Details of the Target

General Information of Target

Target ID LDTP12874
Target Name ADP-ribosylation factor-binding protein GGA3 (GGA3)
Gene Name GGA3
Gene ID 23163
Synonyms
KIAA0154; ADP-ribosylation factor-binding protein GGA3; Golgi-localized, gamma ear-containing, ARF-binding protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLTSSSSVRVEWIAAVTIAAGTAAIGYLAYKRFYVKDHRNKAMINLHIQKDNPKIVHAF
DMEDLGDKAVYCRCWRSKKFPFCDGAHTKHNEETGDNVGPLIIKKKET
Target Bioclass
Transporter and channel
Family
GGA protein family
Subcellular location
Golgi apparatus, trans-Golgi network membrane
Function
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation. Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination. Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane.
Uniprot ID
Q9NZ52
Ensemble ID
ENST00000537686.6
HGNC ID
HGNC:17079

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.M1? .
AGS SNV: p.D333N .
DOTC24510 SNV: p.E270Q DBIA    Probe Info 
HCC1143 SNV: p.P574L .
HCT116 SNV: p.L632V .
HEC1 SNV: p.A362D; p.P542H .
HEC1B SNV: p.P542H .
ICC8 SNV: p.E393G .
NCIH1155 SNV: p.A345T DBIA    Probe Info 
NCIH3122 SNV: p.A596D .
REH SNV: p.D242N .
SKHEP1 SNV: p.N633K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K100(5.15)  LDD0277  [1]
m-APA
 Probe Info  		11.38  LDD0403  [2]
DBIA
 Probe Info  		C255(1.68)  LDD3332  [3]
FBPP2
 Probe Info  		4.93  LDD0054  [4]
DA-P3
 Probe Info  		4.89  LDD0180  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C617(0.00); C72(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C255(0.87); C617(0.85)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C255(0.88)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C255(1.05); C617(1.09)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C255(0.93)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C255(1.01); C617(1.02)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C255(0.91); C617(1.11)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C255(0.91); C617(1.01)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C255(0.93)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C255(0.84); C617(0.93)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C255(1.12)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C255(0.91)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C255(0.91); C617(0.84)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C255(0.86); C617(1.03)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C255(0.93); C617(1.07)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C255(1.00)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C255(0.93); C617(0.81)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C255(0.89)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C255(0.96); C617(0.91)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C255(0.97)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C255(0.95); C617(0.89)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C255(0.94); C617(0.91)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C255(0.95); C617(0.99)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C255(0.94); C617(1.01)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C255(1.02)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C255(0.76); C617(0.92)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C255(0.96)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C255(0.92); C617(1.10)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C255(0.93)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C255(1.05); C617(0.91)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C255(1.02); C617(1.10)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C255(0.90); C617(1.04)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C255(0.96)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C255(0.95)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C255(0.81); C617(1.05)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C255(0.92)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C255(0.93); C617(0.98)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C255(0.94)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C255(1.04); C617(0.90)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C255(1.08); C617(1.25)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C255(0.91); C617(1.01)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C255(1.01)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C255(0.94); C617(1.03)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C255(1.06); C617(0.79)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C255(0.93)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C255(0.98); C617(1.01)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C255(0.98)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C255(0.97); C617(0.89)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C255(0.96); C617(1.02)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C255(0.85); C617(1.06)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C255(0.88)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C255(0.87); C617(0.89)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C255(0.95)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C255(0.91); C617(1.03)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C255(1.01); C617(0.89)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C255(0.89)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C255(0.93); C617(1.08)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C255(1.03); C617(1.04)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C255(0.88); C617(1.00)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C255(1.11)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C255(0.89); C617(1.00)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C255(0.91)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C255(1.07); C617(1.00)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C255(0.90); C617(0.91)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C255(0.87)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [2]
 LDCM0367  CL1 HEK-293T C255(0.88); C617(1.01)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C255(0.92); C617(0.93)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C617(0.95)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C255(0.85); C617(0.88)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C255(1.03); C617(0.89)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C255(0.92)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C617(1.08)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C255(0.88); C617(0.90)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C255(1.09); C617(0.85)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C255(1.00)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C617(1.01)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C255(0.93); C617(1.06)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C255(0.91); C617(1.04)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C255(0.97); C617(0.87)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C255(1.01)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C617(1.03)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C255(0.88); C617(1.00)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C255(0.87); C617(0.93)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C255(0.99)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C617(0.92)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C255(0.97); C617(1.19)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C255(0.97); C617(0.96)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C255(0.91)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C255(0.90)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C617(0.92)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C255(0.87); C617(1.04)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C255(0.94); C617(1.03)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C255(0.91)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C617(0.82)