Details of the Target

General Information of Target

Target ID LDTP02217
Target Name Procathepsin L (CTSL)
Gene Name CTSL
Gene ID 1514
Synonyms
CTSL1; Procathepsin L; EC 3.4.22.15; Cathepsin L1; Major excreted protein; MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase C1 family
Subcellular location
Lysosome; Nucleus
Function
Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter. In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation. Secreted form generates endostatin from COL18A1. Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation. Required for maximal stimulation of steroidogenesis by TIMP1.; (Microbial infection) In cells lacking TMPRSS2 expression, facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via a slow acid-activated route with the proteolysis of coronavirus spike (S) glycoproteins in lysosome for entry into host cell. Proteolysis within lysosomes is sufficient to activate membrane fusion by coronaviruses SARS-CoV and EMC (HCoV-EMC) S as well as Zaire ebolavirus glycoproteins.; [Isoform 2]: Functions in the regulation of cell cycle progression through proteolytic processing of the CUX1 transcription factor. Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and localize to the nucleus where they cleave the CUX1 transcription factor and modify its DNA binding properties.
TTD ID
T41141
Uniprot ID
P07711
DrugMap ID
TTS586L
Ensemble ID
ENST00000340342.11
HGNC ID
HGNC:2537
ChEMBL ID
CHEMBL3837

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.S290Ter .
CORL88 SNV: p.E26Q .
HEC1B SNV: p.L235P .
HT115 SNV: p.G13Ter .
KMCH1 SNV: p.C178F .
LNCaP clone FGC SNV: p.G177D .
SKMEL24 SNV: p.P3L .
SKMEL30 SNV: p.S326L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		20.00  LDD0387  [1]
FBP2
 Probe Info  		6.87  LDD0317  [2]
BTD
 Probe Info  		C322(0.38)  LDD2127  [3]
FBPP2
 Probe Info  		7.07  LDD0054  [2]
Acrolein
 Probe Info  		N.A.  LDD0231  [4]
DBIA
 Probe Info  		C138(0.97)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		55.33  LDD1850  [7]
C171
 Probe Info  		15.56  LDD1851  [7]
C363
 Probe Info  		22.63  LDD2024  [7]
C364
 Probe Info  		25.28  LDD2025  [7]
BD-F
 Probe Info  		P244(0.00); S255(0.00); D250(0.00); A251(0.00)  LDD0024  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C135(0.60); C138(1.02)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C135(0.70); C138(0.74)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C135(1.48)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C135(1.46)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C135(1.41)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C135(1.05)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C135(0.91)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C135(1.87)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C135(1.71)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C135(1.43)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C135(1.34)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C135(1.39)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C135(0.66); C138(1.16)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C135(1.38)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C135(1.82)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C135(1.34)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C135(0.66); C138(0.66)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C135(0.51); C138(0.51)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C135(0.45); C138(0.45)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C135(0.34); C138(0.34)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C135(0.41); C138(0.41)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C135(0.58); C138(0.58)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C135(0.27); C138(0.27)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C135(0.70); C138(0.86)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C135(0.24); C138(0.24)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C135(0.44); C138(0.44)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C135(0.65); C138(0.65)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C135(0.46); C138(0.46)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C135(0.73); C138(0.73)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C135(0.48); C138(0.48)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C135(0.48); C138(0.48)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C135(0.47); C138(0.47)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C135(1.53); C138(0.80)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C135(1.78); C138(1.30)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C135(1.47); C138(1.00)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C135(1.34); C138(0.90)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C135(1.42); C138(0.97)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C135(1.58); C138(1.00)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C135(1.36); C138(1.04)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C135(1.49); C138(1.22)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C135(1.24); C138(0.87)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C135(0.81); C138(0.66)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C135(1.56); C138(1.14)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C135(1.32); C138(0.80)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C135(0.91); C138(1.03)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C135(1.51); C138(0.97)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C135(1.32); C138(0.88)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C135(1.82); C138(1.51)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C135(1.39); C138(1.38)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C135(0.84); C138(1.12)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C138(1.04); C135(1.18)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C138(0.93); C135(0.98)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C135(0.68); C138(1.14)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C135(0.76); C138(0.88)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C138(1.66); C135(1.70)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C135(0.89); C138(0.97)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C135(0.69); C138(0.81)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C135(0.82); C138(1.13)