Details of the Target

General Information of Target

Target ID LDTP04650
Target Name Microfibrillar-associated protein 2 (MFAP2)
Gene Name MFAP2
Gene ID 4237
Synonyms
MAGP1; Microfibrillar-associated protein 2; MFAP-2; Microfibril-associated glycoprotein 1; MAGP; MAGP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRAAYLFLLFLPAGLLAQGQYDLDPLPPFPDHVQYTHYSDQIDNPDYYDYQEVTPRPSEE
QFQFQSQQQVQQEVIPAPTPEPGNAELEPTEPGPLDCREEQYPCTRLYSIHRPCKQCLNE
VCFYSLRRVYVINKEICVRTVCAHEELLRADLCRDKFSKCGVMASSGLCQSVAASCARSC
GSC
Target Bioclass
Other
Family
MFAP family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Component of the elastin-associated microfibrils.
Uniprot ID
P55001
Ensemble ID
ENST00000375534.7
HGNC ID
HGNC:7033

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C142(4.38)  LDD3469  [2]
FBPP2
 Probe Info  		2.26  LDD0054  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C169(0.98)  LDD1571  [5]
 LDCM0370  CL101 HEK-293T C169(0.73)  LDD1574  [5]
 LDCM0374  CL105 HEK-293T C169(0.87)  LDD1578  [5]
 LDCM0378  CL109 HEK-293T C169(1.40)  LDD1582  [5]
 LDCM0383  CL113 HEK-293T C169(0.90)  LDD1587  [5]
 LDCM0387  CL117 HEK-293T C169(0.82)  LDD1591  [5]
 LDCM0392  CL121 HEK-293T C169(0.90)  LDD1596  [5]
 LDCM0396  CL125 HEK-293T C169(0.98)  LDD1600  [5]
 LDCM0400  CL13 HEK-293T C169(0.75)  LDD1604  [5]
 LDCM0413  CL25 HEK-293T C169(0.83)  LDD1617  [5]
 LDCM0426  CL37 HEK-293T C169(0.93)  LDD1630  [5]
 LDCM0439  CL49 HEK-293T C169(1.12)  LDD1643  [5]
 LDCM0453  CL61 HEK-293T C169(1.00)  LDD1656  [5]
 LDCM0466  CL73 HEK-293T C169(0.71)  LDD1669  [5]
 LDCM0479  CL85 HEK-293T C169(0.98)  LDD1682  [5]
 LDCM0492  CL97 HEK-293T C169(0.95)  LDD1695  [5]
 LDCM0022  KB02 A204 C84(1.67); C142(1.77)  LDD2252  [2]
 LDCM0023  KB03 A204 C84(1.81)  LDD2669  [2]
 LDCM0024  KB05 TE4 C142(4.38)  LDD3469  [2]
 LDCM0008  Tranylcypromine SH-SY5Y 2.26  LDD0054  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402