Details of the Target

General Information of Target

Target ID LDTP10889
Target Name Perilipin-2 (PLIN2)
Gene Name PLIN2
Gene ID 123
Synonyms
ADFP; Perilipin-2; Adipophilin; Adipose differentiation-related protein; ADRP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
Target Bioclass
Other
Family
Perilipin family
Subcellular location
Membrane
Function Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Uniprot ID
Q99541
Ensemble ID
ENST00000276914.7
HGNC ID
HGNC:248

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TG42
 Probe Info  		5.38  LDD0326  [3]
W1
 Probe Info  		28.71  LDD0235  [4]
TH211
 Probe Info  		Y82(10.02); Y216(7.99)  LDD0257  [5]
TH216
 Probe Info  		Y82(12.98); Y217(5.11)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
STPyne
 Probe Info  		K243(1.69); K265(6.25)  LDD0277  [7]
BTD
 Probe Info  		C47(0.65)  LDD2095  [8]
FBPP2
 Probe Info  		2.46  LDD0054  [9]
AHL-Pu-1
 Probe Info  		C302(5.20)  LDD0171  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
IA-alkyne
 Probe Info  		C302(20.00)  LDD1706  [12]
Acrolein
 Probe Info  		N.A.  LDD0225  [13]
DBIA
 Probe Info  		C84(1.68)  LDD0080  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		C302(0.00); C325(0.00)  LDD2226  [16]
TFBX
 Probe Info  		C47(0.00); C302(0.00)  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		N.A.  LDD0010  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		5.46  LDD0398  [19]
C362
 Probe Info  		43.71  LDD2023  [20]
FFF probe11
 Probe Info  		20.00  LDD0471  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe2
 Probe Info  		20.00  LDD0463  [21]
FFF probe3
 Probe Info  		20.00  LDD0465  [21]
A-DA
 Probe Info  		9.04  LDD0143  [22]
OEA-DA
 Probe Info  		20.00  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C47(0.65)  LDD2095  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C302(5.20)  LDD0171  [10]
 LDCM0259  AC14 HEK-293T C84(1.03)  LDD1512  [24]
 LDCM0282  AC22 HEK-293T C84(1.01)  LDD1521  [24]
 LDCM0291  AC30 HEK-293T C84(1.03)  LDD1530  [24]
 LDCM0299  AC38 HEK-293T C84(1.21)  LDD1538  [24]
 LDCM0308  AC46 HEK-293T C84(1.13)  LDD1547  [24]
 LDCM0317  AC54 HEK-293T C84(1.06)  LDD1556  [24]
 LDCM0323  AC6 HEK-293T C84(1.03)  LDD1562  [24]
 LDCM0326  AC62 HEK-293T C84(0.91)  LDD1565  [24]
 LDCM0156  Aniline NCI-H1299 12.99  LDD0403  [1]
 LDCM0083  Avasimibe A-549 9.04  LDD0143  [22]
 LDCM0368  CL10 HEK-293T C84(1.04)  LDD1572  [24]
 LDCM0410  CL22 HEK-293T C84(1.04)  LDD1614  [24]
 LDCM0423  CL34 HEK-293T C84(1.04)  LDD1627  [24]
 LDCM0436  CL46 HEK-293T C84(1.07)  LDD1640  [24]
 LDCM0449  CL58 HEK-293T C84(0.88)  LDD1652  [24]
 LDCM0463  CL70 HEK-293T C84(1.19)  LDD1666  [24]
 LDCM0476  CL82 HEK-293T C84(1.04)  LDD1679  [24]
 LDCM0489  CL94 HEK-293T C84(1.10)  LDD1692  [24]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0022  KB02 HCT 116 C84(1.68)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C84(1.24)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C84(1.51)  LDD0082  [14]
 LDCM0109  NEM HeLa N.A.  LDD0225  [13]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C47(1.46)  LDD2137  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C302(1.35)  LDD2150  [8]
 LDCM0084  Ro 48-8071 A-549 9.15  LDD0145  [22]
 LDCM0008  Tranylcypromine SH-SY5Y 2.46  LDD0054  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deubiquitinase DESI2 (DESI2) DeSI family Q9BSY9
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) Peptidase S33 family Q8WTS1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle transport protein SFT2B (SFT2D2) SFT2 family O95562

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402