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C135(0.68); C138(0.71)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C135(0.81); C138(0.88)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C135(0.88); C138(0.94)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C135(1.06); C138(1.17)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C135(1.55); C138(1.32)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C135(3.00); C138(1.82)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C135(1.10); C138(1.11)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C138(0.82); C135(0.94)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C138(0.83); C135(0.90)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C135(0.85); C138(1.17)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C135(0.92); C138(0.93)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C138(0.73); C135(0.79)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C135(1.13); C138(1.19)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C135(1.16); C138(1.26)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C138(1.23); C135(1.36)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C138(0.99)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C138(0.81)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C138(0.85)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C138(1.03)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C138(0.74)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C135(0.68); C138(1.23)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C138(0.94)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C138(0.97)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C138(1.43)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C138(1.52)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C138(1.07)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C135(0.89); C138(1.09)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C135(0.88); C138(0.52)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C135(0.83); C138(1.05)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C135(0.94); C138(0.97)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C135(0.94); C138(1.15)  LDD0898  [5]
 LDCM0301  AC4 HCT 116 C135(0.74); C138(0.93)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C135(0.81); C138(0.68)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C135(0.87); C138(0.82)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C135(0.93); C138(0.72)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C135(0.92); C138(0.95)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C135(1.33); C138(0.93)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C135(0.89); C138(0.96)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C138(1.01)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C138(0.89)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C138(0.90)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C138(0.95)  LDD0909  [5]
 LDCM0312  AC5 HCT 116 C135(0.66); C138(1.05)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C138(1.20)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C138(1.03)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C138(0.88)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C138(1.28)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C138(1.05)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C138(0.80)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C138(1.05)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C138(0.98)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C138(1.05)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C138(1.04)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C135(1.03); C138(1.54)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C138(1.01)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C138(1.05)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C138(0.97)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C138(1.10)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C138(0.93)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C138(1.02)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C138(1.19)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C138(0.93)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C135(0.84); C138(0.97)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C135(0.88); C138(1.03)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C135(1.09); C138(1.13)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C138(0.80); C135(0.87)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C135(0.80); C138(0.90)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C135(1.32); C138(1.47)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C135(0.95); C138(1.17)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C135(0.96); C138(1.18)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C135(1.00); C138(1.13)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C135(0.88); C138(1.04)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C135(1.17); C138(1.42)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C135(1.09); C138(1.25)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C135(0.92); C138(1.00)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C138(0.94); C135(1.05)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C135(0.99); C138(1.16)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C135(0.81); C138(0.85)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C138(0.58); C135(0.60)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C135(1.15); C138(1.30)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C138(1.09); C135(1.14)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C138(1.04); C135(1.34)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C138(0.99); C135(1.11)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C135(1.07); C138(1.28)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C138(0.86); C135(1.09)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C138(0.70); C135(1.03)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C135(1.13); C138(1.40)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C138(0.75); C135(1.01)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C135(1.20); C138(1.30)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C138(1.05); C135(1.25)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C138(0.60); C135(1.21)