)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C561(0.72)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C561(1.04)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C561(1.04)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C561(0.95)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C561(1.14)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C561(1.03)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C561(0.94)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C561(0.92)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C561(0.97)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C561(1.07)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C561(0.97)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C561(0.95)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C561(1.04)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C561(1.05)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C561(1.02)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C561(1.02)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C561(0.96)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C561(1.12)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C561(0.83)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C561(0.77)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C561(1.07)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C561(0.81)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C561(0.97)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C561(1.07)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C561(0.92)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C561(0.90)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C561(1.11)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C561(1.16)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C561(0.93)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C561(0.87)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C561(1.01)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C561(0.98)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C561(0.92)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C561(0.88)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C561(1.06)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C561(0.90)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C561(1.06)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C561(1.12)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C561(1.37)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C561(1.16)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C561(0.83)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C561(1.05)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C561(1.02)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C561(1.30)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C561(1.41)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C561(1.30)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C561(1.15)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C561(1.08)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C561(1.32)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C561(1.10)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C561(1.16)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C561(1.08)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C561(0.72)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C561(1.16)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C561(1.19)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C561(1.05)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C561(1.13)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C561(1.01)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C561(0.94)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C561(0.85)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C561(0.95)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C561(1.09)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C561(1.00)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C561(0.63)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C561(0.86)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C561(0.91)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C561(0.89)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C561(1.02)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C561(1.20)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C561(0.86)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C561(0.77)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C561(0.79)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C561(0.85)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C561(0.83)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C561(0.63)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C561(0.86)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C561(0.80)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C561(0.80)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C561(0.76)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C561(0.79)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C561(0.90)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C561(0.94)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C561(0.89)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C561(0.92)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C561(1.09)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C561(0.70)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C561(0.93)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C561(0.90)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C561(0.88)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C561(0.97)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C561(0.97)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C561(1.04)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C561(1.19)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C561(1.27)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C561(1.04)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C561(1.09)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C561(0.84)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C561(0.99)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C561(1.13)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C561(0.99)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C561(1.15)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C561(0.97)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C561(0.87)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C561(0.94)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C561(0.92)  LDD0648  [8]
 LDCM0334  AC7 HCT 116 C561(0.82)  LDD0651  [8]
 LDCM0345  AC8 HCT 116 C561(0.95)  LDD0662  [8]
 LDCM0349  AC83 HCT 116 C561(1.04)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C561(1.11)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C561(1.01)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C561(0.90)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C561(1.07)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C561(0.91)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C561(0.93)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C561(0.86)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C561(0.90)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C561(0.95)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C561(1.08)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C561(1.08)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C561(0.93)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C561(1.00)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C561(0.93)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C561(0.85)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C561(0.90)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C561(0.75)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C561(0.80)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C561(0.95)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C561(1.10); C103(1.05); C93(1.05)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa H336(0.00); H131(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C561(1.03)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C561(0.84)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C561(0.67)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C561(0.92)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C561(1.01)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C561(0.98)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C561(1.00)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C561(0.92)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C561(1.11)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C561(1.07)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C561(1.23)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C561(1.10)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C561(0.91)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C561(1.18)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C561(1.14)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C561(0.95)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C561(1.08)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C561(1.06)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C561(1.24)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C561(0.94)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C561(0.98)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C561(0.85)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C561(0.78)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C561(0.79)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C561(0.78)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C561(0.68)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C561(0.94)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C561(1.41)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C561(1.12)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C561(1.06)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C561(1.04)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C561(0.95)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C561(0.99)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C561(0.86)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C561(0.92)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C561(1.23)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C561(0.82)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C561(1.09)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C561(0.89)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C561(1.10)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C561(0.98)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C561(1.06)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C561(1.46)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C561(1.11)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C561(0.94)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C561(0.77)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C561(0.82)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C561(1.00)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C561(0.92)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C561(0.92)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C561(0.99)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C561(0.99)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C561(0.88)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C561(1.08)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C561(1.28)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C561(1.30)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C561(0.94)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C561(1.50)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C561(1.24)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C561(1.46)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C561(1.24)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C561(1.16)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C561(1.26)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C561(1.14)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C561(1.39)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C561(1.33)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C561(1.35)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C561(1.26)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C561(0.91)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C561(0.97)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C561(0.99)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C561(0.81)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C561(0.88)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C561(0.91)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C561(0.74)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C561(0.91)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C561(1.44)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C561(0.86)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C561(0.88)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C561(0.92)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C561(0.95)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C561(0.76)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C561(0.79)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C561(0.90)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C561(0.69)  LDD0769  [8]
 LDCM0453  CL61 PaTu 8988t C561(1.14)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C561(0.81)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C561(0.74)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C561(0.82)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C561(1.16)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C561(0.74)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C561(1.02)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C561(1.09)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C561(1.21)  LDD1340  [8]
 LDCM0462  CL7 HCT 116 C561(0.66)  LDD0779  [8]
 LDCM0463  CL70 PaTu 8988t C561(0.86)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C561(1.02)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C561(0.91)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C561(0.96)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C561(1.15)  LDD1346  [8]
 LDCM0469  CL76 HCT 116 C561(1.36)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C561(1.82)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C561(0.96)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C561(0.87)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C561(1.18)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C561(0.84)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C561(0.88)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C561(0.76)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C561(1.10)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C561(0.98)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C561(1.30)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C561(1.28)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C561(1.04)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C561(1.35)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C561(1.07)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C561(0.94)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C561(1.04)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C561(0.87)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C561(1.17)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C561(1.01)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C561(1.21)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C561(1.04)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C561(0.92)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C561(0.88)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C561(0.60)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C561(0.62)  LDD0811  [8]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0468  Fragment33 PaTu 8988t C561(0.81)  LDD1347  [8]
 LDCM0427  Fragment51 HCT 116 C561(2.06)  LDD0744  [8]
 LDCM0107  IAA HeLa H336(0.00); H131(0.00)  LDD0221  [12]
 LDCM0022  KB02 769-P C561(5.58)  LDD2246  [17]
 LDCM0023  KB03 769-P C561(6.78)  LDD2663  [17]
 LDCM0024  KB05 COLO792 C561(3.34)  LDD3310  [17]
 LDCM0109  NEM HeLa H336(0.00); H131(0.00)  LDD0223  [12]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0388  [1]
 LDCM0021  THZ1 HCT 116 C561(1.10); C103(1.05); C93(1.05)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) SAMHD1 family Q9Y3Z3
Interferon-induced GTP-binding protein Mx1 (MX1) Dynamin/Fzo/YdjA family P20591
F-box only protein 6 (FBXO6) . Q9NRD1
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) . O00220
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) Bcl-2 family Q9BZR8
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840