Details of the Target

General Information of Target

Target ID LDTP17246
Target Name Sodium-dependent glucose transporter 1 (MFSD4B)
Gene Name MFSD4B
Gene ID 91749
Synonyms
KIAA1919; NAGLT1; Sodium-dependent glucose transporter 1; Major facilitator superfamily domain-containing protein 4B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQPPIGGAAPATAAASPAAAATEARLHPEGSSRKQQRAQSPARPRDSSLRQTIAATRSP
VGAGTKLNSVRQQQLQQQQQQGNKTGSRTGPPASIRGGGGGAEKATPLAPKGAAPGAVQP
VAGAEAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEPPPLGEGGGGGGEGGGAGGGS
GEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAG
GGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRSSPVSGPPAVC
ETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEEMEKLR
EENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKR
LRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVE
IAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMR
KKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANI
LGRKIVELEVENRGLKAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLR
RNVADLEEQNKRITAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVM
QLQYENRVLMSNMQRYDLASHLGIRGSPRDSDAESDAGKKESDDDSRPPHRKREGPIGGE
SDSEEVRNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTSTII
TEARIYVANGDLFGLMDEEDDGSRIREHELLYRINAQMKAFRKELQTFIDRLEVPKSADD
RGAEEPISVSQMFQPIILLILILVLFSSLSYTTIFKLVFLFTLFFVL
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily
Subcellular location
Apical cell membrane
Function May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.
Uniprot ID
Q5TF39
Ensemble ID
ENST00000671876.2
HGNC ID
HGNC:21053

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.75  LDD0054  [1]
DBIA
 Probe Info  		C281(0.98)  LDD1509  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C281(0.98)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C281(0.99)  LDD1512  [2]
 LDCM0278  AC19 HEK-293T C281(0.74)  LDD1517  [2]
 LDCM0282  AC22 HEK-293T C281(1.07)  LDD1521  [2]
 LDCM0287  AC27 HEK-293T C281(1.01)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C281(1.04)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C281(0.83)  LDD1530  [2]
 LDCM0296  AC35 HEK-293T C281(1.11)  LDD1535  [2]
 LDCM0299  AC38 HEK-293T C281(0.98)  LDD1538  [2]
 LDCM0305  AC43 HEK-293T C281(1.07)  LDD1544  [2]
 LDCM0308  AC46 HEK-293T C281(1.19)  LDD1547  [2]
 LDCM0314  AC51 HEK-293T C281(1.05)  LDD1553  [2]
 LDCM0317  AC54 HEK-293T C281(1.15)  LDD1556  [2]
 LDCM0322  AC59 HEK-293T C281(1.12)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C281(0.85)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C281(1.07)  LDD1565  [2]
 LDCM0368  CL10 HEK-293T C281(0.90)  LDD1572  [2]
 LDCM0406  CL19 HEK-293T C281(0.90)  LDD1610  [2]
 LDCM0410  CL22 HEK-293T C281(1.18)  LDD1614  [2]
 LDCM0420  CL31 HEK-293T C281(0.82)  LDD1624  [2]
 LDCM0423  CL34 HEK-293T C281(1.19)  LDD1627  [2]
 LDCM0433  CL43 HEK-293T C281(0.74)  LDD1637  [2]
 LDCM0436  CL46 HEK-293T C281(1.00)  LDD1640  [2]
 LDCM0446  CL55 HEK-293T C281(0.83)  LDD1649  [2]
 LDCM0449  CL58 HEK-293T C281(0.96)  LDD1652  [2]
 LDCM0459  CL67 HEK-293T C281(0.88)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C281(0.85)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C281(1.09)  LDD1666  [2]
 LDCM0472  CL79 HEK-293T C281(0.91)  LDD1675  [2]
 LDCM0476  CL82 HEK-293T C281(0.76)  LDD1679  [2]
 LDCM0486  CL91 HEK-293T C281(1.17)  LDD1689  [2]
 LDCM0489  CL94 HEK-293T C281(1.03)  LDD1692  [2]
 LDCM0008  Tranylcypromine SH-SY5Y 3.75  LDD0054  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Major facilitator superfamily domain-containing protein 6 (MFSD6) MFSD6 family Q6ZSS7

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402