Details of the Target

General Information of Target

Target ID LDTP03748
Target Name Alpha-L-iduronidase (IDUA)
Gene Name IDUA
Gene ID 3425
Synonyms
Alpha-L-iduronidase; EC 3.2.1.76
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPLRPRAALLALLASLLAAPPVAPAEAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQ
ADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDL
LRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETW
NEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRH
CHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFADTPIYNDEA
DPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPF
AQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGV
LASAHRPQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGL
CSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHV
CARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPS
TFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 39 family
Subcellular location
Lysosome
TTD ID
T98430
Uniprot ID
P35475
DrugMap ID
TT0IUKX
Ensemble ID
ENST00000247933.9
HGNC ID
HGNC:5391
ChEMBL ID
CHEMBL5169131

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P631L .
ETK1 SNV: p.L216M .
HCC827 SNV: p.P357A .
HCT15 SNV: p.E508D .
IM95 Substitution: p.D203G .
JURKAT SNV: p.F247L .
MDAMB231 SNV: p.F352L .
MFE319 SNV: p.G129W .
MOLT4 SNV: p.A211D .
NCIH2172 SNV: p.K598T .
REH SNV: p.P510Q .
RL952 SNV: p.R527H .
SKMEL2 SNV: p.M133I .
SW1116 SNV: p.L334P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.52  LDD0054  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0008  Tranylcypromine SH-SY5Y 3.52  LDD0054  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Chondroitin Sulfate . DB09301
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sb-318 Gene therapy DYWK46
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rgx-111 Gene therapy D8XHT1

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580