Details of the Target

General Information of Target

Target ID LDTP02799
Target Name N-acetylglucosamine-6-sulfatase (GNS)
Gene Name GNS
Gene ID 2799
Synonyms
N-acetylglucosamine-6-sulfatase; EC 3.1.6.14; Glucosamine-6-sulfatase; G6S
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV
LGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSS
KSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSK
YYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTA
APQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVD
DLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIK
PNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEG
RNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYN
LTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRG
SVRTRRFSKHLL
Target Bioclass
Enzyme
Family
Sulfatase family
Subcellular location
Lysosome
Uniprot ID
P15586
Ensemble ID
ENST00000258145.8
HGNC ID
HGNC:4422

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ICC137 SNV: p.G62D .
MFE319 SNV: p.P5S .
NCIH1944 Substitution: p.G43I .
SW620 SNV: p.V369F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		10.00  LDD0387  [1]
Alkylaryl probe 2
 Probe Info  		7.00  LDD0391  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K502(5.88)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K502(0.59)  LDD3494  [4]
Probe 1
 Probe Info  		Y344(10.96)  LDD3495  [5]
P11
 Probe Info  		20.00  LDD0201  [6]
BTD
 Probe Info  		C140(0.98)  LDD2137  [7]
FBPP2
 Probe Info  		6.72  LDD0054  [8]
DBIA
 Probe Info  		C140(1.01)  LDD1507  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
PAL-AfBPP Probe
Click To Hide/Show 58 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.41  LDD1714  [13]
C022
 Probe Info  		9.00  LDD1728  [13]
C041
 Probe Info  		5.66  LDD1741  [13]
C045
 Probe Info  		17.51  LDD1744  [13]
C053
 Probe Info  		12.04  LDD1751  [13]
C063
 Probe Info  		16.80  LDD1760  [13]
C070
 Probe Info  		8.57  LDD1766  [13]
C073
 Probe Info  		10.48  LDD1769  [13]
C078
 Probe Info  		4.99  LDD1771  [13]
C079
 Probe Info  		9.85  LDD1772  [13]
C087
 Probe Info  		12.21  LDD1779  [13]
C106
 Probe Info  		22.47  LDD1793  [13]
C108
 Probe Info  		10.63  LDD1795  [13]
C112
 Probe Info  		19.56  LDD1799  [13]
C115
 Probe Info  		18.38  LDD1802  [13]
C130
 Probe Info  		8.34  LDD1812  [13]
C140
 Probe Info  		8.17  LDD1822  [13]
C149
 Probe Info  		15.45  LDD1830  [13]
C164
 Probe Info  		6.36  LDD1844  [13]
C170
 Probe Info  		37.01  LDD1850  [13]
C171
 Probe Info  		18.00  LDD1851  [13]
C184
 Probe Info  		5.62  LDD1862  [13]
C186
 Probe Info  		17.63  LDD1864  [13]
C197
 Probe Info  		15.67  LDD1873  [13]
C208
 Probe Info  		24.25  LDD1883  [13]
C211
 Probe Info  		22.01  LDD1885  [13]
C213
 Probe Info  		22.78  LDD1887  [13]
C221
 Probe Info  		14.12  LDD1895  [13]
C223
 Probe Info  		37.53  LDD1897  [13]
C225
 Probe Info  		6.23  LDD1898  [13]
C233
 Probe Info  		8.63  LDD1906  [13]
C237
 Probe Info  		13.18  LDD1910  [13]
C281
 Probe Info  		6.92  LDD1951  [13]
C293
 Probe Info  		23.43  LDD1963  [13]
C296
 Probe Info  		15.78  LDD1966  [13]
C302
 Probe Info  		10.63  LDD1971  [13]
C310
 Probe Info  		13.93  LDD1977  [13]
C314
 Probe Info  		15.89  LDD1981  [13]
C346
 Probe Info  		21.56  LDD2007  [13]
C348
 Probe Info  		13.64  LDD2009  [13]
C349
 Probe Info  		9.58  LDD2010  [13]
C354
 Probe Info  		7.01  LDD2015  [13]
C355
 Probe Info  		27.47  LDD2016  [13]
C356
 Probe Info  		8.69  LDD2017  [13]
C363
 Probe Info  		19.03  LDD2024  [13]
C376
 Probe Info  		7.21  LDD2036  [13]
C390
 Probe Info  		28.84  LDD2049  [13]
C413
 Probe Info  		15.14  LDD2069  [13]
C420
 Probe Info  		10.56  LDD2075  [13]
C425
 Probe Info  		22.32  LDD2080  [13]
C431
 Probe Info  		13.64  LDD2086  [13]
FFF probe11
 Probe Info  		10.53  LDD0471  [14]
FFF probe12
 Probe Info  		20.00  LDD0473  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [14]
FFF probe14
 Probe Info  		16.83  LDD0477  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
FFF probe9
 Probe Info  		20.00  LDD0470  [14]
JN0003
 Probe Info  		20.00  LDD0469  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C140(1.01)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C140(1.09)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C140(1.03)  LDD1509  [9]
 LDCM0259  AC14 HEK-293T C140(1.05); C118(1.04)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C140(1.04)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C140(1.06)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C140(0.98)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C140(1.20)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C140(1.14)  LDD1518  [9]
 LDCM0281  AC21 HEK-293T C140(1.05); C518(1.13)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C140(1.03); C118(1.12)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C140(1.08)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C140(0.96)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C140(1.08)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C140(1.00)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C140(1.06)  LDD1526  [9]
 LDCM0289  AC29 HEK-293T C140(1.04); C518(1.13)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C140(1.07)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C140(0.98); C118(1.15)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C140(1.02)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C140(0.93)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C140(1.02)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C140(1.04)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C140(1.14)  LDD1535  [9]
 LDCM0298  AC37 HEK-293T C140(1.00); C518(1.21)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C140(0.98); C118(1.03)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C140(0.99)  LDD1539  [9]
 LDCM0302  AC40 HEK-293T C140(0.93)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C140(1.10)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C140(1.06)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C140(1.10)  LDD1544  [9]
 LDCM0307  AC45 HEK-293T C140(1.03); C518(1.34)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C140(1.03); C118(0.94)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C140(1.00)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C140(0.98)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C140(1.03)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C140(1.05); C518(1.16)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C140(1.03)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C140(1.04)  LDD1553  [9]
 LDCM0316  AC53 HEK-293T C140(0.98); C518(1.33)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C140(1.03); C118(1.11)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C140(1.04)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C140(0.96)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C140(1.09)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C140(1.06)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C140(1.08)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C140(1.01); C118(1.06)  LDD1562  [9]
 LDCM0325  AC61 HEK-293T C140(1.04); C518(1.16)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C140(1.02); C118(1.11)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C140(0.86)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C140(1.05)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C140(1.00)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C140(0.94)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C140(0.97); C518(1.23)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C140(1.05)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C140(0.97)  LDD1514  [9]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [6]
