Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FBPP2  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Tranylcypromine  Competitor Info 
Competitor Concentration 100 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Adrenal
Disease Model Bone marrow neuroblastoma [ICD11: 2A00]
Model Name Human neuroblastoma cells (SH-SY5Y)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10884  Sialidase-1 (NEU1) 13.0
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 9.0
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) 8.4
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 7.6
 LDTP14801  Di-N-acetylchitobiase (CTBS) 7.3
 LDTP02217  Procathepsin L (CTSL) 7.1
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 6.7
 LDTP02366  Pro-cathepsin H (CTSH) 5.7
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 5.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 5.3
 LDTP12135  Sialate O-acetylesterase (SIAE) 4.2
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 4.1
 LDTP02141  Alpha-galactosidase A (GLA) 4.0
 LDTP13172  Cathepsin F (CTSF) 3.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 3.7
 LDTP00316  Ribonuclease T2 (RNASET2) 3.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 3.6
 LDTP03748  Alpha-L-iduronidase (IDUA) 3.5
 LDTP02223  Cathepsin B (CTSB) 3.4
 LDTP13294  Dipeptidyl peptidase 2 (DPP7) 3.3
 LDTP10888  Legumain (LGMN) 3.3
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 3.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 3.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 2.8
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 2.8
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 2.8
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 2.5
 LDTP02883  Alpha-N-acetylgalactosaminidase (NAGA) 2.4
 LDTP00185  Deoxyribonuclease-2-alpha (DNASE2) 2.3
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 2.3
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 2.2
 LDTP02865  Carboxypeptidase E (CPE) 2.2
 LDTP00282  Beta-mannosidase (MANBA) 2.1
 LDTP02807  Arylsulfatase B (ARSB) 2.1
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 2.1
 LDTP04255  Transmembrane ascorbate-dependent reductase CYB561 (CYB561) 2.0
 LDTP02539  Lysosomal acid phosphatase (ACP2) 2.0
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12042  Proton-activated chloride channel (PACC1) 5.4
 LDTP12874  ADP-ribosylation factor-binding protein GGA3 (GGA3) 4.9
 LDTP12981  Proton-transporting V-type ATPase complex assembly regulator TMEM9 (TMEM9) 4.3
 LDTP17246  Sodium-dependent glucose transporter 1 (MFSD4B) 3.7
 LDTP08327  Osteopetrosis-associated transmembrane protein 1 (OSTM1) 3.5
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 2.9
 LDTP02266  Synaptophysin (SYP) 2.8
 LDTP03061  Cation-dependent mannose-6-phosphate receptor (M6PR) 2.7
 LDTP10885  Sortilin (SORT1) 2.4
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 2.4
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 2.2
Cytokine and receptor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03377  Ciliary neurotrophic factor receptor subunit alpha (CNTFR) 2.1
Other
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04172  Tissue factor pathway inhibitor 2 (TFPI2) 4.5
 LDTP03773  Metalloproteinase inhibitor 3 (TIMP3) 3.2
 LDTP02937  Insulin-like growth factor-binding protein 2 (IGFBP2) 3.0
 LDTP13281  ProSAAS (PCSK1N) 2.9
 LDTP03175  Galanin peptides (GAL) 2.8
 LDTP02927  Ganglioside GM2 activator (GM2A) 2.8
 LDTP02715  CD99 antigen (CD99) 2.7
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 2.6
 LDTP11461  Seizure 6-like protein (SEZ6L) 2.5
 LDTP10889  Perilipin-2 (PLIN2) 2.5
 LDTP04650  Microfibrillar-associated protein 2 (MFAP2) 2.3
 LDTP07703  Seizure 6-like protein 2 (SEZ6L2) 2.1

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580