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C255(0.89); C617(1.28)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C255(0.93); C617(0.99)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C255(0.90)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C617(0.96)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C255(0.93); C617(0.99)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C255(0.91); C617(0.93)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C255(0.98)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C617(0.97)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C255(0.82); C617(0.86)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C255(0.94)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C255(0.97); C617(1.07)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C255(0.93); C617(0.89)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C255(0.99)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C255(0.89); C617(1.07)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C255(1.02); C617(1.16)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C255(0.94); C617(1.02)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C255(1.00)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C255(0.84); C617(1.00)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C255(0.85); C617(0.91)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C255(0.94)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C617(0.91)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C255(0.92); C617(0.96)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C255(0.96)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C255(0.99)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C255(0.91); C617(1.00)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C255(0.96)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C255(0.90); C617(0.94)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C255(0.98); C617(0.87)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C255(0.95); C617(0.91)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C255(0.99)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C255(0.86); C617(1.00)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C255(1.08)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C617(0.84)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C617(1.15)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C255(0.90); C617(1.00)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C255(1.00)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C255(1.04); C617(1.06)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C255(0.98)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C255(0.96); C617(0.93)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C255(1.04); C617(1.03)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C255(1.04); C617(0.95)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C255(0.93)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C255(0.91); C617(0.95)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C255(0.86); C617(1.04)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C255(0.96); C617(0.93)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C617(0.95)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C255(0.87); C617(0.87)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C255(0.90)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C255(0.94); C617(1.07)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C255(1.05)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C255(1.01); C617(1.15)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C255(1.07); C617(1.04)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C255(0.96); C617(0.98)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C255(0.90)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C255(0.93)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C255(0.90); C617(0.92)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C255(0.96); C617(0.87)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C255(0.94)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C617(0.95)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C255(0.93); C617(1.13)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C255(1.01)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C255(0.98); C617(1.05)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C255(0.97)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C255(0.96); C617(1.14)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C255(0.95); C617(1.04)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C255(1.08); C617(1.06)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C255(1.03); C617(1.00)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C255(0.93)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C255(0.90); C617(0.94)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C255(0.99); C617(0.98)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C617(0.88)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C255(0.88); C617(0.75)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C255(0.99)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C255(1.01); C617(1.03)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C255(0.74)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C255(1.05)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C255(1.13); C617(1.05)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C255(1.12); C617(1.18)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C255(0.91); C617(1.05)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C255(0.95)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C255(0.86); C617(1.23)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C255(0.93); C617(1.03)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C255(1.00)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C617(0.93)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C255(0.84); C617(0.95)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C255(1.06); C617(1.02)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C255(0.88)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C255(1.00); C617(0.97)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C255(0.92)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C255(0.98); C617(1.17)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C255(1.13); C617(1.11)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C255(0.82); C617(0.96)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C255(0.92)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C255(1.00); C617(0.95)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C255(0.92); C617(0.96)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C255(1.02)  LDD1697  [8]
 LDCM0028  Dobutamine HEK-293T 4.89  LDD0180  [5]
 LDCM0495  E2913 HEK-293T C255(0.96)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C255(1.11)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C255(0.93); C617(0.94)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C255(1.07)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C255(1.00)  LDD1497  [8]
 LDCM0024  KB05 MKN45 C255(1.68)  LDD3332  [3]
 LDCM0008  Tranylcypromine SH-SY5Y 4.93  LDD0054  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Beta-secretase 1 (BACE1) Peptidase A1 family P56817
ADP-ribosylation factor 6 (ARF6) Arf family P62330
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Uracil phosphoribosyltransferase homolog (UPRT) UPRTase family Q96BW1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-binding protein GGA1 (GGA1) GGA protein family Q9UJY5
Cation-independent mannose-6-phosphate receptor (IGF2R) MRL1/IGF2R family P11717
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
ADP-ribosylation factor-binding protein GGA2 (GGA2) GGA protein family Q9UJY4
Phosphofurin acidic cluster sorting protein 1 (PACS1) PACS family Q6VY07
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Polyubiquitin-B (UBB) Ubiquitin family P0CG47
DAZ-associated protein 2 (DAZAP2) . Q15038
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402