Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Alkylaryl probe 1  Probe Info 
Probe concentration 1 mM
Criteria Quantification: Probe vs DMSO
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP18414  5'-nucleotidase domain-containing protein 2 (NT5DC2) 20.0
 LDTP05905  Acid ceramidase (ASAH1) 20.0
 LDTP07979  FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) 20.0
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 20.0
 LDTP02217  Procathepsin L (CTSL) 20.0
 LDTP15725  Secernin-2 (SCRN2) 20.0
 LDTP17022  Secernin-3 (SCRN3) 20.0
 LDTP10888  Legumain (LGMN) 19.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 18.0
 LDTP05992  Bleomycin hydrolase (BLMH) 17.0
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) 16.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 15.0
 LDTP03511  Flavin reductase (NADPH) (BLVRB) 15.0
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 15.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 15.0
 LDTP02386  Fructose-bisphosphate aldolase C (ALDOC) 14.0
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) 14.0
 LDTP13147  Cathepsin Z (CTSZ) 13.0
 LDTP02918  S-adenosylmethionine decarboxylase proenzyme (AMD1) 13.0
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 12.0
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 12.0
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 12.0
 LDTP02008  Fructose-bisphosphate aldolase A (ALDOA) 11.0
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 10.0
 LDTP02223  Cathepsin B (CTSB) 9.0
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 9.0
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 8.0
 LDTP02198  Cathepsin D (CTSD) 7.0
 LDTP03858  Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA) 7.0
 LDTP07092  Probable arginine--tRNA ligase, mitochondrial (RARS2) 7.0
 LDTP02837  Beta-galactosidase (GLB1) 6.0
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) 6.0
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 5.0
 LDTP03730  Sepiapterin reductase (SPR) 5.0
Transporter and channel
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 20.0
 LDTP12966  Vesicle-associated membrane protein-associated protein A (VAPA) 20.0
 LDTP02071  Amyloid-beta precursor protein (APP) 16.0
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 12.0
 LDTP02215  Prosaposin (PSAP) 12.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 6.0
Other
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 20.0
 LDTP03453  Progranulin (GRN) 20.0
 LDTP01279  Protein CREG1 (CREG1) 20.0
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 19.0
 LDTP02085  Plasminogen activator inhibitor 1 (SERPINE1) 17.0
 LDTP11737  Nonsense-mediated mRNA decay factor SMG9 (SMG9) 16.0
 LDTP02238  Thrombospondin-1 (THBS1) 16.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 9.0
 LDTP13684  NSFL1 cofactor p47 (NSFL1C) 8.0
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 7.0
 LDTP00808  Density-regulated protein (DENR) 5.0
 LDTP11176  Protein canopy homolog 3 (CNPY3) 5.0
 LDTP06105  Protein FAM50A (FAM50A) 5.0

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.