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C138(0.95); C135(1.11)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C138(0.84); C135(1.11)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C138(0.93); C135(1.23)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C135(1.54)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C135(1.44)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C135(0.86); C138(0.72)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C135(0.81); C138(1.41)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C138(0.90); C135(1.26)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C138(0.97)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C135(1.27)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C135(1.40)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C135(0.56); C138(0.95)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C135(1.07); C138(1.63)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C135(0.86); C138(0.87)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C135(0.88); C138(1.45)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C135(0.92); C138(1.19)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C135(0.78); C138(0.82)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C138(0.72); C135(0.72)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C138(0.71); C135(0.73)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C135(0.63); C138(0.70)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C138(0.71); C135(0.81)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C135(1.25)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C135(0.71); C138(0.73)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C138(0.83); C135(0.93)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C138(0.87)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C138(0.98)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C138(1.15)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C138(1.07)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C138(1.43)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C135(0.82); C138(0.86)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C135(0.74); C138(0.64)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C135(0.89); C138(0.75)  LDD0987  [5]
 LDCM0390  CL12 HCT 116 C135(1.14)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C135(0.89); C138(0.96)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C138(0.97)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C138(1.07)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C138(0.83)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C138(1.07)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C138(1.08)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C138(2.51)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C138(1.56)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C138(0.85)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C135(1.27)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C135(1.27)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C135(1.01)  LDD0719  [5]
 LDCM0403  CL16 PaTu 8988t C138(0.79); C135(0.79)  LDD1282  [5]
 LDCM0404  CL17 HCT 116 C135(0.94)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C135(0.93)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C135(0.95)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C135(1.58)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C135(1.12)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C135(0.99)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C135(1.41)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C135(1.07)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C135(0.98)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C135(0.79)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C135(0.89)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C135(0.98)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C135(0.99)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C135(1.43)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C135(0.82)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C135(0.81)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C135(0.93)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C135(1.02)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C135(1.00)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C135(2.10)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C135(1.27)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C135(2.58)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C135(1.24)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C135(0.98)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C135(1.43)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C135(2.60)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C135(1.48)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C135(1.07)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C135(1.26)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C135(0.92)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C135(1.09)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C135(0.89)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C135(1.01)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C135(2.05)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C135(0.96)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C135(0.89)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C135(1.12)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C135(0.92)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C135(1.17)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C135(1.37)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C135(0.91)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C135(0.92)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C135(0.94)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C135(1.48)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C135(1.35)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C135(0.94)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C135(1.13)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C135(1.07)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C138(1.33)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C138(0.94)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C138(1.01)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C138(1.13)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