Details of the Target

General Information of Target

Target ID LDTP02865
Target Name Carboxypeptidase E (CPE)
Gene Name CPE
Gene ID 1363
Synonyms
Carboxypeptidase E; CPE; EC 3.4.17.10; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELR
EALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVG
RELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRS
NAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIP
FVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPC
RKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWED
NKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYK
LTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase M14 family
Subcellular location
Cytoplasmic vesicle, secretory vesicle
Function
Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
TTD ID
T46546
Uniprot ID
P16870
DrugMap ID
TTXPWO6
Ensemble ID
ENST00000402744.9
HGNC ID
HGNC:2303

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.H210L .
HUPT3 SNV: p.A226D .
KYSE30 SNV: p.M326I .
LNCaP clone FGC SNV: p.G31A .
LS513 SNV: p.A266V .
PF382 SNV: p.G85D; p.Y258H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.17  LDD0054  [1]
DBIA
 Probe Info  		C300(0.94)  LDD1508  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		12.21  LDD1850  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C300(0.94)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C300(1.32)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C300(0.95)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C300(1.08)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C300(0.85)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C300(1.23)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C300(1.44)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C300(0.80)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C300(1.04)  LDD1522  [2]
 LDCM0286  AC26 HEK-293T C300(1.12)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C300(1.14)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C300(0.94)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C300(1.25)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C300(1.00)  LDD1531  [2]
 LDCM0295  AC34 HEK-293T C300(0.93)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C300(1.09)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C300(1.00)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C300(0.87)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C300(0.85)  LDD1540  [2]
 LDCM0304  AC42 HEK-293T C300(1.71)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C300(1.16)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C300(0.88)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C300(1.21)  LDD1548  [2]
 LDCM0313  AC50 HEK-293T C300(1.21)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C300(1.20)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C300(1.12)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C300(0.93)  LDD1557  [2]
 LDCM0321  AC58 HEK-293T C300(1.04)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C300(1.03)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C300(0.98)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C300(1.03)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C300(0.98)  LDD1568  [2]
 LDCM0367  CL1 HEK-293T C300(1.27)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C300(1.32)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C300(1.19)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C300(1.04)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C300(1.21)  LDD1583  [2]
 LDCM0383  CL113 HEK-293T C300(1.50)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C300(1.18)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C300(1.38)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C300(1.11)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C300(1.03)  LDD1604  [2]
 LDCM0405  CL18 HEK-293T C300(1.06)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C300(1.33)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C300(0.84)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C300(1.05)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C300(1.34)  LDD1617  [2]
 LDCM0419  CL30 HEK-293T C300(0.81)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C300(1.04)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C300(0.94)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C300(0.86)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C300(1.12)  LDD1630  [2]
 LDCM0432  CL42 HEK-293T C300(0.88)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C300(1.10)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C300(1.01)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C300(1.02)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C300(1.42)  LDD1643  [2]
 LDCM0445  CL54 HEK-293T C300(1.45)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C300(1.07)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C300(1.11)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C300(1.09)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C300(0.79)  LDD1654  [2]
 LDCM0453  CL61 HEK-293T C300(1.25)  LDD1656  [2]
 LDCM0458  CL66 HEK-293T C300(1.28)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C300(1.17)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C300(0.78)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C300(1.12)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C300(0.97)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C300(1.22)  LDD1669  [2]
 LDCM0471  CL78 HEK-293T C300(0.62)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C300(1.01)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C300(0.80)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C300(0.86)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C300(1.10)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C300(1.04)  LDD1682  [2]
 LDCM0485  CL90 HEK-293T C300(0.73)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C300(1.19)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C300(0.81)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C300(1.02)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C300(1.33)  LDD1695  [2]
 LDCM0008  Tranylcypromine SH-SY5Y 2.17  LDD0054  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Insulin Human BiotechDrug DB00030
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587