 LDCM0367  CL1 HEK-293T C140(1.05)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C140(1.25); C118(1.20)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C140(1.12)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C140(1.08)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C140(1.08)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C140(1.03)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C140(1.05)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C140(0.98)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C140(1.11)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C140(0.91)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C140(1.06)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C140(1.05)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C140(1.04)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C140(1.07)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C140(1.05)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C140(1.10)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C140(1.08)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C140(1.11)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C140(1.00)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C140(1.07)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C140(1.08)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C140(1.01)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C140(1.05)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C140(0.92)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C140(1.12)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C140(1.15)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C140(1.10)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C140(1.16)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C140(1.12)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C140(1.14)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C140(1.10)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C140(1.08)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C140(1.10)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C140(1.09)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C140(1.07)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C140(1.05)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C140(1.00)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C140(1.13)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C140(1.01)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C140(1.02)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C140(1.13)  LDD1611  [9]
 LDCM0409  CL21 HEK-293T C140(1.20); C518(1.30)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C140(0.91); C118(1.03)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C140(0.97)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C140(0.87)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C140(1.05)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C140(1.05)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C140(0.98)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C140(0.95)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C140(0.95)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C140(1.02)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C140(0.96)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C140(0.98)  LDD1624  [9]
 LDCM0422  CL33 HEK-293T C140(1.29); C518(1.34)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C140(0.94); C118(0.97)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C140(0.98)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C140(0.90)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C140(1.07)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C140(1.10)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C140(1.07)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C140(0.90)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C140(1.08)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C140(0.97)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C140(0.92)  LDD1637  [9]
 LDCM0435  CL45 HEK-293T C140(1.23); C518(1.22)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C140(0.89); C118(0.94)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C140(0.90)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C140(0.99)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C140(1.11)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C140(1.07)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C140(1.05)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C140(1.01)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C140(1.11)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C140(1.09)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C140(1.01)  LDD1649  [9]
 LDCM0448  CL57 HEK-293T C140(1.24); C518(1.11)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C140(0.97); C118(0.98)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C140(0.89)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C140(1.07)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C140(0.94)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C140(1.01)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C140(1.08)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C140(0.99)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C140(1.20)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C140(0.96)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C140(1.02)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C140(1.02)  LDD1662  [9]
 LDCM0461  CL69 HEK-293T C140(1.03); C518(1.25)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C140(1.03)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C140(0.98); C118(1.10)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C140(0.93)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C140(0.90)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C140(1.06)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C140(1.04)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C140(1.06)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C140(1.22)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C140(1.03)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C140(1.00)  LDD1675  [9]
 LDCM0475  CL81 HEK-293T C140(0.95); C518(1.36)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C140(0.98); C118(1.02)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C140(0.98)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C140(0.96)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C140(1.13)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C140(1.14)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C140(1.02)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C140(1.09)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C140(1.06)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C140(1.06); C518(1.07)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C140(1.44)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C140(1.01)  LDD1689  [9]
 LDCM0488  CL93 HEK-293T C140(1.07); C518(1.17)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C140(0.91); C118(1.20)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C140(1.24)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C140(1.00)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C140(1.14)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C140(1.13)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C140(1.07)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C140(1.03)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C140(0.95)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C140(1.07)  LDD1631  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C140(0.98)  LDD2137  [7]
 LDCM0099  Phenelzine MDA-MB-231 3.00  LDD0388  [1]
 LDCM0008  Tranylcypromine SH-SY5Y 6.72  LDD0054  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.