C138(1.01)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C138(1.21)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C138(0.97)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C138(1.01)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C138(1.15)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C135(1.07)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C138(1.10)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C138(1.06)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C138(0.85)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C138(1.07)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C138(1.24)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C135(0.99); C138(1.03)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C135(0.94); C138(0.81)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C135(1.06); C138(1.09)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C135(1.03); C138(0.94)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C135(1.03)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C135(1.35); C138(1.40)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C135(0.97); C138(1.01)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C135(0.73); C138(0.86)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C135(0.82); C138(0.87)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C135(0.92); C138(0.94)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C135(0.90); C138(0.85)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C135(0.76); C138(0.79)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C135(1.02); C138(0.95)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C135(0.87); C138(0.87)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C135(0.80); C138(0.88)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C135(1.19)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C135(0.98); C138(0.86)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C135(1.35); C138(1.17)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C135(1.30); C138(0.94)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C135(1.00); C138(0.84)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C135(0.76); C138(1.42)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C135(1.12); C138(0.78)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C135(1.16); C138(1.35)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C135(0.97); C138(1.25)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C135(1.06); C138(1.02)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C135(0.81); C138(0.92)  LDD0811  [5]
 LDCM0468  Fragment33 HCT 116 C138(1.01)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C135(1.20)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C135(1.61)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C135(3.00)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C135(2.18)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0231  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C322(0.38)  LDD2127  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C322(1.17)  LDD2137  [3]
 LDCM0008  Tranylcypromine SH-SY5Y 7.07  LDD0054  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Trastuzumab Deruxtecan . DB14962
Clinical trial
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Kgp94 Small molecular drug D0X6QL
Preclinical
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Clik-148 Small molecular drug DW24LQ
Clik-181 Small molecular drug DYU3I8
L-006235-1 Small molecular drug D0Z0PR
Sd1002 Small molecular drug DCZ16N
Sd1003 Small molecular drug DSM03D
Z-phe-ala-diazomethylketone Small molecular drug DM69TL
Investigative
Click To Hide/Show 30 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(3-bromobenzoylpyridine)Thiosemicarbazone Small molecular drug D09NBP
(S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate Small molecular drug D0VE0F
(S)-tert-butyl 1-oxohexan-2-ylcarbamate Small molecular drug D0T7QF
1-(1,3-diphenylpropylidene)Thiosemicarbazide Small molecular drug D0B4JS
1-(Phenyl(P-tolyl)Methylene)Thiosemicarbazide Small molecular drug D03JYN
6-(Benzylamino)-9-butyl-9h-purine-2-carbonitrile Small molecular drug D0J7OM
9-benzyl-6-(Benzylamino)-9h-purine-2-carbonitrile Small molecular drug D0MD6D
Biphenyl-4-yl-acetaldehyde Small molecular drug D02RWL
Bis(3-bromophenyl)(4-hydroxy)Thiosemicarbazone Small molecular drug D04DFX
Bis(3-bromophenyl)(5-hydroxy)Thiosemicarbazone Small molecular drug D01CSE
Bis(3-fluorophenyl)-ketone]Thiosemicarbazone Small molecular drug D0M3AP
Caa0225 Small molecular drug D01YTS
Cysteinesulfonic Acid Small molecular drug D05AMX
Felbinac Small molecular drug DB07477
L-873724 Small molecular drug D0D0LD
L-cysteic Acid Small molecular drug DB03661
N-(4-phenylbenzoyl)-phenylalanyl-glycine-nitrile Small molecular drug D07RSA
N-(Benzyloxycarbonyl)-leucyl-glycine-nitrile Small molecular drug D0G8OD
N-(Tert-butoxycarbonyl)-isoleucyl-glycine-nitrile Small molecular drug D01YNC
N-(Tert-butoxycarbonyl)-leucyl-glycine-nitrile Small molecular drug D09AHN
N-(Tert-butoxycarbonyl)-methionyl-glycine-nitrile Small molecular drug D0U0XG
N-(Tert-butoxycarbonyl)-norleucyl-glycine-nitrile Small molecular drug D07FLB
N-(Tert-butoxycarbonyl)-tyrosyl-glycine-nitrile Small molecular drug D0JF8D
N-(Tert-butoxycarbonyl)-valyl-glycine-nitrile Small molecular drug D06VIP
N-acetyl-phenylalanyl-glycine-nitrile Small molecular drug D0A8OV
N-benzoyl-phenylalanyl-glycine-nitrile Small molecular drug D0JN8Q
Peptide Alpha-keto-beta-aldehyde-based Inhibitors Small molecular drug D08TWJ
[(3-bromophenyl)-m-tolyl-ketone]Thiosemicarbazone Small molecular drug D00VAN
[(3-bromophenyl)-p-tolyl-ketone]Thiosemicarbazone Small molecular drug D0B2JC
[2-phenylacetophenone]Thiosemicarbazone Small molecular drug D0LL1F
Patented
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenylalanine Derivative 1 Small molecular drug D01MKD
Pmid25399719-compound-17 Small molecular drug D06LLT
Pmid27998201-compound-1 Small molecular drug D0J0WG
Pmid27998201-compound-12 Small molecular drug D06XCD
Pmid27998201-compound-17 Small molecular drug D06XTA
Pmid27998201-compound-19 Small molecular drug D0ZN3M
Pmid27998201-compound-5 Small molecular drug D05OIU
Pmid27998201-compound-6 Small molecular drug D0X1AF
Pmid27998201-compound-7 Small molecular drug D0JD5W
Pmid27998201-compound-9 Small molecular drug D04VGR

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652