Details of the Target

General Information of Target

Target ID LDTP11461
Target Name Seizure 6-like protein (SEZ6L)
Gene Name SEZ6L
Gene ID 23544
Synonyms
KIAA0927; Seizure 6-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEF
SLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQ
IVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILG
KIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQD
EYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQV
HILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMN
MLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEK
RILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNP
RSTWDVEAKMPLSALYGTLSLLQQLAEA
Target Bioclass
Other
Family
SEZ6 family
Subcellular location
Endoplasmic reticulum membrane
Function May contribute to specialized endoplasmic reticulum functions in neurons.
Uniprot ID
Q9BYH1
Ensemble ID
ENST00000248933.11
HGNC ID
HGNC:10763

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.T261N .
CASKI SNV: p.G699R .
HCT116 SNV: p.R108C .
HCT15 SNV: p.G43C; p.V943L .
IGR37 SNV: p.L348M .
IM95 SNV: p.K503N .
Ishikawa (Heraklio) 02 ER SNV: p.I737M .
JEKO1 SNV: p.R188Ter .
LNCaP clone FGC SNV: p.G402V .
LS180 SNV: p.V312M .
MCC13 SNV: p.G37E .
MCC26 SNV: p.E663Q .
MELJUSO SNV: p.P104T .
NCIH1666 SNV: p.V406L .
NCIH1703 SNV: p.A4S; p.D712Y .
NCIH1944 SNV: p.V612E .
NCIH2286 SNV: p.F389L; p.M390I; p.L970F .
NCIH23 SNV: p.G630V .
REH SNV: p.G319R .
RT112 SNV: p.E424Q .
RVH421 SNV: p.R741K .
SUPT1 SNV: p.I540T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.47  LDD0054  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0008  Tranylcypromine SH-SY5Y 2.47  LDD0054  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580